TREATMENT RESISTANT DEPRESSION

This study is testing an experimental brain implant for people with severe depression that hasn't improved with medications or therapy. Ten participants will have a device surgically placed in their brain to deliver mild electrical stimulation, aiming to reduce symptoms. Research…

This large Phase 3 trial is testing whether two doses of a psilocybin-based therapy (COMP360), given with psychological support, can help adults with severe treatment-resistant depression. The study will compare different dose strengths to see which works best at reducing depress…

This study is testing whether a combination of two drugs, dasatinib and quercetin, can slow down accelerated aging in older adults with schizophrenia or treatment-resistant depression. The drugs are taken for just eight days over a month, alongside lifestyle coaching. Researchers…

This study is testing a refined version of electroconvulsive therapy (ECT) for people with severe, treatment-resistant depression. The goal is to see if adjusting where the electrical current is applied in the brain can provide the same relief from depression while causing fewer …

This study is testing whether deep brain stimulation (DBS), a surgical treatment sometimes called a 'brain pacemaker,' can help people with severe depression that hasn't improved with other treatments like multiple medications, therapy, or electroconvulsive therapy (ECT). Researc…

This study is testing whether adding high-dose omega-3 fish oil supplements to standard antidepressant medication can help people with depression that hasn't fully responded to treatment. Researchers want to see if the supplements reduce body inflammation and if that reduction is…

This large, late-stage trial is testing whether a single dose of a psilocybin-based therapy (COMP360), given with psychological support, can reduce symptoms in people with treatment-resistant depression. About 255 participants will be randomly assigned to receive either the activ…

This small pilot study is testing whether a new, non-invasive brain stimulation technique called low-intensity focused ultrasound (LIFUP) is safe and helpful for people with severe depression that hasn't improved with standard medications. The treatment aims to target a specific …

This study is testing a faster version of a non-invasive brain stimulation treatment for people with severe depression that hasn't improved with standard medications. Researchers are giving the treatment over just 5 days instead of the usual 6 weeks to see if it works better and …

This study is testing if a precise, low-dose form of radiation therapy can help people with severe depression that hasn't improved with standard medications. It targets a specific area of the brain thought to be involved in depression. The goal is to see if this non-invasive appr…

This study aimed to test if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce severe suicidal thoughts and depression in people arriving at the emergency room. It planned to compare the gas to a placebo, given alongside standard emergency care, …

This small study is testing if a gentle, non-invasive brain stimulation technique called tDCS is practical and acceptable for hospitalized adults with severe depression that hasn't responded to other treatments. Over five days, participants receive short stimulation sessions whil…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with psychological support, can help people with treatment-resistant depression who struggle with anhedonia—the inability to feel pleasure. The trial involves 40 adults who have not respo…

This study aims to find a brain signal that can predict whether ketamine treatment will work for people with hard-to-treat depression. Researchers will measure specific brain wave patterns (called gamma oscillations) in 100 participants before and after ketamine therapy. The goal…

This study aims to understand how brain wave patterns during and after electroconvulsive therapy (ECT) relate to changes in depression symptoms. Researchers are monitoring 31 adults with treatment-resistant depression who are already scheduled for ECT. By measuring specific brain…