TREATMENT-RESISTANT DEPRESSION

This study is tracking 500 people with treatment-resistant depression who receive Vagus Nerve Stimulation (VNS) therapy, a device that sends mild pulses to a nerve in the neck. The goal is to see how well it reduces depression symptoms over 12 months and beyond. Participants must…

This study is for people with hard-to-treat depression who have already benefited from a type of brain stimulation called rTMS. It tests whether continuing rTMS sessions over 6 months can help maintain that improvement. 75 participants will be randomly assigned to one of three gr…

This early-stage study tests if deep brain stimulation (DBS) is safe and effective for people with depression that hasn't improved with other treatments. Twenty adults aged 18-65 with major depression or bipolar disorder will have a DBS device implanted. Their symptoms will be tr…

This study tests a brain pacemaker (deep brain stimulation) for adults with severe depression that hasn't improved with multiple treatments. The device targets a specific brain area to help regulate mood. Researchers will measure changes in depression scores and overall improveme…

This study tests a device that stimulates a nerve in the neck to help people with depression that hasn't improved with standard treatments. About 6,800 adults will either get the active device or a sham (no stimulation) to see if it safely reduces depression symptoms over a year.…

This study tests whether adding intravenous ketamine to internet-based cognitive behavioural therapy (i-CBT) can quickly reduce suicidal thoughts and behaviors in people with treatment-resistant depression. About 110 adults will receive weekly i-CBT for 13 weeks, and half will al…

This study is for people with depression that hasn't improved with medication. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking. The goal is to see if this combination works better than brain stimulation alone…

This study tests an experimental nasal spray called BPL-003, given with psychological support, in 64 adults whose depression has not improved with at least two prior treatments. The main goal is to see if the spray is safe and tolerable, and to measure its effects on mood. Partic…

This study tests whether a 40 Hz flickering light, used at home for one hour daily, can reduce depression symptoms in adults with major depressive disorder. Sixty participants will receive either the active flickering light or a placebo light for six weeks. The goal is to see if …

This study tests a non-invasive brain stimulation technique called accelerated theta burst stimulation (aTBS) to see if it can reduce suicidal thoughts in people with treatment-resistant depression. Researchers will compare two types of stimulation (bilateral vs. unilateral) in 7…

This study tests a type of talk therapy called schema therapy for people with chronic or treatment-resistant depression. Researchers want to see if it works better than standard psychotherapy. The study will include 129 adults from six psychiatric centers in Denmark. Half will ge…

This study tests a new medicated film placed inside the cheek (VLS-01) for people whose depression hasn't improved with at least two other treatments. About 142 adults aged 18-65 will receive either the film or a placebo to see if it safely eases depression symptoms. The goal is …

This study tests if mild electrical stimulation on the brain's surface can help people with severe depression that hasn't improved with other treatments. About 15 participants will have a small device surgically placed under the scalp to deliver targeted pulses. The goal is to se…

This study tests a new, fast brain stimulation treatment for people with depression that hasn't improved with medication. 78 adults will receive either real or fake stimulation over 5 days, with the goal of easing symptoms. The treatment uses MRI scans to target each person's bra…

This study is testing whether combining psilocybin (the active ingredient in magic mushrooms) with a type of brain stimulation called aiTBS is safe and helpful for people with depression that hasn't improved with other treatments. About 100 adults aged 22-65 with treatment-resist…

This early study tests whether a precise, low-dose radiation treatment (stereotactic radiotherapy) can safely reduce symptoms in people with treatment-resistant depression. Nine adults aged 18-50 who have not responded to at least two antidepressants will receive the procedure an…

This study tests whether very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) combined with short-term talk therapy can safely reduce depression in people who haven't gotten better with standard treatments. Twenty adults aged 18-65 with treatment-re…

This early-stage study tests whether psilocybin, given with therapy, is safe and tolerable for autistic adults with depression that hasn't improved with other treatments. Twenty participants will receive two doses of psilocybin along with psychotherapy. The study also uses brain …

This study tests whether using brain scans to guide magnetic stimulation (rTMS) can improve depression treatment for people who haven't gotten better with medication. About 348 adults aged 22 to 65 with moderate to severe depression will receive rTMS tailored to their brain conne…

This study tests whether a 6-week intensified drug treatment (including esketamine) works better than usual care for people with major depression whose first antidepressant failed. About 418 adults aged 18-65 will take part. The goal is to quickly reduce symptoms and prevent the …

This study looks at how the brain handles negative beliefs in people with treatment-resistant depression. Researchers will use brain scans (fMRI) to see how beliefs change before and after a single dose of ketamine. The goal is to understand why some depressed patients hold onto …

This study aims to understand how electroconvulsive therapy (ECT) changes sleep patterns and brain communication in people with depression that hasn't improved with other treatments. Researchers will measure brain activity during sleep and wakefulness in 50 adults receiving ECT. …

This study looks at how deep brain stimulation (DBS) affects electrical signals in the brain for people with severe depression that hasn't improved with other treatments. Ten participants will have a DBS device implanted and will track their mood and brain activity daily for a ye…

This study aims to learn more about how depression, bipolar disorder, and suicide risk affect people and how treatments work. Researchers will follow 500 adults already receiving care at the NIH, using interviews, questionnaires, and optional tests like blood draws and brain scan…

This study aims to understand why some people with depression do not get better with standard medications. Researchers will use brain scans to compare dopamine receptors in three groups: people with treatment-resistant depression, those whose depression responds to treatment, and…

This study explores why some people with depression don't get better with standard treatments. Researchers will use low-intensity focused ultrasound to temporarily change activity in specific brain connections in 140 adults with treatment-resistant depression. The goal is to see …

This study uses special brain recordings (intracranial electrodes) to map how the brain processes social and emotional information in people with treatment-resistant depression or epilepsy. Researchers aim to understand the brain networks involved in these feelings, which could l…

This study follows 1,000 adults with hard-to-treat depression or OCD who are getting advanced treatments like ECT, TMS, or ketamine. Researchers collect brain scans, voice recordings, and other tests before, during, and after treatment. The goal is to find biological markers that…