OVERWEIGHT

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who use a breathing device. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Partic…

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This study tests two versions of the experimental drug cagrilintide in 234 adults with overweight or obesity. Participants receive either version D or version B by injection once a week for about 6 months. The goal is to see how the drug is processed in the body, not to measure w…

This study tests whether a virtual weight management program that includes a support person (like a family member or friend) helps Veterans with obesity lose weight. 320 Veterans and their partners will participate in 8 virtual sessions over 14 weeks. The main goal is to see if t…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who do not use a CPAP machine. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Par…

This study tests a new once-weekly medicine called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for around 75 weeks. Researchers will measure changes in body weight, fat, waist …

This Phase 2 trial is testing several experimental drugs—including tirzepatide and others—for long-term weight management in adults with obesity or overweight. About 1,481 participants will receive one of the drugs or a placebo. The goal is to see if these treatments are safe and…

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will receive the drugs or a placebo for 48 weeks. The main goal is to see how much weight the…

This study tests a new once-weekly injection called eloralintide to help adults with obesity or overweight lose weight. About 1980 people who do not have type 2 diabetes will take part for up to 75 weeks, with some continuing for 2 more years. The goal is to see if the drug safel…

This study tests a new weekly injection called eloralintide in 900 adults with obesity or overweight who are already taking a weekly incretin drug (like Ozempic or Wegovy) but still have excess weight. Participants will receive either eloralintide or a placebo for about 80 weeks …

This study tests an experimental drug called KDS2010 for weight loss in 75 overweight or obese adults. Participants take the drug or a placebo daily for 12 weeks. The main goal is to see how much weight they lose and if the drug is safe. It is a Phase 2a trial, meaning it is stil…

This phase 3 trial tests a weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The study looks at whether the drug can improve sleep apnea symptoms and help with weight loss. Participants are …

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This Phase 2b trial is testing whether two experimental drugs, macupatide and eloralintide, can help adults with obesity or overweight lose weight. About 400 participants will receive either one or both drugs or a placebo for 64 weeks. The study measures weight change and safety,…

This study tests a new weekly injection called KAI-9531 to help people with obesity or overweight lose weight. It is for adults who do not have diabetes but have weight-related health problems like high blood pressure or sleep apnea. About 1800 participants will receive either th…

This study tests a once-daily pill called orforglipron to help teenagers with obesity or overweight lose weight. About 150 teens will take either the pill or a placebo for 18 months, along with lifestyle advice. The goal is to see if the pill safely reduces body mass index (BMI) …

This phase 3 study is testing whether a new drug called maridebart cafraglutide (MariTide) can reduce the risk of heart attacks, strokes, and death in people with heart disease who are overweight or obese. About 12,800 participants will receive either the drug or a placebo, added…

This Phase 3 trial is testing an oral medication called orforglipron for chronic weight management in children and teens with obesity or overweight. The study will enroll 125 participants who have already tried lifestyle changes without success. The goal is to see if the drug is …

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study is testing whether two different versions of the drug survodutide are equally effective in the body. It involves 80 healthy overweight or obese adults who will receive both formulations in a crossover design. The goal is to see if the new formulation matches the origin…

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults with overweight or obesity. About 872 participants will receive either the drugs or a placebo injection. The main goal is to see how much weight they lose over…

This early-stage trial tests a new drug called NNC0497-0040 in healthy people, those with overweight or obesity, and people with type 1 diabetes who are also overweight. The goal is to see if the drug is safe and tolerable when given as a weekly injection. About 146 participants …

This early-stage study tests an experimental oral drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check safety and how the drug interacts with common statins (rosuvastatin and pitavastatin). Participants will receive the drug or a placebo in …

This study examines weight loss in adults who took semaglutide (a prescription weight management drug) as part of their routine care. Researchers will analyze medical records from about 35,000 people with overweight or obesity to see how much weight they lost and whether they ach…

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This study tests whether a daily orange peel fermentation supplement can lower body fat in 124 overweight adults with fatty liver. Participants take one sachet per day for two months. Researchers will measure changes in body fat, cholesterol, and other health markers.

