Omega-3s show promise for Tough-to-Treat depression

NCT ID NCT05774665

Ongoing Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in adults with treatment-resistant depression. Fourteen participants who were already on antidepressants but still depressed were randomly given either omega-3 supplements or a placebo for 12 weeks. The researchers measured anti-inflammatory compounds in the blood and tracked depression symptoms to see if omega-3s could help.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant Inflammation inflammatory disease major depressive disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLAMMATION OVERWEIGHT TREATMENT RESISTANT DEPRESSION

Contacts and locations

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Locations

Depression Clinical and Research Program at Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Emory University School of Medicine

Atlanta, Georgia, 30322, United States
University of Utah

Salt Lake City, Utah, 84108, United States