A surgical showdown: can a newer bariatric procedure outsmart blood sugar drops?
NCT ID NCT07747779
First seen Aug 05, 2026 · Last updated Aug 07, 2026 · Updated 2 times
Summary
This trial compares two weight-loss surgeries in people with severe obesity (BMI 50-60). One is the standard Roux-en-Y gastric bypass, the other a newer sleeve gastrectomy with duodenojejunal bypass. The goal is to see which procedure leads to healthier hormone responses after meals, potentially reducing the risk of low blood sugar (hypoglycemia) that can occur after bariatric surgery. By measuring gut hormones like GLP-1 and insulin, researchers hope to understand how each surgery affects metabolism and weight loss.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Two surgical procedures: Roux-en-Y gastric bypass (standard) and sleeve gastrectomy with duodenojejunal bypass (novel)
- What this could lead to
- If the newer surgery causes fewer blood sugar drops after meals, it could become a preferred option for people with super obesity, offering safer long-term weight loss.
- What could go wrong
- This is a small, early study, so results may not apply to everyone. Both surgeries carry risks, and the newer procedure may not prove better in real-world settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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King Chulalongkorn Memorial Hospital
RECRUITINGPathum Wan, Bangkok, 10330, Thailand
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