CHRONIC PAIN

This study tests a new way to help people with chronic non-cancer pain who have been taking opioids long-term. Instead of usual care, a team of doctors, pharmacists, physiotherapists, and psychologists will work with each patient to create a personalized plan to reduce opioid use…

This study tests whether a gentle, non-invasive brain stimulation technique (tDCS plus ultrasound) can reduce drug use and pain in people with opioid addiction and chronic pain. About 126 adults on methadone treatment will receive either real or fake stimulation over several week…

This study is testing a device called Inceptiv, which uses mild electrical pulses to block pain signals in the spinal cord. It is for adults with long-lasting, hard-to-treat pain who have not tried this therapy before. Researchers will track how many people get at least 50% pain …

This study tests whether a combination of THC and CBD, taken by mouth, can help people with both opioid use disorder and chronic low back pain. Participants are already on methadone treatment. The goal is to see if these cannabis compounds can reduce pain sensitivity and curb cra…

This study is tracking 2000 people who get an Abbott neurostimulator implant to manage chronic pain. Researchers will monitor safety and how well the device works over time in everyday life. The goal is to understand real-world benefits and risks, not to cure the pain.

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study tests whether treating PTSD symptoms soon after acute pain starts can stop the pain from becoming chronic. Researchers will use either a nerve block (stellate ganglion block) or talk therapy (Cognitive Processing Therapy) in 345 adults with PTSD and acute pain. The goa…

This study is testing a low-cost training program for doctors and their patients with chronic pain. The program teaches team-based skills to manage pain without relying on opioids. About 1,188 participants (patients aged 14–80 and their doctors) will take part to see if the progr…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, on stable …

This study tests an internet-based therapy for people with both PTSD and long-term pain. About 40 adults will receive the therapy or be placed on a waiting list. The goal is to see if this approach reduces PTSD symptoms and helps people cope better with pain.

This study tests an internet-based guided self-help program for adults with chronic pain. The program uses Acceptance and Commitment Therapy (ACT) to help people accept their pain and focus on living a meaningful life. Researchers will enroll 140 participants to see if the progra…

This study tests two approaches for adults with chronic pain who take long-term opioids: a mindfulness program called MORE and patient-centered pain management visits. The goal is to see if these methods can reduce pain, improve quality of life, and lower the risk of opioid misus…

This study tests whether customizing magnetic brain stimulation to each person's brain signals can better relieve chronic pain. About 90 adults with long-term pain will receive personalized treatment based on their brain activity. The goal is to improve pain intensity and overall…

This study is for adults with chronic pain who have been taking prescription opioids for at least 90 days and face extra risks like using sedatives or having a substance use disorder. Researchers will test three steps in sequence: switching to a low-dose buprenorphine patch, addi…

This study tests whether low-intensity focused ultrasound (LIFU) can help reduce chronic back pain, opioid cravings, and anxiety in adults aged 18-65. Participants will receive LIFU and be monitored for side effects, changes in heart rate, blood pressure, and mood. The goal is to…

This study tests a coaching program for Black patients with long-term muscle or joint pain and depression. The program helps patients learn about and try non-drug pain treatments, like physical therapy or counseling. 304 participants will be randomly assigned to either the coachi…

This study looks at whether doing yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be assigned to 12 weeks of yoga, physical therapy, or their usual care. …

This study tests whether doing neck exercises with virtual reality (VR) can reduce pain and disability better than the same exercises without VR. About 72 adults with long-term neck pain or whiplash will take part in 12 sessions over 6 weeks. Researchers will measure changes in p…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study tests whether magnetic stimulation of the brain can be personalized to better treat chronic pain. Researchers will measure brain signals before treatment to customize the stimulation for each person. The goal is to improve pain relief and quality of life for the 90 adu…

This study compares two treatments for long-lasting tailbone pain (coccydynia): hands-on osteopathic manual therapy and a nerve block injection. About 100 adults with chronic pain will be randomly assigned to one treatment and followed for 3 months. The goal is to see which appro…

This study tests whether a mind-body program can reduce disability and pain in adults with chronic back pain. About 150 participants will be randomly assigned to the mind-body intervention, an active control, or usual care. The main goal is to see if the program improves daily fu…

