Northwell Health

This study is testing a small, leadless pacemaker placed in the heart's upper chamber (atrium) for people with sinus node dysfunction, a condition where the heart's natural pacemaker doesn't work properly. Participants receive the Aveir AR pacemaker and a loop recorder to track h…

This study tests the drug belimumab (Benlysta) in 30 people who were diagnosed with lupus within the last two years. Participants will receive either the drug or a placebo for one year, and then some may switch to placebo in the second year. The goal is to see if early treatment …

This study is for people aged 18-35 experiencing their first episode of psychosis. Researchers will use genetic tests and MRI brain scans to see if certain markers can predict which antipsychotic drug (aripiprazole, risperidone, or clozapine) will work best. The goal is to improv…

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…

This early study tests if deep brain stimulation (DBS) is safe and effective for people with severe depression that hasn't improved with other treatments. Twenty adults will have a device implanted in their brain and be monitored for five years. The device will be turned on and o…

This study tests whether adding the chemotherapy drug capecitabine to the standard temozolomide regimen can help people with newly diagnosed glioblastoma live longer without their tumor growing. About 67 adults who have completed initial radiation and chemo will take both pills a…

This study tests whether giving the drug bevacizumab (Avastin) directly into the brain's arteries, repeated over time, is safe and effective for people with recurrent glioblastoma or anaplastic astrocytoma. The approach uses a special infusion to bypass the blood-brain barrier. A…

This early study tests if a piece of belly tissue placed in the brain during surgery can safely bypass the blood-brain barrier in people with recurrent glioblastoma, an aggressive brain cancer. Ten adults will be followed for 6 months to check for side effects like rapid tumor gr…

This study looks at whether pulsed field ablation (PFA), a standard treatment for atrial fibrillation, creates lasting changes in the heart's electrical pathways. Researchers will check this during a follow-up procedure to close the left atrial appendage, and may do extra ablatio…

This phase III trial is testing whether delivering the drug bevacizumab (Avastin) directly to the brain through a catheter, along with standard chemo and radiation, can help people with newly diagnosed glioblastoma live longer. The study will enroll 432 adults with this aggressiv…

This early-phase trial tests a new way to deliver chemotherapy directly to the lining of the abdomen in people with pancreatic cancer that has spread there. The treatment, called PIPAC, uses a spray of chemotherapy drugs under pressure to reach tumor spots more effectively. The s…

This study tests a new surgical technique for people with glioblastoma, an aggressive brain cancer. Surgeons place a piece of the patient's own tissue (from the scalp or skull lining) into the area where the tumor was removed. This tissue flap may help bypass the blood-brain barr…

This trial tests a new way to treat glioblastoma, an aggressive brain cancer. The drug cetuximab, which blocks a protein that helps tumors grow, is infused directly into the brain's arteries after temporarily opening the blood-brain barrier. Up to 33 newly diagnosed patients will…

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and abatacept) can prevent graft-versus-host disease (GvHD) in people receiving a stem cell transplant for blood cancers. About 74 adults will take part. The goal is to reduce severe immune react…

This study tests two integrated care models (high-touch vs. low-touch) to see if they can reduce severe maternal morbidity in Black and Hispanic pregnant women at high risk. About 674 participants will be randomly assigned to one of the two approaches early in pregnancy. The goal…

This study tests a noninvasive device that gently stimulates a nerve in the ear to help children with steroid-resistant nephrotic syndrome, a kidney condition that doesn't respond to standard steroids. The goal is to see if this approach is feasible and tolerable, and if it can r…

This phase 2 trial tests whether anakinra (Kineret), an anti-inflammatory drug, can improve hearing in people with Meniere's disease or autoimmune inner ear disease who cannot take steroids. About 57 participants will receive daily injections of anakinra or a placebo for 42 days,…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can help control nephrotic syndrome in children aged 3-17. The goal is to reduce relapses and the need for steroids or other immune-suppressing drugs. Thirty children will be randomly as…

