CHRONIC PAIN

This study tests a new way to help people with chronic non-cancer pain who have been on long-term opioids. Instead of usual care, a team of doctors, pharmacists, physiotherapists, and psychologists works with the patient to create a personalized plan. The goal is to reduce pain i…

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This study tests a non-invasive brain stimulation technique (tDCS plus ultrasound) to help people with opioid use disorder and chronic pain reduce drug use. Researchers will compare active stimulation to a sham (fake) treatment in 126 adults already on methadone. The goal is to s…

This study tests whether daily text reminders and mindfulness messages can help people taking medication for opioid use disorder stay on track with their treatment. About 60 adults who recently started or restarted methadone or buprenorphine will receive texts for up to 6 months …

This study is testing whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in people who smoke daily, have chronic pain, and are on buprenorphine for opioid use disorder. Sixty participants will be randomly assigned to either very low nicoti…

This study follows 2,000 people with chronic pain who are implanted with Abbott neurostimulators (spinal cord or dorsal root ganglion stimulators). Researchers will track side effects, device problems, and how well the devices control pain over time. It is an observational study,…

This study tests whether reducing PTSD symptoms can prevent acute pain from turning into chronic pain. Researchers will give 345 adults either a nerve block injection (stellate ganglion block) or trauma-focused talk therapy (cognitive processing therapy). The goal is to see if th…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study is testing a new type of spinal cord stimulator that automatically adjusts its signal based on how your nerves respond. It aims to improve pain relief and quality of life for 25 adults with long-term, hard-to-treat pain in the trunk or limbs. The device is already appr…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for people who have ongoing pain after a serious orthopedic injury. Researchers want to see if it's possible to run a larger study by checking how many people sign up, attend sessions…

This study is testing whether open-label placebo pills—capsules with no active ingredients that patients know are fake—can reduce chronic pain and improve sleep in people with temporomandibular disorder (TMD). About 111 participants will be split into three groups: one gets the p…

This study tests whether a mobile app that teaches cognitive behavioral therapy (CBT) can reduce chronic pain and improve daily functioning in adolescent survivors of childhood cancer. Researchers will compare the app to standard pain education in 228 participants (teens and thei…

This study tests whether dance therapy can help teens aged 12-20 with chronic pain feel better and move more freely. 160 participants will either attend weekly dance sessions for 15 weeks or receive standard care. The goal is to see if dancing reduces pain intensity and fear of m…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study tests whether giving people with chronic pain a placebo pill—told openly that it's a placebo—can help them safely reduce their opioid painkiller use. 86 participants will either receive the placebo alongside a mind-body program or just electronic monitoring for 6 weeks…

This study tests whether a special laser (MLS class IV) can reduce chronic pain and fatigue in people with hypermobile Ehlers-Danlos syndrome (hEDS), a condition that causes loose joints and widespread pain. Twenty-five adults will receive 10 laser sessions over 5 weeks, with pai…

This pilot study is testing a 12-session virtual therapy that combines two proven treatments—one for PTSD and one for chronic pain—into a single program. Researchers want to see if this integrated approach is feasible and acceptable for adults who suffer from both conditions. The…

This study tests whether a capsaicin 8% patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for over 3 months after surgery or injury. Half the teens get the real patch, the other half get a placebo dressing. Pain leve…

This study is testing a psychological treatment for chronic pain that is adapted to the culture of American Indian and Alaska Native peoples. About 30 adults with chronic pain will take part to see if the program is acceptable and helpful. The goal is to gather information for a …

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce pain and depression in people with fibromyalgia. About 36 adults with chronic pain, some also depressed, will receive either real or sham (fake) rTMS to two brain areas. Researchers will tr…

This study tests a 6-week video program called Reclaim Your Day, where older adults with chronic pain watch peers share how they cope and improve their lives. 100 participants aged 55+ will be randomly assigned to watch either these peer stories or general health videos. The goal…

This study tests whether group-based pain management can help low-income adults with chronic pain feel better and more supported. About 360 people from safety-net clinics will join group sessions that address pain, stigma, and social isolation. The goal is to reduce pain's impact…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study tests whether a coaching program combined with a decision aid can help Black patients with long-term muscle and joint pain and depression use non-drug treatments like physical therapy or counseling. 304 patients will be randomly assigned to either the coaching program …

