CHRONIC PAIN

This study tests whether adding a type of talk therapy (Acceptance and Commitment Therapy) and a smartphone care management app can improve outcomes for people being treated for opioid use disorder with buprenorphine who also have chronic pain. About 123 adults will participate. …

This study is for adults with chronic pain who have been taking prescription opioids for at least 90 days and face extra risks like using benzodiazepines or having a substance use disorder. Researchers will test three approaches in sequence: a low-dose buprenorphine patch, a brie…

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study is following 2,000 adults with chronic pain who receive an Abbott neurostimulator implant. The goal is to see how safe and effective the device is over time by tracking side effects and device problems. Participants must have severe pain (score 6 or higher) and be sche…

This study is testing a non-invasive brain stimulation technique (tDCS plus ultrasound) to see if it can reduce drug use and pain in people with opioid addiction and chronic pain. About 126 adults on methadone treatment will receive either real or fake stimulation over several we…

This study tests whether combining motivational interviewing with guided opioid tapering, plus either tizanidine or a placebo, helps people who have used opioids long-term stop them after spine surgery. About 375 adults aged 18-64 with chronic back or neck pain will be randomly a…

This study tests whether a combination of THC and CBD, taken by mouth, can reduce both pain and cravings for opioids in people who have opioid use disorder and chronic pain. About 147 adults on methadone therapy will take part. Researchers will measure pain sensitivity and opioid…

This study tests a new device that uses tiny electrical pulses to try to restore feeling in the breast after mastectomy. It also aims to reduce chronic pain. The trial will include 8 women who are scheduled for double mastectomy with reconstruction. The goal is to see if this app…

This study is testing whether a 10-session phone or online coaching program can help people who have both chronic pain and problems with opioid use. Researchers want to see if this program helps participants manage their pain better and stay engaged in treatment for opioid use di…

This study tests whether treating PTSD symptoms soon after acute pain starts can stop the pain from becoming long-term. Researchers will use either a nerve block or talk therapy to reduce PTSD, and then track pain levels over time. The goal is to prevent chronic pain in 345 adult…

This study is testing a training program for doctors and their patients with chronic pain. The program teaches team-based, non-drug ways to manage pain and improve daily life. About 1,188 people (ages 14-80) with long-lasting pain will take part. The goal is to see if the program…

This study compares a 10-week program called GetActive+ (which combines mind-body techniques with walking) to usual care for 200 older adults aged 55+ who have had musculoskeletal pain for at least 3 months. The goal is to see if the program improves physical function, such as wa…

This study tests whether a team of pain specialists—including doctors, psychologists, pharmacists, dietitians, and physical therapists—can help veterans with chronic pain feel better and live more fully. About 150 veterans will either join the program right away or wait six month…

This study tests a brief, 4-session cognitive behavioral therapy (CBT) program for people with urological chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The goal is to reduce pain and improve daily life. Researchers will enroll 240 …

This study tests whether injecting platelet-rich plasma (PRP) into the shoulder, combined with a personalized exercise program, provides better and longer-lasting pain relief than standard steroid injections. About 86 adults aged 35-75 with chronic shoulder pain from rotator cuff…

This study tests whether an 8-week program combining art, mindfulness, and body awareness in a university museum can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to the museum program or a control group. The goal is…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce chronic leg pain in people with both type 2 diabetes and peripheral artery disease. Fifteen adults who already have a permanent stimulator will receive two weeks o…

This study tests a wearable device called the Sana Pain Reliever (Sana PR) to see if it can reduce chronic pain in people with Post-treatment Lyme Disease Syndrome. The device uses flashing lights and sounds while measuring heart rate. Thirty participants will use it at home for …

This study tests whether virtual reality (VR) therapy can reduce pain and disability in people with chronic low back pain. Two hundred adults aged 18 to 85 with back pain for at least 6 months will use VR for 8 weeks. One group gets distraction-based VR, the other skills-based VR…

This study tests whether using a weighted blanket at night can reduce chronic pain and improve sleep in veterans. Researchers will give 160 veterans either a light (3-pound) or heavy (15-pound) blanket to use at home for 6 weeks. The goal is to see if the heavier blanket provides…

This study tests if a 2-week, entirely home-based treatment combining mild brain stimulation (tDCS) with prolonged exposure therapy can reduce chronic pain and PTSD symptoms better than therapy alone. About 146 adults with both conditions will participate remotely. The goal is to…

