HIV

This early-stage trial tests two experimental mRNA vaccines designed to train the immune system to make special antibodies that could block HIV. The study involves 40 healthy adults without HIV who will receive the vaccines and be monitored for safety and immune responses. It is …

This early-stage trial will test two experimental mRNA vaccines designed to teach the immune system to make antibodies that target HIV. About 42 adults with well-controlled HIV will receive the vaccines and then temporarily pause their regular HIV medication under close monitorin…

This study is testing how well the 9-valent HPV vaccine (Gardasil9) triggers an immune response in people born male who have used estrogen or androgen blockers, including those living with HIV. Participants receive three doses of the vaccine over six months, and their immune resp…

This Phase 1 trial is testing a new HIV vaccine called GRAdHIVNE1, made using a harmless gorilla virus to deliver HIV protein pieces. The study will enroll 120 healthy adults in southern Africa, some living with HIV and some without, to check safety and measure immune responses. …

This Phase 1 trial tests a two-part HIV vaccine regimen in 42 healthy adults without HIV. The first shot primes the immune system, and later booster shots aim to mature antibody-producing cells. The main goal is to see if the regimen is safe and whether it triggers a specific imm…

This small Phase 2 trial tests whether alendronate, a drug used for bone health, can reduce the hidden HIV reservoir in people already on antiretroviral therapy. About 30 participants will receive either alendronate or a placebo, and researchers will measure changes in HIV DNA an…

This study tests a program that sends personalized text messages and provides nicotine patches to help people with HIV in Cambodia stop smoking. Researchers will enroll 800 smokers and check if they quit after 6 months using self-reports and breath tests. The goal is to find a pr…

This study tests whether a combination of three drugs (cyclophosphamide, bortezomib, and maraviroc) can safely prevent graft-versus-host disease after a half-matched bone marrow transplant in people living with HIV who also have a blood cancer. The trial involves 265 participants…

This phase 2 trial tests whether a mix of intensified antiretrovirals, a latency-reversing drug, an anti-proliferative drug, and a personalized vaccine can shrink the hidden HIV reservoir enough to allow people to stop their daily medication. The study will enroll 70 adults with …

This trial tests a program called Kupambana for young people with HIV in Zambia. It combines weekly peer-led support groups to reduce stigma with a voucher for vocational training and a financial literacy session. Researchers want to see if this approach can improve mental health…

This study tests an enhanced Mentor Mother strategy, where trained peer counselors provide tailored support to pregnant and postpartum women living with HIV. The goal is to see if this approach can be successfully implemented and improve health outcomes, such as keeping mothers i…

This trial tests whether 16 weeks of high-intensity interval training (HIIT) can improve blood vessel function and thinking skills in adults aged 50 and older living with HIV. Participants are randomly assigned to either HIIT or continuous moderate exercise. The study also explor…

This study tests whether an internet-based depression treatment called cognitive behavioral therapy (iCBT-D) can prevent insulin resistance from getting worse in adults with HIV who are on antiretroviral therapy and have depression. Researchers will compare the online therapy pro…

This study tests a program that combines peer support and text message reminders to help young LGBTQ+ people with HIV in Nigeria stay on their medication and lower their virus levels. One hundred participants aged 15-29 will receive the program for 24 weeks. The goal is to see if…

This study tests three approaches to help older adults with HIV become more physically active: one-on-one coaching, cognitive behavioral therapy to overcome barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear a Fitbit …

This study tests whether giving young people (ages 18-35) living with HIV a monthly payment of $500 for 18 months helps them stay in care and keep the virus under control. About 304 participants who have faced financial hardship will be randomly assigned to receive either the cas…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …

People living with HIV face high risks after leaving the hospital. This trial tests whether regular home visits by nurse-counselor teams — with or without food parcels — can lower the chance of death within six months. About 780 adults in South Africa will be randomly assigned to…

This study tests whether giving people with HIV or those taking PrEP two dedicated case managers helps them achieve better financial stability, food security, and health outcomes. Participants will work with their case managers to set goals and stay connected to care. The trial c…