This study tests whether a capsaicin 8% skin patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 whose pain started after surgery or injury. About 46 teens will receive either the real patch or a placebo dressing. The main goal is to se…

This study tests whether personalized lifestyle coaching can help older adults manage long-term muscle and joint pain. 268 participants will work with a health coach to set goals, while a comparison group receives usual care. The goal is to reduce pain intensity and improve daily…

This study tests whether four coaching sessions can help veterans with chronic pain use their own cannabis products more effectively. Researchers will enroll 468 veterans who already use or plan to use cannabis for pain. The goal is to improve pain management and related symptoms…

This study tests whether probenecid, a safe drug already used for gout, can reduce the unpleasant symptoms of opioid withdrawal in people with chronic pain who are voluntarily lowering their opioid dose. About 40 adults will receive either probenecid or a placebo to see if it hel…

This study tests if a safe, non-invasive brain stimulation technique called tDCS can reduce chronic pain in 100 military members and veterans. Participants will use a head device at home while continuing their usual care. The goal is to see if this adds extra pain relief and impr…

This study tests a new virtual program called PREP-Y designed to help teenagers (ages 12-17) with long-term muscle, bone, or joint pain become more physically active and better at managing their pain. The program includes four weekly online sessions teaching skills like motivatio…

This study tests whether daily text reminders and mindfulness messages can help 60 adults taking medication for opioid use disorder stick to their treatment and better manage cravings, pain, and withdrawal symptoms. Participants receive medication reminders for 6 months and up to…

This study explores whether a virtual reality (VR) mindfulness program can help veterans with spinal cord injury (SCI) manage chronic pain. Researchers will first adapt an existing mindfulness course for SCI needs, then test 1-2 modules using VR in 10 veterans. The goal is to see…

This study is testing a smartphone app called Digital SPA, co-designed with teens, to help young people aged 12–17 manage chronic pain (like headaches or stomach aches) that has lasted at least 3 months. About 195 teens and a parent will use the app, answer questionnaires, and gi…

This early-stage study tests if stem cells taken from a patient's own bone marrow can reduce pain and improve pancreas function in people with chronic pancreatitis. About 40 adults with long-term pain will receive the treatment and be monitored for changes in pain scores, medicat…

This study tests if a 2-week, fully remote treatment can help people with both chronic pain and PTSD. Participants receive either real or fake brain stimulation (tDCS) along with talk therapy, all from home. The goal is to see if this combination reduces pain and PTSD symptoms be…

This study tests a specially adapted mindfulness program for older Black adults (age 50+) who have both chronic pain and mild to moderate depression. The goal is to see if this approach can improve quality of life and reduce how much pain interferes with daily activities, compare…

This study tests two short behavioral treatments—mindfulness and cognitive-behavioral therapy—for adults with chronic pain. Both are offered in English and Spanish. The goal is to see which approach is more feasible and acceptable, and how well they reduce pain, depression, and a…

This study looks at whether adding acceptance and commitment therapy (ACT) and a care management app can help people who are already taking buprenorphine for opioid use disorder and also have chronic pain. About 123 adults will be assigned to different groups to see if these tool…

This study looks at whether ozone therapy can improve quality of life for people with long-lasting pain or side effects from cancer treatments like radiation and chemotherapy. About 105 adults who have not found relief from standard treatments will receive ozone therapy as an add…

This pilot study is testing whether a mind-body intervention can improve daily function and reduce pain in 40 adults with chronic upper extremity pain (like repetitive stress injury). Participants will learn techniques to change how they think about and respond to pain. The goal …

This study looks at whether adding short lessons about how pain works to a supervised exercise program can help adults over 65 with chronic pain feel better and move easier. About 100 participants will be split into three groups: exercise only, exercise plus 8 weeks of pain educa…

This study tests whether an 8-week program combining art, mindfulness, and body awareness in a university museum can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to either the museum program or a control group. The …

This study looks at whether using a weighted blanket at night can reduce pain and improve sleep in veterans who have both chronic pain and sleep trouble. About 160 veterans will use either a light or heavy blanket for 6 weeks at home. Researchers will track pain levels, sleep qua…

This study tests whether adding shiatsu therapy to standard medical care can improve quality of life for children and teens aged 10-18 with chronic pain that is not caused by inflammation. About 40 participants will receive a 30-minute shiatsu session once a week for six weeks an…

