Can Weight-Loss surgery alter how medications work?
NCT ID NCT07748273
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This study looks at how two common medications, rosuvastatin (a cholesterol drug) and losartan (a blood pressure drug), are absorbed in people who have had weight-loss surgery. Sixty adults scheduled for either Roux-en-Y gastric bypass or sleeve gastrectomy will take a single dose of each drug before and about 12 weeks after surgery. Researchers will measure drug levels in the blood to see if surgery changes how much of the drug gets into the body, and they will also examine stool samples to explore whether gut bacteria play a role.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rosuvastatin and losartan, given as single oral doses before and after bariatric surgery
- What this could lead to
- If successful, this could help doctors adjust medication doses for people after weight-loss surgery, improving treatment safety and effectiveness.
- What could go wrong
- This is a small, early-stage study with only 60 participants, so results may not apply to everyone. It measures drug levels, not health outcomes, and the findings may not lead to immediate clinical changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital das Clínicas, Ribeirão Preto Medical School, University of São Paulo
Ribeirão Preto, São Paulo, 14048900, Brazil
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