Could STI testing be the key to getting more women on HIV prevention?
NCT ID NCT06743204
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to either standard screening or standard screening plus STI testing. Researchers will track PrEP use, adherence, and persistence over six months to see if the extra testing makes a difference.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- STI diagnostic testing for chlamydia, gonorrhea, trichomonas, and syphilis
- What this could lead to
- If it works, this could show that routine STI testing helps identify more women at risk for HIV and encourages them to use PrEP consistently, potentially reducing new HIV infections in Africa.
- What could go wrong
- This is a large trial, but it's testing a screening strategy, not a new drug. The benefit depends on whether women act on the test results, and results may not apply outside Uganda.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Rakai Health Sciences Program
RECRUITINGKalisizo, Uganda
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