Can a new pill help older adults lose weight without losing strength?

This phase 2 trial is testing whether adding an experimental oral drug called LUM-201 to the weight-loss medication semaglutide can improve physical function in older adults with obesity. The study enrolls people aged 60 to 85 with a body mass index (BMI) between 30 and 45 who have mild mobility limitations. Participants receive either LUM-201 plus semaglutide or a placebo plus semaglutide for 26 weeks. The main goal is to see if the combination helps preserve or improve physical performance, as measured by a standard mobility test, while also tracking changes in body fat and muscle mass.