HIV

This early-stage study tests whether a new two-part HIV vaccine is safe and can trigger the immune system to produce broadly neutralizing antibodies. The vaccine uses a prime shot followed by booster shots, both with an adjuvant to strengthen the response. The study enrolls 42 he…

This early-stage trial tests a new HIV vaccine called GRAdHIVNE1 in 120 healthy adults, some living with HIV and some without. The main goal is to check if the vaccine is safe and tolerable. Researchers will also measure the immune response it triggers. The study is taking place …

This early-stage study tests two experimental mRNA vaccines designed to teach the immune system to make powerful antibodies against HIV. The trial involves 40 healthy adults without HIV to check safety and immune responses. Researchers will give up to four doses and monitor for s…

This study tests whether starting HIV treatment right after diagnosis, instead of waiting, can reduce stigma and improve health for people who inject drugs. Researchers will enroll 135 participants and measure changes in stigma and viral load. The goal is to make care faster and …

This study looks at whether giving low-income Black men living with HIV a monthly payment of $500 for six months helps them get more HIV care and stick with their medication. Researchers in Arkansas want to see if this extra money can reduce the effects of poverty and racism on h…

This study tests whether using medical drones to deliver HIV medication to people living in hard-to-reach islands in Uganda can help keep the virus under control. About 1,086 adults and teens will either get their medicine delivered by drone or through standard methods. Researche…

This study tests a support package for people with HIV in Malawi who are starting or restarting antiretroviral therapy. The package includes counseling, a hotline, and multi-month medication dispensing to help patients stay on treatment even when they travel or move. Researchers …

This study tests whether adding the HIV drug efavirenz to standard ART can kill cells that still harbor HIV, even when the virus is well-controlled. About 26 adults with HIV who have very low but detectable virus levels will take efavirenz for 8 weeks. The goal is to see if this …

This study looks at whether peer support and long-acting injectable HIV medication can help teenagers in South Africa keep the virus under control and stay in care. About 720 teens aged 12-19 who already take HIV pills will either get peer support or switch to monthly injections.…

This study tests whether trained peers can help people with tuberculosis (TB) and HIV stick to their treatments. About 1,920 adults in Uganda will receive either standard care or extra peer-led education and counseling. The goal is to see if this approach increases TB cure rates …

This study tests a new way to help people living with HIV quit smoking. Instead of waiting for patients to ask for help, the program proactively reaches out to offer support. Researchers will compare this approach to standard care and look at what helps or hinders success. The go…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders. The program uses text messages and coaching to help reduce shame and stigma, improve self-care, and support HIV medication adherence. The goal is to help more pa…

This study adapts a proven peer-led program for pregnant and breastfeeding women who drink alcohol. Researchers will enroll 100 pregnant women in South Africa to see if brief motivational sessions from trained 'mentor mothers' can reduce alcohol use and improve adherence to HIV p…

This study compares two sets of strategies to help HIV patients who also have depression start and stay on effective treatment. Researchers will look at how many patients begin depression therapy and whether their depression and HIV virus levels improve within a year. Ten clinics…

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. The program combines weekly supervised workouts with home-based exercise, plus coaching and education. Researchers want to see if it helps participants become more active and improv…

This study tests a program called Enhanced Friendship Bench, which combines problem-solving therapy with HIV support, for pregnant women with HIV and depression in Malawi. Researchers will enroll 400 women to see if the program reduces depression symptoms and helps them stay in H…

This study tests whether giving people with HIV a choice of nicotine replacement products (like e-cigarettes, nicotine pouches, or patches) helps them quit smoking tobacco. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either standard care…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past two years. The program teaches skills to find inner strength, improve communication, and connect with HIV care resources. Researchers will check if the …

This pilot study tests whether a program that teaches coping skills and supports HIV care engagement is practical and helpful for people living with HIV who also use substances. The study will enroll 50 adults and measure satisfaction, retention, and medication adherence. The goa…

This study tests if switching to a two-drug combination (dolutegravir and lamivudine) can safely keep HIV under control in transgender women who are already on a stable three-drug regimen. About 50 participants will take the new pills for 48 weeks. The goal is to see if the simpl…

This study is testing an experimental injectable drug called LP-98 in 30 adults with HIV who have never taken HIV medication. The goal is to see if the drug can lower the amount of virus in the blood and improve immune cell counts. Participants will receive the injection and be m…

This study tests if gabapentin, a medication for nerve pain, can help people with HIV who drink heavily achieve an undetectable viral load. About 220 participants will receive either gabapentin or a placebo for 3 months, along with counseling. The goal is to see if the drug impro…

