HIV

This early-stage trial tests a new HIV vaccine called GRAdHIVNE1 in 120 healthy adults in southern Africa, including some living with HIV. The vaccine uses a harmless gorilla virus to deliver HIV protein bits to train the immune system. The main goal is to check safety and see if…

This early-stage study tests two experimental mRNA vaccines designed to train the immune system to make powerful antibodies against HIV. About 40 healthy adults without HIV will receive the vaccines to check for safety and measure immune responses. The goal is to see if this appr…

This early-stage study tests whether a new two-part HIV vaccine is safe and can trigger the immune system to produce special antibodies that may fight HIV. About 42 healthy adults without HIV will receive the vaccine and be monitored for side effects and immune responses over a y…

This study tests a harm reduction approach for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, the program helps participants cut down, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to reduce smoking-relat…

This study tests whether trained peer educators can help people with tuberculosis (TB) and HIV stick to their treatments. About 1,920 adults in Uganda will take part. The goal is to see if peer-led counseling improves TB cure rates and keeps people with HIV on their medications.

This study tests two remote programs—peer support groups and strengths-based case management—to help rural adults aged 50+ with HIV stick to their medications and improve quality of life. Researchers will enroll 352 participants across 17 Southern U.S. states. The goal is to see …

This study aims to help people with HIV stay in care, especially during the first six months after starting or restarting treatment—a time when many drop out. Researchers are creating a toolkit that includes a risk assessment, a menu of support options, a treatment roadmap, and a…

This study is testing a program that combines counseling and technology to help young sexual and gender minority people (ages 18-24) in Rio de Janeiro, Brazil, take their HIV medication consistently. The goal is to improve social support, confidence, and problem-solving skills to…

This study aims to reduce sexually transmitted infections like chlamydia and gonorrhea among Black youth aged 15-26 in New Orleans. Participants receive free testing for four STIs and, if positive, get counseling and no-cost treatment options for themselves and their partners. Th…

This study tests an 8-week exercise program for people with HIV who are at risk for heart failure. The program combines weekly supervised workouts at a center with two home-based sessions, plus education and coaching. The goal is to see if this approach helps participants become …

This study compares two sets of strategies to help HIV patients with depression start evidence-based treatment. Researchers will track how many patients begin depression care and whether their mood and viral levels improve within a year. Ten clinics in Cape Town will be randomly …

This early-stage study tests whether lab-made antibodies that target HIV are safe and how the body processes them. About 83 healthy adults without HIV will receive the antibodies through an IV or under-the-skin shots, alone or combined. The goal is to check for side effects and m…

This study tests whether adding the HIV drug efavirenz to a person's regular antiretroviral therapy (ART) can kill cells that still harbor HIV, even when the virus is well-controlled. About 26 adults with HIV who have very low but detectable virus levels despite good medication a…

This study tests a program that combines peer support and text messages to help young men and transgender women (ages 15-29) with HIV stay engaged in care and keep the virus under control. About 100 participants in Nigeria will receive the program for 24 weeks. The goal is to see…

This study in Botswana tests whether a combination of three lab-made antibodies can safely control HIV in children who started treatment early. About 41 kids will either receive the antibodies or pause their regular HIV medication under close monitoring. The goal is to see if the…

This study is testing whether a medication normally used for other conditions can help people with HIV reduce their alcohol use. Researchers will enroll 30 adults with HIV and alcohol use disorder to see if the treatment is practical, safe, and effective. The goal is to improve h…

This study tests whether giving people with HIV a choice of nicotine replacement products (like e-cigarettes, nicotine pouches, or patches) helps them quit smoking tobacco. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either standard care…

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them focus better, take their HIV medication regularly, and stay in care after giving birth. About 100 women will receive the payments or usual care. The goal is to see if this simp…

This study tests a 5-session program for Black women living with HIV who have experienced intimate partner violence in the past two years. The program teaches skills to find strength, improve communication, and overcome barriers to HIV care. Researchers will check if the program …

This early-stage study tests whether a patient's own modified immune cells (CAR-T cells) can control HIV without daily antiviral drugs. Only 3 adults with well-controlled HIV are being enrolled to check safety first. If successful, this approach could lead to a functional cure, m…