This study tests a new pain self-management program designed specifically for Black adults aged 50 to 92 who have long-term muscle or joint pain (like arthritis or back pain). The program aims to reduce pain during movement and improve daily life. Researchers will compare pain le…

This early study is testing whether metformin, a common diabetes medicine, can reduce pain and help heal chronic Achilles tendon problems. Forty people with long-term tendon pain will take either metformin or a placebo pill for 16 weeks, along with a home exercise program. Resear…

This study is testing a new way to use an already-approved spinal cord stimulator to treat chronic, hard-to-manage back and leg pain. The device sends mild electrical pulses to the spine, and the new setting (called TVP-SCS) varies the timing of those pulses. Researchers will enr…

This study tests a program called SPARK for adults aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants receive 8 nurse visits at home to help them cope with pain and improve their mood. The goal is to see if this approach reduces pain int…

This study tests whether cannabidiol (CBD), a compound from cannabis, can ease chronic pain in 468 veterans. Participants take either CBD or a placebo for 28 days and report their pain levels. The goal is to see if CBD improves pain symptoms better than a dummy pill.

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Researchers aim to see if coaching improves pain, anxiety, and overall well-being. The trial is recruiting 468 veterans across the U.S.

This study looks at two types of nerve blocks given before mastectomy to see which one better prevents chronic pain. About 132 adults having a mastectomy will be randomly assigned to receive either an erector spinae block or a paravertebral block. Researchers will track pain, opi…

This study tests whether a pharmacist-led program can help patients reduce their opioid use by about half in the weeks before knee or hip replacement surgery. 45 adults on stable, moderate-dose opioids will work with a pharmacist to create a taper plan and get weekly check-ins. T…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This study is testing two holistic, non-drug programs to help military members manage chronic musculoskeletal pain. About 608 participants will be randomly assigned to either a single-session class called Empowered Relief, a multi-session program called Move to Health, or usual c…

This study tests an internet-based guided self-help program for adults with chronic pain. The program uses Acceptance and Commitment Therapy (ACT) to help participants accept their pain and focus on meaningful activities. Over seven weeks, participants complete weekly online modu…

This study tests a new spinal cord stimulator device for people with long-term pain in the trunk or limbs. The device uses closed-loop technology to adjust stimulation based on nerve signals. Researchers will enroll 200 participants to see if the new features improve pain control…

This study tests whether a physiotherapy program that combines gentle exercise with pain education can reduce pain and improve daily life for women with endometriosis. About 62 women will take part, with half receiving the combined program and half receiving pain education alone.…

This study tests a device called the Sana Pain Reliever, a mask with earbuds that delivers pulses of light and sound for 15 minutes at a time. Researchers want to see if it can reduce chronic pain and improve sleep in people with post-treatment Lyme disease syndrome. The trial in…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) and a smartphone care management app can help people with both opioid use disorder and chronic pain. About 127 adults already on buprenorphine treatment will try one or both tools. The …

This study tests whether a synthetic THC drug (dronabinol) can safely reduce chronic low back pain. About 75 adults with pain lasting at least 3 months will take either the drug or a placebo daily for 8 weeks. The goal is to see if the drug is safe enough for larger trials.

This study tests a 9-week online program called RAMP that teaches mind-body skills to help rural veterans manage chronic pain. Participants attend weekly group sessions with videos, skill practice, and discussions. The goal is to see if the program reduces how much pain interfere…

This study tests four different approaches—behavioral therapy, physical therapy, medication changes, and buprenorphine rotation—to help cancer survivors reduce their opioid use while keeping pain under control. It involves 294 veterans who have finished cancer treatment but still…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all method, researchers will use each participant's brain signals to tailor the treatment. The goal is to improve pain relief and quality of life for th…

This study tests whether personalized health coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions focused on exercise, diet, stress, sleep, social support, and avoiding risky substa…

This study tests a pain acceptance training program for adults with chronic pain and emotional distress. The training uses dialectical thinking to help participants accept pain while still wanting it to end. Researchers will measure changes in pain levels, self-efficacy, and depr…

