OVERWEIGHT

This study is testing whether a chewing gum containing a special ingredient (GOS) can help overweight adults lose weight and improve their health. Researchers will measure changes in body mass index (BMI), blood pressure, and gut bacteria over time. The study aims to find a simpl…

This study tests whether a new medicine called UBT251 is safe and helps people with overweight or obesity lose weight. About 333 adults will receive either UBT251 or a placebo (dummy treatment) by chance. The main goals are to check for side effects and measure weight change over…

This study tests whether a diet plan based on your genetic makeup helps you lose more weight and body fat than standard dietary advice. About 88 overweight adults will receive either personalized genetic counseling or general diet tips. Researchers will measure changes in body we…

This study tests a new medicine called KAI-9531, given as a weekly shot, to help people with obesity or overweight who also have weight-related health problems (like high blood pressure or sleep apnea) but do not have diabetes. About 1,800 adults will receive either the drug or a…

This study tests a new once-weekly medicine called eloralintide to help adults who are overweight or obese and also have type 2 diabetes lose weight. About 1035 participants will receive either the drug or a placebo for 75 weeks. The main goal is to see how much weight they lose …

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study tests a 9-month program for women who had preeclampsia in their first pregnancy. The program includes online group meetings, a smartphone app for tracking blood pressure and weight, and lifestyle coaching. Researchers want to see if it lowers blood pressure and helps w…

This study tests the safety and effectiveness of tirzepatide in 344 Indian adults with type 2 diabetes or obesity. Participants receive the drug for 46 weeks. Researchers will track side effects, weight loss, and blood sugar control to see if tirzepatide helps manage these condit…

This study looks at whether eating protein and/or fiber bars as part of a low-calorie diet helps overweight or obese adults lose weight and improve heart, joint, and metabolic health. About 144 participants will eat three bars daily for 12 weeks. Researchers will track weight, bo…

This study tests a once-weekly injection called eloralintide to help adults with obesity or overweight lose weight. About 1,980 participants who do not have type 2 diabetes will receive either the drug or a placebo for 75 weeks, with some continuing for up to 2 more years. The go…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will take the drugs or a placebo for 48 weeks. The main goal is to see how much weight they l…

This study tests different ways to increase the dose of the drug retatrutide to help people with obesity or overweight lose weight. About 600 participants without diabetes will receive the drug or a placebo for up to 113 weeks. The main goal is to see how much weight they lose an…

This study tests a new drug called brenipatide in 150 healthy adults with overweight or obesity. Participants receive injections under the skin to see how different doses affect body weight and safety. The study lasts about 42 weeks and aims to find out if the drug can help contr…

This study tests whether a new drug, maridebart cafraglutide, can reduce the risk of heart attacks, strokes, and heart-related death in people who have heart disease and are overweight or obese. About 12,800 adults aged 45 and older will receive either the drug or a placebo, alon…

This study tests an experimental daily pill called KAI-7535 to see if it helps people with obesity or overweight lose more weight than a placebo. The trial includes 320 adults who also have at least one weight-related health problem like high blood pressure or sleep apnea. Partic…

This study tests two minimally invasive procedures—EndoZip and Apollo ESG—to help obese adults lose weight. Participants (ages 21-65, BMI 30-50) who haven't succeeded with diet or exercise will get one of the two treatments, plus lifestyle coaching. The main goal is to see which …

This study tests whether adding extra virgin olive oil to the diet can reduce liver fat and improve blood sugar and cholesterol in people with a common fatty liver condition called MASLD. Researchers will enroll 60 overweight adults and measure changes in liver health, inflammati…

This study tests a once-daily pill called orforglipron in 125 teens aged 12–17 who have obesity or are overweight with related health issues. Participants take either the drug or a placebo for about 18 months. The goal is to see if the pill helps lower body mass index (BMI) and i…

This study tests a new once-weekly injection called eloralintide for adults who are still obese or overweight despite taking a weekly incretin drug (like Ozempic or Wegovy). About 900 participants will receive either eloralintide or a placebo for 80 weeks to see if it helps them …

This study is testing several new experimental treatments to help adults with obesity or overweight manage their weight over the long term. About 1,200 participants will be assigned to different treatment groups to see which approach works best and is safest. The goal is to find …

This study looks at whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and thinking skills in women aged 20-65 who have prediabetes and are overweight. Researchers will also check if it changes gut bacteria. The goal is to see if t…

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a program that includes counseling, text messages, phone support, and self-monitoring tools. About 1,785 drivers in New York City will take part. The goal is to find the most effective and…

