Centre For Addiction And Mental Health

This study looks at whether adding topiramate (a seizure medication) to clozapine can help with weight loss and improve symptoms in people with treatment-resistant schizophrenia or schizoaffective disorder. About 50 overweight or obese adults aged 17-59 who are already on clozapi…

This study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with schizophrenia who are overweight or obese and did not lose weight on metformin. About 92 participants will receive either semaglutide or a placebo. The main goal is to see if sema…

This study tests a phone-based care management program for adults with depression, anxiety, or risky drinking. Participants get regular check-ins and support from a mental health technician, while their primary care doctor receives treatment recommendations. The goal is to see if…

This study tests whether a home-based program combining cognitive exercises (like puzzles) with mild brain stimulation can improve thinking and memory in older adults with mild cognitive impairment or late-life depression. About 40 participants will use the program at home with h…

This study tests a new way of delivering mental health and addiction services to youth aged 14-17. Instead of standard hospital outpatient care, an integrated team offers rapid access to various services like therapy, peer support, and primary care in a youth-friendly setting. Re…

This 7-year study tests whether a combination of mild electrical brain stimulation (tDCS) and computer-based memory exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression (both risk factors for…

This small early-phase study is testing whether psilocybin, the active ingredient in magic mushrooms, combined with supportive therapy can safely help people with obsessive-compulsive disorder (OCD) that hasn't responded to standard treatments. Ten adults with treatment-resistant…

This pilot study tests a youth-adapted therapy called NECT-Y to see if it can reduce self-stigma in 96 young people with bipolar disorder or multiple mental health conditions. Participants will either join a 14-week virtual group therapy or continue their usual care. The main goa…

This study tests whether a non-invasive brain stimulation technique called paired associative stimulation (PAS) can improve memory and thinking in 150 older adults with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Participants receive daily sessio…

This study tests a structured care pathway for treating agitation and aggression in people with Alzheimer's disease. The pathway combines personalized activities with medication guidelines to reduce symptoms and avoid using too many drugs. Researchers will compare this approach t…

This study aimed to compare online group cognitive behavioral therapy (CBT) with in-person group CBT for adults with major depression. The goal was to see if online therapy is just as effective and more cost-effective. However, the trial was withdrawn before enrolling any partici…

This study tests a 4-session psychological intervention for people with borderline personality disorder who come to the emergency department with suicidal thoughts or self-harm. The therapy focuses on education, problem-solving, and safety planning, and may include a family membe…

This study looks at how the antipsychotic drug olanzapine changes the way the brain responds to insulin, which may explain why these drugs often lead to weight gain and diabetes. Healthy volunteers will receive olanzapine or placebo, along with insulin nasal spray, and undergo te…

This study looks at how gut bacteria change when young people (ages 12-35) with psychosis start taking antipsychotic medication. Researchers want to see if these changes are linked to weight gain and other metabolic problems. Participants provide stool and blood samples over 12 w…

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study explores why Black, Indigenous, and People of Color (BIPOC) may have lower rates of starting and sticking with antidepressants after a one-time psychiatric consultation. Researchers will survey 60 adults diagnosed with depression to see if race affects whether they get…

This study explores how non-invasive brain stimulation can help understand and treat agitation in people with Alzheimer's and mixed dementia. Researchers will use transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to study brain activity, and test whether tr…

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study tests a brain stimulation technique called paired associative stimulation (PAS) using transcranial magnetic stimulation (TMS) in 72 adults with schizophrenia. The goal is to see if daily sessions over two weeks can improve working memory, as measured by a letter-matchi…

This study looks at how people with anorexia nervosa learn to associate positive feelings with sounds like baby laughter. Researchers will measure brain activity, heart rate, and pupil responses in 90 females aged 12-22. The goal is to understand if and how positive associations …

This study aimed to develop a digital health worker named PAHOLA to deliver brief counseling for people who drink too much but avoid traditional treatment. The goal was to see if a computer-based coach could help reduce alcohol use and improve health. The study was withdrawn befo…

This small pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can increase the density of synapses (connections between brain cells) in people with mild memory problems. Ten participants—six with amnestic mild cognitive impairment and four health…