This study is tracking 970 adults with chronic pain who receive an Inceptiv™ spinal cord stimulator, a device that sends mild electrical pulses to the spine to block pain signals. Researchers want to see if at least half of patients get significant pain relief and better quality …

This pilot study tests whether probenecid, a drug currently used for gout, can reduce withdrawal symptoms in people with chronic pain who are voluntarily lowering their opioid dose. Researchers will enroll 40 adults and randomly assign them to take probenecid or a placebo for 12 …

This study tests a program called the Transitional Pain Service Program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and safely reduce opioid use. Researchers will com…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

This study tests whether an 8-week program of mindfulness and body awareness, held in a university museum, can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to either the museum program or a control group. The goal i…

This early study tests a small device temporarily implanted in the breast during mastectomy. The device sends tiny electrical pulses to nerves to try to restore touch sensation and reduce chronic pain. Only 8 people having both breasts removed will take part, to see if the idea i…

This study looks at whether yoga-based occupational therapy can improve body awareness and daily function in adolescents aged 11-21 with chronic pain. Participants will attend 8-12 weekly yoga sessions and complete questionnaires before and after treatment. The goal is to see if …

This study is testing whether a weighted blanket can help veterans with chronic pain and sleep problems. 160 veterans will use either a light (3-pound) or heavy (15-pound) blanket at home for 6 weeks. Researchers will track changes in pain, sleep quality, and medication use to se…

This study is testing whether a group music therapy program, called POPSINGER, is practical and well-liked by people with chronic pain. The program includes both in-person and online sessions. Researchers will track how many people stay in the study and attend sessions to see if …

This study compares two behavioral programs for people with chronic pain, chronic insomnia, and long-term opioid use. One program uses cognitive behavioral therapy for insomnia (CBT-I), the other is standard treatment. The goal is to see if improving sleep can also reduce opioid …

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests whether a 6-week music program—including drumming and rhythm exercises—can reduce stress, anxiety, depression, and chronic pain in adults living in rural residential care facilities. Sixty participants will attend weekly hour-long sessions and complete surveys be…

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will enroll 48 adults with persistent pain and track changes in pain scores, opioid use, and quality of life over 6 months. The goal is to see if…

This early-phase study at Yale tests whether cannabidiol (CBD) is safe and can reduce pain and opioid cravings in 34 adults with opioid use disorder and chronic pain. Participants are already on methadone or buprenorphine and will receive different doses of CBD or a placebo in a …

This study tests a group-based parent training program called SPACE-Pain, originally developed for anxiety, to see if it is feasible and acceptable for parents of children aged 10-17 with chronic pain. The program teaches parents to reduce accommodation while staying warm and sup…

This study is testing whether a painless brain stimulation technique called tDCS can reduce chronic pain in 100 military members and veterans. Participants will receive tDCS while taking part in a behavioral health program, and researchers will track changes in pain levels and da…

This study is testing a trilingual smartphone app and telehealth coaching program to help Black, Chinese, and Latinx people with chronic pain find non-drug ways to feel better. About 586 adults in the San Francisco Bay Area will join, using the app and getting coaching for 12 mon…

This early-stage trial tests whether stem cells taken from a patient's own bone marrow can reduce pain caused by chronic pancreatitis and possibly improve pancreas function. Forty adults with long-term painful pancreatitis will receive either the stem cells or a placebo. The stud…

This study tests whether a 2-week, fully remote program combining mild brain stimulation (tDCS) with prolonged exposure therapy can reduce chronic pain and PTSD symptoms. About 146 adults with both conditions will receive either real or sham stimulation alongside therapy, all fro…

This study looks at whether adding a Whole Health Coach to standard pain management teams helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans will work with a coach to set personal health goals and learn self-management strategies. The mai…

This study tests two types of virtual reality therapy to see if they can reduce pain and improve daily function in people with chronic low back pain. Two hundred adults aged 18 to 85 with back pain lasting at least 6 months will use VR headsets for 8 weeks. Researchers will track…

