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Brain stimulation trial targets depression in autistic teens

NCT ID NCT04972136

Recruiting now Symptom relief Sponsor: Centre for Addiction and Mental Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive brain stimulation technique called rTMS can safely and effectively reduce depression in autistic youth aged 16-24. Eighty participants will receive either real or sham rTMS over 30 sessions. The goal is to see if this approach, already used for depression in the general population, works well for autistic individuals who often lack tailored treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS) device
What this could lead to
If it works, this could provide a new, well-tolerated treatment option for depression in autistic youth, who currently have few evidence-based therapies.
What could go wrong
This is an early-stage trial with only 80 participants. The sham control means some may not improve, and results may not apply to all autistic individuals. Side effects like headache or discomfort are possible.

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Conditions

The condition(s) this trial relates to.

autism spectrum disorder major depressive disorder Self-Injurious Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTISM SPECTRUM DISORDER MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

  • Centre for Addiction and Mental Health

    RECRUITING

    Toronto, Ontario, M6J 1H4, Canada

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