Omega-3 shows promise for Hard-to-Treat depression

NCT ID NCT05774665

First seen Feb 23, 2026 · Last updated May 16, 2026 · Updated 10 times

Summary

This study looked at whether omega-3 fatty acids can reduce inflammation and improve mood in people with treatment-resistant depression. 14 adults who were still depressed despite taking antidepressants were randomly given either omega-3 or a placebo for 12 weeks. Researchers measured anti-inflammatory compounds in the blood and tracked depression symptoms to see if omega-3 offered additional benefit.

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Contacts and locations

Locations

  • Depression Clinical and Research Program at Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Emory University School of Medicine

    Atlanta, Georgia, 30322, United States

  • University of Utah

    Salt Lake City, Utah, 84108, United States

Conditions

Explore the condition pages connected to this study.