This study tests a program that combines peer support and phone-based tools to help young men who have sex with men and young transgender women (ages 15-29) in Nigeria stick with their HIV treatment and lower their virus levels. Participants will receive guidance from trained pee…

This study tests whether letting people with HIV choose how they receive their care helps them stay on treatment and achieve viral suppression. It involves 800 adults in Malawi who have interrupted their HIV treatment before. Participants are randomly assigned to either a flexibl…

This study tests if automated text messages can help people living with HIV quit smoking. Researchers will enroll 800 smokers in Cambodia and provide tailored text-based support. The goal is to see if this approach helps them stop smoking for good.

This study tests whether an internet-based depression treatment (cognitive behavioral therapy) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy program to standa…

This study offers free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15–26 in New Orleans. Those who test positive get counseling and free treatment options, including for their partners, with a follow-up test after 3 months. The goal is to reduce the hi…

This study tests a new combination of drugs (cyclophosphamide, bortezomib, and maraviroc) to prevent graft-versus-host disease after a bone marrow transplant. It involves 265 people living with HIV who also have a blood cancer that can be treated with a transplant. The goal is to…

This study tests a new way to provide HIV care for people who have trouble keeping regular doctor appointments. It offers drop-in visits and mobile care at convenient locations, like a needle exchange site and community health centers. The goal is to help 400 participants in Cali…

This study is testing a counseling program called Friendship Bench + Safety Planning to see if it can reduce suicidal thoughts and help teens with HIV stay engaged in their HIV care. The study will include 60 teens aged 13-19 in Malawi who have HIV and have had suicidal thoughts.…

This study tests a counseling program designed to help Black women living with HIV take their medication regularly and achieve viral suppression. Participants must be Black, cis-gender women aged 18 or older, with a history of trauma and recent unsuppressed viral load. The progra…

This early-phase study tests whether a patient's own modified immune cells (CAR-T cells) can help control HIV without needing daily antiviral drugs. Only 3 adults with well-controlled HIV will receive the treatment to check safety and see if the virus stays undetectable. The goal…

This study tests a program called We-INtervention for 160 Chinese male couples where one partner has HIV and the other does not. The program helps couples work together to reduce stigma, improve quality of life, and support HIV care and prevention. Each partner meets separately w…

This study tests two remote programs—support groups and personalized case management—for people aged 50+ living with HIV in rural Southern U.S. The goal is to improve medication adherence, viral suppression, and quality of life while reducing depression. 352 participants will be …

This study looks at whether a program that provides housing to people with HIV can improve their health. Researchers will compare those who get into the program right away with those on a waitlist. They will track viral suppression, medication adherence, and overall well-being ov…

This study tests two types of support for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation, and the other gets extra help with employment and small financial incentives. The goal is to see which approach helps more…

This study tests whether metformin, a standard diabetes medicine, can reduce harmful inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, with or without HIV. Participants will take metformin or a placebo for 16 weeks and hav…

This study tests a simpler, two-drug HIV treatment (dolutegravir/lamivudine) against the standard three-drug regimen in people who have both HIV and tuberculosis (TB). About 150 participants who have never taken HIV medication will be followed for 48 weeks. The goal is to see if …

This study tests a program to help women in Botswana who have both HIV and a serious mental illness. The goal is to reduce stigma and help them keep their HIV virus levels low after leaving the hospital. About 360 women will take part, and the program involves group sessions and …

This study tests whether combining HIV vaccines with long-acting antibodies (bNAbs) can help people with HIV control the virus without daily antiretroviral therapy (ART). 48 adults with suppressed HIV will receive the combination and undergo a short treatment pause to see if thei…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce these health risks. About 200 adults from a North Carolina HIV clinic will take part. T…

This study tests several new antifungal drug combinations for cryptococcal meningitis, a brain infection that is fatal without treatment and still kills many people with HIV. Researchers will enroll 2,000 adults with HIV and this infection to see which combination works best and …

This study tests a behavioral program for sexually active young people aged 16-24 who use stimulants like meth or cocaine. The goal is to help them reduce drug use and lower their risk of getting or spreading HIV. Participants will receive counseling and support through video cha…

This study tests a combination program to improve HIV testing, quick connection to care, and rapid start of antiretroviral therapy in coastal Alabama. Researchers will work with local health departments to target testing in high-need areas and help people start treatment as soon …