This phase 2 trial tests a new way to deliver the cancer drug cetuximab directly into the brain's arteries, along with mannitol to open the blood-brain barrier, plus targeted radiation. It is for adults with recurrent glioblastoma or other aggressive brain tumors that have high l…

This early-phase trial is testing whether a drug called Nelitolimod, given directly into the liver through a special catheter, can safely boost the immune system in 10 people with colorectal cancer that has spread to the liver. Participants will receive the drug three times befor…

This phase 2 trial tests a new approach for people with metastatic pancreatic cancer: alternating two standard chemotherapy regimens every month instead of using just one. The goal is to see if this switching strategy can keep the cancer from growing for at least 6 months. About …

This study compares two treatments for bleeding after heart surgery: FEIBA (a special clotting medicine) and fresh frozen plasma (standard care). About 140 adults having non-emergency heart surgery will be enrolled. The goal is to see if FEIBA reduces the need for blood transfusi…

This study tests if using two devices together can help people with advanced heart failure. Participants get a CardioMems sensor to monitor heart pressure and later a BaroStim device to regulate blood pressure. The goal is to improve symptoms, walking ability, and reduce hospital…

This pilot study tests whether adding high-dose vitamin D to standard methimazole therapy helps control thyroid function and antibodies in children aged 9-17 newly diagnosed with Graves' disease. The main goal is to see if a larger trial is possible by measuring recruitment, adhe…

This study tests a 10-week cognitive training program called SCORES for teens at high risk for psychosis. The program aims to improve processing speed (how fast the brain handles information) through game-like tasks, group coaching, and rewards. Researchers hope better processing…

This study tests whether a lower dose of the drug venetoclax can be safely given to adults with acute myeloid leukemia (AML) who are already in remission. The goal is to reduce severe side effects like low white blood cell counts while still preventing the cancer from coming back…

This study tests a device called Reclaim DBS, which uses electrical pulses to target brain areas linked to OCD. It's for adults with severe, treatment-resistant OCD who have tried at least three medications and therapy. The goal is to see if it safely reduces obsessive-compulsive…

This study is testing whether a simpler type of MRI, called biparametric MRI (bpMRI), can improve prostate cancer screening in men at high risk, such as Black men or those with a family history of the disease. The researchers will combine bpMRI with standard PSA blood tests to se…

This study is testing a blood test called NavDx that looks for tiny pieces of HPV DNA shed by cancer cells. The goal is to see if this simple blood draw can accurately detect cervical cancer and precancer, and monitor how patients respond to treatment. The study will enroll 100 w…

This study looks at whether ultrasound can be used through a clear skull implant to see brain structures and detect problems after surgery. Fifty adults who have had this type of skull reconstruction will get standard CT or MRI scans plus an ultrasound. The goal is to see if ultr…

This pilot study tests an online program called StEP OUT that teaches healthy eating and feeding habits to pregnant women and new mothers from Latino families. The goal is to see if the program is easy to deliver and acceptable to participants, with the hope of preventing early c…

This study compares a newer, less invasive endoscopic procedure to standard surgery for treating gastric outlet obstruction, a blockage that prevents food from leaving the stomach. The trial will enroll 32 adults with advanced cancers causing this blockage. The main goal is to se…

This pilot study is testing whether the PureWick, an external urine collection device, can help women aged 50 and older who wake up to urinate at least twice a night. The goal is to see if using the device reduces the number of nighttime bathroom visits and lowers the risk of fal…

This study tests if a lidocaine infusion into blood vessels in the skull can reduce chronic migraine pain, frequency, and duration. It involves 40 adults aged 18-75 with severe, hard-to-treat migraines. The treatment numbs pain receptors to provide relief.

