ARTHRITIS

This study compares two types of wrist fusion surgery for people with post-traumatic wrist arthritis. One surgery fuses four wrist bones and removes the scaphoid. The other fuses three or two bones and also removes the triquetrum. The goal is to see which approach gives better gr…

This study is testing a new prosthetic implant for the elbow joint in people with arthritis, instability, or limited motion. The implant replaces the damaged joint to reduce pain and improve function. About 84 participants will be followed for two years to see if the device is sa…

This study tests whether sleeping near a special device that claims to emit 'biophotons' can reduce chronic severe arthritis pain. About 102 adults with long-term arthritis pain will use either the active device or a placebo (inactive) device for 12 weeks. Researchers will measur…

This study tests whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty participants will exercise together online for 3 months, then get either text reminders or extra group sessions for 6 more months. Resea…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests whether dapansutrile tablets can reduce joint pain from an acute gout flare better than a placebo. About 300 adults with confirmed gout will take the drug or a dummy pill for 7 days. The main goal is to see if pain drops significantly within 72 hours of the first…

This study tests whether eating freeze-dried wild blueberry powder every day for 12 weeks can improve gut health, reduce inflammation, and ease joint pain in adults with arthritis. Fifty participants will take either the blueberry powder or a placebo, with a 2-week break between …

This study is testing whether herbal medicine and vitamin IV therapy can reduce symptoms of anxiety, fibromyalgia, arthritis, chronic pain, and high blood pressure. Researchers plan to enroll 25 people and measure improvements in health and quality of life. The approach uses natu…

This study aims to understand the causes and progression of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) by observing up to 2,000 participants over time. Researchers will collect medical history, blood samples, and genetic data to identify …

This study follows up to 2,000 people with spondyloarthritis (a group of inflammatory joint and spine conditions) and their healthy relatives. Researchers aim to identify symptoms, genetic factors, and medical tests that predict who will develop more severe forms of the disease. …

This study aims to learn more about the causes of rheumatic diseases—conditions that cause joint pain, stiffness, and swelling—and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing…

This study is creating a large collection of joint fluid and blood samples from 500 people with different types of arthritis. Researchers will use these samples to test new biomarkers that could help diagnose arthritis earlier and monitor how the disease changes over time or with…

This study aims to better understand why people with inflammatory arthritis experience chronic pain. Researchers will look at how the brain processes pain and how it affects daily life. 350 adults starting or switching arthritis medications will be followed over time. The goal is…

This study aims to understand how rheumatic side effects (like arthritis) from cancer immunotherapy affect patients' daily lives. Researchers will interview 20 adults who have experienced these side effects to learn about their severity and impact. The goal is to improve future c…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect bone issues like cancer, infection, or arthritis. About 200 adults will receive a tiny amount of radioactive tracer and be scanned on a high-sensitivity machine. The go…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…