Northwell Health

This study looks at whether a lower dose of the drug venetoclax can help people with acute myeloid leukemia (AML) stay in remission while causing fewer serious side effects. About 41 adults whose AML is in remission after initial treatment will take a reduced dose of venetoclax. …

This study tests a noninvasive device that stimulates a nerve in the ear to help children with steroid-resistant nephrotic syndrome, a kidney condition that doesn't respond to standard steroids. The device aims to calm the immune system and reduce inflammation, potentially allowi…

This study is for people with metastatic pancreatic cancer that has spread. It tests a new way of giving two standard chemotherapy treatments, switching between them each month. The goal is to see if this alternating schedule helps keep the cancer from growing longer than usual. …

This early-phase study tests whether a new drug, Nelitolimod, can safely boost the immune system's ability to fight colorectal cancer that has spread to the liver. Ten adults will receive the drug directly into the liver through a special catheter before their scheduled surgery. …

This study tests whether deep brain stimulation (DBS) can help people with severe obsessive-compulsive disorder (OCD) who have not gotten better with medication or therapy. DBS uses a device implanted in the brain to send electrical pulses to areas linked to mood and anxiety. The…

This study tests two devices in people with advanced heart failure. The CardioMems monitors pressure in the lungs, and the BaroStim stimulates nerves to improve heart function. Researchers will track changes in symptoms, walking ability, and hospital visits over a year. The goal …

This study tests a new way to deliver a cancer drug directly to the brain along with repeat radiation for people whose aggressive brain tumors have come back. The drug, cetuximab, targets a protein common on these cancer cells. The goal is to see if this combination can stop tumo…

This study looks at whether genetic markers and brain scans can help doctors choose the most effective medication for people experiencing their first episode of psychosis. Researchers will compare a standard antipsychotic to clozapine in 180 participants aged 18-35. The goal is t…

This early-phase trial tests a new way to deliver chemotherapy directly to the abdomen using a pressurized spray, called PIPAC, in people with pancreatic cancer that has spread to the lining of the belly. The goal is to see if this approach is safe and tolerable when combined wit…

This study tests a drug called anakinra (Kineret) in people with Meniere's disease or autoimmune inner ear disease that hasn't responded to steroids. About 57 participants will receive either anakinra or a placebo for 42 days, with follow-up over several months. The goal is to se…

This study tests whether a high-touch integrated care program can reduce severe maternal morbidity (life-threatening complications around childbirth) compared to a lower-touch version. It will enroll 674 Black and Hispanic pregnant women who are at increased risk due to health co…

This early-stage study tests if deep brain stimulation (DBS) is safe and effective for people with depression that hasn't improved with other treatments. Twenty adults aged 18-65 with major depression or bipolar disorder will have a DBS device implanted. Their symptoms will be tr…

This study compares two treatments for bleeding after heart surgery: FEIBA (a drug that helps blood clot) versus fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood trans…

This pilot study tests whether adding high-dose vitamin D to standard methimazole therapy can help control thyroid function and antibody levels in children aged 9-17 newly diagnosed with Graves' disease. The main goal is to see if a larger trial is possible by measuring recruitme…

This small pilot study is testing whether a gentle, non-invasive nerve stimulation device worn on the ear can help children with a frequently relapsing kidney disease. The goal is to see if this approach can reduce disease flare-ups and the need for strong steroid medications. Re…

This study is testing a new blood test that looks for tiny pieces of HPV DNA shed by cancer cells. The goal is to see if this simple blood draw can tell the difference between pre-cancer and invasive cervical cancer, and help monitor patients during and after treatment. The study…

This study tests whether doctors can use ultrasound through a special clear skull implant to see brain structures and detect problems after surgery. About 50 adults who are already getting this implant as part of their care will take part. The goal is to see if this method is acc…

This study is testing whether a special type of MRI (called bpMRI) can help find prostate cancer earlier in men who are at high risk. The study includes 100 men with slightly elevated PSA levels who are Black, have a family history of prostate cancer, or have certain genetic risk…

This study tests an online program called StEP OUT that teaches healthy habits during pregnancy and baby's first year to prevent early childhood obesity in Latino families. About 130 pregnant women will be assigned to either the program (group chats and video calls) or a control …

This study tests a minimally invasive procedure called radiofrequency ablation (RFA) for LatinX adults with benign thyroid nodules that cause discomfort or cosmetic issues. RFA uses heat to shrink the nodule without surgery. The goal is to see if it safely reduces symptoms and no…

This study tests a special catheter (Optrell) to treat heart rhythm problems coming from the papillary muscles. About 20 adults with frequent or bothersome extra heartbeats will undergo a mapping procedure to see if this catheter works faster and more accurately than standard one…

This study tests whether a non-invasive brain stimulation technique called TMS, applied to the cerebellum, can improve brain connectivity and thinking skills in people with schizophrenia. Forty adults aged 18-60 will receive either real or sham TMS daily for four weeks, alongside…

This study looks at whether a 10-day low-residue diet (low fiber) is better than a 6-week one for helping bowel function return to normal after elective colon surgery. About 222 adults who have planned colon resection will be randomly assigned to one of the two diet plans. They w…

This early study tests whether a device that sends mild electrical pulses to the spinal cord and muscles can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions per …

This study tests a small device placed inside liver tumors from colorectal cancer to see how they respond to different drugs. Ten adults will have the device implanted a few days before their scheduled liver surgery, then removed with the tumor. The goal is to check if the proced…

This study is building a registry of up to 900 people with Diamond Blackfan anemia (DBA), a rare inherited bone marrow condition that causes low red blood cells. Researchers will collect medical information and genetic data to learn more about how DBA develops and affects patient…

This early-phase study looks at how a non-invasive sound wave treatment called histotripsy affects the immune system in 12 people with colorectal cancer that has spread to the liver. Researchers will take blood samples before and after treatment to measure changes in immune T-cel…

This study looks at brain scans of 120 people experiencing their first episode of psychosis to see if certain brain connections can predict how well they will respond to standard antipsychotic medications. Participants receive either risperidone or aripiprazole for 12 weeks, and …

This study aims to understand why some people with Alzheimer's disease develop psychotic symptoms like delusions. Researchers will use brain scans to measure tau protein buildup and brain network changes in 91 older adults with and without psychosis, plus healthy volunteers. The …

This study is a first step toward making gene therapy possible for Diamond Blackfan anemia. Researchers want to see if patients can produce enough blood stem cells to be collected for future gene correction. About 10 people aged 3 to 30 will receive two medications to move stem c…

This study compares a mobile app called Always Uniquely Me (AUM) to standard care for people with intellectual and developmental disabilities who visit the emergency department. The goal is to see if the app helps reduce the use of physical or chemical restraints and improves the…

This study tests a 10-week, at-home program called SCORES that uses computer exercises and group support to boost processing speed—how quickly the brain handles information—in 54 teens at high risk for psychosis. The goal is to see if faster thinking leads to better social skills…

This early-phase study tests a small implantable device that delivers tiny amounts of different cancer drugs directly into a pancreatic tumor during surgery. After about 4 hours, the device is removed with the tumor, and researchers check which drugs killed the most cancer cells.…

This study is for people starting a type of blood cancer medication called BTK inhibitors. Researchers want to see if a small heart monitor (implanted under the skin) can detect irregular heartbeats that these drugs might cause. The goal is to catch problems early and guide treat…

This study aims to learn more about how a new, small heart device called the Micra AV2 works in people with a history of a specific irregular heartbeat (paroxysmal atrial fibrillation). Researchers will observe 50 patients who are getting the device as part of their standard care…