This study tests whether a newer therapy called Pain Reprocessing Therapy (PRT) works better than standard Cognitive Behavioral Therapy (CBT) or usual care for veterans with chronic back or neck pain. About 360 veterans will be randomly assigned to one of three groups and complet…

This study tests a high-CBD, low-THC sublingual product against a placebo in 25 adults with chronic pain conditions like arthritis or injury-related pain. Over 9 weeks, researchers will track pain levels, medication use, quality of life, and thinking skills to see if CBD offers r…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This study tests if adding online pain education to standard physical therapy helps people with chronic low back pain. Sixty adults aged 20-60 will be split into two groups: one gets physiotherapy plus six weekly online sessions about how pain works, and the other gets physiother…

This study looks at whether spinal cord stimulation (SCS) actually reduces chronic pain or if it's just a placebo effect. Researchers will compare pain ratings from 25 patients when their SCS device is on, off, or when they are told it's on but it isn't. The goal is to understand…

This study tests whether a 6-week group pain education program can help people with chronic pain become more active, feel less pain, and have lower depression. Fifty adults with pain lasting over 3 months will attend weekly 2-hour sessions covering sleep, stress, exercise, pain s…

This study tests whether listening to a brief mindfulness audio recording while waiting for an orthopedic appointment can help reduce pain. 400 adults will be randomly assigned to hear either a mindfulness practice or a standard pain management recording. The goal is to see if a …

This study tests a faster form of brain stimulation (accelerated TMS) for people with long-term chronic pain that hasn't improved with medication. Researchers will use a smart algorithm to choose the best spot to stimulate each person's brain, based on their individual pain patte…

This study tests whether mind-body techniques can help people with chronic back pain feel better and move more easily. Researchers will compare two different mind-body programs to usual care in 150 adults. The goal is to see if these approaches reduce pain-related disability and …

This small study tests a mind-body intervention for people with chronic migraines. Ten adults with frequent headaches will attend educational sessions and get personalized coaching. The goal is to see if the program is feasible and whether it can reduce migraine-related disabilit…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which one better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, have H…

This study looks at whether combining mindfulness training (MBSR) with an open-label placebo—a pill that patients know has no active drug—is a practical way to help people with chronic pain. Researchers will randomly assign 45 adults to receive either mindfulness alone, the place…

This study tests a program called SCOOP for older adults (60+) living in rural areas who have chronic pain and feel lonely. Participants watch short videos and have up to 7 weekly coaching sessions with a community health worker to learn pain management and social connection stra…

This study compares two types of nerve blocks (pectoral nerve block vs. paravertebral block) given during mastectomy to see which better prevents chronic pain. Ninety women aged 20-65 undergoing mastectomy will be randomly assigned to one of the two blocks. The goal is to reduce …

This study compares two treatments for chronic shoulder pain: injections of platelet-rich plasma (PRP) made from your own blood, versus standard steroid shots. Both groups also do personalized exercises. The goal is to see if PRP provides better and longer-lasting pain relief. Th…

This study explores whether a virtual reality version of a mindfulness program called VA CALM can help veterans with spinal cord injuries manage chronic pain. Ten veterans will try the program, and researchers will see if it's practical and acceptable. The goal is to make mindful…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a nonsteroidal anti-inflammatory drug (NSAID) only before planned walks to reduce pain while avoiding long-term side effects. The program also includes proper footwear, educat…

This study tests a stepped care approach that uses complementary health treatments (like acupuncture or yoga) for people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive this stepped care or their usual treatment. Researchers want…

This study compares two treatments for chronic tailbone pain (coccydynia): osteopathic manual therapy (a hands-on approach) and a nerve block injection. Researchers will enroll 100 adults who have had tailbone pain for at least 3 months and have not gotten relief from other treat…

This study tests whether virtual reality exercises can reduce neck pain and disability better than standard physical therapy. Seventy-two adults with chronic neck pain or whiplash will do 12 sessions over six weeks. Half will use VR, the other half will do the same exercises with…

This study tests a non-invasive brain stimulation technique called HD-tDCS for people with chronic pain that hasn't improved with other treatments. 144 participants will be randomly assigned to receive either real (anodal or cathodal) or sham (placebo) stimulation over five sessi…