This early study tests whether a neuroprosthesis can restore touch sensation to the breast and reduce chronic pain in 8 women who have had both breasts removed and are undergoing reconstruction. Researchers will use tiny electrical pulses to stimulate nerves and measure what part…

This study tests a smartphone app called QoLibri designed to help people with chronic pain (pain lasting more than 3 months) improve their quality of life and daily function. About 410 adults with at least moderate pain will either use the app right away or wait and receive it la…

This study tests a high-CBD product (taken under the tongue) against a placebo in 25 adults with chronic pain conditions like arthritis or injury. Over 9 weeks, researchers will track pain levels, medication use, quality of life, and thinking skills. The goal is to see if CBD can…

This study tests a single-session program called Empowered Relief (ER) to see if it reduces pain and improves recovery after elective orthopedic surgery compared to standard care. About 134 adults with chronic pain related to their surgery will take part. The goal is to find a si…

This study tests Scrambler Therapy, a non-invasive device that sends gentle electrical signals through the skin to retrain how the brain feels pain. It is for adults with chronic pancreatitis whose belly pain has not improved with standard treatments. About 40 participants will r…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce severe leg pain and improve blood flow in people with both painful diabetic neuropathy and peripheral artery disease. Fifteen adults who already have a permanent s…

This study tests whether combining counseling with a muscle relaxant (tizanidine) can help people who have used opioids for a long time reduce their painkiller use after elective surgery. About 375 adults aged 18–75 will be randomly assigned to receive the combined treatment, cou…

This study tests whether a 6-week music class (drumming and rhythm exercises) can reduce stress, anxiety, depression, and chronic pain in older adults living in residential care. About 60 participants will attend weekly hour-long sessions and complete surveys before and after. Th…

This study tests whether a 6-week pain education program helps people with chronic pain become more active and feel less pain and depression. About 50 adults with pain lasting over 3 months will attend group sessions on sleep, stress, and pain science. There is no comparison grou…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve both depression and chronic pain symptoms. Fifty-four adults with moderate-to-severe major depressive disorder and pain will receive 30 treatments over several weeks. Researchers will trac…

This study tests a single online class called Empowered Relief, delivered in Spanish, to help adults with chronic pain. Participants learn pain relief skills in a group video session. The goal is to see if the class reduces pain and distress and is well-liked. Researchers will fo…

This study tests whether a continuous pain-relief catheter placed in the thigh works better than a single injection to reduce opioid painkiller use after total knee replacement. About 64 adults scheduled for knee surgery will be randomly assigned to receive either the catheter or…

This study tests whether a specially designed mobile app (WebMAP Onc) can help teen survivors of childhood cancer manage chronic pain better than standard pain education. The app uses cognitive behavioral therapy techniques adapted for this group. Researchers will enroll 228 part…

This study tests two behavioral programs designed to improve sleep in people who have both chronic pain and chronic insomnia and take prescribed opioids. Researchers want to see if better sleep can help reduce pain and lower opioid use. About 165 adults who are motivated to cut b…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all method, researchers will tailor the stimulation based on each participant's brain signals. The goal is to improve pain relief and quality of life fo…

This study tests whether adding six weekly online pain-education sessions to standard physical therapy helps people with chronic low back pain. The education teaches how the brain processes pain, aiming to reduce fear of movement and improve function. Sixty adults aged 20-60 will…

This early-stage study tests whether adding lacosamide, a seizure medication, to standard opioid therapy is safe and tolerable for people with long-term abdominal pain from chronic pancreatitis. About 24 adults will take the drug for 7 days and be monitored for side effects and p…

This study looks at whether getting Chuna (a type of manual therapy) every two weeks for 20 weeks can reduce chronic neck pain better than just doing lifestyle changes and self-exercises. It involves 250 adults aged 19 to 69 who have had mild but bothersome neck pain for at least…

This study tests a new, personalized brain stimulation technique (HD-tDCS) to reduce chronic pain. 144 adults with long-lasting pain will receive either real or placebo stimulation over five sessions. Researchers will measure pain relief and brain changes using scans and question…

This study tests a group therapy program done over Zoom for adults who have both chronic pain and opioid use disorder. The therapy focuses on helping people understand and express their emotions to reduce pain, disability, and related problems like depression and anxiety. About 3…

