Brain zaps may boost memory in schizophrenia patients

NCT ID NCT01545999

Ongoing Knowledge-focused Sponsor: Centre for Addiction and Mental Health Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a brain stimulation technique called paired associative stimulation (PAS) using transcranial magnetic stimulation (TMS) in 72 adults with schizophrenia. The goal is to see if daily sessions over two weeks can improve working memory, as measured by a letter-matching task. Researchers will also use EEG to track brain activity changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS)
What this could lead to: If successful, this could point toward a non-drug treatment to improve memory and thinking in people with schizophrenia.
What could go wrong: This is an early-stage study with only 72 participants, and it is not testing a cure. The effects may be small or not last long, and the treatment requires daily sessions for two weeks.

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Conditions

The condition(s) this trial relates to.

schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SCHIZOPHRENIA

Contacts and locations

Locations

Centre for Addiction and Mental Health

Toronto, Ontario, M6J 1H4, Canada

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