This study tests if freezing the nerves around the knee (cryoneurolysis) one day before total knee replacement surgery can lower pain and help patients move better afterward. About 100 adults with knee arthritis will be randomly assigned to get the freezing procedure plus surgery…

This study tests whether a painless brain stimulation technique (tDCS plus ultrasound) can reduce chronic pain in people with carpal tunnel syndrome. About 95 adults with long-term wrist pain will receive either real or fake (sham) stimulation to see if it lowers their pain score…

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study tests whether a 13-week mind-body program can help people with chronic wrist, elbow, or shoulder pain from repetitive stress. Participants attend twice-weekly sessions for the first month, then weekly sessions, learning techniques to reduce pain and improve arm functio…

This study tests an internet-based therapy called acceptance and commitment therapy (iACT) for people with both PTSD and chronic pain. Forty adults will either receive the therapy immediately or join a waitlist. The program includes mindfulness, value-based exercises, and written…

This study tests whether a team of five pain specialists—including doctors, psychologists, pharmacists, dietitians, and physical therapists—can help veterans with chronic pain feel better and get more out of life. About 150 veterans will either join the program right away or wait…

This pilot study tests whether internet-based Acceptance and Commitment Therapy (ACT) can help people with endometriosis cope with chronic pain. Ten participants will receive online sessions focused on mindfulness, acceptance, and value-based behavior change, with phone support f…

This study tests whether a smartphone-based mindfulness program is practical and liked by teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use a guided meditation app for about 8 weeks. The goal is to see if people…

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available. The …

This study tests whether a smartphone app can help Black and LGBTQ+ adults with long-term chronic pain manage their symptoms and improve daily life. Participants will use the app for pain self-management and report changes in pain interference and confidence. The goal is to see i…

This study tests whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will measure changes in pain interference, quality of life, and pain severity after …

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests whether a noninvasive procedure called transcutaneous pulsed radiofrequency can reduce chronic pain from postherpetic neuralgia, a complication of shingles. The procedure delivers electrical pulses through electrodes placed on the skin over the painful area. Rese…

This study tests whether a single, 2-hour group class called Empowered Relief can help reduce pain and improve recovery after elective orthopedic surgery compared to standard care. The class teaches pain education, self-regulation skills, and mindfulness. Researchers will follow …

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study looks at whether taking methadone once a day or twice a day works better for people who have both chronic pain and opioid use disorder. About 150 adults currently on methadone treatment will be randomly assigned to one of the two dosing schedules. Researchers will trac…

This study tests a smartphone app called QoLibri designed to help people with chronic pain manage their symptoms and improve their quality of life. About 410 adults with moderate or worse pain lasting over 3 months will be randomly assigned to use the app right away or after a wa…

This study compares two online programs—yoga and Acceptance and Commitment Therapy (ACT)—to see which better helps veterans manage long-term muscle and bone pain. About 274 veterans with chronic pain for over 6 months will participate. The goal is to find which approach reduces p…

This study tests a brief, 4-session cognitive behavioral therapy (CBT) program for people with urologic chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The treatment is mostly home-based with minimal therapist contact, teaching skill…

This study tests whether a 12-week progressive resistance exercise program can reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist control group. The goal is to see if exercise provides a mea…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This phase 2 study at Yale University is testing whether a combination of THC and CBD can reduce both pain sensitivity and opioid cravings in people who have opioid use disorder and chronic low back pain. The 147 participants are all on methadone therapy and will receive either a…

This study tests a new method for placing spinal cord stimulators in people with chronic back pain. The device uses electrical recordings to confirm the lead is in the right spot. Twenty adults with long-term back pain will take part, and researchers will measure pain relief and …

This study looks at whether teaching older adults about how pain works, combined with supervised exercise, can reduce chronic pain and improve daily life. One hundred people aged 65 and older with pain lasting over 3 months will be split into three groups: exercise only, exercise…

This study tests a single online class called Empowered Relief, delivered in Spanish to adults with chronic pain. The class teaches pain relief skills, and participants fill out surveys right after, at 2 weeks, and at 1 month. The goal is to see if the class is helpful and satisf…

