OVERWEIGHT

This study is testing two new investigational drugs, macupatide and eloralintide, to see if they help with weight loss in adults who have type 2 diabetes and are overweight or have obesity. About 200 participants will receive the drugs alone, in combination, or a placebo for near…

This study is testing several different weight management treatments for adults with obesity or overweight. The trial will evaluate how safe and effective these new interventions are for long-term weight control. Participants will be assigned to different treatment groups based o…

This early-stage study aims to understand how the body absorbs a new weight management medicine when it's injected into different areas, like the thigh, arm, or abdomen. It will involve 54 adults who are overweight or have obesity, who will receive a single dose. Researchers will…

This study is testing if a weekly injection called semaglutide can help adults who are quitting smoking avoid gaining weight. Researchers want to see if the medication helps control appetite and food intake during the challenging period after stopping cigarettes. The trial will e…

This study is testing whether a chewing gum containing a special fiber (GOS) can help overweight adults manage their weight and improve their metabolism. Researchers will enroll 120 participants to see if using the gum affects their body mass index (BMI), blood pressure, blood su…

This study is testing a new weekly injection called MET097 to help adults with type 2 diabetes and overweight or obesity lose weight and better control their blood sugar. About 1,000 participants will receive either the real injection or a placebo (a shot with no medicine) for ab…

This study is testing whether a new weekly injection called eloralintide helps people with obesity or overweight lose more weight when added to their current weekly weight-loss medication. It will involve about 900 adults, some with type 2 diabetes and some without, over roughly …

This study is testing if eating special protein and fiber bars helps people lose weight and improve their joint and heart health. 144 adults with overweight or obesity will follow a low-calorie diet for 12 weeks, with some groups adding these bars to their meals. Researchers will…

This study is testing a new drug, RO7204239, to see if it can help the body use insulin more effectively in people with type 2 diabetes who are also overweight or have obesity. It will compare the drug against a placebo (a dummy treatment) in 30 participants over 24 weeks. Resear…

This study is testing whether a diet that replaces some animal protein (like meat and dairy) with plant protein (like beans and nuts) can help people with type 2 diabetes manage their blood sugar levels better than a standard diabetes diet. About 146 overweight or obese adults wi…

This study is testing a new weekly injection called eloralintide to see if it helps adults with obesity and type 2 diabetes lose weight. Over 1,000 participants will receive either the real injection or a placebo (dummy shot) for about 75 weeks. Researchers will measure changes i…

This study is testing a once-daily oral medication called orforglipron to see if it helps adolescents with obesity or overweight with related health conditions manage their weight. It will compare the drug to a placebo (a pill with no medicine) in about 125 participants over 18 m…

This study is testing a once-daily pill called orforglipron to see if it helps people with obesity or overweight and type 2 diabetes lose weight and better control their blood sugar. It will compare the pill's effects to a placebo (a dummy pill) in about 600 participants over 18 …

This study is testing whether a structured meal replacement program can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and lower their blood sugar. Researchers will provide participants with a low-calorie nutrition plan and track their weight, bl…

This study is testing whether a new drug called UBT251 is safe and helps people with overweight or obesity manage their weight. About 333 participants will be randomly assigned to receive either the actual drug or a placebo (inactive substance) for comparison. Researchers will me…

This study is testing whether changing when night shift nurses eat can improve their health. It will compare three approaches: just tracking food, limiting eating to a 10-hour daytime window, or that same window plus a special snack during the night shift. The goal is to see if t…

This study is testing a weight loss program designed for taxi and ride-share drivers in New York City. It will compare four different support methods—like personal counseling, text messages, and weekly calls—to see which combination works best to help drivers lose at least 5% of …

This study is testing whether a daily pill called orforglipron helps people with obesity or overweight lose weight. It will involve about 600 adults who have not succeeded with diet alone and have at least one other weight-related health issue. The study will compare the pill's e…

This large study is testing whether a new injectable medication, maridebart cafraglutide, can help prevent serious heart problems in people who already have heart disease and are overweight or obese. It will compare the drug to a placebo (inactive shot) in over 12,000 participant…

