Could a common diabetes drug curb weight gain in people with intellectual disabilities?
NCT ID NCT05744479
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether metformin, a diabetes drug, can help adults with intellectual disabilities who have gained weight from antipsychotic medications. One hundred participants will receive either metformin or a placebo for 24 weeks, along with lifestyle advice. The goal is to see if metformin can safely reduce weight and improve health in this often-overlooked group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metformin
What this could lead to
If it works, this could provide a safe and accessible medication option to help manage weight gain caused by antipsychotics in people with intellectual disabilities.
What could go wrong
This is a small Phase 4 trial with only 100 participants, and metformin may not work for everyone. Side effects like stomach upset are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre for Addiction and Mental Health
RECRUITINGToronto, Ontario, M6J1H3, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••