This study tests whether a smartphone app can help Black and LGBTQ+ adults with long-term chronic pain manage their symptoms better. Researchers will enroll 300 people who have had pain for at least 3 months and have trouble with daily activities. Participants use the app to lear…

This study looks at whether taking methadone once or twice a day is better for managing both chronic pain and opioid use disorder. About 150 adults currently on methadone will be randomly assigned to one of two dosing schedules. Researchers will track changes in pain levels and p…

This study tests a non-invasive treatment called transcutaneous pulsed radiofrequency for chronic pain after shingles (postherpetic neuralgia). Researchers want to see if it can reduce pain better than current options. The trial will enroll 35 adults with this condition and measu…

This study tests a 6-month mobile program that combines group support, coaching, and activity tracking to help older adults with knee or hip osteoarthritis become more active and lose weight. Researchers want to see if it reduces pain interference and improves physical function. …

This study tests if an internet-based therapy called Acceptance and Commitment Therapy (ACT) can help people with endometriosis manage chronic pain and improve daily functioning. Ten participants will receive online sessions focusing on pain education, mindfulness, and behavior c…

This study compares two online programs—yoga and Acceptance and Commitment Therapy (ACT)—to see which better reduces chronic muscle and bone pain in veterans. About 274 veterans with pain lasting over 6 months will participate from home. The goal is to find which approach helps d…

About 20-30% of people still have pain after total knee replacement. This study tests if freezing the knee nerves at least 24 hours before surgery can lower pain and help patients move better. One hundred adults with knee arthritis will be randomly assigned to get the freezing pr…

This study tests a new type of brain stimulation (called accelerated TMS) for people with long-term chronic pain that hasn't improved with medication. The treatment is personalized using brain scans and a smart algorithm to target the right spot for each person. The goal is to se…

This study tests whether virtual reality (VR) therapy can reduce pain and improve daily function in people with chronic low back pain. Two hundred adults aged 18 to 85 with back pain lasting at least six months will be randomly assigned to one of two VR programs. Participants wil…

This study is testing a trilingual smartphone app and telehealth coaching program to help Black, Chinese, and Latinx adults in the San Francisco Bay Area manage chronic pain without medication. About 586 people with long-term pain will be randomly assigned to use the app plus coa…

This study tests whether cannabidiol (CBD) is safe and can help reduce pain and opioid cravings in 34 adults who are already on medication (methadone or buprenorphine) for opioid use disorder and also have chronic pain. Participants will receive CBD or a placebo in random order o…

This study looks at whether combining mindfulness training with a placebo pill (a pill with no active drug, but taken honestly) can help people with long-term pain. 45 adults with chronic pain will be split into three groups: mindfulness only, placebo only, or both together. The …

This study tests a program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients reduce opioid use and manage pain. Researchers will compare how many patients successfully wean off opioids…

This study is testing a new group music therapy program called POPSINGER for people with chronic pain. 24 adults will attend 16 sessions, half in-person and half online, to see if the program is practical and helpful. The goal is to see if people stick with it and use music exerc…

This study tests a very brief, 4-session cognitive behavioral therapy (CBT) for people with urological chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The goal is to see if this short treatment can reduce pain and improve daily life.…

This study looks at two types of nerve blocks (pectoral nerve block and paravertebral block) to see which one better prevents long-term pain after mastectomy. About 90 women having mastectomy will be randomly assigned to one of the two blocks. The goal is to reduce the chance of …

This study tests whether group-based pain management can help low-income adults with chronic pain feel better and more supported. About 360 participants will join group sessions that address pain, stigma, and social isolation. The goal is to reduce pain's impact on daily life and…

This study looks at whether adding Whole Health Coaching (a program that focuses on overall well-being) to standard pain management helps veterans with chronic pain. About 432 veterans who take long-term opioids and have safety concerns will take part. The goal is to see if coach…

This study tests a wearable device called the Sana Pain Reliever (Sana PR) to see if it can reduce chronic pain in people with Post-treatment Lyme Disease Syndrome. About 30 participants will use the device at home for 15 minutes at a time over 14 weeks. The device uses flashing …

This study tests whether Pain Reprocessing Therapy (PRT) helps veterans with chronic back or neck pain more than Cognitive Behavioral Therapy (CBT) or usual care. About 360 veterans will be randomly assigned to one of the three groups. Those in PRT or CBT will have nine weekly vi…

This study tests whether a synthetic THC drug (dronabinol) can safely reduce pain in people with chronic low back pain. About 75 adults will take either the drug or a placebo daily for 8 weeks. The goal is to see if the drug is safe enough for larger future studies.