This study tests two programs for people recently in jail or under supervision. One offers health navigation; the other adds employment help and small financial incentives. The goal is to see which better helps participants access HIV care, prevention, and jobs. About 350 Black m…

This study looks at whether a 12-week exercise program with support from a peer is something women with HIV and high blood pressure will stick with and find helpful. About 50 women aged 40 and older will take part. The goal is to see if the program is easy to follow and if it hel…

This study tests if gabapentin, a medication for nerve pain, can help people with HIV who drink heavily achieve undetectable viral loads. About 220 participants will receive either gabapentin or a placebo for 3 months, along with alcohol counseling. The goal is to see if the drug…

This study is testing whether tirzepatide, a drug already used for diabetes and weight loss, can help overweight or obese people with well-controlled HIV lose weight and reduce chronic inflammation. Twelve adults will receive weekly injections for 12 weeks, with doses gradually i…

This study is testing a 6-month behavioral health program for 200 people who either have HIV or are seeking HIV prevention. The program includes counseling, peer support, and education tailored to each person's needs. Researchers want to see if it helps reduce depression, anxiety…

This study tests a new approach for people with HIV: combining a vaccine with powerful antibodies (bNAbs) that may control the virus for months. Participants will stop their daily HIV pills for a short time to see if the combo can keep the virus in check. The goal is to find a wa…

This study tests whether giving low-income Black men living with HIV in Arkansas $500 each month for six months helps them get more HIV care and stick with their medication. Researchers want to see if this extra money improves health outcomes like viral suppression. The study inv…

This study looks at whether an online depression treatment program can improve how the body uses insulin to control blood sugar in people with HIV who are on HIV medication. Researchers will compare the online therapy to standard depression education. The goal is to see if treati…

This study tests a combination program to improve HIV testing, linkage to care, and rapid treatment in coastal Alabama. Researchers will work with local health departments to direct testing to high-need areas, help people connect to care right after diagnosis, and start antiretro…

This study looks at a Philadelphia program that provides housing to people with HIV who are homeless or at risk. Researchers want to see if having a stable home helps people stay on their HIV medication and keep the virus under control. About 200 people will be randomly chosen to…

This study tests whether metformin, a standard diabetes medicine, can reduce harmful inflammation and improve immune function in 100 adults aged 18-64 who have a history of injection drug use, some of whom also have HIV. Participants will take metformin or a placebo for 16 weeks …

This study tests whether starting HIV treatment right after diagnosis, instead of waiting, can reduce stigma and improve health for people who inject drugs. Researchers will compare the rapid-start approach to usual care in 135 participants. The goal is to lower viral levels and …

This study is testing a program where trained 'mentor mothers' from the community provide one-on-one support to pregnant women who drink alcohol. The goal is to help them reduce drinking and improve their use of HIV prevention (PrEP) or treatment (ART). About 100 pregnant women i…

This study tests new drug combinations for cryptococcal meningitis, a brain infection that is always fatal without treatment and still kills many people with HIV. The trial aims to find safer, more effective therapies that are easier to access worldwide. About 2,000 adults with H…

This study is for people living with HIV who also have a blood cancer that can be treated with a bone marrow transplant. Researchers want to see if a new mix of three drugs can safely prevent graft-versus-host disease, a common complication after transplant. The study involves a …

This study tests whether using medical drones to deliver HIV medication to people living in hard-to-reach islands in Uganda can help keep the virus under control. About 1,086 adults and teens will either get their medicine by drone or through standard pickup. The main goal is to …

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a bilingual program that combines peer support and mobile health tools to help reduce these health risks. About 200 adults from a North Carolina HIV clinic will ta…

This study tests a new approach for people with HIV who have stopped taking their medication. Instead of a one-size-fits-all plan, participants can choose which services they receive and how. The goal is to see if this flexibility helps more people achieve viral suppression after…

This study tests a 5-session virtual program called MATTER for 256 people living with HIV and substance use disorders. The program uses text messages and coaching to address internalized stigma and shame, helping participants stay engaged in HIV care and achieve viral suppression…

This study tests a behavioral program for sexually active young people aged 16-24 who use stimulants like meth or cocaine. The program aims to reduce risky sexual behavior and stimulant use to help prevent HIV. About 360 participants will take part remotely via video chat.