This study tests whether a very short (7-minute) mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for back pain. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard ca…

This early-stage study tests whether metformin, a standard diabetes medication, can reduce pain and improve healing in people with chronic Achilles tendon pain. Forty non-diabetic adults will take either metformin or a placebo for 16 weeks, combined with a home exercise program. …

This study tests a specially adapted mindfulness program for older Black adults (age 50+) who have both chronic pain and mild to moderate depression. The goal is to see if this program can improve quality of life and reduce how much pain interferes with daily activities, compared…

This study tests a telehealth program that teaches rural veterans with chronic pain how to use the connection between their mind and body to feel better. About 500 veterans will take part, learning skills to reduce pain's impact on daily life. The goal is to help them manage pain…

This study looks at whether a type of IV called a midline catheter can be used safely and effectively for repeated lidocaine infusions to treat chronic pain outside the hospital. About 500 adults who need ten sessions of lidocaine will get the infusions through this catheter. The…

This study tests if listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults with pain will be randomly assigned to hear either a mindfulness practice or standard injury advice. The goal is to see if a simple, no-drug ap…

This study looks at whether a specific exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans who suffer from chronic pain, fatigue, or depression. Twenty-five veterans will do 90 exercise sessions over 18 m…

This study tests whether group-based pain management can help low-income adults with chronic pain feel better and more supported. About 360 participants will join group sessions that address pain, stigma, and social isolation. The goal is to reduce pain's impact on daily life and…

This study tests a program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and reduce opioid use. Researchers will see if more patients in the program can safely stop tak…

This study tests whether personalized lifestyle coaching can reduce chronic muscle and joint pain in people aged 60 and older. About 268 participants will be randomly assigned to either receive four coaching sessions or continue their usual care. The goal is to see if lifestyle c…

This study tests if a mobile app (WebMAP Onc) can help teen cancer survivors manage chronic pain better than standard pain education. About 228 adolescents and their caregivers will participate across four U.S. hospitals. The app uses cognitive behavioral therapy techniques to re…

This study is testing a spinal cord stimulation device called Inceptiv to see if it can safely reduce chronic pain over time. About 970 adults with hard-to-treat pain will get the device and be followed for at least 6 months. The main goal is to see how many people have at least …

This study tests whether cognitive behavioral therapy for chronic pain (CBT-CP) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will measure changes in pain interference, quality of life, and …

This study tests whether adding shiatsu therapy to usual care can improve quality of life for children and teens (ages 10-18) with chronic non-inflammatory pain. About 40 participants will receive six weekly 30-minute shiatsu sessions and complete questionnaires. The goal is to s…

This early-phase study tests whether adding lacosamide, a seizure medication, to standard opioid therapy can safely reduce pain and opioid-related side effects in people with chronic pancreatitis. About 24 adults with ongoing abdominal pain who already take opioids will receive l…

This study tests an internet-based therapy program for 10 people with endometriosis and chronic pain. The program teaches skills like mindfulness and acceptance to help reduce pain's impact on daily life. Participants work through online exercises and have phone support from a ps…

This study looks at whether taking methadone once or twice a day is better for managing both chronic pain and opioid use disorder. Researchers will enroll 150 adults who have been on methadone for at least 90 days. Participants will be assigned to either once-daily or twice-daily…

This study tests whether a 6-week pain education program helps people with chronic pain become more active and feel less pain and depression. About 50 adults with pain lasting over 3 months will attend group sessions on sleep, stress, and pain science. There is no comparison grou…

This study tests if an internet-based therapy called Acceptance and Commitment Therapy can help people with both PTSD and chronic pain. About 40 adults will be randomly assigned to start therapy right away or wait. The goal is to see if symptoms like PTSD severity, anxiety, and d…

This study tests whether probenecid, a safe drug already used for gout, can reduce the unpleasant symptoms of opioid withdrawal. About 40 adults with chronic pain who are voluntarily lowering their opioid dose will receive either probenecid or a placebo. The goal is to see if the…

This pilot study tests a group-based Zoom therapy called Emotional Awareness and Expression Therapy (EAET) for 30 adults with both chronic pain and opioid use disorder. The goal is to see if the therapy is acceptable and feasible, and whether it helps reduce pain, disability, dep…

This study looks at whether cannabidiol (CBD) is safe and can help with pain and opioid cravings in 34 adults who are on medication (methadone or buprenorphine) for opioid use disorder and also have chronic pain. Participants will receive CBD or a placebo in four separate session…

