ARTHRITIS

This study compares two surgical techniques for treating wrist arthritis caused by old injuries. 170 adults with specific types of wrist collapse will be randomly assigned to have either a four-corner fusion or a three-corner fusion (which removes one small bone). The goal is to …

This study is testing a new prosthetic device for people with painful, unstable elbow joints caused by arthritis or injury. The goal is to see if the implant safely improves motion, reduces pain, and stabilizes the joint. About 84 adults under 85 years old will take part and be f…

This study tests whether a tablet called dapansutrile can safely reduce joint pain during an acute gout flare. About 300 adults with gout will receive either the study drug or a placebo. The main goal is to measure pain relief 72 hours after the first dose.

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking improvements in 150 participants, including hea…

This study looks at how three different levels of physical activity (45, 90, or 150 minutes per week) affect arthritis symptoms like pain and physical function. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. …

This study is testing whether a group exercise program done over video calls is practical and helpful for Veterans with knee or hip arthritis. Fifty Veterans will take part in a 3-month exercise program, followed by 6 months of maintenance with either text messages or extra group…

This study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. It blocks abnormal blood vessels in the knee to reduce pain and improve function. Twenty adults aged 40–70 will be randomly assigned to get the procedure plus …

This study explores whether herbal medicines, vitamin IV therapy, and supplements can reduce symptoms of anxiety, arthritis, fibromyalgia, chronic pain, and high blood pressure. About 25 participants will receive natural treatments aimed at improving health and quality of life. T…

This study aims to learn more about spondyloarthritis, a group of disorders causing back and joint pain and stiffness. Researchers will observe 2000 people with the condition and their healthy relatives to find symptoms and tests that predict who may develop more severe disease. …

This study aims to understand the natural history, genetics, and causes of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD). Researchers will observe up to 2,000 people with these conditions over time, collecting medical history, blood samples,…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study aims to understand how severe and life-altering rheumatic side effects (like arthritis) can be for cancer patients treated with immunotherapy. Researchers will interview 20 English-speaking adults who have been diagnosed with these side effects by a rheumatologist. The…

This study is testing a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect bone issues like cancer, infection, and arthritis. Researchers will enroll 200 adults to see if the new technique still produces clear images. Participants get a r…

This study aims to understand why people with inflammatory arthritis (like rheumatoid or psoriatic arthritis) feel chronic pain. Researchers will follow 350 patients starting new medications to identify different pain types and risk factors. The goal is to pave the way for more p…

This study aims to learn more about the causes of rheumatic diseases, such as arthritis, and why they often affect minority groups more severely. Researchers will observe up to 7,500 adults with known or suspected rheumatic disease, providing standard medical care and tests. No e…