This study is testing a smartphone app called Digital SPA, designed with input from teens, to help adolescents aged 12–17 manage chronic pain. The app uses Acceptance and Commitment Therapy techniques to reduce pain interference and emergency room visits. About 195 teens and thei…

This study tests whether adding a sugar solution (dextrose) to numbing injections around the knee nerves provides better pain relief than numbing medicine alone for people with chronic knee osteoarthritis. Sixty adults with knee arthritis will receive a series of three injections…

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all treatment, researchers will use each person's brain signals to customize the stimulation. The goal is to improve pain relief for the 90 participants…

This small study looks at whether combining chiropractic care with group medical visits is a practical way to help adults 65 and older who have chronic neck or back pain. Ten participants will receive both chiropractic adjustments and virtual group support sessions. The goal is t…

This study tests a low-cost training program for doctors and their patients with chronic pain. The program teaches team-based skills to manage pain and reduce reliance on opioids. About 1,188 participants (patients aged 14–80 and their doctors) will take part. The goal is to see …

This study tests a 10-week program called GetActive+ that combines gentle walking with mind-body techniques to help older adults (55+) with long-term muscle or joint pain. Researchers want to see if it improves physical function, mood, and daily activity compared to usual care. T…

This study is testing three treatments one after another for people with chronic pain who are already taking long-term opioids. First, participants try a low-dose buprenorphine patch (a safer opioid) without going through withdrawal. Then, they receive a brief cognitive behaviora…

This study compares two short behavioral therapies—mindfulness (B-MORE) and cognitive-behavioral therapy (CBT)—for adults with chronic pain. Both treatments are just two hours long and offered in English or Spanish. The goal is to see if these brief programs are practical and acc…

This study is testing whether low-intensity focused ultrasound (LIFU) — a noninvasive device that sends sound waves to the brain — can help people with chronic back pain, opioid cravings, and anxiety. Researchers will enroll 25 adults and measure safety, mood, heart rate, and oth…

This study tests whether high-frequency spinal cord stimulation can reduce leg pain and improve quality of life in people with both peripheral arterial disease (PAD) and painful diabetic neuropathy. Fifteen adults who already have a spinal cord stimulator implanted will receive t…

This study is for active-duty military members and their families who have chronic back or neck pain. It will test treatments like acupuncture, laser therapy, and shockwave therapy to see if they reduce pain and improve daily life. The goal is to find safer, non-drug options to h…

This study tests a new program called PREP-Y, designed to help adolescents aged 12-17 with chronic musculoskeletal pain become more physically active and better manage their pain. The program includes four weekly virtual sessions teaching resilience skills like motivation and cop…

This pilot study tests a mindfulness-based program called Quiet Focus, adapted for older Black adults (age 50+) who have both chronic pain and mild depression. Researchers want to see if it's feasible and acceptable, and whether it can improve quality of life and reduce pain inte…

This study is for people with chronic back or leg pain who are already scheduled to get a spinal cord stimulator. Researchers want to see if a new method called telefitting can find the best stimulation settings faster and more effectively. Participants will try different stimula…

This study is testing whether herbal medicine and vitamin IV therapy can reduce symptoms of anxiety, fibromyalgia, arthritis, chronic pain, and high blood pressure. Researchers plan to enroll 25 people and measure improvements in health and quality of life. The approach uses natu…

This study is testing whether a focused muscle contraction exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans. Twenty-five veterans with pain, fatigue, or low energy will do 90 exercise sessions over 18 …

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of major depression and chronic pain at the same time. Fifty-four adults with moderate depression and pain will receive 30 sessions of active rTMS over several weeks. Researchers …

This pilot study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain the brain's pain response. Forty adults with chronic pancreatitis and persistent abdominal pain will receive 5-10 daily sessions. Researchers will measure pai…

This study tests whether adding shiatsu—a gentle Japanese bodywork therapy—to standard medical care can improve quality of life for children aged 10 to 18 with chronic non-inflammatory pain. About 40 participants will receive one 30-minute shiatsu session per week for six weeks a…

This study tests whether a 7-minute guided mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for spine pain. Half of the 80 participants will do the mindfulness exercise, while the other half will receive standard pa…

This study follows 105 adults with chronic pain, nerve damage, or slow wound healing from cancer treatments. They receive ozone therapy as an add-on to their usual care. Researchers track changes in quality of life, anxiety, and depression to see if ozone therapy helps.