This study looks at whether adding short lessons about how pain works to a supervised exercise program can improve pain, movement, and quality of life in adults 65 and older with long-term pain. About 100 participants will be split into three groups: exercise only, exercise plus …

This study tests a high-CBD (cannabidiol) product taken under the tongue for 9 weeks in 25 adults with chronic pain conditions like arthritis or injury-related pain. Researchers will measure changes in pain levels, quality of life, and medication use compared to a placebo. The go…

This study tests a new, personalized brain stimulation technique (HD-tDCS) to help people with long-term chronic pain. Researchers will give 144 adults either real or placebo stimulation over five sessions, targeting a brain area linked to pain. The goal is to see if this approac…

This study looks at whether daily text reminders and mindfulness messages can help people taking medication for opioid use disorder stick to their treatment and better manage cravings, pain, and withdrawal. About 60 adults who recently started or resumed methadone or buprenorphin…

This study tests a single online class called Empowered Relief, delivered in Spanish, to help adults with chronic pain learn pain management skills. About 110 Spanish-speaking adults with pain lasting 3 months or more will take part. Researchers will check if the class is helpful…

This study tests whether a painless brain stimulation technique (tDCS plus ultrasound) can reduce chronic pain in people with carpal tunnel syndrome. About 95 adults with long-term wrist pain will receive either real or fake stimulation to see if it lowers their pain scores. The …

This early-stage study tests if stem cells from a patient's own bone marrow can reduce pain and improve pancreas function in people with chronic pancreatitis. About 40 adults with long-term pain will receive the treatment and be monitored for changes in pain scores, medication us…

This study looks at whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in daily smokers who have chronic pain and are being treated for opioid use disorder with buprenorphine. About 60 participants will be randomly assigned to either very …

This study tests whether Pain Reprocessing Therapy (PRT) works better than cognitive behavioral therapy or usual care for veterans with long-term back or neck pain. About 360 veterans will be randomly assigned to one of the three options. PRT teaches the brain to reinterpret pain…

This study tests whether virtual reality-based exercises can reduce neck pain and improve daily activities in adults with chronic neck pain or whiplash. Participants will do 12 sessions over 6 weeks, either with VR or without. The goal is to see if VR makes rehabilitation more ef…

This study tests if injecting a sugar (dextrose) solution around knee nerves can reduce chronic pain from knee osteoarthritis better than a numbing medicine alone. About 60 adults with knee arthritis will receive a series of three injections. Researchers will measure pain levels …

This study tests four coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Researchers want to see if this approach improves pain and related symptoms. The study involves 468 veterans and is conducted entirely online.

This study is testing whether a non-invasive brain stimulation technique called tDCS can help reduce chronic pain in veterans and military members. About 100 participants will use a headset that sends a mild electrical current to the brain while they also take part in a behaviora…

This study looks at whether a 12-week progressive resistance exercise program can help reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist group receiving usual care. The goal is to see if ex…

This study looks at two types of nerve blocks (pectoral nerve block and paravertebral block) given during mastectomy to see which one better prevents chronic pain. About 90 women having mastectomy will be randomly assigned to one of the blocks. The goal is to reduce long-term pai…

This small pilot study is testing whether a mind-body program can help people with long-term wrist, elbow, or shoulder pain (often from repetitive stress). Researchers want to see if it improves daily function, lowers pain intensity, and reduces pain-related worry. The study enro…

This study tests an internet-based guided self-help program based on Acceptance and Commitment Therapy (ACT) for adults with chronic pain. The program helps people accept their pain and focus on living a meaningful life rather than fighting the pain. Researchers will measure pain…

This study compares two online programs—yoga and Acceptance and Commitment Therapy (ACT)—to see which better helps veterans with long-term muscle and bone pain. About 274 veterans will take part. The goal is to find which approach reduces pain's impact on daily life, mood, and sl…

This study tests whether a mind-body program can help people with long-term back pain feel better and move more easily. About 150 adults with chronic back pain will be randomly assigned to the mind-body program, a different mind-body approach, or usual care. Researchers will meas…

This study enrolls 40 adults with chronic pancreatitis whose abdominal pain persists despite standard treatments. Researchers will test Scrambler Therapy, an FDA-cleared device that sends gentle electrical signals through the skin to retrain how the brain perceives pain. Particip…