This study tests a new medicine called MET097, given as a weekly shot under the skin, to help adults with overweight or obesity and type 2 diabetes lose weight. About 1,000 people will take part for 21 months, with some receiving the study drug and others a placebo. The goal is t…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in adults aged 45-65 with high blood pressure. Researchers will measure blood pressure, artery stiffness, and memory over time. The goal is to see if a simple diet chan…

This study tests two new drugs, CagriSema and cagrilintide, to help children and adolescents with overweight or obesity lose weight. About 460 participants will be randomly assigned to receive one of the study drugs, an existing drug (semaglutide), or a placebo. The main study la…

This early-stage study tests the safety and how the body handles a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. Participants will receive multiple doses of the drug and be monitored for about 8 weeks. The goal is to see if the drug is safe a…

This study tests a new once-weekly injection called NNC0487-0111 for people who are overweight or obese and have type 2 diabetes. About 630 adults will receive either the active drug or a placebo to see if it safely helps reduce body weight and improve blood sugar control. The go…

This study looks at whether personalized nutrition and exercise plans can help reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (androgen deprivation therapy). About 50 participants will receive tailored advice and be monitored f…

This early-stage study tests a new injection called HRS-5817 in healthy adults, some with obesity and some without. The main goal is to check if the drug is safe and how the body processes it. About 92 volunteers aged 18-55 will receive single or multiple doses under close monito…

This study compares two ways to help people with overweight or obesity lose weight and eat healthier. One approach focuses on avoiding tempting situations (AVOID), while the other trains the brain to resist impulses (RESIST). About 500 adults will be followed for 12 months to see…

This study tests whether meal replacements can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and improve blood sugar control. About 20 participants will follow an intensive nutrition program for several weeks. The goal is to see if this approach…

This study tests whether new medications can help children and teens (ages 12 to 17) with obesity or overweight manage their weight long-term. Participants must have tried diet and exercise without enough success. The trial will compare different drugs to see which are safe and e…

This study tests if a once-weekly medicine called semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive the drug or a placebo while trying to quit. The goal is to see if the drug helps control appe…

This study tests whether adding a specially trained doula to standard care helps women who had high blood pressure during pregnancy get their blood pressure under control after giving birth. About 454 women will be randomly assigned to either usual blood pressure monitoring at ho…

This early-stage study tests a new medicine called LY4167586 in people with obesity or overweight who are otherwise healthy. The main goal is to check if the drug is safe and how the body processes it after a single dose. About 84 participants will receive either the drug or a pl…

This study tests whether partially replacing animal protein with plant protein in the diet can improve blood sugar control in people with type 2 diabetes who are overweight or obese. Over 24 weeks, 146 adults will follow either a plant-based diet or a standard healthy diet. The m…

This study looks at whether changing when you eat can lower disease risk for night-shift nurses and nursing assistants who are overweight. About 180 participants will be split into three groups: one just tracks their diet, another eats only during a 10-hour daytime window, and th…

This study tests a medicine called cagrilintide to see how it changes appetite and how much people eat. About 120 adults with overweight or obesity will get either the drug or a placebo for around 30 weeks. The main goal is to measure the change in total calories eaten during mea…

This study tests a once-weekly medicine called eloralintide in 800 adults with moderate-to-severe sleep apnea who are also overweight or have obesity. The goal is to see if it can improve breathing during sleep and help with weight loss. Some participants use a CPAP machine, whil…

This study tests a new once-weekly injection (NNC0487-0111) to see if it helps people with excess weight and knee osteoarthritis lose weight and feel less knee pain. About 400 adults will receive either the study drug or a placebo for comparison. The main goals are to measure wei…

This early-stage study is testing a new medicine called NNC6989-0001 to see if it is safe for healthy people who are overweight or have obesity. About 96 participants will receive either the drug or a placebo by chance. The main goal is to check for any side effects and how the d…

This early-stage study tests a new medicine called SHR-2906, given as an injection, to see if it is safe and how the body processes it. The study involves 124 people: healthy volunteers receiving a single dose, and obese patients receiving multiple doses. The main goal is to chec…

This early-stage study tests a new nasal spray form of semaglutide (a drug used for weight loss) in 60 overweight or obese adults. The main goal is to check safety and how the drug moves through the body, not yet to prove weight loss. Participants receive a single dose and are mo…