This Phase 3 trial tests a drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese. Participants receive weekly injections of either the drug or a placebo for 48 weeks. The main goal is to see if IBI362 lowers blood pressure more th…

This study follows overweight and obese adults aged 45-65 to see if a tailored program of counseling, supervised exercise, and digital tools helps them lose weight and improve heart health over 18 months. Participants are compared to a group that only gets general written advice.…

This study tests tirzepatide, a once-weekly injection, in 344 Indian adults with type 2 diabetes or obesity. Over 46 weeks, researchers will check for serious side effects and measure weight loss and blood sugar control. The goal is to see if this drug is safe and effective for t…

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This study is testing whether adding extra virgin olive oil to the diet can improve liver fat, inflammation, and blood sugar in people with MASLD (fatty liver disease) who are overweight. Researchers will give 60 participants either 3 or 9 tablespoons of olive oil daily for a per…

This trial tests a 9-month program for women who had preeclampsia during their first pregnancy. The program includes online screening, group meetings, and a smartphone app to help monitor blood pressure and weight. Researchers want to see if it improves heart health and promotes …

This study tests whether UBT251 is safe and effective for people who are overweight or have obesity. About 333 participants will receive either UBT251 or a placebo injection. The main goals are to check for side effects and measure weight change over time.

This early-stage trial is testing a new drug called brenipatide in 150 healthy people with overweight or obesity. Participants receive different doses of the drug or a placebo as injections under the skin. The study lasts about 42 weeks and aims to see how well the drug works for…

This study tests two drugs, cagrilintide and semaglutide (alone or together as CagriSema), to help children and adolescents with overweight or obesity lose weight. About 460 participants will receive either the drugs or a placebo for up to 5 years. The main goal is to see how muc…

This study looks at whether eating wild blueberries can improve heart health, thinking skills, and gut bacteria in Black and White adults aged 45-65 with high blood pressure. Participants will eat blueberries daily and have their blood pressure, artery stiffness, and cognitive fu…

This study tests whether a daily dose of freeze-dried wild blueberry powder can improve blood sugar, blood pressure, and brain function in women with prediabetes. Thirty overweight women aged 20-65 will take either the blueberry powder or a placebo for six weeks. Researchers will…

This early-stage study is testing a new medicine called LY4167586 in people who are overweight or have obesity but are otherwise healthy. The main goal is to see if the drug is safe and how the body processes it after a single dose. About 84 participants will be randomly assigned…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study compares two ways to help people with overweight or obesity lose weight: avoiding tempting situations (AVOID) or practicing self-control when faced with cravings (RESIST). About 500 adults will be followed for 12 months to see which approach works better for weight los…

This study tests whether a weekly injection of semaglutide (a drug used for weight loss and diabetes) can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will also use nicotine patches to help them quit. The goal is to s…

This study compares two types of diet counseling for weight loss: one based on your genetic makeup and the other on standard healthy-eating guidelines. About 88 overweight adults will receive personalized advice and be followed to see which approach leads to greater fat loss and …

This study looks at whether partly replacing animal protein with plant protein can improve blood sugar control in people with type 2 diabetes who are overweight. About 146 adults will follow either a plant-based diet or a standard healthy diet for 24 weeks. The main goal is to se…

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a combination of counseling, text messages, phone support, and self-monitoring tools. Researchers will enroll about 1,785 drivers in New York City to find out which parts of the program wo…

This study tests two minimally invasive procedures, EndoZip and Apollo ESG, to help people with obesity lose weight. Participants are adults aged 21-65 with a BMI of 30-50 who have not succeeded with non-surgical methods. Both procedures reshape the stomach using an endoscope, fo…

This study tests whether meal replacement products can help low-income adults with obesity, prediabetes, or type 2 diabetes lose weight and lower blood sugar. Twenty participants will use meal replacements and be monitored for weight loss and blood sugar changes. The goal is to s…

This study is testing whether a special chewing gum containing galactooligosaccharides (GOS) can help overweight adults lose weight and improve their metabolism. Researchers will measure changes in body mass index (BMI), blood pressure, and gut bacteria over time. The study aims …

This early-stage study tests a new injectable drug called HRS-5817 in healthy adults, some with obesity and some without. The main goal is to check safety and how the body handles the drug, not weight loss. About 92 volunteers will receive either the drug or a placebo to gather i…

This study tests whether eating special protein and fiber bars three times a day, as part of a low-calorie diet, helps overweight or obese adults lose weight and improve heart and joint health. About 144 participants will be split into four groups, each receiving a different bar …

This study looks at whether adjusting meal timing can reduce health risks for night-shift nurses and nursing assistants who are overweight. Participants will either just track their diet, follow a 10-hour daytime eating window, or add a low-sugar snack during night shifts. The go…

This study tests whether cagrilintide, a new injectable drug, causes fewer stomach side effects than a placebo in people with obesity who previously quit GLP-1 medications due to nausea, vomiting, or diarrhea. About 114 participants will receive either cagrilintide or a dummy sho…

