Could a hormone pill lift depression in HIV patients?
NCT ID NCT05570812
First seen Oct 31, 2025 · Last updated May 20, 2026 · Updated 33 times
Summary
This study tests whether a natural hormone called pregnenolone can improve depression and brain function in people living with HIV. About 120 adults with HIV and depression will take either pregnenolone or a placebo pill for several weeks, while continuing their usual antidepressant medications. Researchers will use brain scans and questionnaires to see if the hormone reduces inflammation and depressive symptoms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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