This study looks at how heavy drinking affects sexual decision-making in men who have sex with men (MSM) and whether a brief intervention can reduce risky behavior. Participants receive either a single motivational session plus text messages or basic information about drinking an…

This study tests a behavioral program designed to reduce stigma and improve healthcare engagement among people newly diagnosed with HIV in Indonesia. Participants attend counseling sessions adapted for a Muslim-majority population. Researchers measure changes in perceived stigma,…

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them better manage their health. Researchers want to see if the money improves their ability to stick to HIV medication and stay in care after giving birth. About 100 women will tak…

This early-stage trial is testing whether lab-made antibodies that target HIV are safe and how long they stay in the body. About 83 healthy adults without HIV will receive the antibodies by vein or under the skin, alone or in combination. The goal is to find the right dose and ch…

This study looks at whether people with HIV who have stopped their medication for at least 12 weeks can safely restart treatment with a single daily pill (B/F/TAF) on the same day they return to care. About 200 adults will take part to see if this quick restart helps lower the vi…

This study tests whether combining an HIV vaccine with powerful antibodies can help people with HIV control the virus without daily antiretroviral therapy. 48 adults with well-controlled HIV will receive the combination and briefly stop their regular medication to see if their im…

This study tests a program called Mentor Moms+ for pregnant women in South Africa who drink alcohol. Trained mentor mothers—women who have successfully reduced alcohol use while on HIV medication—provide one-on-one counseling sessions. The goal is to see if this approach helps wo…

This study tests a program to help women living with HIV in Ghana get screened for cervical cancer more easily. The program includes self-sampling kits, patient navigators, and training for healthcare providers. Researchers want to see if these tools increase screening rates and …

This study tests whether a combination of a special diet, omega-3 and L-carnitine supplements, and resistance exercise can improve muscle quality and reduce fat in veterans with HIV and obesity. The trial will enroll 70 participants and measure changes in muscle density, metaboli…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders in Boston and Miami. The program uses text messages and coaching to help people manage shame and stigma, set health goals, and stay connected to HIV care. The goa…

This study follows 200 people with HIV who need a kidney transplant. Half will receive a kidney from a donor with HIV, half from a donor without HIV. Researchers track how many patients experience organ rejection or death over time to see if donor HIV status affects outcomes.

This study tests a behavioral program for sexually active young people aged 16-24 who use stimulants like meth, cocaine, or MDMA. The goal is to help them reduce stimulant use and lower the risk of passing or getting HIV. Participants will receive counseling and support through v…

This study tests a mobile app called DynamiCare, combined with a patient navigator, to help people recently released from jail or prison reduce their use of stimulants like methamphetamine or cocaine. The app uses at-home saliva tests and financial rewards to encourage healthy be…

This study tests two smoking cessation methods—varenicline pills and nicotine patches with gum—in 660 people with HIV in South Africa. Participants will receive one of these treatments for 12 weeks, along with counseling. The goal is to see which approach works best to help them …

This study tests a program called Friendship Bench + Safety Planning for teens aged 13-19 living with HIV who have had suicidal thoughts. The goal is to see if the program is practical, acceptable, and helps reduce suicidal thoughts and improve engagement in HIV care. Sixty parti…

This study tests whether offering a choice of e-cigarettes, nicotine pouches, or nicotine patches helps people with HIV stop smoking tobacco. About 972 participants in Switzerland will receive their preferred product free for 6 months, plus standard care. The main goal is to see …

This study in Botswana tests whether giving three powerful antibodies by infusion can help children who started HIV treatment early keep the virus suppressed without taking daily antiretroviral pills. About 41 children aged 2 to 12 will receive the antibodies while stopping their…

This study tests whether semaglutide, a drug used for diabetes, can help adults with HIV reduce their alcohol intake and smoking, and lower their risk of heart disease. About 200 participants will take semaglutide or a placebo for 3 months and provide blood, stool, and saliva sam…

