Chulalongkorn University

This study tests whether adding calcitriol to vitamin D2 helps children with cholestatic liver disease correct their vitamin D deficiency faster than vitamin D2 alone. Cholestasis makes it hard for the body to absorb vitamin D. The trial will enroll 54 children and track vitamin …

This study tests whether a blood-filtering device called DPMAS can help people with acute-on-chronic liver failure, a life-threatening condition. The device removes toxins and inflammatory substances from the blood, which may improve immune function and survival. Forty intensive …

This study tests whether empagliflozin, a diabetes drug, can prevent death, new dialysis, or lasting kidney damage in people with cardiorenal syndrome type 1—a condition where heart failure suddenly worsens kidney function. About 200 hospitalized adults will receive either empagl…

This study is testing whether the steroid dexamethasone can help people with severe dengue. The researchers will give either dexamethasone or a placebo to 200 infected adults in Thailand. They want to see if the drug lowers the death rate and shortens hospital stays.

This study tests a special monitor that predicts low blood pressure during dialysis in ICU patients. The goal is to prevent dangerous drops by alerting doctors early. About 46 adults with kidney injury or failure will take part. If successful, this approach could make dialysis sa…

This study compares curcumin nanogels (a natural turmeric extract) to a standard steroid paste for treating atrophic-erosive oral lichen planus, a chronic inflammatory mouth condition. Thirty adults will apply either treatment three times daily for four weeks. Researchers will me…

This early-stage trial is testing a new type of cell therapy called B7H3-IL7Ra CAR T-cells in children and young adults (ages 1-25) whose solid tumors have returned or not responded to standard treatments. The therapy uses the patient's own immune cells, modified in a lab to bett…

This early-stage trial tests a new type of CAR T-cell therapy (CMD63) in 16 children whose B-cell acute lymphoblastic leukemia has returned or not responded to standard treatments. The therapy uses specially engineered immune cells to target and kill cancer cells. The main goal i…

This study tests a new approach for people with motor neuron disease (ALS) that combines personalized brain stimulation with mixed reality exercise games. The goal is to slow disease progression and improve quality of life. One hundred adults with mild to moderate ALS will be ran…

This study is translating and testing a questionnaire called PainPREDICT for Thai-speaking people with diabetes. The goal is to create a mobile app that can screen for painful diabetic neuropathy, a common complication that causes nerve pain. Researchers will check if the Thai ve…

This study tests if mulberry leaf extract capsules are safe for healthy people with slightly high blood sugar. 48 volunteers will take either the extract or a placebo three times a day for 8 weeks. Researchers will check blood counts, liver and kidney function, and blood sugar le…

This study tests a new formula for treating constipation in children aged 6 months to 18 years. It compares the new formula to the standard treatment over 8 weeks, looking at how often children have bowel movements and how easy the medicine is to take. The goal is to find a bette…

This phase 2 trial tests whether a transdermal patch containing ethinyl estradiol and norelgestromin can stop irregular vaginal bleeding in women using contraceptive implants. Forty women over 18 who have abnormal bleeding will apply the patch or a placebo for 21 days. Researcher…

This study follows 70 adults with moderate to severe tooth pain from an infected tooth. Researchers will measure how much pain and quality of life improve after emergency dental treatment, and look at factors like age, tooth type, and treatment method that might affect recovery. …

This study looks at the genes of 47 Thai people with actinic prurigo, a rare skin condition triggered by sunlight. Researchers will compare their DNA to healthy volunteers to find genetic links. The goal is to understand why some people get this disease and why treatments work di…

This study examines whether bariatric surgery changes how the body absorbs drospirenone-only birth control pills in obese Thai women. Sixteen women will take the pill before and after surgery, and researchers will measure drug levels in their blood. The goal is to see if the surg…

This study looks at how a type of birth control pill (Drospirenone-only) changes cervical mucus in obese Thai women who are planning weight-loss surgery. Researchers will measure mucus quality before and after surgery to see if the pill's effects differ. The goal is to understand…

This study is creating a national registry of 100 people with ALS in Thailand. Researchers will collect data on symptoms, genetics, and survival to better understand the disease. The goal is to build a foundation for future research and improve care for ALS patients.