This early-stage study tests whether a new drug called NNC0113-5840 is safe for people with overweight or obesity. About 48 adults aged 18-55 with a BMI between 25 and 35 will receive either the drug or a placebo. The main goal is to check for side effects and how the drug moves …

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This study tests a once-weekly injection called retatrutide to see if it can reduce chronic low back pain and help with weight loss in people who have obesity or overweight. About 586 participants will receive either the drug or a placebo for up to 80 weeks. The goal is to find a…

This early-stage study tests a new injection called SHR-2906 to see if it is safe and tolerable. It involves 124 healthy volunteers and obese patients. The goal is to check for side effects and how the drug moves through the body.

This study tests a medicine called cagrilintide to see how it affects appetite and how much people eat. About 120 adults with overweight or obesity will receive either the drug or a placebo for around 30 weeks. The goal is to measure changes in total energy intake from meals and …

This study tests whether personalized nutrition and exercise plans can reduce frailty and improve body composition in prostate cancer survivors who are on hormone therapy (ADT). Fifty participants will receive diet advice, exercise coaching, and educational sessions. Researchers …

This early-stage trial is testing whether combining two experimental weight loss drugs—cagrilintide and a GIP receptor agonist—causes fewer stomach side effects like nausea and vomiting compared to taking cagrilintide alone. About 100 women who are overweight or obese will receiv…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This early-stage study tests a new nasal spray form of semaglutide (a weight-loss drug) in 60 overweight or obese adults. The main goal is to check safety and how the body processes the drug, not to prove weight loss yet. Participants receive a single dose and are monitored close…

This early-stage study tests a new medicine, NNC6989-0001, for safety and tolerability in 96 healthy adults who are overweight or have obesity. Participants receive either the drug or a placebo by chance. The goal is to check for side effects and how the drug moves through the bo…

This early-stage study looks at how a new weight-loss drug, maridebart cafraglutide, changes the way the body processes oral contraceptives. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth control hormone…

This study looks at whether the artificial sweetener sucralose (found in many diet drinks and foods) changes how the body absorbs and processes certain medications. Researchers will give 150 healthy, overweight Black and Hispanic women either sucralose or a placebo capsule for 28…

This study tests whether starting with a low-carb diet and then switching to low-fat leads to more body fat loss than the opposite order. Over 8 weeks, 42 overweight adults will eat only provided meals and track their weight, activity, and glucose. Researchers want to see if diet…

This study looks at how a supplement called nicotinamide riboside (NR) and a low-carb, high-fat 'ketogenic' diet affect the way the body burns fat and uses energy. Researchers will measure changes in metabolism in 100 overweight or obese adults. Participants will eat a standard d…

This study looks at how a person's natural sleep pattern (chronotype) affects their body's ability to handle sugar. Researchers will compare blood sugar and insulin responses in 70 overweight young adults (ages 18-23) who are either night owls or early birds. Participants will ta…

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study looks at how a high-protein drink versus a high-carbohydrate drink influences what people choose to eat afterward. Researchers will test 45 adults with normal weight, overweight, or obesity to see if the type of meal changes their 'food memory' and calorie intake. The …

This early-stage study is testing whether a new weekly injection called NNC0662-0419 changes how the body processes birth control pills and a common painkiller. Researchers will measure drug levels in the blood of 45 women who cannot become pregnant and have overweight or obesity…

This early-stage study tests an experimental drug called PF-08653944 in 20 overweight or obese adults. Researchers want to see how it affects the speed at which the stomach empties food, using a common painkiller as a marker. The main goals are to understand the drug's effects an…

This study looks at what happens to appetite when physically active men aged 40-55 suddenly become inactive for two weeks. Forty healthy, normal-weight men who bike or exercise regularly will either keep their routine or cut steps to under 1,500 per day. Researchers will measure …

This study is testing whether eating honey-flavored yogurt every day for 4 weeks can lower inflammation and improve gut health in overweight women aged 45 to 65. Twenty participants will eat both honey yogurt and sugar-sweetened yogurt at different times to compare effects. Resea…

This study examines whether community park-based fitness programs can improve cardiovascular health in adults aged 50 and older. Researchers will analyze data from 1,000 participants who took part in exercise sessions including aerobics, strength training, and balance exercises. …

This study follows 5,000 children in a Miami-Dade park-based after-school program called Fit2Play. The program includes daily physical activity and nutrition lessons. Researchers will track changes in weight, fitness, blood pressure, and mental health over time to see if the prog…