This study tests whether a mobile app with a virtual group support feature can help young Black women (ages 18-30) who misuse alcohol reduce their drinking and risky sexual behavior, and increase their use of PrEP (a daily pill that prevents HIV). About 500 HIV-negative women in …

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for HIV or already living with it, and who also have substance use issues. The program provides prevention, treatment, and support to help them start HIV prevention medication (PrEP) or lo…

This study is testing an experimental injection called LP-98 in 30 adults with HIV who have never taken HIV medication. The goal is to see if the drug can safely lower the amount of virus in the blood and improve immune cell counts. Participants will receive the injection and be …

This study provides free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15-26 in New Orleans. Those who test positive can get treatment at no cost and are encouraged to bring their partners. The goal is to reduce STI rates and health disparities in this c…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past two years. The program teaches skills to find inner strength, build a safety net, improve communication, and overcome barriers to HIV care. Researchers …

This study tests a program called Enhanced Friendship Bench that combines problem-solving therapy with HIV support for pregnant women in Malawi who have HIV and depression. About 400 women will take part to see if the program reduces depression symptoms and helps them stay in HIV…

This study tests a program to reduce stigma for women in Botswana who have both HIV and a serious mental illness. The program helps women challenge negative stereotypes and build coping skills after leaving a psychiatric hospital. Researchers will compare viral suppression rates …

This study tests whether metformin, a common diabetes drug, can reduce harmful inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, some of whom also have HIV. Participants take metformin or a placebo for 16 weeks and receive…

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down on smoking, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve o…

This study tests whether high-dose zinc supplements can improve immune function in people with HIV who still have low CD4 counts despite successful antiretroviral therapy. 120 participants will receive either zinc or a placebo for 16 weeks. Researchers will measure changes in CD4…

This study in South Africa tests whether peer support and long-acting injectable HIV medication help teens (ages 12-19) stay virally suppressed and keep up with care. 720 teens living with HIV will take part. The goal is to see if these approaches improve health and retention ove…

This study aims to help people with HIV stay in care, especially during the first six months of treatment when the risk of dropping out is highest. Researchers will create and test a toolkit that includes risk assessments, a treatment roadmap, and a WhatsApp support coach. The st…

This pilot study tests whether semaglutide, a drug used for diabetes and weight loss, can help people with HIV reduce their alcohol use. Thirty participants will receive the drug along with support from a pharmacist and psychiatrist. The goal is to see if this approach is feasibl…

This study tests a new way to help doctors in Mozambique and Zambia decide if a sick child has tuberculosis (TB). The approach uses simple checklists and decision guides, supported by a computer system, to improve diagnosis and treatment, especially for children with HIV or sever…

This study looks at a Philadelphia program called Arms Around You, which provides housing to people with HIV who are experiencing housing instability. Researchers will compare 200 people who get into the program right away versus those on a waitlist, tracking their health, housin…

This pilot study tests whether adding the HIV drug efavirenz to a person's current antiretroviral therapy (ART) can kill cells that harbor hidden HIV. About 26 adults with HIV who have low but detectable virus levels despite good adherence will take efavirenz for 8 weeks. The goa…

This early-stage trial tests whether a patient's own immune cells, modified to target HIV (called CAR-T cells), can help control the virus without daily medication. Only 3 people with well-controlled HIV will receive the treatment. The main goal is to check safety, but researcher…

This study tests a new way to provide HIV care for people who have trouble keeping regular doctor appointments. It offers drop-in visits and mobile care at convenient locations like a needle exchange site. The goal is to help 400 participants in California stay in care and get th…

This study tests whether a very low dose of semaglutide (a drug used for weight loss and diabetes) can help people with HIV avoid regaining weight after an initial weight-loss period. About 30 adults with HIV who are on stable HIV treatment and are overweight or obese will take p…

This study tests a short, computer-based program to help people with HIV and alcohol use disorder avoid returning to heavy drinking. About 150 adults from a Johns Hopkins HIV clinic will take part. The goal is to see if the program helps them stay alcohol-free longer and drink le…

