CARDIOVASCULAR DISEASE

This study tests whether anifrolumab, a drug that blocks certain immune signals, can improve blood vessel function and reduce inflammation in people with lupus. About 45 adults with lupus will receive either the drug or a placebo over 8 months. Researchers will measure changes in…

This study looks at whether taking omega-7 oil (palmitoleic acid) can improve cholesterol levels and help control appetite in healthy adults. About 110 participants will take omega-7 capsules daily for 24 weeks and have their blood and health checked. The goal is to see if this n…

This phase 3 trial is testing an experimental daily pill called AZD0780 in about 15,100 people who have had a heart attack, stroke, or are at high risk for one. The drug works by blocking a protein called PCSK9 to lower cholesterol. Researchers want to see if it reduces the chanc…

This study is testing a community-based program that uses exercise training and lifestyle changes to help people with high blood pressure, high blood sugar, or high cholesterol. The goal is to improve heart and lung function and overall disease control. The program will enroll 10…

This study is testing whether a year-long program of daily blueberries, protein powder, and three weekly exercise sessions can reduce frailty and lower the risk of heart disease in older adults. Researchers will enroll 240 people aged 65 and older in Nova Scotia. The goal is to s…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This Phase 3 trial tests olpasiran, a drug that lowers lipoprotein(a), a genetic risk factor for heart disease. About 406 adults with stable heart disease and high Lp(a) will receive either olpasiran or a placebo. The main goal is to see if olpasiran reduces non-calcified plaque …

This study tests a new digital tool called P3-EX that helps doctors create personalized exercise plans for patients with heart disease risk factors like high blood pressure, diabetes, and obesity. Researchers will recruit 24 doctors and 48 patients to compare the new tool with a …

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests a program where trained peers deliver blood pressure medications directly to patients' homes and use health technology to support adherence. The goal is to see if this approach helps people with uncontrolled high blood pressure take their pills regularly and lowe…

This study tests whether empagliflozin (Jardiance), a drug used for diabetes, can protect the kidneys and heart in people who have had a heart transplant. About 200 veterans will take either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney funct…

This study tests whether a drug-coated balloon can reduce fatty deposits in heart arteries better than standard medications alone. Researchers will enroll 400 adults who recently had a heart-related event (acute coronary syndrome). Participants will get either the balloon treatme…

This study tests a program called MINDSET for veterans with chronic conditions like heart disease or diabetes who smoke or drink too much. Participants receive a mailed packet with personalized health information and a brief motivational phone call. The goal is to see if this app…

This study looks at whether taking fish oil and/or metformin for 12 months can improve heart health in women with Polycystic Ovary Syndrome (PCOS). PCOS raises the risk of heart disease and diabetes. The trial will enroll 146 women with PCOS who are overweight and have high blood…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This phase 3 study tests whether the drug olpasiran can prevent first major heart events (like heart attacks) in 11,000 people aged 50+ who have high levels of lipoprotein(a), a genetic risk factor. Participants receive either olpasiran or a placebo as a shot under the skin. The …

This large study in Denmark is testing whether the shingles vaccine (Shingrix) can do more than prevent shingles—it may also lower the risk of heart attacks, strokes, and dementia. About 162,000 adults aged 65 and older will either get the vaccine or no vaccine, and researchers w…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study tests whether a new drug called Fx-5A is safe in healthy adults. Researchers will give a single infusion of the drug and monitor participants for side effects. The goal is to see if Fx-5A can be used in future studies for heart disease and inflammation.

This study aims to collect blood and tissue samples from up to 10,000 people with rare genetic vascular or cardiovascular diseases, as well as their healthy relatives. Researchers will use these samples to identify genetic causes and understand how these diseases work. The goal i…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study is tracking 2,000 adults over time to understand how obesity and disruptions to the body's internal clock (circadian rhythm) influence aging and heart health. Participants will provide health data, questionnaires, and biological samples during annual check-ups. The goa…

This study looks at whether training doctors on quickly starting and adjusting heart failure medications (called GDMT) during a hospital stay leads to better treatment after discharge. About 438 adults with heart failure and reduced ejection fraction will be observed across multi…

This study tests whether a new referral program helps more Veterans with heart conditions get into cardiac rehabilitation. Researchers will compare referral and attendance rates before and after the program starts at three VA hospitals, involving 816 participants over 12 months. …

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study works with Black churches in Washington, D.C. to understand heart health risks like obesity, high blood pressure, and diabetes. About 200 adults will get a health exam, wear an activity monitor for a month, and answer health questions. The results will help design a fu…

This study tests whether a 12-week nutrition and kidney health program, called THINK-Well, works well for adults with chronic kidney disease. The program includes group nutrition classes, cooking practice, and food bucks to buy healthy foods. Researchers want to see how many peop…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…

This study uses a survey to find out how well people with existing heart disease understand their risk factors and their chances of having another heart problem. Researchers will compare answers from 200 women and men to see if there are differences. The goal is to learn where aw…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study brings together health data from about 3 million people across 40 countries to see how common risk factors like high blood pressure, smoking, and diabetes affect heart disease and death rates. Researchers want to understand how these risks differ by region and sex. No …

This study aims to understand how obesity and aging are connected by looking at blood markers in 650 young and older adults with or without obesity. Participants will provide blood samples and undergo imaging tests to measure biological age and fat distribution. The goal is to la…

This study will use advanced PET/MRI scans to see how exercise affects brain activity and blood vessel inflammation in 10 people with PTSD who also have heart disease or risk factors. Participants will follow a gradually increasing exercise program. The goal is to understand whet…

This study tests whether a single dose of the beta-blocker propranolol can reduce inflammation caused by psychological stress. Researchers will measure immune markers and brain activity in 120 healthy young adults before and after a stressful task. The goal is to understand the l…

This study looks at how whole milk and skim milk affect blood sugar and cholesterol in 100 adults who drink at least one cup of dairy milk daily. Participants will switch between drinking only whole milk and only skim milk for set periods, while researchers track changes in their…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…