SPASTICITY

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can reduce spasticity (muscle stiffness) in adults with cerebral palsy. Forty participants aged 16 and older with stable, one-sided motor disability will receive the implant. Re…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study tests whether adding Functional Electrical Stimulation (FES) to standard rehab can reduce leg stiffness, build muscle strength, and improve walking in people with paraplegia. Forty adults with spinal cord injury will be split into two groups: one gets rehab alone, the …

This study tests two types of spiral arm straps (TheraTogs and TogRite) to see if they help children with unilateral spastic cerebral palsy use their affected arm and hand more effectively. Twenty-seven children aged 4 to 15 will be split into three groups: one gets rehab plus Th…

This study tests an extended-release tablet called arbaclofen to see if it safely reduces muscle stiffness (spasticity) in people with multiple sclerosis. About 442 adults aged 18 to 65 with MS-related spasticity will receive either the drug or a placebo. The goal is to measure c…

This study will test whether combining botulinum toxin (Botox) injections with physical or occupational therapy helps people with spasticity—uncontrollable muscle tightness and spasms. Thirty adults will receive personalized treatment from a team of experts, and researchers will …

This study looks at whether a diagnostic nerve block can predict how well cryoneurolysis—a procedure that uses extreme cold to temporarily freeze nerves—will work for people with long-term muscle and bone pain. Researchers will enroll 50 adults with chronic pain and measure pain …