This study tests whether semaglutide, a drug used for diabetes, can help adults with HIV drink less alcohol and smoke fewer cigarettes. Researchers will also check if it lowers heart disease risk. Two hundred participants will take semaglutide or a placebo for 3 months and provid…

This study tests a new way to provide HIV care for people who have trouble keeping regular doctor appointments. It offers drop-in visits and mobile care at convenient locations, including a needle exchange site and community health centers. The goal is to help 400 participants st…

This study tests a counseling program called Friendship Bench + Safety Planning for teens aged 13-19 living with HIV who have had suicidal thoughts. The goal is to see if the program is practical, acceptable, and helps reduce suicidal thoughts and improve HIV care. Sixty particip…

This study looks at how well the HIV drug doravirine works in pregnant women. It involves 76 women who start HIV treatment in their second trimester. The goal is to find the right dose to keep the mother healthy and reduce risks to the baby.

This early-stage study tests an injectable drug called LP-98 in 30 adults with HIV who have never taken antiretroviral therapy. The goal is to see if the drug can lower the amount of virus in the blood and improve immune cell counts. Participants will receive the injection and be…

This study tests a program to help women in Botswana who have both HIV and a serious mental illness. The program aims to reduce stigma related to both conditions, so the women can stick with their HIV medication and keep the virus under control after leaving the hospital. About 3…

This study tests whether automated, personalized text messages can help 800 smokers living with HIV in Cambodia quit smoking. Participants will receive tailored messages and set a quit date within two weeks. Researchers will check progress using self-reports and carbon monoxide b…

This study tests a support package for people with HIV in Malawi who are starting or restarting antiretroviral therapy. The package includes counseling, a hotline, and multi-month medication dispensing to help patients stay on treatment even when they travel or move. Researchers …

This study looks at whether peer support and long-acting injectable HIV medication can help teenagers in South Africa keep the virus under control and stay in care. About 720 teens aged 12-19 who already take HIV pills will either get peer support or switch to monthly injections.…

This study tests a new way to help people living with HIV quit smoking. Instead of waiting for patients to ask for help, the program proactively reaches out to offer support. Researchers will compare this approach to standard care and look at what helps or hinders success. The go…

This study tests a three-session program called We-INtervention for 160 Chinese male couples where one partner has HIV and the other does not. The program focuses on improving relationship dynamics to reduce stigma and enhance quality of life, mental health, and HIV management. E…

This study tests a program called Enhanced Friendship Bench, which combines problem-solving therapy with HIV support, for pregnant women with HIV and depression in Malawi. Researchers will enroll 400 women to see if the program reduces depression symptoms and helps them stay in H…

This pilot study tests whether a program that teaches coping skills and supports HIV care engagement is practical and helpful for people living with HIV who also use substances. The study will enroll 50 adults and measure satisfaction, retention, and medication adherence. The goa…

This study tests if switching to a two-drug combination (dolutegravir and lamivudine) can safely keep HIV under control in transgender women who are already on a stable three-drug regimen. About 50 participants will take the new pills for 48 weeks. The goal is to see if the simpl…

This study tests a counseling program designed to help Black women living with HIV take their medication regularly and achieve viral suppression. Participants must be Black, cis-gender women aged 18 or older, with a history of trauma and recent unsuppressed viral load. The progra…

This study tests a simpler, two-drug HIV treatment (dolutegravir/lamivudine) against the standard three-drug regimen in people who have both HIV and tuberculosis (TB). About 150 participants who have never taken HIV medication will be followed for 48 weeks. The goal is to see if …

This study tests a short, computer-based relapse prevention program for 150 adults with HIV and alcohol use disorder. Participants will receive two sessions designed to help them avoid returning to risky drinking. The goal is to see if the program helps people stay alcohol-free l…

This study tests a 4-session counseling program to help people with tuberculosis (TB) and HIV reduce unhealthy alcohol use. The program is added to regular TB and HIV care in India. Researchers will check if it lowers drinking and improves TB and HIV health outcomes. About 450 ad…

This study tests whether taking 75 mg of zinc daily can improve immune function in people with HIV whose CD4 counts remain low despite antiretroviral therapy. About 120 participants will be randomly assigned to receive zinc or continue their usual care. The goal is to see if zinc…