This study is testing whether eating freeze-dried wild blueberry powder every day for six months can help control high blood pressure, improve gut bacteria, and enhance memory and thinking skills. It will involve 40 Black and White adults aged 45-65 who have elevated blood pressu…

This study is testing two different endoscopic procedures that use stitches to make the stomach smaller, helping with weight loss. It's for adults with obesity who haven't succeeded with diet and exercise alone. Researchers will compare the safety and effectiveness of the new End…

This study is testing two new weekly injection drugs, CagriSema and cagrilintide, to see how well they help children and adolescents with overweight or obesity manage their weight. About 460 participants, aged 8 to 18, will receive either one of the new drugs, an existing drug (s…

This is an early-stage study to check the safety and how the body processes a new nasal spray version of a weight loss medication called semaglutide. It will involve 60 overweight or obese adults who will receive a single dose. The main goal is to see how safe the spray is and ho…

This study is testing whether a new weekly injection called retatrutide is safe and effective for weight loss. It will involve about 250 adults who have obesity or are overweight but do not have type 2 diabetes. Participants will receive either the real injection or a placebo (a …

This is an early-stage study to check the safety and how the body processes a new drug called LY4086940. It will involve about 201 healthy people and people who are overweight, have obesity, or have type 2 diabetes. The main goal is to see if the drug is safe and well-tolerated a…

This study is testing if adding a specially trained 'heart health doula' to standard care helps new mothers recover from pregnancy-related high blood pressure. Researchers will compare two groups: one gets standard home blood pressure monitoring, and the other gets that plus week…

This large, Phase 3 study aims to test the safety and effectiveness of different weight management medications for children and teenagers with obesity or overweight. It will enroll 125 young participants aged 12 to under 18 who have previously tried lifestyle programs without eno…

This is a very early-stage study to check the safety and how the body processes a new injectable drug called HRS-5817. It will involve 92 healthy adult volunteers, some with obesity and some without. The main goal is to see how safe the drug is and how it behaves in the body when…

This study looks at whether free exercise classes in community parks help older adults improve their health. Researchers will analyze data from 1,000 Miami-Dade County residents aged 50+ who participate in regular park-based fitness sessions. The program includes aerobic exercise…

This is the first human study to test the safety and basic effects of a new drug called LY4167586 for weight management. It will involve 84 otherwise healthy adults with obesity or overweight. Researchers will give single doses to see how the body handles the drug and monitor for…

This study is testing a new weekly injection called KAI-9531 to see if it helps people with obesity or overweight lose weight and improve related health issues like high blood pressure or cholesterol. About 1,800 adults who have struggled to lose weight through diet and exercise …

This study aims to see if two different versions of the drug survodutide work the same way in the body. It will involve 80 adults who are living with overweight or obesity. Participants will receive both drug versions in a random order to compare how much of the drug gets into th…

This study is testing a new weekly injection called NNC0662-0419 to see if it is safe and helps people lose weight. It will involve about 220 adults living with overweight or obesity. Some participants will receive the new medicine, while others will get a placebo (an inactive sh…

This study is testing a new weekly injection called eloralintide to see if it helps adults with obesity or overweight lose weight and improve their health. It will involve nearly 2,000 people who do not have type 2 diabetes. Participants will receive either the real injection or …

This early-stage study aims to check the safety and how the body processes a new drug called LY3549492 in healthy adults who are overweight or have obesity. About 120 participants will receive multiple doses over approximately 8 weeks while researchers monitor for side effects an…

This large, late-stage study is testing a weekly injection called eloralintide for adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The goal is to see if the drug can help reduce the number of breathing pauses during sleep (sleep apn…

This large, late-stage study is testing a once-daily pill called orforglipron to see if it helps people lose weight and is safe. It will enroll about 1,200 adults who have obesity or are overweight, some of whom also have type 2 diabetes. The main goal is to see how well the pill…

This study is testing whether personalized diet advice based on a person's genetic makeup helps people lose more weight and body fat than standard diet advice. It will involve 88 overweight adults in Greece. Participants will receive either DNA-based guidance or general healthy e…