This study is testing a program that combines counseling and technology to help young sexual and gender minority people (ages 18-24) in Rio de Janeiro, Brazil, take their HIV medication regularly. The goal is to improve social support and problem-solving skills to overcome barrie…

This study tests a short, computer-based relapse prevention program for 150 adults with HIV and alcohol use disorder. Participants will receive two sessions designed to help them avoid returning to risky drinking. The goal is to see if the program helps people stay alcohol-free l…

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of focusing only on quitting, the program helps participants cut back on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to reduce the he…

This study tests three approaches to help older adults with HIV increase their physical activity: one-on-one coaching, cognitive behavioral therapy to address barriers like low motivation or pain, and a Fitbit-based social support program. Researchers will track daily steps to se…

This study aims to find the best dose of the HIV drug doravirine for pregnant women. It includes 76 pregnant women with HIV who will take doravirine plus two other HIV drugs. Researchers will measure drug levels in the blood, breastmilk, and cord blood to ensure the dose controls…

This study tests a 6-month holistic wellness program for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants receive counseling, peer support, and education tailored to their needs. Researchers will measure changes in depression, anxiety, sub…

This study aims to help people with HIV stay in treatment, especially during the first six months when many stop coming to appointments. Researchers will create and test a toolkit that includes risk assessments, a treatment roadmap, and a WhatsApp support tool. About 30,000 patie…

This study tests whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Researchers will enroll 30 adults with HIV and alcohol use disorder to see if the treatment is practical, safe, and effective. The goal is to improve health…

This study tests whether lab-made antibodies that target HIV are safe in healthy adults. About 83 volunteers without HIV will receive the antibodies by vein or under the skin, alone or combined with two other antibodies. The goal is to check for side effects and measure how the b…

This study tests a 4-session counseling program to help people with tuberculosis (TB) and HIV reduce unhealthy alcohol use. The program is added to regular TB and HIV care in India. Researchers will check if it lowers drinking and improves TB and HIV health outcomes. About 450 ad…

This study tests whether taking 75 mg of zinc daily can improve immune function in people with HIV whose CD4 counts remain low despite antiretroviral therapy. About 120 participants will be randomly assigned to receive zinc or continue their usual care. The goal is to see if zinc…

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for or living with HIV and also have substance use issues. The program provides support to start HIV prevention medicine (PrEP) or to lower the amount of virus in the body for those alread…

This study is testing whether giving monthly cash payments to pregnant women living with HIV in Botswana helps them better manage their health. Researchers want to see if the money reduces stress, helps women take their HIV medication more consistently, and keeps them connected t…

This study is testing whether the medication tirzepatide can help people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve overweight or obese adults with HIV will receive weekly injections of tirzepatide for 12 weeks. Researchers will measure changes i…

This study is testing a new program where pharmacists talk with people living with HIV who drink alcohol and take multiple medications. The goal is to see if these conversations can help reduce the risk of falls and memory problems that may be caused by mixing alcohol, cannabis, …

This study is checking how well a new device called MagIA H3S works for detecting HIV, hepatitis B, hepatitis C, and syphilis at the same time. About 2,950 people in Ivory Coast and Kenya will provide blood samples to see if the device gives accurate results compared to standard …

This study tests a program where people who use drugs become "Prevention Ambassadors." They give HIV self-test kits and information about HIV services to their friends and peers. The goal is to increase HIV testing and use of prevention or treatment services among a group that of…

This study looks at whether long-acting antiretroviral drugs could be a better way to prevent HIV in Thai men who have sex with men and transgender women. Researchers will survey over 10,000 people about their preferences and analyze costs and health impacts. The goal is to see i…

This study tests a new way to help Latinx men at risk for HIV start and stay on PrEP, a daily pill that prevents HIV. It combines a one-stop-shop clinic, a social network support program, and a national pharmacy chain to make getting PrEP easier. Researchers will enroll 624 cis-g…

This study aims to find low-cost ways to encourage people at higher risk of HIV to get retested. Researchers will test several simple behavioral interventions, like phone messages, in 40,000 adults in Kenya and Uganda. The goal is to see which methods work best to increase repeat…

This study tests a program called STEP-UP, which helps community organizations offer HIV prevention pills (PrEP) through telehealth. About 92 adults in Philadelphia who could benefit from PrEP will take part. Researchers want to see if this approach makes it easier for people to …

This study follows 5,000 HIV-negative adults in Italy who are taking or starting PrEP, a daily pill that prevents HIV. Researchers will track how well PrEP works in real life, how often people take it, and what barriers they face. The goal is to gather data to help eliminate new …

