Northwell Health

This early-stage study is testing a new approach for people with colorectal cancer that has spread to the liver. Researchers want to see if a drug called Nelitolimod, delivered directly to the liver through a special catheter, is safe and feasible to use before surgery. The goal …

This study is testing if a shorter, 14-day cycle of the drug venetoclax is easier for patients to tolerate while still keeping their acute myeloid leukemia (AML) in remission. It is for 41 adults with AML who are in remission but cannot receive intensive treatments like stem cell…

This early-stage study is testing whether gentle electrical stimulation applied to the skin over nerves and the spinal cord can help improve arm, hand, or leg movements in people with paralysis or weakness. Researchers are recruiting 64 adults with conditions like stroke or spina…

This early-stage study is testing whether a surgically implanted brain stimulation device can help people with severe depression that hasn't responded to other treatments. Researchers will implant a device in 20 participants and track their symptoms over 5 years, periodically tur…

This study is testing a 10-week online brain training program called SCORES for adolescents showing early warning signs of psychosis. The program combines thinking speed exercises with group support, aiming to improve social skills and potentially reduce the risk of developing fu…

This study is testing if switching between two different chemotherapy combinations each month works better than standard treatment for people with metastatic pancreatic cancer. It aims to see if this alternating approach can keep the cancer from growing for longer and help patien…

This is a small pilot study to see if it's practical to run a larger trial testing high-dose vitamin D in children with Graves' disease. It will enroll 30 children and teens (ages 9-17) who are newly diagnosed. The main goal is to check if families are willing to join, if kids ca…

This study is testing a surgical treatment called deep brain stimulation (DBS) for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard medications and therapy. DBS involves implanting a small device, similar to a pacemaker, that sends electri…

This study is testing if using two implanted devices together helps people with severe heart failure feel better and stay out of the hospital. First, a small sensor (CardioMems) is placed to monitor heart pressure. After three months of adjusting medications, a second device (Bar…

This study is testing a new blood test to detect and monitor HPV-related cervical cancers and pre-cancers. It aims to see if the test can distinguish between early pre-cancerous changes and invasive cancer. If successful, it could offer a less invasive alternative to current scre…

This study is testing whether adding MRI scans to standard PSA blood tests can improve prostate cancer detection in high-risk men. Researchers are enrolling 100 men aged 40-55 who have higher-than-average risk factors but normal PSA levels. Participants will receive MRI scans and…

This study is testing two different levels of a support program designed to prevent severe health problems during and after pregnancy. It focuses on Black and Hispanic pregnant patients who are at higher risk for complications. Participants are randomly assigned to receive either…

This study is testing an online program called StEP OUT that teaches healthy habits during pregnancy and infancy to help prevent childhood obesity in Latino families. Researchers want to see if the program is practical to run and acceptable to participants. They will compare the …

This study is testing whether a mobile app called 'Always Uniquely Me' can improve emergency room visits for adults with intellectual and developmental disabilities. Researchers want to see if using the app reduces the need for physical or chemical restraints and makes the overal…

This study is testing whether magnetic stimulation of the brain can improve thinking skills and brain function in people with schizophrenia. 40 participants will receive either real or fake magnetic stimulation five days a week for four weeks. Researchers will use brain scans and…

This study is testing whether a gentle electrical stimulation on the outer ear can reduce the number of extra, early heartbeats called PVCs. Participants will wear a heart monitor for a month and use a small device on their ear for 10 days, comparing real stimulation to a fake ve…

This study is testing whether a 10-day low-fiber diet after colon surgery works as well as the standard 6-week diet. Researchers want to see if the shorter diet helps patients return to normal bowel function faster without increasing complications. The study involves 222 adults w…

This study is testing a minimally invasive procedure called radiofrequency ablation (RFA) as an alternative to surgery for LatinX adults with bothersome, non-cancerous thyroid nodules. The procedure uses heat from a small needle to shrink nodules that cause symptoms like neck pre…

This study aims to learn more about how a new, small heart device called the Micra AV2 works in people with a history of a specific irregular heartbeat (paroxysmal atrial fibrillation). Researchers will observe 50 patients who are getting the device as part of their standard care…

This study is testing a new way to monitor the brain after skull reconstruction surgery. It checks if ultrasound, a safe and portable scan, can work effectively through a special clear implant placed in the skull. The goal is to see if this method can provide accurate brain image…

This is a small, early safety study to see if a tiny implantable device can be safely placed into liver tumors that have spread from colorectal cancer. The device, placed a few days before the patient's scheduled tumor removal surgery, releases small amounts of cancer drugs direc…

This study aims to find brain patterns that predict how well antipsychotic medications will work for people experiencing their first episode of psychosis. Researchers will scan the brains of 120 young patients before and after 12 weeks of standard medication treatment. The goal i…

This small, early-stage study aims to understand how a non-invasive treatment called histotripsy affects the body's immune system in people with colorectal cancer that has spread to the liver. Histotripsy uses focused sound waves to destroy liver tumors. Researchers will take blo…

This study aims to understand how people with spinal cord injuries respond to flu and COVID-19 vaccines compared to people without injuries. Researchers will measure blood markers and antibodies in 140 participants to see if injury severity affects immune protection. The goal is …

This study is a first step to see if future gene therapy might be possible for people with Diamond Blackfan Anemia (DBA), a rare and serious inherited blood disorder. Researchers will give two drugs to 10 participants with DBA to see if they can move enough of their own stem cell…

This early study is testing the safety of a tiny, implantable device in patients with pancreatic cancer who are already scheduled for surgery. The device, placed and removed during the operation, releases tiny amounts of different chemotherapy drugs into the tumor tissue to see h…

This study aims to understand how often irregular heartbeats occur in cancer patients starting BTK inhibitor medications. Researchers will implant small heart monitors in 50 patients to continuously track their heart rhythms for up to five years. The goal is to see how frequently…