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Enzyme injection could loosen stiff muscles in stroke survivors

NCT ID NCT07693569

Not yet recruiting Symptom relief Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This early-phase trial investigates whether injecting collagenase—an enzyme that breaks down collagen—can reduce spasticity (muscle tightness) in people who have had a stroke, brain injury, or spinal cord injury. The study enrolls 15 adults who are at least six months post-injury and have significant muscle stiffness. Researchers measure changes in muscle tone and range of motion, while closely monitoring for side effects like tendon damage or swelling.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Collagenase (XIAFLEX) injection
What this could lead to
If it works, this could offer a new, non-surgical option to ease muscle tightness and improve range of motion in people with neurological conditions.
What could go wrong
This is a very early, small trial with only 15 participants. Collagenase injections carry risks like tendon rupture, swelling, and pain. The treatment may not work or could cause serious side effects.

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Conditions

The condition(s) this trial relates to.

Muscle Spasticity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPASTICITY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • The University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

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