This study tests a real-time data dashboard to help clinics in Alabama better track and improve access to HIV prevention pills (PrEP). Researchers will work with 7 clinics to see if the dashboard helps more Black patients get PrEP and reduces racial gaps. The study involves clini…

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. Researchers want to see if this referral network increases the number of men who use HIV prevention or get treated. About 245 peopl…

This study looks at a new way to offer HIV prevention medicine (PrEP) to people in the Dallas County Jail. Researchers will use a risk score from medical records and referrals to identify who might benefit, then a navigator will meet with them to discuss HIV risk, offer testing, …

This study tests two approaches—contingency management (rewards for progress) with or without motivational interviewing—to help 400 men who use methamphetamine start or restart PrEP, a daily pill that prevents HIV. Participants receive support via telehealth and are followed for …

This study tests whether a combination of three lab-made antibodies, given through an IV, is safe and can help prevent HIV in healthy adults. About 200 participants aged 18-65 will receive the antibodies or a placebo and be followed for 18 months. The goal is to see if this appro…

This study is testing whether a long-acting injectable HIV prevention medication, called cabotegravir, works well for adults who inject drugs. One hundred participants will receive the shot along with support services. The goal is to see how many people stick with the treatment a…

This study looks at people with HIV aged 65 to 74 to find those at risk for frailty—a condition that makes older adults weak and more likely to get sick or be hospitalized. Participants will be screened using a simple test called the Fried scale, and those at risk will get a spec…

This study tests a peer-led program to help Black men in Prince George's County, Maryland, start taking PrEP—a daily pill that prevents HIV. Participants attend events focused on reducing HIV stigma and building community support. Researchers will compare how many men in the prog…

This study tests whether adding testing for curable STIs (like chlamydia and gonorrhea) to standard HIV risk screening helps more women in Uganda start and continue taking PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to…

This study tests whether doing tai chi and qigong online can reduce depressive symptoms in people aged 50-75 living with HIV. Participants will take either a 12-week tai chi class or a health education class, both via Zoom. Researchers will compare the groups to see if tai chi im…

This study tests whether a type of brain stimulation called accelerated theta burst stimulation can reduce cravings for methamphetamine in people living with HIV. Thirty adults aged 18-65 with HIV and a history of methamphetamine use will receive the treatment. Researchers will m…

This study compares two drugs, pramipexole and escitalopram, to see which works better for treating major depression in people with HIV. About 186 participants will take one of the medications for several weeks, and researchers will track mood changes and side effects. The goal i…

This study is testing whether a 12-week exercise program with support from a peer (a buddy) is practical and liked by women aged 40+ who have both HIV and high blood pressure. About 50 women will take part. The goal is to see if the program helps them be more active and possibly …

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will first interview 20 participants to refine the program, then test it in a small group of …

This study tests two phone-based programs—brief behavioral therapy for insomnia and brief mindfulness training—in 200 adults with HIV, chronic pain, and insomnia. The goal is to see which approach better improves sleep quality, reduces pain, and may slow biological aging. Partici…

This study is testing whether an AI-powered conversational agent can deliver a proven therapy (Dialectical Behavior Therapy) to help older adults with HIV manage suicidal thoughts and emotions. The goal is to see if this approach is practical, easy to use, and helps participants …

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study tests whether a supplement called pregnenolone can improve depression in people with HIV. Researchers will give 120 participants either pregnenolone or a placebo pill, while allowing them to continue their current antidepressants. Brain scans and mood questionnaires wi…

This study looks at whether menopause and HIV together increase the risk of heart disease in women. Researchers will use blood tests and whole-body MRI scans to measure inflammation and body fat in 90 women with HIV at different stages of menopause. The goal is to understand why …

This study enrolls 100 people with HIV to donate large numbers of white blood cells through a process called leukapheresis. Researchers will measure HIV DNA and RNA in these cells to learn how the virus persists despite treatment. The goal is to better understand inflammation and…

This study will follow up to 300,000 people over 20 years at HIV and sexual health clinics in Thailand. Researchers will collect information on behaviors, mental health, and medical history to better understand how to improve services. Participants receive standard care like HIV …

This study collects blood plasma and white blood cells from healthy volunteers and patients using a procedure called apheresis. The samples are used in laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH study or be a healthy vo…

This study looks at how chronic marijuana use changes brain inflammation and thinking skills in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults, comparing those who use marijuana regularly with those who do not. The goal is …