This study looks at how the HIV drug doravirine works in pregnant women. Researchers want to find the right dose to keep the virus under control and protect the baby. About 76 pregnant women with HIV will take either doravirine or standard HIV medication starting in the second tr…

This study tests whether using drones to deliver HIV medication to people living in remote islands of Uganda can improve viral suppression. Over 1,000 participants will either get their medication via drone or through standard methods. Researchers will compare viral load and rete…

This study tests whether starting antiretroviral therapy within 7 days of an HIV diagnosis can reduce stigma and improve health outcomes for people who inject drugs. Researchers will develop a rapid-start strategy and pilot it with 135 participants at HIV clinics. The goal is to …

This study tests a three-session program called We-INtervention for 160 Chinese male couples where one partner has HIV and the other does not. The program focuses on improving relationship dynamics to reduce stigma and boost well-being. Participants are randomly assigned to the p…

This pilot study tests a program where a clinical pharmacist talks with people with HIV about the risks of drinking alcohol (with or without cannabis) while taking multiple medications, especially those that affect the brain. The goal is to see if this approach can reduce falls a…

This study tests a support package for people with HIV in Malawi who start or restart antiretroviral therapy (ART). The package includes mobility counseling, a toll-free hotline, and multi-month medication dispensing. Researchers want to see if this approach is acceptable to pati…

This study tests a proactive approach to help people living with HIV quit smoking. A pharmacist calls participants, offers counseling, and sends cessation medication unless they opt out. The goal is to see if this method works better than standard care. The trial involves 231 adu…

This study in Malawi tests a new approach for people with HIV who have stopped taking their medication. Instead of a one-size-fits-all plan, participants can choose from different services to fit their changing needs. The goal is to see if this flexible, client-driven care helps …

This study tests whether giving low-income Black men living with HIV a universal basic income of $500 per month for six months helps them get regular HIV care and stick with their medication. Researchers in Arkansas will compare 80 men who receive the payments to those who don't,…

This study tests whether a two-drug HIV regimen (dolutegravir plus lamivudine) works as well as the standard three-drug regimen in people who also have tuberculosis and are on TB treatment. About 150 participants who have never taken HIV medication will be randomly assigned to on…

This study tests two remote programs—peer support groups and strengths-based case management—for adults aged 50+ living with HIV in rural Southern U.S. counties. The goal is to see if these programs help with viral suppression, medication adherence, quality of life, and depressio…

This study tests a 10-session counseling program called STEP-AD for Black women living with HIV who have a history of trauma. The goal is to help them stick to their HIV medication and achieve viral suppression. Researchers will enroll 250 participants and compare the program to …

This study is testing a group-based support program to help young sexual and gender minority people (ages 18-24) in Rio de Janeiro take their HIV medication consistently. The program includes four sessions that focus on building social support, self-confidence, and problem-solvin…

This study is testing whether switching to a two-drug HIV pill (dolutegravir plus lamivudine) can keep the virus under control in transgender women who are already on a stable three-drug regimen. About 50 participants will take the new pill once daily for 48 weeks. The main goal …

This study tests a new device called MagIA H3S that can screen for HIV, hepatitis B, hepatitis C, and syphilis using a single blood sample. Researchers will enroll about 2,950 people in Ivory Coast and Kenya to see how accurate the device is compared to standard lab tests. If it …

This study tests a model called STEP-UP, which partners community organizations with telehealth PrEP services to help people access HIV prevention medication. Researchers will enroll 92 participants in the Philadelphia area to see if this approach is acceptable and increases PrEP…

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This trial tests whether offering a menu of HIV prevention options — including daily pills and a vaginal ring — helps more young women aged 18–30 start and continue using PrEP. About 1,400 women seeking reproductive health services at clinics in Kenya will be offered either stand…

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network increases the number of men who use HIV prevention or get treated. About 245 participan…

This study tests four different approaches to help people who inject drugs remember and stick with their daily HIV prevention pill (PrEP). Researchers will enroll 256 adults who are newly on medication for opioid use disorder and have started PrEP. The goal is to see which method…

