Centre For Addiction And Mental Health

This study is testing whether cannabidiol (CBD) can help people with alcohol use disorder drink less and feel fewer cravings. Thirty-six adults will try both CBD and a placebo in random order, with a two-week break in between. The goal is to see if CBD can be a safe, new option t…

This pilot study tests a personalized brain stimulation treatment for people with severe addiction who haven't been helped by other treatments. Ten participants will first undergo detox, then have temporary electrodes placed in their brain to map addiction-related areas, followed…

This study tests a new type of brain stimulation (rTMS) to help people with cannabis use disorder reduce or stop using cannabis. About 46 adults who use cannabis frequently and want to cut back will receive 4 weeks of treatment. The goal is to see if the treatment is safe, tolera…

This study tests magnetic seizure therapy (MST) as a gentler alternative to electroconvulsive therapy (ECT) for people with schizophrenia that hasn't improved with medication. About 80 adults with treatment-resistant schizophrenia or schizoaffective disorder will receive MST to s…

This study tests whether metformin, a diabetes medication, can help reduce weight gain caused by antipsychotic drugs in adults with intellectual or developmental disabilities. About 100 participants will receive either metformin or a placebo for several months. The goal is to fin…

This study looks at whether taking antipsychotic medication every other day is just as effective as taking it daily for people with schizophrenia. The goal is to see if the extended dosing schedule can reduce side effects while keeping symptoms under control. About 120 adults wil…

This study is testing a personalized approach to therapy for young people (ages 13–23) who have bipolar disorder or a strong family history of it. Instead of a one-size-fits-all treatment, the program offers different levels of support—from low to high intensity—based on each per…

This study looks at whether extra therapy sessions (called boosters) help young people aged 14 to 26 who have or are at risk for bipolar disorder. Participants have already completed one year of dialectical behavior therapy (DBT) in a previous study. The goal is to see how often …

This study tests if a non-invasive brain stimulation technique called rTMS can help people with mental illness quit smoking. Forty daily smokers with a psychiatric condition will either receive rTMS or standard care. Researchers will also talk to patients and doctors to see if ad…

This study looks at whether starting a quit attempt during the first half of the menstrual cycle (follicular phase) helps women stop smoking more successfully than starting during the second half (luteal phase) or without cycle timing. About 1,200 women who smoke daily and have r…

This study tests whether giving multiple brain stimulation sessions per day works better than one session per day for treating depression in people aged 60 and older. About 280 participants will receive active treatment, but some get the accelerated version and some get the stand…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce symptoms in adults with obsessive-compulsive disorder that hasn't improved with standard treatments. Ten participants will receive two 25mg dose…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can safely reduce depression in 80 autistic youth and young adults. Participants receive either real or fake rTMS sessions to see if the treatment improves mood and reduces suicidal thoughts. The goal is…

This study tests if a type of brain stimulation called theta-burst stimulation can reduce depression symptoms in people with bipolar disorder that hasn't improved with other treatments. About 124 adults will receive either real or fake (sham) stimulation daily for 30 days. Resear…

This study tests a safe, painless brain stimulation method called tACS to see if it can improve working memory in older adults with mild cognitive impairment (MCI). Twenty participants aged 60+ will receive daily 1-hour sessions for two weeks. The goal is to see if the treatment …

This study tests a new therapy called A-EMDR, where people use eye movements on their own to help with PTSD and substance use problems. 24 adults with both conditions will try A-EMDR or continue their usual care for 4 weeks. Researchers will check if symptoms and substance use im…

This study tests whether N-acetylcysteine (NAC), a safe antioxidant supplement, can reduce early psychosis-like symptoms in 90 people at high risk for schizophrenia. Participants take NAC or a placebo for 8 weeks, and researchers measure changes in symptoms and brain activity. Th…

This study is testing whether dialectical behavior therapy (DBT) can help young people aged 13 to 23 who have bipolar disorder or have a close family member with it. Over one year, participants will attend group skills training and individual therapy sessions to learn mindfulness…

This pilot study tests whether a non-invasive brain stimulation method called tDCS can reduce vaping in daily e-cigarette users. Forty adults who vape nicotine daily will receive either real or fake tDCS for 10 sessions over two weeks. Researchers will measure changes in vaping f…

This early-stage study tests whether psilocybin, given with therapy, is safe and tolerable for autistic adults with depression that hasn't improved with other treatments. Twenty participants will receive two doses of psilocybin along with psychotherapy. The study also uses brain …

This study tests a non-invasive treatment called rTMS that uses magnetic pulses to stimulate brain areas linked to addiction and decision-making. About 40 daily smokers will receive daily sessions for 3 weeks, then weekly sessions for 3 more weeks. The goal is to see if offering …

This study checks if a website called Creyos can accurately measure thinking skills in older adults who have mild memory problems or a history of depression. About 150 participants will take online tests every three months and in-person tests once a year for up to five years. The…

This study looks at whether a gentle brain stimulation technique called tDCS changes the number of connections between brain cells in people with schizophrenia. Researchers will use special PET scans to measure these connections before and after treatment. The goal is to better u…

This observational study looks at brain changes in people who developed major depression within 3 months after a mild or moderate COVID-19 infection. Researchers will use special PET scans to measure two brain chemicals in 90 adults aged 18 to 75. The goal is to understand the bi…

This study looks at whether a non-invasive brain stimulation technique called rTMS can help autistic adults with motor difficulties. Researchers think an overactive brain plasticity might be the cause. They will test 150 adults aged 18-40 to see if rTMS can reduce this over-plast…

This study looks at why people with body dysmorphic disorder (BDD) see their appearance in a distorted way. Researchers will use brain scans, eye-tracking, and emotion measurements in 146 adults aged 18-40 with BDD to understand these perceptual problems. The goal is to build a m…

This study looks at how haloperidol, an antipsychotic medication, may interfere with insulin's normal action in the brain. Insulin helps control blood sugar and supports brain function, but long-term use of haloperidol can lead to weight gain and diabetes. Researchers will give h…

This study looks at how smoking cannabis, tobacco, or both affects driving skills, thinking, and blood THC levels. About 60 regular cannabis users will drive a simulator and take tests after smoking different combinations. The goal is to understand why people mix cannabis and tob…

This study aims to see if creating personalized profiles for children with disruptive behavior disorders and their parents can help predict which treatment works best. Researchers will assess psychological, emotional, and neuropsychological factors before treatment. About 200 chi…

This study looks at how antipsychotic drugs might disrupt insulin action in the brains of healthy young women, and how this changes across the menstrual cycle. Fifteen participants will receive olanzapine or a placebo, plus intranasal insulin, and undergo MRI scans. The goal is t…

This study looks at how cannabis affects driving in younger (19-25) versus middle-aged (35-45) adults. Half of the 128 participants will be occasional users, and half will be frequent users. They will use a driving simulator to measure weaving and speed after using cannabis.

This study is for 400 adults with alcohol or cannabis use disorder who are willing to try group therapy. Researchers will measure thinking skills, motivation, and emotions before and during 12 weeks of cognitive behavioral therapy. The goal is to see how these brain functions rel…