This study tests whether adding online pain education to standard physical therapy helps people with chronic low back pain. 60 adults aged 20-60 will be split into two groups: one gets physical therapy plus six weekly online sessions about how pain works, the other gets physical …

This study looks at whether adding Whole Health Coaching (WHC) to standard pain management helps veterans with chronic pain. About 432 veterans who take long-term opioids and have safety concerns will be split into two groups: one gets usual care, the other also gets WHC. The goa…

This study looks at whether combining mindfulness-based stress reduction (MBSR) with open-label placebo pills (pills that people know are fake) can help adults with chronic pain. About 45 participants will be randomly assigned to MBSR alone, placebo alone, or both together for 8 …

This study tests a small, battery-powered headband that delivers a gentle electrical stimulation to the scalp to reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is…

This study tests two approaches to help adults with chronic pain who take long-term opioids: a mindfulness program called MORE and patient-centered pain management visits. The goal is to see if these methods can reduce pain, improve quality of life, and lower the risk of opioid m…

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will measure pain changes, opioid use, and quality of life in 48 adults over 6 months. The goal is to see if this approach is safe and offers rel…

This study is testing a group training program for parents of children aged 10-17 who have had chronic pain for at least 3 months. The program aims to help parents better support their child, with the goal of reducing the child's pain and improving their daily functioning. About …

This study is testing whether low-intensity focused ultrasound (LIFU) can safely reduce pain, drug cravings, and anxiety in adults with chronic back pain and opioid use disorder. About 25 participants will receive the ultrasound and be monitored for side effects and changes in mo…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if the app is acceptable and helpful for adults who are in recovery from opioid use disorder and also have chronic pain. Ten participants will use the app and p…

This study tests a new type of spinal cord stimulation (called TVP-SCS) in 70 adults with long-term back and leg pain that hasn't responded to other treatments. The goal is to see if this approach can reduce pain by at least 50% after 3 months. Participants will use a commerciall…

This study tests whether a capsaicin 8% skin patch (made from chili pepper extract) can reduce long-term nerve pain in teens aged 12 to 17 whose pain started after surgery or an injury. Half the teens get the real patch, half get a plain sticky dressing. The patch is applied once…

This study tests a faster type of brain stimulation (called accelerated TMS) for people with long-term chronic pain that hasn't improved with medication. Researchers will use a smart computer algorithm to choose the best spot on the brain for each person. The goal is to see if th…

This study is testing a new group music therapy program called POPSINGER for people with chronic pain. 24 adults will attend 16 sessions, half in-person and half online, to see if the program is practical and helpful. The goal is to see if music therapy can ease pain and improve …

This study tests a 6-month mobile program for 200 older adults (65+) with knee or hip arthritis pain, overweight, and low activity. Participants get weekly group or individual coaching on physical activity and healthy eating, plus goal-setting calls. The goal is to increase daily…

This study is for active-duty military members and their families who have chronic back or neck pain. It will test treatments like acupuncture, laser therapy, and shockwave therapy to see if they help reduce pain and improve quality of life. The goal is to find safer, non-drug op…

This study tests a new training program that teaches people with chronic pain and emotional distress to accept their pain rather than fight it. The program is based on dialectical thinking, which helps people hold two ideas at once: wanting the pain to stop while also accepting i…

This study tests a smartphone app called QoLibri designed to help people with chronic pain. The goal is to see if using the app improves quality of life and reduces how much pain interferes with daily activities. About 410 adults with moderate or worse pain lasting over 3 months …

This study tests two behavioral programs to improve sleep in people with chronic pain who take prescribed opioids. Researchers want to see if better sleep can help reduce pain and lower opioid use. The study involves 165 adults who have chronic pain, insomnia, and take opioids at…

This study tests a program called SCOOP for adults aged 60 and older living in rural areas who have chronic pain and feel lonely. Participants watch short videos and have up to 7 weekly coaching sessions with a community health worker. The goal is to see if the program reduces ho…

This study looks at whether adding yoga or physical therapy to standard care can help people with chronic back pain who are also being treated for opioid use disorder. About 180 adults will be randomly assigned to 12 weeks of onsite yoga, onsite physical therapy, or usual care. R…

This small study tests a mind-body program for people with chronic migraines. The goal is to see if the approach is practical and which tools best measure its effects on pain and daily life. Ten adults with frequent migraines will participate in remote sessions to help design a f…

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. About 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available…