This study tests a program called PrTNER that helps young people aged 15-29 who are at risk for or living with HIV and also have substance use issues. The program provides support to start HIV prevention medicine (PrEP) or to lower the amount of virus in the body for those alread…

This study evaluates a new point-of-care device called MagIA H3S that can test for HIV, hepatitis B, hepatitis C, and syphilis from a single blood sample. Researchers will enroll about 2,950 people in Ivory Coast and Kenya to see how accurate the device is compared to standard la…

This study looks at people with HIV between 65 and 74 years old to find those at risk for frailty—a condition that makes older adults weak and more likely to have health problems. Researchers will use a simple test called the Fried scale to screen participants, then offer a speci…

This study tests whether adding motivational interviewing to contingency management (rewards for healthy behaviors) helps men who have sex with men and use methamphetamine start or restart HIV prevention (PrEP) or treatment (ART). Four hundred participants will receive either con…

This study tests a new data dashboard to help clinics in Alabama better track and improve HIV prevention services (PrEP). Researchers will work with seven clinics to see if the dashboard helps more Black and other at-risk people get PrEP prescriptions. The study involves clinic s…

This study tests a method called SAIA to help family planning clinics in Kenya better offer HIV testing, prevention, and treatment services. About 40 clinics will take part, with some using SAIA and others continuing usual care. The goal is to see if this approach increases the n…

This study follows 5,000 HIV-negative adults in Italy who are taking or starting PrEP, a daily pill that prevents HIV. Researchers will track how well PrEP works in real life, how often people take it, and any side effects. The goal is to gather data to help eliminate new HIV inf…

This study tests whether adding testing for common sexually transmitted infections (STIs) to standard risk screening helps more young women in Uganda start and stay on PrEP, a daily pill that prevents HIV. About 5,560 women aged 15-39 will be randomly assigned to either standard …

This study looks at how to better provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part. The goal is to find the best way to combine cancer care with existing HIV services to prevent cervical cancer and improve healt…

This study tests whether a program that provides farming tools, training, and family support can reduce sexually transmitted infections (STIs) and improve mental health in 900 teen girls (ages 15-19) in Kenya. The program aims to reduce food insecurity and poverty, which are link…

This study looks at whether a program called STEP-UP can make it easier for people to get PrEP, a daily pill that prevents HIV. Instead of going directly to a doctor, participants get PrEP through trusted community organizations that offer telehealth appointments. Researchers wil…

This study tests whether text messages can encourage HIV testing in teens aged 13-19 who have had sex but never been tested. Participants are split into two groups: one gets helpful texts, the other gets basic info. The main goal is to see if more teens get tested for HIV and sha…

This study tests whether a peer-led community program can help more Black men in Prince George's County, Maryland, start taking PrEP—a daily pill that prevents HIV. Participants will attend events focused on reducing HIV stigma and building social support. Researchers will compar…

This study tests a long-acting injectable HIV prevention medication (cabotegravir) in 100 adults who inject non-prescription drugs and are at risk for HIV. Participants receive the shot plus support services. The goal is to see if people stick with the treatment over 7 months.

This study tests several low-cost, easy-to-use strategies to encourage people at higher risk for HIV to get retested. Researchers will enroll 40,000 adults in Kenya and Uganda who have access to a mobile phone. The goal is to see which approaches work best to increase repeat HIV …

This study tests a program called JUNTOS that helps HIV test counselors refer Latino men who have sex with men to prevention and treatment services. The goal is to see if this referral network increases the number of men who use HIV prevention or get treated. About 245 participan…

This study looks at whether a long-acting injectable medication can help prevent HIV more effectively than daily pills. Researchers will survey over 10,000 men and transgender women in Thailand to understand preferences and analyze costs. The goal is to see if this new option cou…

This study tests a program where people who use drugs (called "Prevention Ambassadors") give HIV self-test kits and service information to their friends. The goal is to see if this approach increases HIV testing and use of prevention or treatment services. The study involves 210 …

This study tests a new way to help Latinx men at risk for HIV start and stay on PrEP, a daily pill that prevents HIV. It combines a one-stop-shop clinic, a social network support program, and a national pharmacy chain to make getting PrEP easier. Researchers will enroll 624 cis-g…

