TREATMENT RESISTANT DEPRESSION

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Sixteen adults aged 22 to 70 will have electrodes implanted in a brain region called the medial forebrain bundle. The device delivers mild elec…

This study tests a personalized form of brain stimulation (rTMS) for people with depression that hasn't improved with standard treatments. Sixty participants will receive either real or sham stimulation over five days, with up to ten sessions per day. The goal is to see if target…

This study tests a special deep brain stimulation (DBS) device that can both stimulate and record brain activity in people with treatment-resistant depression. Ten participants will have electrodes implanted in a brain region called the subcallosal cingulate. The goal is to ident…

This study tests whether a combination of dasatinib and quercetin, two drugs that clear out aging cells, can safely slow down accelerated aging in older adults with treatment-resistant depression or schizophrenia. Forty participants aged 50 and older will take the drugs and be mo…

This study tests a new approach for people with depression that hasn't responded to medication. It combines an FDA-approved brain stimulation technique called rTMS with digital mindfulness exercises. The goal is to see if this combination can improve both mood and cognitive funct…

This study tested a new approach for people with severe depression that hasn't improved with other treatments. A small wire was placed on the surface of the brain to send gentle electrical pulses to areas that control mood. The goal was to see if this is safe and could help reduc…

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in people visiting the emergency department. It was designed for adults aged 18-65 with major depressive disorder who were actively sui…

This study tests a new way of doing electroconvulsive therapy (ECT) for people with treatment-resistant depression. The goal is to target the brain more precisely to reduce side effects like memory loss while still helping with depression. Twenty participants will receive the new…

This study tests an accelerated version of transcranial magnetic stimulation (TMS) for people with treatment-resistant depression. Instead of the usual 6-week course, participants receive 10 sessions per day for 5 days. The goal is to see if this intense schedule can quickly redu…

This study tests a drug called COMP360 (a form of psilocybin, the active ingredient in magic mushrooms) in people with depression that hasn't improved with other treatments. About 572 adults will receive either a high or low dose, and researchers will measure changes in mood and …

This small pilot study tested whether low-intensity focused ultrasound can safely ease symptoms in people with treatment-resistant depression. The device targets a brain region linked to mood. Only 1 person was enrolled, and the trial is currently suspended, so results are very l…

This phase 3 trial tests whether a single dose of COMP360 psilocybin, given under supportive conditions, can safely reduce depression symptoms in 255 adults with treatment-resistant depression. Participants are randomly assigned to receive either the drug or a placebo, and their …

This study looks at whether a safe, non-invasive brain stimulation method called tDCS is practical and well-liked by hospitalized adults whose depression hasn't improved with standard treatments. Ten participants will receive 10 sessions of tDCS alongside their usual care. The ma…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with depression that hasn't improved with standard treatments. Twenty adults will receive one or two doses and be followed for a year to see if their symptoms…

This study aimed to see if nitrous oxide (laughing gas) could help people with major depression, especially those who hadn't improved with other treatments. Participants would have received four weekly sessions of the gas or a placebo. However, the study was withdrawn before any …

This study looks at whether brain wave patterns recorded during and after electroconvulsive therapy (ECT) can predict how much depression symptoms improve. About 31 adults with treatment-resistant depression will have their brain activity measured with a wearable EEG device. The …

This study aims to find which patients with treatment-resistant depression are most likely to get relief from a single low dose of IV ketamine. Researchers will use interviews, questionnaires, brain wave tests, and computer tasks to look for clues. The goal is to make this treatm…

This study looks at whether specific brain wave patterns (gamma oscillations) can help predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity using EEG before and during ketamine treatment and track depressi…