This study tests a digital health program to help women involved in the criminal justice system start PrEP (a daily pill to prevent HIV) and get treatment for opioid use disorder. Researchers will compare the program to a simpler decision aid alone. The goal is to reduce stigma a…

This study tests a program called CUPID that helps couples make decisions together about HIV prevention. About 1,424 women in Uganda will join with their male partners to choose and use PrEP (medicines that prevent HIV). The goal is to see if partner support increases women's use…

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study tests two approaches to help men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). 400 participants will receive either contingency management (rewards for filling prescriptions) alone or combined with motivational…

This study tests a program to help Latinx men lower their HIV risk by combining easy access to PrEP medication, social support from friends, and a national pharmacy chain. Researchers will enroll 624 men aged 18-54 and track how many start and stick with PrEP. The goal is to crea…

This study tests a program called Shamba Maisha that provides farming tools, training, and school gardens to families in Kenya. The goal is to reduce food insecurity and poverty, which are linked to higher STI and HIV risk in adolescent girls. Researchers will follow 900 girls an…

This study looks at people with HIV between the ages of 65 and 74 to find those at risk for frailty—a condition that can lead to falls, hospital stays, and disability. Participants will be screened using a simple test called the Fried scale, and those at risk will receive a speci…

This study is testing whether a long-acting injectable HIV prevention drug, called cabotegravir, can work for people who inject drugs. The trial will enroll 100 adults who have injected non-prescription drugs in the past 6 months and are at risk for HIV through sexual contact. Pa…

This study is testing a new data dashboard to help clinics in Alabama track and improve how they provide PrEP, a daily pill that prevents HIV. The dashboard shows real-time data on PrEP prescriptions and patient needs, aiming to reduce racial gaps in HIV prevention. Researchers w…

This study tests a program in the Dallas County Jail that identifies people at high risk for HIV and offers them testing and education about PrEP, a daily pill that prevents HIV. A patient navigator helps interested individuals connect with PrEP providers after they are released.…

This study tests a program where people who use drugs (called 'Prevention Ambassadors') give HIV self-testing kits and service information to friends in their social network. The goal is to increase HIV testing and use of prevention or treatment services. About 210 participants w…

This study aims to find low-cost ways to encourage people at higher risk of HIV to get retested. Researchers will test several simple behavioral interventions, like phone messages, in 40,000 adults in Kenya and Uganda. The goal is to see which methods work best to increase repeat…

This study tests a peer-led community program to help Black men in Prince George's County, Maryland, start taking PrEP, a daily pill that prevents HIV. The program uses in-person events to reduce stigma, build social support, and teach skills for getting HIV care. Researchers wil…

This study is testing a new approach called PAC-Man to help prevent HIV from passing from mothers to their babies. About 2,426 mothers and infants in Malawi will take part. The goal is to see if this model helps more babies get tested for HIV early and ensures mothers receive pro…

This study will follow 5,000 HIV-negative adults in Italy who are taking PrEP, a daily pill that prevents HIV. Researchers want to see how well PrEP works in real life, how many people stick with it, and what barriers they face. The goal is to use this information to improve HIV …

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

This study tests a 10-session peer-led program called Bridge to Belonging, designed to reduce loneliness and depression in older gay and bisexual men living with HIV. The program uses group sessions to build social skills and connect participants with LGBTQ+-affirming community s…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which one better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, have H…

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers wil…

This study is testing a type of talk therapy for people who have both HIV and PTSD. The therapy helps people understand how trauma affects their emotions and relationships. The goal is to see if this therapy is helpful and acceptable for this group. About 20 adults with HIV and P…

This study tests a 6-month holistic behavioral health program called EASE for 200 adults with HIV or seeking HIV prevention who also use alcohol or drugs. Participants receive counseling, case management, peer support, and education. Researchers will measure changes in depression…

This study tests an 8-week hybrid exercise program for people with HIV who are at risk for heart failure. Participants attend one supervised session at a center and do two unsupervised home workouts each week, plus receive education and coaching. The goal is to see if this approa…

