Can a diabetes drug improve joint replacement outcomes?
NCT ID NCT07755085
First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time
Summary
This trial tests whether taking a GLP-1 medication (semaglutide) for at least six months before hip or knee replacement surgery can improve recovery and reduce complications in patients with obesity. Participants will be randomly assigned to receive either the medication plus behavioral support (diet, exercise, counseling) or a placebo with the same support. The study will track wound complications, weight loss, and mobility changes to see if this approach helps high-risk patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- semaglutide (a GLP-1 receptor agonist) combined with structured behavioral modification (diet, exercise, counseling)
- What this could lead to
- If effective, this approach could reduce surgical complications and improve recovery for obese patients undergoing joint replacement, potentially leading to better standard care.
- What could go wrong
- This is a small pilot study, so results may not be conclusive. The medication may not reduce complications and could have side effects, and the behavioral program adds complexity.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Nova Scotia Health
Dartmouth, Nova Scotia, B2Y 2N5, Canada
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