This study evaluates a questionnaire called the Emotional Allodynia Questionnaire (AEQ), which measures how people with fibromyalgia react emotionally to everyday social cues. Researchers want to see if the tool can reliably identify fibromyalgia and tell it apart from other type…

This study uses MRI scans to look at brain and spinal cord structure and function in people with cerebral palsy who experience chronic pain. Researchers hope to find patterns in the brain that are linked to pain and sensory issues. Participants aged 8 and older with cerebral pals…

This study asks 200 adults with chronic pain about their preferences between pain relief and common side effects like drowsiness, nausea, or addiction risk. Participants rate how much each side effect bothers them compared to the benefit of pain relief. The goal is to help doctor…

This study tests whether a special band-aid (called the A-Band) and a smartwatch can measure pain in women with chronic pain using AI. About 115 women with chronic pain and healthy women will wear the devices for a week and report their pain levels. The goal is to see if the devi…

This study looks at how emotional intelligence—the ability to understand and manage emotions—relates to chronic orofacial pain (pain in the face or mouth lasting over three months). Researchers will compare 88 adults with and without this pain using questionnaires about emotions,…

This study will look at the medical records of 15,000 people with chronic pain to see how well different treatments, like spinal cord stimulation, worked for them. The goal is to learn which approaches provide the best pain relief. No new treatments are being tested; instead, res…

This study looks at how mindfulness meditation and self-hypnosis work in the brains of adults aged 60 and older who have had chronic pain for at least 3 months. Participants will be randomly assigned to mindfulness, hypnosis, or story listening, and will undergo brain scans and E…

This study looks at how spinal cord stimulation (SCS) affects brain activity in veterans with long-term nerve pain. Researchers will use non-invasive brain scans (fNIRS and EEG) to compare brain connectivity in SCS users and those being evaluated for SCS. The goal is to understan…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain and/or opioid use to healthy women. The goal is to find new ways to treat chronic pain without relyi…

This study compares two widely used drug classes—anti-convulsants and anti-depressants—for treating chronic pain in 450 real-world patients. Unlike typical trials that exclude many patients, this one includes people with other health issues to get results that apply to more peopl…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study explores how dopamine, a brain chemical linked to motivation, influences chronic pain. Ten adults with chronic pain will receive two dopamine-boosting drugs (methylphenidate and carbidopa-levodopa) or a placebo, then undergo brain scans to measure changes in key pain-r…

This study aims to find out why some people with sickle cell disease develop severe, disabling chronic pain while others do not. Researchers will enroll 70 participants aged 15 to 40 and use surveys, virtual visits, and in-person pain sensitivity tests to track pain and related o…

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study looks at whether a type of IV line called a midline catheter can be used safely and effectively for repeated lidocaine infusions in an outpatient clinic. About 500 adults with chronic pain will receive ten lidocaine infusions through a midline catheter. Researchers wil…

This study aims to create a large e-cohort of 5,000 chronic pain patients using a smartphone app called eDOL. The app lets patients report their pain, treatments, and daily life, while doctors can monitor them through a web platform. The goal is to better understand chronic pain …

This study will enroll 200 adults who have ongoing low back pain for at least 3 months after back surgery. Researchers will classify each person's pain as nerve-related, muscle/joint-related, or other, and then compare how these pain types affect pain severity, disability, and qu…

This study watches how daily emotional stress impacts memory and thinking in adults aged 60 and older living in Seoul, Korea. Participants use a smartphone app to report their feelings and do quick brain games, wear a smartwatch, and give blood samples. Researchers will check in …

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Researchers will use non-invasive brain stimulation and computer tasks to record brain signals.…

This study is observing 120 people with chronic pain to learn how to design a more effective pain clinic. Researchers will track pain levels, medication use, and overall well-being. The goal is to understand what patients need, not to test a new treatment.

