SPASTICITY

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study tests a new medicine called IPN10200 for adults with arm muscle stiffness (spasticity) after a stroke or traumatic brain injury. The goal is to find the safest and most effective dose to reduce stiffness and improve movement. About 240 participants will receive either …

This study tests whether a mild, non-invasive electrical stimulation on the back (transcutaneous spinal cord stimulation) can reduce spasticity—stiff, tight muscles—in children with cerebral palsy. Researchers will compare spinal cord activity in 30 children with CP and typically…

This pilot study tests whether focused shockwave therapy can safely reduce arm spasticity in people with spinal cord injury. Twelve participants will receive three weekly sessions of sound waves applied to the forearm and elbow muscles. Researchers will measure changes in muscle …

This study is testing a wearable robotic exoskeleton that stretches the legs of people with spasticity caused by spinal cord injury. The device aims to mimic the stretching done by nurses or caregivers. Ten veterans will try the device during leg stretching, treadmill walking, an…

This study is testing whether a full-body electrical stimulation suit, used at home, can reduce muscle stiffness (spasticity) and coordination problems (ataxia) in people with multiple sclerosis. Seventy participants will either use the suit for six weeks or receive usual care al…

This pilot study looks at how botulinum toxin (Botox) injections affect the muscles, tendons, and nerves in the feet of people who have had a stroke and developed a tight, twisted foot (equinovarus). Researchers will use special ultrasound and movement tests to track these change…

This study looks at how muscle stiffness (spasticity) patterns in the arms and legs of people with multiple sclerosis relate to their quality of life. Researchers will classify these patterns and measure their impact using patient surveys and physical tests. The goal is to better…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…