This study tests a coaching program for Black patients with long-term muscle or joint pain and depression. The program helps patients learn about and stick with non-drug treatments like physical therapy or counseling. 304 adults will be randomly assigned to either the coaching pr…

This study explores whether a virtual reality mindfulness program can help veterans with spinal cord injury manage chronic pain. Ten veterans will try the adapted VA CALM program using VR headsets. The goal is to see if VR is a practical and acceptable way to deliver mindfulness …

This study tests whether a noninvasive treatment called transcutaneous pulsed radiofrequency can reduce chronic pain caused by postherpetic neuralgia, a complication of shingles. About 35 adults with this nerve pain will receive the treatment, and researchers will measure pain le…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a short-term anti-inflammatory drug only before planned walks to help with movement pain, while also learning about proper footwear and avoiding fear of movement. The goal is …

This study tests whether a continuous nerve catheter placed in the thigh provides better pain relief and reduces opioid use compared to a single nerve block after total knee replacement. About 64 adults scheduled for knee surgery will be randomly assigned to receive either the ca…

This study tests whether a synthetic THC pill (dronabinol) can safely reduce chronic low back pain. About 75 adults with pain lasting at least 3 months will take either the drug or a placebo daily for 8 weeks. The goal is to see if the drug is safe enough for larger future studie…

This study tests two phone-based programs—brief behavioral therapy for insomnia and brief mindfulness training—in 200 adults with HIV, chronic pain, and insomnia. The goal is to see which approach better improves sleep quality, reduces pain, and may slow biological aging. Partici…

This study looks at whether combining chiropractic care with group medical visits can help adults 65 and older who have chronic spine pain. Ten participants will receive chiropractic adjustments and attend virtual group sessions. The goal is to see if this approach is practical a…

This study is looking at whether adding ozone therapy to standard care can improve the quality of life for people with long-lasting pain caused by cancer treatments or other conditions. About 105 adults who have not found relief from other treatments will receive ozone therapy an…

This study looks at how well spinal cord stimulation works for people with long-term pain. About 25 adults who already have a spinal cord stimulator will rate their pain with the device on and off. The goal is to see if the stimulation truly reduces pain compared to a placebo eff…

This study tests whether a stepped care program using complementary health approaches (like mind-body therapies) can help people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive this stepped care or their usual treatment. Research…

This study compares two treatments for chronic tailbone pain (coccydynia): hands-on osteopathic manual therapy and a nerve block injection. About 100 adults with persistent pain will be randomly assigned to one treatment. Researchers will measure pain and daily function at 3 week…

This study explores whether herbal medicines, vitamin IV therapy, and supplements can reduce symptoms of anxiety, arthritis, fibromyalgia, chronic pain, and high blood pressure. About 25 participants will receive natural treatments aimed at improving health and quality of life. T…

This study looks at whether a 6-week music class (drumming and rhythm exercises) can improve mental and physical health in older adults living in residential care. About 60 participants will attend weekly hour-long sessions and complete surveys before and after. The goal is to se…

This study compares two short behavioral treatments—mindfulness and cognitive-behavioral therapy—for adults with chronic pain. Both are offered in English and Spanish. The goal is to see which approach is more feasible and acceptable, and how they affect pain, mood, and anxiety. …

This study tests four different programs to help cancer survivors who have been using opioids for a long time reduce their opioid use and better manage chronic pain. About 294 veterans who have finished cancer treatment and still have pain will try one of these programs. The goal…

This study is testing a smartphone app called Digital SPA, designed with input from teens, to help young people aged 12-17 manage chronic pain. The app provides pain management resources to prevent long-term disability. Participants will use the app, fill out online questionnaire…

This study looks at whether a smartphone-based mindfulness program is practical and helpful for teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use guided mindfulness exercises on their phone for about 8 weeks. Th…

This study is testing a trilingual smartphone app and telehealth coaching program to help Black, Chinese, and Latinx adults in the San Francisco Bay Area manage chronic pain without medication. About 586 people with long-term pain will be randomly assigned to use the app and coac…

This study looks at a new method to fine-tune spinal cord stimulators for people with chronic back or leg pain. Fifteen adults who are already scheduled to get a stimulator will try different stimulation settings without knowing which one they are using. The goal is to see if a s…

About 20-30% of people still have pain after total knee replacement. This study tests freezing the knee nerves at least 24 hours before surgery to see if it lowers pain and helps patients move better. One hundred adults with knee arthritis will be randomly assigned to get the ner…

