Brain pacemaker trial aims to lift severe depression

NCT ID NCT06096207

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests if deep brain stimulation (DBS) is safe and effective for people with severe depression that hasn't improved with other treatments. Twenty adults will have a device implanted in their brain and be monitored for five years. The device will be turned on and off without the participant's knowledge to compare depression symptoms and see if the stimulation truly helps.

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Conditions

The condition(s) this trial relates to.

bipolar disorder Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Zucker Hillside Hospital

    RECRUITING

    Queens, New York, 11004, United States

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