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Magic mushroom compound tested for Hard-to-Treat depression in autism

NCT ID NCT06731621

Recruiting now Symptom relief Sponsor: Centre for Addiction and Mental Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely help autistic adults with depression that hasn't improved with other treatments. Twenty participants will receive two doses of psilocybin along with about 20 hours of therapy. Researchers will also use brain scans to explore how the treatment might work.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
psilocybin (a psychedelic drug) given with talk therapy
What this could lead to
If it works, this could point toward a new treatment option for depression in autistic adults who haven't responded to standard therapies.
What could go wrong
This is a very early, small pilot study with only 20 participants and no placebo group, so results may not apply broadly. Psychedelic drugs can cause intense psychological effects and side effects like anxiety or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autism spectrum disorder Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTISM SPECTRUM DISORDER TREATMENT RESISTANT DEPRESSION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Centre for Addiction and Mental Health

    RECRUITING

    Toronto, Ontario, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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