This study tests whether a very short (7-minute) mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for back pain. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard ca…

This early-stage study tests whether metformin, a standard diabetes medication, can reduce pain and improve healing in people with chronic Achilles tendon pain. Forty non-diabetic adults will take either metformin or a placebo for 16 weeks, combined with a home exercise program. …

This study tests a telehealth program that teaches rural veterans with chronic pain how to use the connection between their mind and body to feel better. About 500 veterans will take part, learning skills to reduce pain's impact on daily life. The goal is to help them manage pain…

This study looks at whether a type of IV called a midline catheter can be used safely and effectively for repeated lidocaine infusions to treat chronic pain outside the hospital. About 500 adults who need ten sessions of lidocaine will get the infusions through this catheter. The…

This study looks at whether a specific exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will do 90 exercise sessions over 18 m…

This study tests whether cognitive behavioral therapy for chronic pain (CBT-CP) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will measure changes in pain interference, quality of life, and …

This study looks at a new method called 'telefitting' to fine-tune spinal cord stimulators in people with chronic back or leg pain. Fifteen adults who are already scheduled to get a spinal cord stimulator will try different stimulation settings (tonic, burst, and multistim) witho…

This study tests a stepped care approach that combines complementary health treatments for people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive this stepped care or their usual treatment. Researchers will check if the approach …

This study compares a 10-week program called GetActive+ (which combines mind-body techniques with walking) to usual care for 200 older adults aged 55+ who have had musculoskeletal pain for at least 3 months. The goal is to see if the program improves physical function, such as wa…

This study tests whether a team of pain specialists—including doctors, psychologists, pharmacists, dietitians, and physical therapists—can help veterans with chronic pain feel better and live more fully. About 150 veterans will either join the program right away or wait six month…

This study tests whether injecting platelet-rich plasma (PRP) into the shoulder, combined with a personalized exercise program, provides better and longer-lasting pain relief than standard steroid injections. About 86 adults aged 35-75 with chronic shoulder pain from rotator cuff…

This study tests whether a painless brain stimulation technique (tDCS plus ultrasound) can reduce chronic pain in people with carpal tunnel syndrome. About 95 adults with long-term wrist pain will receive either real or fake stimulation to see if it lowers their pain scores. The …

This study looks at whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in daily smokers who have chronic pain and are being treated for opioid use disorder with buprenorphine. About 60 participants will be randomly assigned to either very …

This study tests if injecting a sugar (dextrose) solution around knee nerves can reduce chronic pain from knee osteoarthritis better than a numbing medicine alone. About 60 adults with knee arthritis will receive a series of three injections. Researchers will measure pain levels …

This study looks at whether a 12-week progressive resistance exercise program can help reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist group receiving usual care. The goal is to see if ex…

This study tests a small, battery-powered headband that delivers a gentle electrical stimulation to the scalp to reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is…

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will measure pain changes, opioid use, and quality of life in 48 adults over 6 months. The goal is to see if this approach is safe and offers rel…

This study is testing a group training program for parents of children aged 10-17 who have had chronic pain for at least 3 months. The program aims to help parents better support their child, with the goal of reducing the child's pain and improving their daily functioning. About …

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if the app is acceptable and helpful for adults who are in recovery from opioid use disorder and also have chronic pain. Ten participants will use the app and p…

This study tests a new type of spinal cord stimulation (called TVP-SCS) in 70 adults with long-term back and leg pain that hasn't responded to other treatments. The goal is to see if this approach can reduce pain by at least 50% after 3 months. Participants will use a commerciall…

This study is for active-duty military members and their families who have chronic back or neck pain. It will test treatments like acupuncture, laser therapy, and shockwave therapy to see if they help reduce pain and improve quality of life. The goal is to find safer, non-drug op…

