Weight-Loss drug semaglutide may help smokers avoid Post-Quit pounds

NCT ID NCT06173778

Recruiting now Disease control Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a weekly injection of semaglutide (a drug used for weight loss and diabetes) can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will also use nicotine patches to help them quit. The goal is to see if semaglutide limits weight gain and changes appetite and body composition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide (a once-weekly injection) and nicotine replacement therapy (nicotine patch)
What this could lead to: If it works, this could offer a way to prevent the weight gain that often happens when people quit smoking, making it easier to stay smoke-free.
What could go wrong: This is an early phase 2 trial with only 197 people, so results may not apply to everyone. Semaglutide can cause side effects like nausea and vomiting, and it's not yet proven to help with smoking cessation weight gain.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking Obesity obesity disorder Overweight Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIGARETTE SMOKING OBESITY OVERWEIGHT

Contacts and locations

Locations

The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77054, United States
The University of Texas at Austin
RECRUITING

Austin, Texas, 78723, United States

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