This study tests whether an AI-powered therapy program can help older adults (50+) living with HIV who are at risk for suicide. Participants watch short videos teaching coping skills and can chat with a coach. The goal is to see if this approach is practical and helps people mana…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a pill called pregnenolone can help reduce depression in people with HIV. Participants take either the study drug or a placebo for 8 weeks while staying on their current antidepressants. Researchers will use brain scans and mood questionnaires to see if t…

This study tests whether doing tai chi/qigong over Zoom twice a week for 12 weeks can reduce depressive symptoms in people aged 50-75 living with HIV. About 326 participants will be randomly assigned to either tai chi or a health education class. Researchers will track mood, hear…

This study collects white blood cells from HIV patients through a process called leukapheresis to examine how the immune system responds to early treatment. Researchers aim to enroll 60 adults—30 with early HIV and 30 with chronic HIV—who are not yet on antiretroviral therapy. Pa…

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood samples from up to 2,419 adults, both with and without HIV. Researchers will analyze these samples to compare genetic and protein differences. The goal is to better underst…

This study aims to understand where HIV hides in the body when people stop their daily antiretroviral therapy (ART) for a short time. Fifty adults with HIV will either stay on ART or pause it for up to 90 days. Researchers will use PET/CT scans and take small tissue samples from …

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study aims to understand how HIV behaves differently in the blood compared to lymph nodes and bone marrow. Researchers will take samples from 400 people living with HIV and some without HIV to measure virus levels and immune system changes. The goal is to learn more about wh…

This study investigates whether platelets—tiny blood cells involved in clotting—interact with HIV-infected immune cells in ways that affect the virus's ability to persist despite treatment. Researchers will collect blood samples from 90 adults with HIV who have had undetectable v…

This study collects white blood cells and plasma from 400 people with HIV, including rare 'non-progressors' who control the virus without medication. Researchers will analyze immune responses and genetic markers to understand what makes these individuals special. The goal is to u…

This study follows 150 adults with Kaposi sarcoma (KS) for up to 10 years to learn how the disease behaves, why it comes back, and how it affects the immune system and organs. Participants will have regular check-ups, scans, and biopsies, but no new treatments are being tested. T…

This study looks at how natural hormones and hormone therapy (like birth control or gender-affirming hormones) affect the way the HIV prevention drug cabotegravir works in the body. Researchers will measure drug levels in blood, tissues, and fluids in 32 HIV-negative adults. The …

This study investigates how depression and cannabis use together affect brain circuits involved in reward and pain in young people living with HIV. Researchers will use MRI scans and questionnaires to measure brain activity, mood, and substance use. The goal is to understand why …

This study tests whether giving clinics a dedicated coach helps them offer alcohol treatment to people with HIV who drink too much. The coach provides tools and guidance to support a stepped care model, which starts with brief advice and progresses to therapy or medication if nee…

This study compares two sets of strategies to help HIV clinics in Cape Town, South Africa, treat depression and improve medication adherence. Ten clinics will be randomly assigned to receive either basic support or enhanced training and supervision. Researchers will track how man…

This study looks at HIV that stays hidden in the body even when the virus is under control. Researchers will measure the 'latent HIV reservoir' in 130 Ugandans with HIV and compare it to similar groups in the US. Participants give blood samples and answer health questions. No new…

This study tracks the health of people with HIV over time to learn more about the infection and related conditions. It is for adults 18 and older in the Washington, D.C., area who have or may have HIV. Participants visit the clinic every few months for check-ups and blood tests, …

This study looks at how well leg muscles produce energy in older adults (60+) with and without HIV. Researchers will use MRI scans and walking tests to measure muscle metabolism and fatigue. The goal is to understand if metabolic problems in the calf muscle are linked to reduced …

This study collects blood plasma and white blood cells from healthy volunteers and people with HIV using a procedure called apheresis. The samples are used for laboratory research on infectious diseases and immune function. Up to 3,000 participants aged 18 and older will be enrol…

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study looks at whether being more forgiving and holding less resentment can improve quality of life for people living with HIV. Researchers will follow 206 participants at a French hospital, measuring their tendency to forgive and their well-being. The goal is to see if forg…

