Freezing pain away: yale tests Nerve-Blocking procedure for Long-Term relief

NCT ID NCT07639060

Not yet recruiting Symptom relief Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12 months. Participants will fill out questionnaires about their pain and disability before and after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cryoneurolysis (a procedure that uses extreme cold to temporarily block pain signals from nerves)
What this could lead to: If successful, this could show that cryoneurolysis provides meaningful, lasting pain relief for people with various chronic pain conditions.
What could go wrong: This is a small, early-stage study with no comparison group, so results may not apply to everyone. The procedure is not a cure and pain may return.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome complex regional pain syndrome type 2 Muscle Spasticity osteoarthritis osteoarthritis, hip osteoarthritis, knee peripheral nervous system disorder peripheral neuropathy spondylosis spondylosis, cervical

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CAUSALGIA CERVICAL SPONDYLOSIS CHRONIC HIP PAIN CHRONIC LOW-BACK PAIN CHRONIC NECK PAIN CHRONIC PAIN CHRONIC PAIN SYNDROME HIP OSTEOARTHRITIS KNEE OSTEOARTHRITIS LUMBAR SPONDYLOSIS OCCIPITAL NEURALGIA PERIPHERAL NEUROPATHY SHOULDER ARTHRITIS SPASTICITY

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