This study tests whether an online relationship education program can reduce HIV and other sexually transmitted infections in gay, bisexual, queer, and transgender individuals who have sex with cisgender men. About 5,000 participants aged 16-34 will be randomly assigned to either…

This study looks at a new way to offer HIV prevention medicine (PrEP) to people in the Dallas County Jail. Researchers will use a risk score from medical records and referrals to identify who might benefit, then a navigator will meet with them to discuss HIV risk, offer testing, …

This study tests whether a combination of three lab-made antibodies, given through an IV, is safe and can help prevent HIV in healthy adults. About 200 participants aged 18-65 will receive the antibodies or a placebo and be followed for 18 months. The goal is to see if this appro…

This study tests whether a type of brain stimulation called accelerated theta burst stimulation can reduce cravings for methamphetamine in people living with HIV. Researchers will measure changes in craving and brain activity in 30 adults aged 18-65 who have a history of methamph…

This study tests whether a supplement called pregnenolone can help reduce depression in people living with HIV. Researchers will give either pregnenolone or a placebo pill to 120 adults with HIV and depression, while they continue their usual antidepressant medications. Brain sca…

This study compares two drugs, pramipexole and escitalopram, to see which better treats depression in people with HIV. It includes those with mild memory or thinking problems. About 186 adults will take one of the medications for several weeks, and researchers will track mood cha…

This study is testing whether an AI-powered conversational agent can deliver a proven therapy (Dialectical Behavior Therapy) to help older adults with HIV manage suicidal thoughts and emotions. About 50 people aged 50 and older who are at risk for suicide will try the program. Th…

This study tests whether doing tai chi and qigong online can reduce depressive symptoms in people aged 50-75 living with HIV. Participants will take either a 12-week tai chi class or a health education class, both via Zoom. Researchers will compare the groups to see if tai chi im…

This study tests a new program called 'One Mind One Heart' that combines mindfulness and behavior change to help older adults with HIV reduce stress and improve heart health. Researchers will first interview 20 participants to refine the program, then test it in a small group of …

This study tests two phone-based programs—brief behavioral therapy for insomnia and brief mindfulness training—in 200 adults with HIV, chronic pain, and insomnia. The goal is to see which approach better improves sleep quality, reduces pain, and may slow biological aging. Partici…

This study tests a group counseling program combined with peer support to help adults with obesity, skin disease, cancer, HIV, diabetes, or chronic pain reduce the internal shame and worry caused by health-related stigma. Researchers want to see if this approach improves quality …

This study enrolls 100 people with HIV to donate large numbers of white blood cells through a process called leukapheresis. Researchers will measure HIV DNA and RNA in these cells to better understand how the virus persists despite treatment. The goal is to gather knowledge that …

This study looks at whether a two-day employment program can help young Black men who have sex with men stay engaged in HIV care. About 132 participants will attend the program and complete surveys over 13 months. The main goal is to see if the program is acceptable and feasible,…

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, for several years. Researchers track how the liver and immune system change over time, especially when standard antiviral treatments are started. The goal is to better understand the disease, not to tes…

This study reviews medical records from up to 1 million people with HIV in Malawi to see how different ways of delivering treatment are working. The goal is to understand which models help patients stay healthy and use resources wisely. No new treatments are tested, and no direct…

This study tests whether traditional healers can encourage more adults in rural South Africa to get tested for HIV compared to usual care. Over 230,000 people will take part across 42 areas. The goal is to reach those who avoid regular testing and help them learn their HIV status…

This study tests whether a specially designed play can help reduce stigma around Pre-exposure Prophylaxis (PrEP) for young women in Kenya. Researchers will measure how well the play can be performed and if it changes audience attitudes. About 160 young women and community members…

This study is gathering information from 2,500 adults with HIV who are having their first upper digestive tract exam (endoscopy). Researchers want to track what doctors find during these exams over many years. The goal is to better understand digestive health issues in people liv…

This study looks at whether getting legal help can improve HIV care for people who have been in prison. Researchers will also train healthcare providers to better understand legal needs. The goal is to see if this approach helps lower HIV viral load and keeps people connected to …

This study aims to increase the use of needle and syringe programs in Canadian federal prisons to reduce the spread of HIV and hepatitis C among people who inject drugs. Researchers will work in nine prisons, including five women's prisons, to identify barriers and test strategie…

This study tests three approaches to increase physical activity in older adults with HIV: coaching, cognitive behavioral therapy for barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear Fitbits to track steps. The goal …

This study follows 100 HIV patients who started treatment very early and later paused it in a research trial. The goal is to closely monitor their health and virus levels to ensure safety after stopping medication. Participants will be watched for up to 144 weeks to see if and wh…

This study looks at how alcohol, cannabis, and certain medications affect falls and thinking in people with HIV. Researchers will test if a talk with a pharmacist can help. One hundred people with HIV who drink alcohol and take multiple medications will take part.