This study follows up to 30,000 HIV patients in 15 French clinics to track how well treatments work over time. Researchers will collect data on viral load, medications, and related infections like hepatitis C. The goal is to improve care and understand long-term health trends, no…

This study looks at whether a two-day employment program can help young Black men who have sex with men stay connected to HIV care. About 132 participants will attend the program and complete surveys over 13 months. Researchers want to see if the program is acceptable, useful, an…

This study looks at why people with both cancer and HIV in Zimbabwe sometimes struggle to keep up with their HIV care while they are being treated for cancer. The researchers will first watch a group of 150 patients to understand the barriers. Then they will work with hospital st…

This study looks at whether text messages can encourage teenagers (ages 13-19) to get tested for HIV. About 360 teens who have had sex but never been tested will receive either helpful texts or general health information. Researchers will then check if more teens in the text grou…

This study will test new decision-making tools to help doctors at district hospitals and health centers in Mozambique and Zambia better diagnose and treat tuberculosis (TB) in children. The study will involve over 30,000 children under 15, including those with HIV or severe malnu…

This study looks at how to improve needle and syringe programs in Canadian federal prisons so that more people who inject drugs can use them. The goal is to reduce the spread of HIV and hepatitis C. Researchers will work in nine prisons, including five women's prisons, to find ou…

This study follows 150 adults with Kaposi sarcoma (KS) to understand how the disease develops, changes, and may come back over time. Researchers will collect medical history, perform exams, imaging, and biopsies, and track participants for up to 10 years. The goal is to learn mor…

This study looks at why visceral leishmaniasis (a serious parasitic disease) keeps coming back in people who also have HIV. Researchers in Ethiopia will follow 20 adults to find out what factors in the patient and the parasite cause the disease to persist. The goal is to better m…

This study looks at two ways to screen for cervical cancer in women with HIV: sending a mobile team to their usual clinic, or asking them to go to a central hospital. About 1,180 women aged 25-49 will take part. The goal is to see which method helps more women complete all screen…

This study is testing whether setting up special HIV teams in hospitals can help find undiagnosed HIV in patients who have conditions linked to HIV. About 5,200 patients across 10 European countries will be included. The teams will use electronic health records to identify patien…

This study looks at how problems with the vagus nerve (a key nerve connecting the brain and gut) may lead to gut issues and inflammation in people with HIV. Researchers will test 207 adults with HIV to see if a drug called pyridostigmine or vagus nerve stimulation can help. The g…

This study looks at existing medical records from about 7 million people with HIV in South Africa to understand how different ways of delivering HIV treatment are working. Researchers want to see how many people are using these models, how well they control the virus, and what th…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, prevention, and treatment services. About 40 clinics will either use SAIA or continue their usual procedures. The goal is to see if this approach increases the number of women…

This study follows up to 19,000 people with HIV or at high risk for HIV in Washington, DC, to see how well treatments and prevention services work over time. Researchers will track viral suppression rates and new infections to improve care across the city. Participants are from t…

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood and other biological samples from up to 2,419 adults, both with and without HIV. Researchers will compare these samples to better understand the virus and related immune de…

This study follows 380 children in Uganda for two years to see how malaria and HIV treatments interact. Half the children have HIV, half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best treatment plans. The goal is to improve …

This study aims to see if having traditional healers offer HIV testing can reach people who usually avoid testing. Over 230,000 adults in rural South Africa will be invited to test during a healer visit. The goal is to increase testing rates and connect more people to care.

This study looks at how medical care affects the quality of life of pregnant women living with HIV. About 100 women will fill out questionnaires during pregnancy and one year after giving birth. The goal is to learn what helps or hurts their well-being so that care can be improve…

This study looks at how stress changes hormones, pain, and mood in people living with HIV who also have cannabis use disorder and depression. Researchers will measure stress responses using blood samples and pain tests. The goal is to better understand these connections, not to t…

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will track about 6,770 participants, including those with HIV, using advanced genetic tools to see if asymptomatic TB cases cause new infections. The…

This study looks at what happens to HIV when people stop their daily medication for a short time. Researchers want to see how the virus changes in the blood and lymph nodes. About 50 adults with HIV will either stay on their meds or pause them for up to 90 days. The goal is to le…

This study works with five HIV clinics in the southern and eastern U.S. to create programs that reduce stigma against people living with HIV. Clinic staff and patients will take surveys every six months for two years to see if the programs help improve well-being and access to ca…

This study looks at medical records from up to 1 million people in Malawi to see how different ways of delivering HIV treatment are working. The goal is to find out which models help more patients stay healthy and use resources wisely. No new treatments are being tested—just exis…