This early-stage study looks at whether combining two experimental weight-loss drugs (cagrilintide and NNC0480-0389) causes less nausea, vomiting, and diarrhea than taking cagrilintide alone. About 100 women with overweight or obesity will receive both combinations at different t…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This study looks at whether an 8-week Pilates exercise program can improve breathing in overweight and obese women. About 48 women will be split into an exercise group and a control group. Researchers will measure lung function, breathing rate, and quality of life before and afte…

This early-stage study tests a new medicine called LY4086940 in healthy people and those who are overweight or have obesity, with or without type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will take part in differ…

This study is testing whether a weekly injection called retatrutide can help reduce chronic low back pain in adults who have obesity or are overweight. The 80-week trial will compare the drug against a placebo in 586 participants to see if it improves pain and leads to weight los…

This study looks at how a low-carbohydrate diet and a supplement called nicotinamide riboside (NR) change the way the body burns fat. About 100 healthy overweight adults and some with a specific type of diabetes will stay in the clinic, eat a low-carb diet, and take either NR or …

This study looks at whether starting with a low-carb diet and then switching to low-fat helps people lose more body fat than the opposite order. Over 8 weeks, 42 overweight adults will eat specially prepared meals at home and have body scans and metabolism tests. The goal is to s…

This study looks at how a new drug (NNC0662-0419) changes the way the body processes birth control pills and a common painkiller in women who are overweight or obese and cannot become pregnant. About 45 women will receive all three treatments in sequence to measure drug levels an…

This early-stage study tests an experimental drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check if the drug is safe and how it interacts with common statins (pitavastatin and rosuvastatin). Participants will receive either the drug or a pl…

This study looks at how being overweight affects insulin sensitivity and heart and muscle fitness in people with type 1 diabetes. Researchers will compare people with and without diabetes, before and after a high-intensity interval training program. The goal is to understand why …

This study looks at how your natural sleep type (night owl vs. early bird) affects blood sugar control in overweight young adults aged 18-23. Researchers will compare glucose tests and meals given at times that match or clash with each person's internal clock. No treatment is giv…

This study tests whether eating honey-flavored yogurt every day for 4 weeks can lower low-grade inflammation and improve gut health in overweight women aged 45 to 65. Researchers will measure markers of inflammation and gut bacteria changes. The goal is to understand how diet aff…

This study looks at what happens to appetite when physically active men aged 40-55 suddenly stop exercising for two weeks. Researchers want to see if inactivity changes how much they eat and what foods they prefer. Participants are randomly assigned to either keep their normal ro…

This early-stage study looks at how a new weight-loss drug, maridebart cafraglutide (AMG 133), changes the way the body processes oral contraceptives. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth contr…

This early-stage study tests a medicine called PF-08653944 in 20 adults who are overweight or have obesity. The goal is to see how it changes the speed at which the stomach empties food after a meal. Researchers will also check for side effects. The results will help plan future …

This study looks at whether the artificial sweetener sucralose (found in many diet foods and drinks) affects how the body absorbs and breaks down certain medicines. Researchers will give healthy, overweight Black and Hispanic women either sucralose or a placebo for four weeks and…

This study follows 5,000 children in a park-based afterschool program to see if it improves their physical fitness, weight, and mental health. Researchers will measure changes in body measurements, fitness tests, and questionnaires about anxiety and well-being. The goal is to und…

This study looks at how long you need to fast and how stopping the diabetes drug tirzepatide changes the amount of food or drink left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 adults with type 2 diabetes or obesity. The goal is …

This study looks at how a park-based fitness program affects the health of adults aged 50 and older in Miami-Dade County. Researchers will measure changes in weight, blood pressure, strength, and mobility in 1,000 participants. The goal is to see if community park programs can he…

This early-stage study is testing a single dose of an experimental medicine called PF-08653944 in 54 overweight or obese adults. The goal is to see how the drug is absorbed when injected into the thigh, upper arm, or abdomen. Researchers will also monitor safety through blood tes…

This study checks if two different versions of the drug survodutide are absorbed the same way in the body. It involves 80 healthy adults who are overweight or obese. Participants will receive both formulations at different times to compare drug levels in the blood.

This study looks at how different types of food affect what we choose to eat later. Researchers will give participants two different liquid meals—one high in carbs, one high in protein—and see how that changes their food choices at a buffet. The goal is to understand if people wi…

This study looks at how body weight relates to women's bathroom habits, genital hygiene, and bladder symptoms. Researchers will compare normal-weight and overweight/obese women aged 18-45 using questionnaires. The goal is to understand these connections and improve quality of lif…