This study tests a new training program that teaches people with chronic pain and emotional distress to accept their pain rather than fight it. The program is based on dialectical thinking, which helps people hold two ideas at once: wanting the pain to stop while also accepting i…

This study tests a program called SCOOP for adults aged 60 and older living in rural areas who have chronic pain and feel lonely. Participants watch short videos and have up to 7 weekly coaching sessions with a community health worker. The goal is to see if the program reduces ho…

This small study tests a mind-body program for people with chronic migraines. The goal is to see if the approach is practical and which tools best measure its effects on pain and daily life. Ten adults with frequent migraines will participate in remote sessions to help design a f…

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. About 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a short-term anti-inflammatory drug only before planned walks to help with movement pain, while also learning about proper footwear and avoiding fear of movement. The goal is …

This study looks at whether combining chiropractic care with group medical visits can help adults 65 and older who have chronic spine pain. Ten participants will receive chiropractic adjustments and attend virtual group sessions. The goal is to see if this approach is practical a…

This study looks at how well spinal cord stimulation works for people with long-term pain. About 25 adults who already have a spinal cord stimulator will rate their pain with the device on and off. The goal is to see if the stimulation truly reduces pain compared to a placebo eff…

This study explores whether herbal medicines, vitamin IV therapy, and supplements can reduce symptoms of anxiety, arthritis, fibromyalgia, chronic pain, and high blood pressure. About 25 participants will receive natural treatments aimed at improving health and quality of life. T…

This study tests four different programs to help cancer survivors who have been using opioids for a long time reduce their opioid use and better manage chronic pain. About 294 veterans who have finished cancer treatment and still have pain will try one of these programs. The goal…

This study looks at whether a smartphone-based mindfulness program is practical and helpful for teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use guided mindfulness exercises on their phone for about 8 weeks. Th…

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study looks at whether a type of talk therapy focused on emotions can help people with ongoing pain after a serious bone injury. About 30 adults who had major orthopedic trauma will attend weekly therapy sessions and complete questionnaires and pain tests. The main goal is t…

This is a small pilot study to test a new virtual therapy program designed to treat PTSD and chronic pain at the same time. The program combines techniques from two established therapies over 12 online sessions. Researchers will check if the combined approach is practical and acc…

This study looks at how well a culturally tailored screening and brief intervention program works for chronic pain and opioid misuse in American Indian and Alaska Native communities. About 225 adults who receive care at three participating clinics and have chronic pain or opioid …

This study aims to better understand chronic pain by following 5,000 patients through a smartphone app called e-DOL. Participants will regularly report their pain levels, treatments, and daily life events. The goal is to learn what factors influence pain over time and improve car…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes long-term, improves, or flares up. A smal…

This study looks at how quitting smoking temporarily increases pain, especially in people with chronic pain. Researchers will use brain scans to see how withdrawal changes pain processing. The goal is to find better ways to help people with chronic pain quit smoking. About 132 sm…

This study looks at how teens aged 11-21 with chronic pain perceive body signals (like hunger or heartbeat) and how well they function in daily life. Researchers will compare these measures before and after the teens complete an occupational therapy plan. The goal is to understan…

This study follows 5,000 children aged 0-16 years for one year after surgery to find out how many develop long-lasting pain and why. Parents and children fill out questionnaires before and after surgery to identify risk factors like anxiety or pain history. The goal is to better …

This study tests whether digital software that talks with you like a person can effectively gather health information from people with chronic pain. Researchers want to see if patients find these tools easy and acceptable to use. The study involves 100 adults with chronic pain wh…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain, those with opioid use, and healthy women. The goal is to find new ways to treat chronic pain withou…

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain. Researchers will measure certain chemicals in the blood and spinal fluid of 30 adults before and after SCS treatment. The goal is to understand how SCS works and find ways to make it mor…

This study looks at how two mind-based treatments—mindfulness meditation and self-hypnosis—work in the brains of adults aged 60 and older with chronic pain. Participants will be randomly assigned to one of three groups: mindfulness, hypnosis, or story listening. The goal is to un…

This study aims to find out why some people with sickle cell disease develop severe, disabling pain while others do not. Researchers will track 70 participants aged 15 to 40 over up to 48 months using surveys and pain tests. The goal is to improve pain management and guide future…

