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NIH launches study to uncover genetic roots of Hormone-Driven high blood pressure in black communities

NCT ID NCT03374215

Recruiting now Knowledge-focused Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronism, as well as their relatives. Participants undergo blood tests, scans, and other evaluations to identify genetic mutations and their effects on health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could reveal genetic causes of primary aldosteronism in Black individuals, leading to better treatments or prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It may not directly benefit participants, and findings may take years to translate into clinical practice.

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Conditions

The condition(s) this trial relates to.

adrenal gland cancer adrenal gland neoplasm Bone Diseases, Metabolic cardiovascular disorder ectopic ACTH secretion syndrome hyperaldosteronism hyperinsulinism hypertensive disorder metabolic bone disorder primary aldosteronism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADRENAL GLAND NEOPLASM BONE DISEASES, METABOLIC CARDIOVASCULAR DISEASE HYPERINSULINEMIA HYPERTENSION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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