This study follows 150 adults with Kaposi sarcoma (KS) to understand how the disease develops, changes, and may come back over time. Researchers will collect medical history, perform exams, and take samples like blood, saliva, and tumor biopsies. Participants continue their usual…

This study looks at whether menopause and HIV together increase the risk of heart disease in women. Researchers will examine blood markers and body scans from 90 women with HIV to understand how inflammation and weight changes play a role. The goal is to fill a knowledge gap, not…

This study looks at medical records from over a million people in Zambia to see how different ways of delivering HIV care are working. The goal is to understand which models help more patients stay on treatment and achieve viral suppression. No new treatments are being tested; in…

This study looks at 320 people with HIV to create tools that predict who might develop fatty liver disease or liver scarring. The goal is to catch these problems early so doctors can help sooner. Participants will have regular check-ups and liver scans over time.

This study collects blood, bone marrow, tumor, and other tissue samples from adults with HIV, KSHV, or certain cancers. The goal is to gather samples for research, not to provide treatment. Up to 999 participants will donate samples over time to help scientists learn more about t…

This study is collecting health data from 30,000 HIV patients at 15 clinics in France to track how well treatments work over time. Researchers will monitor viral suppression rates, treatment changes, and related infections like hepatitis C. The goal is to improve care quality and…

This study uses MRI scans to measure fat around the heart and liver in people with HIV and those without. The goal is to understand why people with HIV have about double the risk of heart attacks. Researchers hope the findings will lead to new ways to reduce heart disease risk in…

This study looks at how chronic marijuana use impacts brain inflammation and thinking skills in people with HIV. Researchers will use brain scans and cognitive tests to compare marijuana users and non-users. The goal is to understand whether marijuana helps or harms brain health …

This 20-year study will collect information from up to 300,000 people who visit HIV and sexual health clinics in Thailand. Researchers will use surveys and interviews to understand behaviors, social factors, and health needs. The goal is to improve services and care for people li…

This study aims to understand why a small group of people with HIV, called long-term non-progressors, can control the virus for years without antiretroviral therapy. Researchers will collect white blood cells and plasma from up to 400 participants through apheresis or blood draws…

This study reviews medical records from about 7 million people with HIV in South Africa to understand how different ways of delivering HIV care are working. Researchers want to see how many people use these services, how well they control the virus, and what the costs are. No new…

This study tests whether setting up special HIV teams in hospitals can help find undiagnosed HIV in patients who have conditions linked to HIV. About 5,200 patients across ten European countries will be included. The teams will review medical records, remind doctors to offer HIV …

This study uses a procedure called leukapheresis to collect large numbers of white blood cells from people with HIV. Researchers want to compare immune function in those treated soon after infection versus those treated later. The study does not provide any treatment—it only coll…

This pilot study will test whether pasteurized donor human milk (PDHM) is a practical feeding option for 10 infants exposed to HIV. Caregivers will use PDHM as a supplement to breastfeeding or formula, and researchers will track how often it's used and any challenges. The goal is…

This study looks at how stress and pain affect hormones and mood in 120 people with or without HIV, cannabis use disorder, and depression. Participants will do a pain stress task and give blood samples to measure stress chemicals. The goal is to understand these connections, not …

This study looks at how to help people in Zimbabwe who have both cancer and HIV stay engaged in their HIV care while they are being treated for cancer. Researchers will first observe 150 patients to understand the barriers, then develop and test strategies to overcome them with a…

This study looks at how problems with the vagus nerve (a key nerve connecting the brain and gut) might lead to gut issues and inflammation in people with HIV. Researchers will measure gut function and inflammation in 207 adults with HIV. They will also test if a drug called pyrid…

