Can a Vitamin-Like pill boost fat burning on a keto diet?

NCT ID NCT06044935

Recruiting now Knowledge-focused Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how a supplement called nicotinamide riboside (NR) and a low-carb, high-fat 'ketogenic' diet affect the way the body burns fat and uses energy. Researchers will measure changes in metabolism in 100 overweight or obese adults. Participants will eat a standard diet and then a ketogenic diet, with some taking NR or a placebo to see if the supplement boosts fat oxidation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Nicotinamide Riboside
What this could lead to: If successful, this could point toward a supplement that helps the body burn fat more efficiently on a low-carb diet.
What could go wrong: This is an early-stage study focused on measuring metabolic changes, not treating disease. Results may not lead to any practical weight-loss or health benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

maturity-onset diabetes of the young type 2 Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OVERWEIGHT

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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