Centre For Addiction And Mental Health

This study is testing a flexible, personalized approach to therapy booster sessions for young people with or at risk for bipolar disorder. Participants who have already completed a year of specialized therapy can choose the type and frequency of follow-up sessions that work best …

This study is testing whether a non-invasive brain stimulation treatment can help people with mental health conditions quit smoking. It compares magnetic stimulation therapy to standard treatment using nicotine patches and counseling. The research aims to see if this new approach…

This study is testing whether a gentle, non-invasive brain stimulation technique can help people who vape daily reduce their habit. Researchers will give 40 participants either real or fake stimulation sessions for two weeks to see if it lowers the number of times they vape and t…

This study is testing whether a non-invasive brain stimulation treatment called rTMS can help reduce symptoms of depression in young people (ages 16-35) who also have autism. Participants will receive either the real magnetic stimulation treatment or a sham (placebo) version for …

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' given with therapy can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten participants will receive two guided psilocybin sessions to se…

This study is testing a one-year therapy program for 60 teens and young adults who have bipolar disorder or are at risk for it because a close family member has it. The therapy, called Dialectical Behavior Therapy (DBT), teaches skills to manage intense emotions and reduce risky …

This study is testing whether a non-invasive brain stimulation technique can help people with cannabis use disorder reduce their use and cravings. Researchers will use a magnetic coil placed on the scalp to target brain areas involved in addiction. The 4-week trial will assess if…

This small pilot study is testing whether a self-guided version of eye movement therapy (A-EMDR) can help people who have both post-traumatic stress disorder (PTSD) and substance use problems. The research team wants to see if this therapy reduces PTSD symptoms and substance use …

This study is testing whether a gentle, non-invasive electrical stimulation applied to the scalp can improve working memory in people with mild cognitive impairment (MCI), a condition that often precedes Alzheimer's disease. Researchers will enroll 20 participants aged 60+ with M…

This study is testing whether Magnetic Seizure Therapy (MST) can work as well as electroconvulsive therapy (ECT) for people with schizophrenia who haven't responded to standard medications. Researchers will compare the two treatments in 80 participants who have tried at least two…

This study is testing a more flexible, personalized approach to therapy for teens and young adults who have bipolar disorder or are at risk for it because a close family member has it. Instead of a one-size-fits-all program, it offers three different levels of therapy intensity, …

This study tests whether giving multiple brain stimulation treatments per day works better than one daily treatment for depression in people aged 60+. All participants receive active treatment, but some get multiple sessions daily for a shorter period while others get one session…

This study is testing whether a medication containing cannabidiol (CBD) can help people with alcohol use disorder drink less and have fewer cravings. Participants will take either CBD or a placebo pill for short periods and complete lab sessions where their alcohol consumption an…

This is a small, early-stage study to see if psilocybin (a psychedelic compound) combined with therapy is safe and tolerable for autistic adults with depression that hasn't responded to other treatments. Twenty participants will receive two doses of psilocybin alongside therapy s…

This study is testing if starting a quit attempt during a specific phase of a woman's menstrual cycle makes it easier to stop smoking. It will enroll 1200 women who smoke daily and want to quit. Participants will be randomly assigned to start their quit attempt in one of two cycl…

This study is testing whether a non-invasive brain stimulation technique can improve motor function in autistic adults. Researchers will use repetitive Transcranial Magnetic Stimulation (rTMS) on 100 autistic adults with significant movement difficulties to see if it reduces over…

This study is testing whether the common diabetes drug metformin can help adults with intellectual disabilities lose weight they've gained from taking necessary antipsychotic medications. It's the first randomized trial specifically for this underserved group, who face high rates…

This study is testing whether a supplement called N-acetylcysteine (NAC) can reduce early warning signs of schizophrenia in young people at high risk. Ninety participants will take either NAC or a placebo pill daily for 8 weeks to see if it improves their symptoms and related bra…

This study is testing whether a non-invasive brain stimulation technique called iTBS can help reduce depression symptoms in people with bipolar disorder who haven't responded well to other treatments. Participants will receive either real or sham stimulation for 30 days, with res…

This study aims to understand why women taking antipsychotic medications often develop serious metabolic side effects like weight gain and diabetes. Researchers will use MRI brain scans on 15 healthy young women to see how a common antipsychotic (olanzapine) and intranasal insuli…

This study aims to understand why some children with disruptive behavior problems and their parents benefit more from standard treatments than others. Researchers will create personalized profiles for 200 children (ages 6-12) and their parents based on psychological and emotional…

This study aims to understand how smoking cannabis and tobacco together affects a person's ability to drive, think clearly, and their mood. Researchers will use a driving simulator and cognitive tests to measure the effects on 60 regular cannabis users. Participants will attend f…

This study aims to understand how cannabis affects driving in a simulator, comparing younger adults (19-25) to middle-aged adults (35-45). It will also compare occasional users to frequent users. The goal is to gather scientific evidence to help inform public safety policies abou…

This study aims to test whether an online brain assessment platform called Creyos works well for older adults with mild memory concerns or past depression. Researchers want to see if this online tool can track changes in thinking skills as accurately as traditional paper-and-penc…

This study aims to understand the brain changes linked to depression that starts after a COVID-19 infection. Researchers will use special brain scans to look at the brain chemistry of 90 adults who developed depression within 3 months of having mild or moderate COVID. The goal is…

This study aims to understand why some people respond better to therapy for alcohol or cannabis addiction than others. Researchers will enroll 400 adults with these disorders, give them detailed brain function tests, and then provide 12 weeks of standard therapy. The main goal is…

This study aims to understand why people with body dysmorphic disorder (BDD) see flaws in their appearance that others don't notice. Researchers will use brain scans and eye-tracking to study how 146 participants with BDD, mild symptoms, or no symptoms process images of their own…

This study aims to understand how people with anorexia nervosa learn to associate positive feelings with certain cues, compared to healthy individuals. Researchers will use brain scans, heart rate monitoring, and eye tracking while participants listen to infant laughter as a posi…

This study aims to understand how a non-invasive brain stimulation treatment (tDCS) might work for schizophrenia. Researchers will use advanced brain scans to measure changes in the brain's connections before and after a 2-week treatment period. The study is enrolling 20 adults w…