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study aims to improve chronic pain treatment by personalizing magnetic brain stimulation. Instead of a one-size-fits-all approach, researchers will use brain signal measurements to tailor the stimulation to each person. The goal is to help more people get relief from their p…

This study looks at whether playing music during common back pain treatments can lower patients' pain and anxiety. About 30 adults will be randomly assigned to either listen to music or not during their procedure. Researchers will measure anxiety and pain levels before and after …

This study compares two 9-week community programs for adults with chronic back or neck pain. One program teaches mind-body skills like mindfulness and cognitive behavioral techniques; the other focuses on general health and well-being. Researchers want to see which program better…

This study is testing whether a smartphone app can help Black and LGBTQ+ adults with long-term pain that makes daily activities hard. The app teaches skills to manage pain and improve quality of life. Researchers will enroll 300 people across the U.S. to see if the app is easy to…

This study looks at whether a type of talk therapy focused on emotions can help people with ongoing pain after a serious bone injury. About 30 adults who had major orthopedic trauma will attend weekly therapy sessions and complete questionnaires and pain tests. The main goal is t…

This study is testing if a single 2-hour educational class about pain and coping skills helps people recover better after knee or hip replacement surgery. Researchers will compare the class to standard post-surgery care. They want to see if the class reduces pain and improves dai…

This study is testing whether a specific type of hands-on manual therapy, given every two weeks, is better than self-managed exercise at reducing chronic neck pain and improving daily function. It will involve 250 adults who have experienced bothersome neck pain for over a year. …

This study tests if a non-invasive brain stimulation technique called rTMS can reduce both depression and chronic pain symptoms. Researchers will enroll 54 adults with moderate major depressive disorder and pain. Participants will receive 30 sessions of active rTMS and complete s…

This is a small pilot study to test a new virtual therapy program designed to treat PTSD and chronic pain at the same time. The program combines techniques from two established therapies over 12 online sessions. Researchers will check if the combined approach is practical and acc…

This study is testing a new virtual program called PREP-Y that teaches teens with chronic muscle or joint pain skills to become more physically active and better manage their pain. The program includes four weekly online sessions focusing on building resilience, motivation, and c…

This study explores whether a technique called Quantitative Sensory Testing (QST) can identify different pain patterns in people with chronic pancreatitis. By using gentle stimulations to map how the nervous system processes pain, researchers hope to predict which patients will b…

This study looks at how well a culturally tailored screening and brief intervention program works for chronic pain and opioid misuse in three clinics serving American Indian and Alaska Native people. Researchers will track how many patients are screened and gather feedback from s…

This observational study looks at why some people with knee osteoarthritis have more severe pain than others, even when their knee damage looks similar. About 300 adults aged 45-80 with chronic knee pain will complete surveys, physical tests, knee X-rays and MRIs, brain imaging, …

This study looks at how oxytocin, a natural hormone given as a shot, affects the part of your nervous system that helps you rest and digest. Researchers will measure tiny changes in pupil size to see the effect. The study includes healthy adults and people with chronic knee pain …

This study looks at nerve-related problems like numbness, tingling, and pain in people who finished treatment for mouth or throat cancer 1 to 5 years ago. Researchers will examine 120 participants to map where these sensations occur and how they affect quality of life. The goal i…

This study follows 5,000 children aged 0-16 years for up to one year after surgery. Researchers use questionnaires to find out how many develop chronic pain and what factors (like anxiety or pain before surgery) increase the risk. The goal is to better understand and eventually p…

This observational study in Seoul, Korea, looks at how everyday emotional stress impacts memory and thinking in adults aged 60 and older. Over two weeks, participants use a smartphone app to report their feelings and do quick brain games, while wearing a smartwatch to track sleep…

This study looks at how brain circuits are connected in people with chronic temporomandibular joint (TMD) pain compared to those without pain. Researchers will use MRI scans to find patterns that may explain pain-related disability. The goal is to better understand TMD and potent…

This study compares two types of pain medications (anticonvulsants and antidepressants) in 450 adults with chronic pain to see which works better in everyday life. Unlike traditional trials, this one includes patients with other health issues, making results more useful for real …

This study gathers information directly from up to 50,000 people who have received or plan to receive a commercially approved medical device or procedure for chronic pain. Researchers will track changes in pain levels over time using patient reports. The goal is to understand how…

