Could intense workouts reverse cognitive decline in older HIV patients?

NCT ID NCT05965518

Recruiting now Disease control Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This trial tests whether 16 weeks of high-intensity interval training (HIIT) can improve blood vessel function and thinking skills in adults aged 50 and older living with HIV. Participants are randomly assigned to either HIIT or continuous moderate exercise. The study also explores what helps or hinders sticking with an exercise routine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: High-Intensity Interval Training (HIIT) compared to continuous moderate exercise
What this could lead to: If HIIT proves more effective than moderate exercise, it could offer a non-drug way to protect brain and heart health in older adults living with HIV.
What could go wrong: This is a small pilot study, so results may not be definitive. Exercise may be challenging for some participants, and the benefits might not be as large as hoped.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTERIAL STIFFNESS COGNITIVE DYSFUNCTION HIV

Contacts and locations

Locations

University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35205, United States

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