Scientists launch Decade-Long quest to unravel rare stroke disorder

NCT ID NCT05072483

First seen Jun 24, 2026 · Last updated Aug 04, 2026 · Updated 8 times

Summary

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinking abilities. Healthy volunteers also participate for comparison. The goal is to better understand the disease's progression, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how CADASIL progresses, pointing toward future treatments or ways to monitor the disease.
What could go wrong
This is an observational study, not a treatment trial. It will not directly benefit participants and may not lead to immediate therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.