This study aims to understand why people with chronic pain or opioid use disorder often have worse pain after spine surgery. Researchers will analyze blood and skin samples from 40 participants to look for unique immune and genetic markers linked to pain. The goal is to find bett…

This observational study looks at why some people with knee osteoarthritis have worse pain than others, even when their knee damage looks similar on X-rays. Researchers will study 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tests, kn…

This study looks at two types of spinal cord stimulation for people with long-term nerve pain after back surgery. One type causes a tingling sensation, while newer types do not. Researchers will use brain scans and pain questionnaires to figure out how each type works and which p…

This study is testing whether conversational AI software can effectively collect health information from people with chronic pain. Participants will chat with a digital tool that asks about their physical symptoms, emotions, and social life. The goal is to see if patients find th…

This study aims to find out if spinal cord stimulation (SCS) truly reduces pain or if the effect is just due to patients' expectations. Twenty-five adults with chronic pain who already have an SCS implant will take part in four test sessions. During each session, the stimulator w…

This study looks at why people with long-term nerve pain often feel less motivated. Researchers will use brain scans (fMRI) and a reward-learning task to compare 50 chronic pain patients with healthy volunteers. The goal is to understand brain changes linked to motivation, not to…

This study looks at whether a special pain test called Pancreatic Quantitative Sensory Testing (P-QST) can predict how well people with chronic pancreatitis will respond to treatments like endoscopy or surgery. About 150 adults with chronic pancreatitis and ongoing pain will take…

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will give a single injection of oxytocin or a placebo to 38 people (some with knee arthritis, some healthy) and measure tiny changes in pupil…

This study tests a new way to adjust spinal cord stimulation in 15 adults with chronic pain who already have spinal cord implants. Researchers will use electrical recordings called ECAPs to find the best stimulation settings. The goal is to see if this approach is feasible and ac…

This study follows 800 adults who spent at least 48 hours in the ICU to understand why some develop chronic pain. Researchers will call participants at 90 and 180 days after discharge to ask about pain, sleep, and quality of life. A smaller group will also have a detailed physica…

This study looks at how quitting smoking temporarily increases pain in people with chronic pain, and how the brain processes this. Researchers will use brain scans and daily reports from 132 smokers—some with chronic back pain, some without—to understand these changes. The goal i…

This study is testing how well a culturally adapted screening and brief counseling program works for American Indian and Alaska Native adults who have chronic pain or misuse opioids. Researchers will work with three clinics to see if the program is easy to use and helpful. The go…

This study follows 5,000 children aged 0-16 before and up to one year after surgery to learn how many develop chronic pain and why. Parents and children fill out questionnaires about pain, anxiety, and recovery. The goal is to find risk factors so doctors can better prevent long-…

This study looks at whether using a CPAP machine for obstructive sleep apnea can also help people with chronic pain. Researchers will follow 80 adults newly diagnosed with sleep apnea who are starting CPAP therapy. Participants will fill out pain and sleep questionnaires at the s…

This study explores whether a sham (fake) neurofeedback system in virtual reality can change brain activity related to attention. About 35 adults with rumination or chronic pain will undergo EEG recordings while experiencing positive, negative, or no feedback. The goal is to see …

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study is testing whether a supplement called Boswellia serrata (also known as frankincense) can change how healthy people feel pain. Twelve volunteers will take either the supplement or a placebo for a short time, then have a small amount of capsaicin (the stuff that makes c…

This study checks if a computer algorithm can correctly identify the cause of chronic pain, just like a pain specialist would. About 200 adults with pain lasting at least one month will have their symptoms and history analyzed by both the algorithm and a doctor. The goal is to se…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study looks at how brain circuits are connected in people with chronic temporomandibular joint (TMD) pain compared to pain-free individuals. Researchers will use MRI scans to map brain activity and structure in 95 female participants. The goal is to find patterns that could …

This study looks at nerve-related problems like numbness, tingling, and pain in people who have been treated for oral cavity or throat cancer. Researchers will use simple tools like brushes and temperature tests to map these sensations. The goal is to better understand how common…

This study looks at how spinal cord stimulation (SCS) changes certain molecules in the blood and spinal fluid of people with long-term nerve pain. Researchers will measure inflammatory markers and other signaling molecules before and after SCS in 30 adults. The goal is to underst…