This early-stage study is testing whether a new experimental drug called NNC6989-0001 is safe for people with overweight or obesity. The trial will enroll 96 healthy adults to receive either the drug or a placebo, with researchers carefully monitoring for side effects. This is th…

This study is testing whether a new injectable drug called taldefgrobep alfa can help adults with overweight or obesity lose weight. Researchers will compare the drug to a placebo (inactive shot) in 150 participants over 24 weeks to see how much body weight changes and check for …

This study is testing different ways to increase the dose of an investigational weight loss medication called retatrutide. It aims to see which dosing plan is most effective and safe for helping people with obesity or overweight lose weight and improve related health measures. Th…

This study is testing if adding one of two behavior strategies to a standard weight loss program helps people lose more weight. The 'AVOID' strategy helps people change their home food environment, while the 'RESIST' strategy uses a game-like app to train impulse control. About 5…

This study is testing whether personalized nutrition and exercise advice can help prostate cancer survivors who are receiving hormone therapy. The goal is to reduce frailty, improve strength, and enhance quality of life. Participants will receive a 6-month program including diet …

This study is testing whether adding laser acupuncture to standard diet and exercise advice helps overweight menopausal women lose weight and improve their body shape. Researchers will compare 40 women who receive the laser treatment to those who only get lifestyle guidance. The …

This study is testing whether an 8-week Pilates exercise program can improve breathing and overall health in overweight and obese women. Participants will do core and abdominal exercises three times a week. Researchers will measure lung function, core strength, and quality of lif…

This study is testing whether a weekly injection called retatrutide can safely reduce chronic low back pain in adults who also have obesity or are overweight. Researchers will compare the injection to a placebo (a dummy treatment) in about 586 participants over 80 weeks. The main…

This study observes adults with risk factors like high blood pressure or diabetes during their regular cardiology visits. Researchers will collect health data to see how structured management affects measures like blood pressure and cholesterol. The goal is to better understand h…

This study is testing whether the order people follow two popular diets affects how much body fat they lose. Overweight adults will try both a low-fat diet and a low-carb diet for 4 weeks each, with the order randomly assigned. Researchers will deliver all meals to participants' …

This study aims to understand how suddenly stopping all exercise affects appetite control in healthy, active men. Researchers will have 40 participants either continue their normal activity or stop all exercise and limit walking for two weeks. They will measure how much people ea…

This study aims to understand how long people should fast and what happens when they temporarily stop taking the medication tirzepatide, in terms of how quickly their stomachs empty after eating. Researchers will use ultrasound scans to measure food and liquid remaining in the st…

This study aims to find out if consuming the artificial sweetener sucralose changes how the body absorbs and processes certain medications. Researchers are enrolling 150 overweight or obese Black and Hispanic women to take either sucralose or a placebo pill for a month. They will…

This study aims to understand how a low-carbohydrate diet and a dietary supplement called nicotinamide riboside (NR) affect the body's metabolism. Researchers will measure how these interventions change the way healthy, overweight adults and people with a specific genetic form of…

This study aims to see if eating honey-flavored yogurt daily for 4 weeks can reduce low-level inflammation and improve gut health in overweight, postmenopausal women. Researchers will compare the effects of honey yogurt to sugar-sweetened yogurt in 20 participants. The goal is to…

This early-stage study aims to check the safety and how the body processes an experimental oral medication called RO7795081 in healthy overweight or obese adults. Researchers will give the drug to 40 participants and measure its levels in the blood, while also checking if it affe…

This study aims to understand the connections between a woman's weight, her personal hygiene and bathroom habits, and symptoms like frequent urination or incontinence. Researchers will compare two groups of women (aged 18-45) based on their weight to see if these factors are link…

This study is observing whether a free, daily after-school program in community parks improves children's health. Researchers will analyze data from about 5,000 kids aged 6-14 who participate in the program, which includes sports, games, and nutrition lessons. The goal is to see …

This early-stage study aims to understand how a new investigational drug for weight management, called HRS-7535, interacts with four common medications: acetaminophen (pain/fever), digoxin (heart), rosuvastatin (cholesterol), and omeprazole (heartburn). It will enroll 40 overweig…