Can a Vitamin-Like pill boost fat burning on a keto diet?

NCT ID NCT06044935

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how a supplement called nicotinamide riboside (NR) and a low-carb, high-fat 'ketogenic' diet affect the way the body burns fat and uses energy. Researchers will measure changes in metabolism in 100 overweight or obese adults. Participants will eat a standard diet and then a ketogenic diet, with some taking NR or a placebo to see if the supplement boosts fat oxidation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Nicotinamide Riboside

What this could lead to

If successful, this could point toward a supplement that helps the body burn fat more efficiently on a low-carb diet.

What could go wrong

This is an early-stage study focused on measuring metabolic changes, not treating disease. Results may not lead to any practical weight-loss or health benefit.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

maturity-onset diabetes of the young type 2 Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••