National Institute Of Diabetes And Digestive And Kidney Diseases (niddk)

This study tests two immune-suppressing medicines—high-dose steroids or a horse-derived antibody—in children with sudden, severe liver failure. The goal is to see if calming the immune system helps the liver heal so children can survive without needing a liver transplant. About 1…

This study tests whether combining two drugs, VIR-2218 and peginterferon alfa-2a, can lower hepatitis B virus levels in people with mild or inactive chronic infection. About 50 adults aged 18 to 65 will receive monthly VIR-2218 shots for 6 months and weekly peginterferon shots fo…

This study tests an experimental drug called rezpegaldesleukin in people diagnosed with type 1 diabetes within the past 100 days. The goal is to see if the drug can help the body keep making its own insulin, reducing the need for injected insulin. About 66 participants will recei…

This study tests whether rosuvastatin, a widely used cholesterol medication, can safely slow or prevent liver scarring and complications in people with cirrhosis. Researchers will enroll 256 adults with early-stage cirrhosis from causes like fatty liver, alcohol, or hepatitis. Pa…

This study looks at how the liver responds to eating in people with non-alcoholic fatty liver disease (NAFLD) and whether the drug semaglutide can reduce liver fat and damage. About 84 adults with NAFLD and healthy volunteers will take part. Participants with NAFLD will receive w…

This study is testing whether combining two immune-suppressing drugs, rituximab and cyclosporine, can safely and effectively treat membranous nephropathy, a kidney disease where the immune system attacks the kidneys, causing protein to leak into urine. About 30 adults with persis…

This study tests a drug called pegvisomant in 25 adults with severe insulin resistance caused by lipodystrophy or insulin receptor gene changes. Participants give themselves daily shots for one month and have two short hospital stays for tests. The goal is to see if blocking grow…

This study aims to better understand why some people experience dangerously low blood sugar (hypoglycemia) and find better ways to diagnose and treat it. Up to 1,500 adults with confirmed low fasting blood sugar or insulin-secreting tumors will undergo supervised fasting and deta…

This study tests whether new PET scans using a radioactive tracer called 18F-FCH can more accurately locate overactive parathyroid glands or tumors than current methods. About 193 adults scheduled for parathyroid surgery will receive both a standard 4D-CT scan and the new PET sca…

This study looks at how well the desmopressin stimulation test can tell apart different types of Cushing's syndrome, a condition caused by too much cortisol. Researchers will test 140 people aged 18 to 70 who have or may have Cushing's, plus healthy volunteers. The goal is to mak…

This study tests two advanced PET scans (68Ga-DOTATATE and F-DOPA) to locate hidden tumors that cause ectopic Cushing syndrome. About 80 adults with this condition will be scanned every 6-12 months until the tumor is found. The goal is to see which scan or combination works best …

This study tests whether a mild electrical current applied to the scalp (TDCS) can reduce food intake and help with weight loss. About 148 obese adults aged 18-60 will receive either real or fake TDCS sessions three times a week for four weeks, while also following a reduced-calo…

This study looks at whether starting with a low-carb diet and then switching to low-fat helps people lose more body fat than the opposite order. Over 8 weeks, 42 overweight adults will eat specially prepared meals at home and have body scans and metabolism tests. The goal is to s…

This study aims to learn more about how to diagnose and treat thyroid nodules and thyroid cancer. It will include up to 2,500 people with known or suspected thyroid issues, as well as family members at genetic risk. Researchers will collect blood, tissue, and imaging data to bett…

This study aims to learn more about kidney diseases caused by the immune system, such as nephrotic syndrome and lupus nephritis. Researchers will follow up to 2,000 adults and children to track symptoms, responses to treatment, and collect blood or urine samples. The goal is to b…

This study collects medical information and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal disorders. The goal is to build a resource for future research to better understand and treat these diseases. Particip…

This study looks at brown adipose tissue (BAT), a type of body fat that may help burn energy and improve metabolism. Researchers want to understand how BAT works and if activating it with a drug called mirabegron can benefit people with Polycystic Ovary Syndrome (PCOS). About 100…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism or hypothyroidism. Researchers aim to learn how these conditions develop, their genetic links, and how they affect patients over time. Participants receive standard medical tests and may provide bloo…

This study looks at women with lipodystrophy, a condition where the body lacks fat tissue, and how taking the drug metreleptin during pregnancy affects both mother and child. Researchers will compare pregnancy outcomes between women who took the drug and those who did not. The go…

This study looks for better ways to measure what people eat, especially sugar. Researchers will give 60 healthy adults different amounts of sugar in soda and check if stable isotopes in blood, hair, and other samples can accurately track those sugar levels. Participants will stay…

This study looks at two ways of giving a test meal to healthy adults: one where everyone gets the same number of calories, and one where the calories are adjusted based on a person's body size. Researchers want to find out which method leads to more consistent blood sugar results…

This study looks at fat and muscle tissue from adults having surgery at NIH to learn how the body stores and uses energy. Researchers want to understand metabolism better, which could lead to new treatments for obesity. Participants don't need extra visits; tissue is collected du…