This study aims to better understand chronic pain by following 5,000 patients through a smartphone app called e-DOL. Participants will regularly report their pain levels, treatments, and daily life impacts. The goal is to identify patterns and factors that influence pain over tim…

This study is testing a mobile app called Wysa for Chronic Pain to see if customizing in-app notifications can help people use it more. The app is designed for adults aged 45 and older who have chronic pain along with depression or anxiety. About 1000 participants will use the ap…

This study aims to find out why some people with sickle cell disease develop severe, disabling chronic pain while others do not. Researchers will track 70 participants aged 15 to 40 over up to 48 months using surveys and pain tests. The goal is to improve pain management and guid…

This study is testing a new method called Pancreatic Quantitative Sensory Testing (P-QST) to see if it can predict how well people with chronic pancreatitis will respond to pain-relieving procedures like endoscopy or surgery. Researchers will measure pain levels before and after …

This study looks at how long-term opioid use changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain, those with opioid use, and healthy women. The goal is to find new ways to treat chronic pain without re…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain, as well as healthy volunteers, over four months. The goal is to find patterns that predict whether pain becomes chronic, improves, or flares up. A smalle…

This study reviews anonymous medical records from 15,000 adults with chronic pain to see how well different treatments worked. No new treatments are given—researchers simply look back at what happened. The goal is to learn which approaches provide the best pain relief.

This study follows 800 adults who spent at least 48 hours in the ICU to see how many develop ongoing pain after leaving the hospital. Researchers will call participants at 90 and 180 days to ask about pain, sleep, mood, and quality of life. A smaller group will also have a detail…

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain. Researchers will measure certain chemicals in the blood and spinal fluid of 30 adults before and after SCS treatment. The goal is to understand how SCS works and find ways to make it mor…

This study looks at how teenagers with chronic pain notice and understand body signals (called interoceptive awareness) and how that relates to their daily function. About 49 adolescents aged 11 to 21 will complete surveys before and after their usual occupational therapy. The go…

This study is testing a computer program (PGS 1.0) that analyzes patient symptoms and history to diagnose chronic pain. Researchers will compare the program's diagnoses to those made by pain specialists in 200 adults with pain lasting at least one month. The goal is to see if the…

This study looks at how CPAP therapy, a common treatment for obstructive sleep apnea, affects pain in people who also have chronic pain. Researchers will ask 80 adults newly starting CPAP to fill out questionnaires about their pain at the start, 3 months, and 6 months. The goal i…

This study tests whether digital software that talks with patients can effectively collect health information from people with chronic pain. Researchers want to see if patients find these conversational tools easy and acceptable to use. The study involves 100 adults with chronic …

This study explores whether a sham (fake) neurofeedback system in a virtual reality environment can change brain wave patterns related to attention. Researchers will compare positive and negative sham feedback to no feedback in 35 adults with rumination, chronic pain, or fibromya…

This study looks at how a natural supplement called Boswellia serrata (frankincense) affects pain in 12 healthy adults. Researchers will use a capsaicin cream to create temporary pain and measure how the supplement changes pain sensitivity. The goal is to understand how Boswellia…

This study looks at how spinal cord stimulation (SCS) helps people with long-term nerve pain in the back or legs. Researchers will use brain scans to compare two types of SCS: one that causes a tingling sensation and one that does not. The goal is to understand how each type work…

This study looks at how chronic pain changes the brain's reward system, making it harder to learn from rewards. Researchers will compare 50 people with chronic pain to healthy volunteers using brain scans and a learning task. The goal is to understand the brain mechanisms behind …

This study aims to understand how different types of low back pain (nerve pain, muscle pain, or other pain) affect pain severity and quality of life in 200 adults who still have chronic pain after back surgery. Participants will complete questionnaires about their pain and daily …

This study is not testing a new drug or treatment. Instead, researchers will observe 120 people with chronic pain to understand their experiences, pain levels, and daily struggles. The goal is to gather information that will help design a future clinic that treats the whole perso…

This study looks at how quitting smoking temporarily increases pain, especially in people with chronic pain. Researchers will use brain scans to see how withdrawal changes pain processing and whether it makes quitting harder. The goal is to find better ways to help people with ch…

This study aims to learn if a new measurement technique can help improve spinal cord stimulation devices for chronic pain. Researchers will test 15 people who already have a temporary spinal cord stimulator implant. They will measure electrical signals from the spinal cord during…