This study is testing a program to help more people in coastal Alabama get tested for HIV, quickly connect to care, and start treatment right away. The program uses data to find areas with high need, helps people link to care when diagnosed, and offers rapid antiretroviral therap…

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, to see how their liver and immune system change over time. Participants join when diagnosed or starting standard antiviral treatment and are monitored for years. The goal is to learn more about the dise…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, treatment, and prevention services. About 40 clinics will either use SAIA or continue their usual routines. The goal is to see if this approach increases the number of women a…

This study collects large amounts of blood cells from people with HIV to help researchers understand why the virus persists even with treatment. It involves up to 100 participants who are either on HIV therapy, elite controllers, or untreated with detectable virus. The goal is to…

This study looks at how CBD and THC, two compounds found in cannabis, affect inflammation and brain health in people with HIV. About 90 participants will take both substances in a random order over six weeks. Researchers will measure blood markers and brain function to better und…

This study looks at how to help people with both HIV and cancer stay engaged in their HIV care while receiving cancer treatment. Researchers will first observe 150 patients to identify barriers, then develop and test strategies to improve care. A second group of 150 patients will…

This study takes small samples of lymph nodes from people with HIV to learn how the virus persists even with effective medication. Researchers want to measure how much HIV remains in these tissues and how much damage has occurred. The goal is to better understand why HIV is so ha…

This study follows 100 HIV patients who were diagnosed early and started antiretroviral therapy (ART) right away. After they completed a research protocol that included a temporary stop of their HIV medications (called an analytic treatment interruption), they join this study for…

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at whether menopause and HIV together increase heart disease risk in women. Researchers will examine inflammation and body fat using MRI scans and blood tests in 90 women with HIV. The goal is to understand why heart risks may worsen after menopause in this group…

This study compares two support programs for Black men who have been in jail or prison and are at risk for or living with HIV. One group gets health navigation only; the other also gets employment help and up to $340 in incentives. Researchers want to see which approach better co…

This study tests a training program for entire HIV clinics to reduce stigma and improve well-being for both patients and staff. About 1,000 people from 5 clinics in the US South will take part. The training includes interactive sessions for all staff and aims to change clinic pol…

This study collects blood samples from people with and without HIV to help researchers learn more about the virus. Up to 2,000 participants will donate blood for scientific studies. No treatment or medication is given as part of this study.

This study tests whether a two-day employment program can help young Black men who have sex with men stay engaged in HIV care. Researchers will ask 132 participants about their satisfaction and track changes in job-seeking confidence and sexual health visits over 13 months. The g…

This 20-year study will collect information from up to 300,000 people who visit HIV and sexual health clinics in Thailand. Researchers aim to understand behaviors, social factors, and health needs to improve services. No new treatments are tested; the focus is on gathering data t…

This study looks at how chronic marijuana use changes brain inflammation and thinking abilities in people with HIV. Researchers will use brain scans and blood tests to measure brain health in 220 adults. The goal is to understand the effects, not to test a new treatment.

This study aims to understand frailty in people with HIV who are 50 or older. Researchers will screen participants for signs of weakness or low stamina, then offer a personalized activity plan with strength, balance, and walking goals. The study will track how well people stick w…

This study looks at 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to find out why the parasite keeps coming back in some patients and how to better monitor treatment. Participants provide samples and attend foll…

This study in Uganda tests whether trained peer counselors can help people with tuberculosis (TB) and HIV stay on track with their medications. About 1,920 adults will take part, and researchers will compare treatment success rates between clinics using peer-led education and tho…

This study looks at whether long-acting antiretroviral drugs for HIV prevention (PrEP) are effective and affordable for key populations in Thailand, including men who have sex with men and transgender women. Researchers will survey over 10,000 people about their preferences, anal…

This study is testing whether setting up special HIV teams in hospitals can increase testing for undiagnosed HIV. The teams will remind doctors to test patients with certain health conditions, reduce stigma, and improve care links. Over 5,200 patients across ten European countrie…