This study looks at families with a history of small bowel carcinoid cancer to understand how the disease develops and spreads. Researchers will follow up to 1,600 people, including those with the disease and their healthy relatives, using advanced imaging and blood tests every t…

This study aims to find more accurate ways to measure metabolism (how your body uses food for energy) by looking at body size and shape. Researchers will study 2000 healthy people and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital …

This study looks at why some adults who had Fontan surgery for a heart defect develop serious liver scarring. Researchers will monitor 100 participants over time using blood tests, imaging, and liver biopsies. The goal is to find early warning signs and better understand the dise…

This study is for 143 adults with primary sclerosing cholangitis (PSC), a rare chronic liver disease. Researchers want to understand what causes PSC by collecting blood, saliva, urine, stool, and tissue samples, along with imaging and surveys. Participants will undergo procedures…

This study aims to find out why people with diabetes often have lower vitamin C levels in their blood. Researchers will measure vitamin C in blood and urine from 5,000 adults with and without diabetes. They will also look at genes that control vitamin C transport. The goal is to …

This study looks at how changing what you eat—like the amount of protein, fat, carbs, and total calories—affects the energy your body uses to digest food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending 24-hour periods…

This study aims to find the genes that cause primary aldosteronism, a condition where an adrenal gland tumor leads to high blood pressure and low potassium. Researchers will study 1150 Black, African American, or Caribbean individuals aged 18-70 with hard-to-control blood pressur…

This study looks at how time restricted eating (eating only during a 6-hour window each day) affects metabolism and immune function in healthy women aged 18 to 50. Participants will stay in the clinic for 5 days, follow the eating schedule, and undergo tests like blood draws and …

This study tests whether a special PET scan using a compound called 68Ga-DOTATATE can better detect thyroid cancer that has spread and is no longer responding to standard radioactive iodine treatment. About 54 adults with metastatic thyroid cancer will receive an injection of the…

This study aims to learn more about endocrine (hormone gland) disorders by observing and treating up to 1000 adults. Participants, including healthy volunteers, will undergo various tests like blood work and imaging. The goal is to improve diagnosis and treatment for these condit…

This study collects blood samples from 250 adults with sickle cell disease, sickle cell trait, and healthy volunteers. Researchers will use the samples to test thousands of compounds, including existing FDA-approved drugs, to find new treatments for sickle cell disease. Participa…

This study involves 30 people with high-risk thyroid cancer that has spread. Researchers want to see if using a special PET scan with a radioactive tracer (124-I) can better predict the right radiation dose for treatment. Participants will be prepared in two different ways (with …

This study aims to understand how fat is stored in people with familial partial lipodystrophy (FPLD), a condition that leads to serious health issues like diabetes and heart disease. Researchers will compare fat tissue samples from 14 participants (some with FPLD, some healthy) a…

This study aims to learn more about parathyroid disorders—conditions where the parathyroid glands produce too much or too little hormone, or the body doesn't respond properly. Researchers will follow up to 3,000 people (ages 6 months and older) who have, are at risk for, or are r…

This study aims to learn more about endocrine (hormone gland) disorders in adults, such as diabetes and thyroid disease, by identifying genes that may cause them. Up to 1,250 adults with known or suspected endocrine conditions, and their adult relatives, will have medical exams, …

This study follows people with or at risk for liver diseases (like hepatitis B, C, D) to learn how these conditions develop and progress. Participants give blood and urine samples, get yearly liver ultrasounds, and may have optional biopsies. The goal is to gather information, no…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to healthy-weight individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants over 18. The goal is …

This study looks at families where multiple members have a common type of thyroid cancer (non-medullary). The goal is to learn how the disease runs in families, find genes that might increase risk, and figure out the best way to screen for it early. Participants will have checkup…

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment during pregnancy affect her child's growth and risk for conditions like obesity, diabetes, and fatty liver. Participants are American Indi…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study follows 930 young people aged 12 to 25 over up to 25 years to learn how type 2 diabetes affects heart and blood vessel health. Participants include those with diabetes, overweight but not diabetic, and healthy lean individuals. They will have yearly 4-day visits with t…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women aged 18-70. Researchers will measure body fat, blood fats, and insulin function to find out why heart disease risk factors differ between African Americans and C…

This study aims to learn more about insulin resistance and diabetes by collecting blood and skin samples from up to 1,200 participants, including patients with severe insulin resistance and their family members. Researchers will study genetics and how insulin works in the body to…

This study follows 400 people aged 12 and older who have or are at risk for noncirrhotic portal hypertension (NCPH), a liver condition that raises blood pressure in the liver without scarring. Researchers will use regular check-ups, imaging, and tests to see how the disease chang…

This study looks at how a low-carbohydrate diet and a supplement called nicotinamide riboside (NR) change the way the body burns fat and uses energy. Researchers will study 100 overweight or obese adults, including some with a specific type of diabetes. Participants will stay in …