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Nasal spray could offer rapid relief for debilitating cluster headaches

NCT ID NCT07714369

Not yet recruiting Symptom relief Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This pilot study tests whether zavegepant nasal spray can quickly relieve pain from episodic cluster headaches. About 40 adults with episodic cluster headaches will use the spray at the start of an attack. The main goal is to see how many achieve minimal or no pain within 30 minutes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
zavegepant nasal spray
What this could lead to
If effective, zavegepant could offer a fast-acting, non-injected option to stop cluster headache attacks quickly.
What could go wrong
This is a small, early pilot study with no placebo group, so results may not confirm true effectiveness or safety.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cluster headache syndrome Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLUSTER HEADACHE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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