This study tests whether a special mapping catheter (Optrell) can better locate and treat heart rhythm problems coming from the papillary muscles, which are small muscle bumps inside the heart. About 20 adults with frequent or bothersome premature ventricular contractions (PVCs) …

This early study tests whether a device that sends electrical pulses to muscles and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend sessions five times a week…

This study tests whether a short 10-day low-residue diet after colon surgery helps bowel function return to normal faster than the usual 6-week restriction. About 222 adults having elective colon resection will be randomly assigned to one of the two diet plans. Participants will …

This pilot study tests whether a non-invasive magnetic brain stimulation technique called TMS can improve brain connectivity and thinking skills in people with schizophrenia. Forty adults will receive either real or sham TMS daily for four weeks, and researchers will measure chan…

This study is testing a minimally invasive procedure called radiofrequency ablation (RFA) to treat benign thyroid nodules that cause symptoms like discomfort or cosmetic issues. It focuses on LatinX patients who want to avoid surgery. The goal is to see if RFA can safely shrink t…

This early-phase study tests a small implantable device placed directly into liver tumors from colorectal cancer. The device releases tiny amounts of several chemotherapy and immunotherapy drugs to see how the tumor responds. After a few days, the device is removed along with the…

This study is testing whether a new 3D ultrasound system can help people with blood vessel disease better understand their condition. Researchers will give 270 patients a 3D image of their blocked or narrowed vessels instead of the usual hand-drawn sketch. They want to see if thi…

This study tests a handheld microscope called CONVIVO that gives surgeons real-time, high-resolution images of brain tissue during surgery. The goal is to see if it can easily tell healthy tissue from tumor tissue in 30 patients with brain tumors. If it works, it could help surge…

This early-phase study aims to understand how repetitive transcranial magnetic stimulation (rTMS) alters brain networks in people with dystonia, a condition causing involuntary muscle contractions. Researchers will use brain scans to track changes in connectivity after two and fo…

This study looks at 120 people having their first episode of psychosis. They get brain scans and then take either risperidone or aripiprazole for 12 weeks. The goal is to see if brain scan patterns can predict who will respond well to which drug, potentially personalizing treatme…

This study tests whether a mobile app called Always Uniquely Me (AUM) can reduce the use of physical or chemical restraints and improve the ER experience for adults with intellectual and developmental disabilities. About 1,500 participants who have visited a Northwell Health ER i…

This study checks if people with Diamond Blackfan Anemia (ages 3-30) can produce enough blood stem cells for future gene therapy. Participants receive two drugs to move stem cells from bone marrow into the blood, then researchers measure the cell count. No actual stem cell collec…

This study is building a large database of people with Diamond Blackfan anemia, a rare inherited bone marrow condition that causes anemia. Researchers will collect medical information from up to 900 participants to better understand how the disease develops and progresses. The go…

This study looks at how tau protein buildup in the brain may cause psychotic symptoms like delusions in Alzheimer's disease. Researchers will use PET scans and MRI to compare brain changes in Alzheimer's patients with and without psychosis, as well as healthy older adults. The go…

This pilot study tests a tiny implantable device that delivers microdoses of several chemotherapy drugs directly into pancreatic tumors during surgery. The device is removed after four hours, and the surrounding tissue is analyzed to see which drugs worked best. Ten adults with p…

This study looks at how well the Micra AV2 pacemaker can detect atrial fibrillation (AFib) in people who already have a history of paroxysmal AFib. Researchers will monitor 50 patients using the pacemaker's signals and a special Holter monitor. The goal is to understand how often…

This early study tests whether a non-invasive sound wave procedure called histotripsy can stir up the immune system in people with colorectal cancer that has spread to the liver. Researchers will take blood samples before and after treatment to see if T-cells become more active. …

This study is for people starting a type of cancer drug called BTK inhibitors, which can sometimes cause irregular heartbeats. Researchers will implant a small heart monitor under the skin to watch for these heart rhythm problems continuously for up to 5 years. The goal is to lea…