This study follows 600 adults with HIV in the Washington, D.C., area to monitor their health over time. Participants visit the clinic every 3-4 months for check-ups and blood tests. The goal is to collect data for research and help train infectious disease doctors. No experimenta…

This study collects blood samples from 2,000 people, both with and without HIV, to provide researchers with specimens for collaborative studies. Participants must have good vein access and be able to consent. No treatment is given; the goal is to advance scientific understanding …

This study aims to identify frailty in people with HIV who are 50 years or older. Researchers will measure physical performance and quality of life to better understand the challenges of healthy aging in this group. No treatment or medication is given; the goal is simply to gathe…

This study follows 20 adults in Ethiopia who have both HIV and visceral leishmaniasis (a serious parasitic disease). Researchers want to understand why the parasite persists and causes repeat infections. They will analyze host and pathogen factors to improve treatment monitoring.…

This study looks at how well leg muscles produce energy in people aged 60 and older, both with and without HIV. Researchers want to see if muscle metabolism problems are linked to difficulty exercising. Participants will undergo muscle tests and walking assessments. The goal is t…

This study collects blood plasma and white blood cells from healthy volunteers and patients using a procedure called apheresis. The samples are used in laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH study or be a healthy vo…

This study will test new decision-making tools to help doctors at district hospitals and health centers in Mozambique and Zambia better diagnose and treat tuberculosis (TB) in children. The study will involve over 30,000 children under 15, including those with HIV or severe malnu…

This study looks at how medical care affects the quality of life of pregnant women living with HIV. Researchers will ask 100 women in Paris to fill out questionnaires during pregnancy and one year after giving birth. The goal is to learn how to better support these mothers and im…

This study looks at two ways to screen for cervical cancer in women with HIV: sending a mobile team to their usual clinic, or asking them to go to a central hospital. About 1,180 women aged 25-49 will take part. The goal is to see which method helps more women complete all screen…

This study follows up to 19,000 people with HIV or at high risk for HIV in Washington, DC, to see how well treatments and prevention services work over time. Researchers will track viral suppression rates and new infections to improve care across the city. Participants are from t…

This study aims to learn more about how HIV infects cells and affects the immune system by collecting blood and other biological samples from up to 2,419 adults, both with and without HIV. Researchers will compare these samples to better understand the virus and related immune de…

This study follows 380 children in Uganda for two years to see how malaria and HIV treatments interact. Half the children have HIV, half do not. Researchers will measure changes in body weight, blood sugar, and drug levels to find the best treatment plans. The goal is to improve …

This study looks at whether people with tuberculosis (TB) who have no symptoms can still pass the infection to others. Researchers will track about 6,770 participants, including those with HIV, using advanced genetic tools to see if asymptomatic TB cases cause new infections. The…

This study looks at what happens to HIV when people stop their daily medication for a short time. Researchers want to see how the virus changes in the blood and lymph nodes. About 50 adults with HIV will either stay on their meds or pause them for up to 90 days. The goal is to le…

This study works with five HIV clinics in the southern and eastern U.S. to create programs that reduce stigma against people living with HIV. Clinic staff and patients will take surveys every six months for two years to see if the programs help improve well-being and access to ca…

This study looks at how cannabis ingredients (CBD and THC) impact inflammation and brain health in people with HIV. Researchers will give 90 participants both compounds in different orders over 6 weeks, then measure blood markers and brain barriers. The goal is to understand how …

This study looks at where HIV hides in the body by comparing virus levels in blood, lymph nodes, and bone marrow. Researchers want to understand how HIV damages the immune system and why it persists even with treatment. About 400 adults with HIV will provide blood and tissue samp…

This study tests a program that gives out special syringes with less leftover space to people who inject drugs in several countries. The goal is to see if these syringes are easier to use and help reduce the spread of HIV and hepatitis. About 2,400 participants will share their t…

This study looks at whether doing cervical cancer screening and treatment in a single visit works better than multiple visits for women with HIV in Cameroon. About 1,422 women will take part to see if a one-visit approach reduces dropouts and is acceptable to patients and staff. …

This study tests whether a telemedicine program is practical and well-received for treating substance use disorders in people living with HIV in Alabama. About 30 participants who misuse opioids or stimulants will receive care via video or phone. The main goal is to see if they a…