Magic mushroom compound tested for dual relief of chronic pain and depression
NCT ID NCT06518720
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether a single 25 mg dose of psilocybin, the active ingredient in 'magic mushrooms', combined with supportive therapy, can ease chronic neuropathic pain and treatment-resistant depression in adults. Sixteen participants aged 18 to 65 with both conditions will receive the drug once and be monitored for safety, tolerability, and changes in depression and pain scores. The study aims to see if this approach is feasible and worth testing in larger trials.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a single 25 mg dose of psilocybin, the active ingredient in 'magic mushrooms', given with supportive therapy
- What this could lead to
- If it works, this could point toward a new treatment option for people living with both chronic nerve pain and depression that hasn't responded to standard therapies.
- What could go wrong
- This is a very small, early-stage trial with only 16 participants and no placebo group, so results may not apply broadly. Psilocybin can cause intense psychological effects and is not without risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CHRONIC PAIN are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Centre for Addiction and Mental Health
RECRUITINGToronto, Ontario, M6J1H4, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Mind-Body physio program aims to tackle chronic pain and depression together
- Can we decode the different types of pain in multiple sclerosis?
- Can yoga ease the pain of endometriosis after surgery?
- A simple pressure test before surgery might reveal your risk of chronic pain
- Rewiring the brain to fight back pain?
- Can a pain drug help you walk better with knee arthritis?