This study looks at whether getting legal help can improve HIV care for people who have been in jail. Researchers will work with 100 adults living with HIV who have a detectable viral load and a history of incarceration. They will also train healthcare providers on how to connect…

This study is a long-term project that collects health information from 30,000 HIV patients at 15 clinics in France. The goal is to track how well HIV treatments are working, monitor changes in the disease over time, and understand related health issues like hepatitis C. No new t…

This study is gathering information from 2,500 adults with HIV who are having their first upper digestive tract endoscopy. Researchers will record patient details, test results, and any diagnoses found during the procedure. The goal is to better understand digestive health issues…

This study compares fat storage around the heart and liver in people with HIV versus the general population using MRI scans. Researchers aim to understand why HIV-positive individuals have double the risk of heart attacks. The study involves 100 participants aged 40 and older wit…

This study looks at how damage to the vagus nerve may cause gut issues and inflammation in people with HIV. Researchers will test two approaches—a drug called pyridostigmine and non-invasive vagus nerve stimulation—to see if they can improve gut function and reduce inflammation. …

This pilot study tests whether telemedicine can help people living with HIV in Alabama who also struggle with opioid or stimulant misuse get follow-up care. Thirty participants will receive either telemedicine or standard care. The goal is to see if telemedicine is feasible and a…

This study looks at better ways to provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part. Researchers will compare two sets of strategies to see which works best for getting women screened and treated. The goal is to…

This long-term study follows 19,000 people with or at risk for HIV in Washington, DC to track their health outcomes and quality of care. Researchers will monitor viral suppression rates and new infections over up to 10 years. The goal is to find ways to improve HIV treatment and …

This study follows 380 children in Uganda for two years to understand how malaria and HIV treatments interact. Half the children have HIV and half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best ways to treat both infections …

This study looks at how medical care affects the quality of life of 100 pregnant women living with HIV. Researchers will ask women to fill out questionnaires about their feelings and experiences during pregnancy and one year after giving birth. The goal is to improve care and sup…

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will follow about 6,770 participants, including those with HIV, and use advanced genetic testing to track TB spread among close contacts. The goal is…

This study looks at how to get more people in Canadian federal prisons to use needle exchange programs, which can help stop the spread of HIV and hepatitis C. Researchers will work in nine prisons, including five women's prisons, to find out what helps or hinders program use and …

This study tests whether having traditional healers offer HIV counseling and testing can increase the number of people who get tested compared to usual care. Over 230,000 adults in rural South Africa will take part. The goal is to reach people who might avoid regular clinics and …

This study looks at two ways to screen for cervical cancer in women with HIV in Cameroon. One way sends self-collected samples to a central lab; the other uses a mobile team that tests and treats on the spot. Researchers want to see which approach helps more women complete all sc…

This study will analyze medical records from up to 1 million people in Malawi to understand how different models of HIV treatment delivery are working. The goal is to see which approaches are most effective and efficient, without directly interacting with patients. Findings could…

This pilot study tests whether pasteurized donor human milk (PDHM) is a practical feeding option for infants born to mothers living with HIV. Ten families in Saskatchewan will try PDHM as a supplement to breastfeeding or formula, and researchers will track how often it's used and…

Researchers are analyzing medical records from about 7 million people with HIV in South Africa to see how different models of care are working. The goal is to understand which approaches help more people stay on treatment and achieve viral suppression. No new drugs or treatments …

This study looks at medical records from 1.2 million people with HIV in Zambia to understand how different models of delivering HIV treatment are working. Researchers want to see how many people are using these models, how well they control the virus, and what the costs are. No n…

This study looks at whether giving out special syringes with less leftover space (low dead-space) can help reduce the spread of HIV and hepatitis among people who inject drugs. Researchers will talk with participants and track their health in several countries. The goal is to fin…

This study tests whether a single-visit approach to cervical cancer screening and treatment can reduce dropout rates among women living with HIV in Cameroon. Researchers will compare the current multi-visit system with a streamlined process that includes HPV testing and same-day …