CARDIOVASCULAR DISEASE

This study is testing a new digital tool called P3-EX, designed to help doctors create personalized exercise plans for their patients. The researchers want to see if the tool is easy for doctors to use and if patients find it helpful. They will also check if using the tool leads …

This study is testing whether a concentrated omega-7 fish oil supplement can improve cholesterol levels and reduce feelings of hunger in healthy adults. Over 24 weeks, 110 participants will take either the omega-7 oil or a control olive oil to see which one better lowers 'bad' LD…

This study is testing whether treating dangerous, fat-filled plaques in heart arteries with a special drug-coated balloon is better than using standard heart medications alone. It involves 400 adults who have recently had a type of heart attack. Researchers will compare how much …

This study is testing a community health program in Kenya that uses trained local peers to deliver blood pressure medications directly to people's homes, supported by mobile health technology. It aims to see if this convenient approach helps people take their medication more cons…

This early-stage study is testing a new drug called Fx-5A that may help treat heart disease by improving cholesterol removal from blood vessels. Researchers are giving single doses to 64 healthy volunteers to check for safety, side effects, and how the body processes the drug. Pa…

This study is testing if a drug called anifrolumab can improve blood vessel health and reduce inflammation in people with lupus (SLE). Lupus patients have a higher risk of heart disease, and no current medications effectively lower this risk. About 45 participants will receive ei…

This study is testing if a medication called empagliflozin can help protect the kidneys and heart in people who have received a heart transplant. Researchers will enroll 200 veteran heart transplant recipients to take either the drug or a placebo for one year. The goal is to see …

This study aims to see if training hospital doctors on the latest heart failure medication guidelines leads to better treatment for patients. It will observe about 438 patients with a specific type of heart failure to see if they receive the recommended drug combinations when lea…

This large, late-stage study is testing whether a new oral drug called AZD0780 can prevent serious heart-related events like heart attacks, strokes, and death. It will involve over 15,000 adults who either already have heart disease or are at high risk for developing it. Particip…

This study is testing whether adding a daily fish oil supplement to the standard medication metformin can better protect the heart health of women with Polycystic Ovary Syndrome (PCOS). It will involve 146 overweight or obese women with PCOS who are already at higher risk for hea…

This study aims to develop and test new MRI scanning methods to improve how doctors diagnose and monitor heart disease. It will enroll 3,400 adults, including both people with known or suspected heart conditions and healthy volunteers, who will undergo MRI scans and be followed f…

This study is testing a special smart mattress for hospital beds. It aims to monitor patients with heart conditions without any wires or patches touching their skin. The mattress tracks heart rate, breathing, temperature, and body position. Researchers want to see if it works as …

This large study is testing whether a drug called olpasiran can prevent first major heart problems in people who have high levels of a specific blood fat called lipoprotein(a). It will involve 11,000 adults aged 50+ who have high risk factors for heart disease but have not yet ha…

This study is creating a collection of DNA, tissue samples, and health information from people with Williams syndrome or supravalvar aortic stenosis (SVAS) and their family members. Researchers want to understand why these genetic conditions affect people so differently, even whe…

This study aims to understand the connection between gut health and heart surgery recovery. Researchers will measure specific chemicals from gut bacteria in the blood and heart tissue of 30 patients. Some patients will receive probiotic supplements after surgery to see if this ch…

This study aims to collect blood and tissue samples from people to help researchers understand the genetic causes of rare vascular and heart diseases. It involves 10,000 participants of all ages who will donate samples like blood, saliva, or small skin biopsies. The goal is to bu…

This study aims to understand how exercise might help people with PTSD who also have a higher risk for heart disease. Researchers will use special PET/MRI scans to look at brain activity and inflammation in blood vessels before and after an exercise program. The goal is to gather…

This study aims to understand the heart health needs of adults in Washington D.C. area churches to design a future community weight loss program. Researchers will partner with church leaders to measure participants' weight, blood pressure, cholesterol, and activity levels. The in…

This study aims to settle a long-standing debate about which type of milk is better for heart health. For four months, 100 adults who regularly drink milk will switch between drinking whole milk and skim milk. Researchers will measure changes in blood sugar, cholesterol, and bloo…

This study aims to understand why some Black individuals develop primary aldosteronism, a condition where adrenal gland tumors cause severe high blood pressure. Researchers will examine the genes of 1,150 participants with difficult-to-control blood pressure to identify genetic c…

This international research project analyzes health data from about 3 million adults across 40 countries to understand how common risk factors for heart disease and death—like high blood pressure, smoking, and diabetes—affect people differently based on where they live and their …

This study aims to understand how CADASIL, a genetic disorder that damages small blood vessels and can lead to strokes and dementia, changes over time. Researchers will follow about 100 people with CADASIL and 40 healthy volunteers for 9 years, performing detailed tests on their …

This early-stage study is testing a new PET scan method that aims to measure both blood flow and how much sugar tissues use from a single injection. Researchers want to see if this works as well as using two separate scans. The goal is to create a simpler tool to help doctors und…

This study aims to understand how psychological stress increases inflammation in the body, which is a known risk factor for heart disease. Researchers will give 120 healthy young adults either a common beta-blocker drug (propranolol) or a placebo, then measure their brain activit…