This study aims to improve a mobile app called Wysa for Chronic Pain, which supports people aged 45 and older who have chronic pain along with depression or anxiety. Researchers will test different types of in-app notifications to see which ones encourage people to use the app mo…

This study looks at why people with similar knee arthritis can have very different levels of pain. Researchers will study walking, brain activity, and knee structure in 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tasks, knee X-rays a…

This study is testing a new method called Pancreatic Quantitative Sensory Testing (P-QST) to see if it can predict which patients with chronic pancreatitis will get pain relief from procedures like endoscopy or surgery. About 150 adults with chronic pancreatitis will take the tes…

This study follows 800 adults who spent at least 48 hours in the ICU to learn why some develop long-lasting pain. Researchers will track pain, sleep, mood, and quality of life at 90 and 180 days after leaving the ICU. A smaller group will get extra tests to understand how pain fe…

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain after back surgery. Researchers will use brain scans to understand why some types of SCS work better than others. The goal is to find out which patients are most likely to benefit, so tre…

This study aims to find out which of two common pain medication classes—anticonvulsants or antidepressants—works better for chronic pain in everyday patients. Researchers will enroll 450 adults with persistent pain and randomly assign them to one of the two drug types. The goal i…

This study checks if a computer algorithm can correctly diagnose chronic pain by analyzing patient symptoms and history. About 200 adults with pain lasting at least one month will participate. The algorithm's diagnoses will be compared to those made by pain specialists. The goal …

This study looks at 200 adults who still have low back pain at least 3 months after back surgery. Researchers will group their pain into three types (nerve pain, muscle/joint pain, or mixed) using simple questionnaires. The goal is to see how each pain type affects daily function…

This study looks at how Boswellia serrata, a natural herb used in Ayurvedic medicine, changes the way healthy adults feel and process pain. Researchers will use a capsaicin (chili pepper) cream to create temporary pain and then measure pain intensity and nerve responses. The goal…

This observational study in Seoul, Korea, looks at how everyday emotional stress impacts memory and thinking in adults aged 60 and older. Over 180 participants will use a smartphone app and a smartwatch to report their feelings and do quick brain games several times a day for two…

This study uses a technique called Quantitative Sensory Testing (QST) to understand pain patterns in people with chronic pancreatitis. Researchers will test 500 participants to see if these pain patterns can predict who will benefit from certain treatments. The goal is to make tr…

This study looks at nerve-related issues like numbness, tingling, and pain in people who finished treatment for mouth or throat cancer 1 to 5 years ago. Researchers will examine 120 participants to map where these problems occur and how severe they are. The goal is to better unde…

This study looks at how different parts of the brain connect in people with long-term jaw pain (TMD) compared to those without pain. Researchers will use MRI scans to find patterns that may explain why pain becomes chronic. The goal is to better understand the condition, not to t…

This study looks at how using a CPAP machine for sleep apnea affects chronic pain. About 80 adults newly diagnosed with sleep apnea will fill out pain questionnaires before starting CPAP and again at 3 and 6 months. Researchers want to see if better CPAP use leads to less pain, a…

This study is gathering information from 120 people with chronic pain to help design a new type of pain clinic. Researchers want to understand different pain types and how they affect daily life. No new treatments are being tested; the goal is to learn what a future clinic should…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will measure tiny changes in pupil size after an injection of oxytocin or a placebo. The study includes 38 adults with knee arthritis or heal…

This study reviews anonymous medical records from 15,000 adults with chronic pain to see how well different treatments worked. No new treatments are given—researchers simply look back at what happened. The goal is to learn which approaches provide the best pain relief.

This study explores whether a sham (fake) neurofeedback system in a virtual reality environment can change brain wave patterns related to attention. Researchers will compare positive and negative sham feedback to no feedback in 35 adults with rumination, chronic pain, or fibromya…

This study looks at how chronic pain changes the brain's reward system, making it harder to learn from rewards. Researchers will compare 50 people with chronic pain to healthy volunteers using brain scans and a learning task. The goal is to understand the brain mechanisms behind …

This study aims to learn if a new measurement technique can help improve spinal cord stimulation devices for chronic pain. Researchers will test 15 people who already have a temporary spinal cord stimulator implant. They will measure electrical signals from the spinal cord during…