Enzyme injection could loosen stiff joints in brain and spinal cord injuries
NCT ID NCT07693556
First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time
Summary
This trial tests whether injecting collagenase—an enzyme that breaks down tough connective tissue—can reduce contracture (stiff, shortened muscles) and spasticity (uncontrolled muscle tightness) in people with neurological impairments like stroke, brain injury, or spinal cord injury. The study enrolls 15 adults who are at least 6 months post-injury and have tendon contracture. Researchers will measure changes in muscle tone and joint movement, while closely watching for side effects such as tendon damage or injection-site reactions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- XIAFLEX (collagenase) injection
- What this could lead to
- If it works, this could offer a new, non-surgical option to reduce muscle tightness and improve joint movement in people with neurological conditions.
- What could go wrong
- This is a very early, small trial (15 people). Risks include tendon rupture, ligament damage, skin tears, and injection-site pain or swelling. It may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States