This study looks at how cannabis ingredients (CBD and THC) impact inflammation and brain health in people with HIV. Researchers will give 90 participants both compounds in different orders over 6 weeks, then measure blood markers and brain barriers. The goal is to understand how …

This study looks at why people with HIV have twice the risk of heart attacks. Researchers will use MRI scans to measure fat stored around the heart and liver in 100 volunteers over age 40. The goal is to understand how this hidden fat affects heart health and may lead to new ways…

This study looks at where HIV hides in the body by comparing virus levels in blood, lymph nodes, and bone marrow. Researchers want to understand how HIV damages the immune system and why it persists even with treatment. About 400 adults with HIV will provide blood and tissue samp…

This study collects blood, bone marrow, tumor, and tissue samples from up to 999 adults with HIV, KSHV, or related cancers like Kaposi's sarcoma and lymphoma. The goal is to provide samples for research to better understand these diseases. Participants do not receive any treatmen…

This study looks at 320 people with HIV to create models that predict who might develop fatty liver disease or liver scarring. Researchers will track changes in liver health over time using ultrasound and a special scan called FibroScan. The goal is to catch liver problems early …

This study aims to understand why a small group of people with HIV, called long-term non-progressors, can control the virus for years without antiretroviral therapy. Researchers will collect white blood cells and plasma from 400 participants to study immune system genes and respo…

This study tests a program that gives out special syringes with less leftover space to people who inject drugs in several countries. The goal is to see if these syringes are easier to use and help reduce the spread of HIV and hepatitis. About 2,400 participants will share their t…

This study follows 100 adults with HIV who were treated early and then stopped their medications as part of a research protocol. The goal is to monitor their health and track when the virus returns. No new treatment is being tested; the focus is on understanding safety and viral …

This study collects blood samples from 2,000 people, both with and without HIV, to provide researchers with specimens for collaborative studies. Participants must have good vein access and be able to give consent. The goal is to advance scientific understanding of HIV, not to pro…

This study gathers information from 2,500 adults with HIV who are having their first upper digestive tract endoscopy. Researchers will record patient details, test results, and any diagnoses found during the procedure. The goal is to learn more about long-term digestive health in…

This study looks at whether getting legal help can improve HIV care for people who have been in prison. About 100 adults with HIV and a recent incarceration will receive legal aid and be tracked for 6 months. The goal is to see if legal support helps lower their viral load and st…

This study follows 600 adults with HIV in the Washington, D.C., area to track their health over time. Participants visit the clinic every 3-4 months for check-ups and blood tests. The goal is to gather data for future research and train doctors, not to test new treatments.

This study tests whether a specially designed play can help reduce stigma around Pre-exposure Prophylaxis (PrEP) for young women in Kenya. Researchers will recruit 160 participants, including young women who use PrEP and community members, to watch the play and share their reacti…

This study looks at whether doing cervical cancer screening and treatment in a single visit works better than multiple visits for women with HIV in Cameroon. About 1,422 women will take part to see if a one-visit approach reduces dropouts and is acceptable to patients and staff. …

This study reviews existing medical records from about 1.2 million people with HIV in Zambia to see how different ways of delivering care are working. Researchers want to understand which models help more people stay on treatment and achieve viral suppression. No new treatments a…

This study tests whether a telemedicine program is practical and well-received for treating substance use disorders in people living with HIV in Alabama. About 30 participants who misuse opioids or stimulants will receive care via video or phone. The main goal is to see if they a…

This study looks at ways to help women living with HIV get screened and treated for cervical cancer. Researchers in Nigeria will compare two different approaches to see which one works better at getting more women screened and completing treatment. The goal is to save lives by co…

This study tests whether pasteurized donor human milk (PDHM) is a practical feeding option for infants exposed to HIV. Ten caregivers in Saskatchewan will try PDHM as a supplement to breastfeeding or formula and report any challenges. The goal is to learn if donor milk can be off…

This study aims to identify frailty and pre-frailty in people with HIV who are 50 years or older. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging in this group. No treatments or medications are being tested; t…

This study collects blood cells from people with HIV to learn how the immune system works during early and chronic infection. Participants will give blood samples before starting HIV treatment and then three times a year. The goal is to understand immune function better, not to t…

This study aims to understand why older adults with HIV experience more fatigue and difficulty exercising than those without HIV. Researchers will use leg MRI scans and blood tests to measure muscle energy production and inflammation in 200 participants aged 60+. The goal is to i…