Can leg muscle metabolism explain fatigue in older adults with HIV?

NCT ID NCT04142047

Recruiting now Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how well leg muscles produce energy in older adults (60+) with and without HIV. Researchers will use MRI scans and walking tests to measure muscle metabolism and fatigue. The goal is to understand if metabolic problems in the calf muscle are linked to reduced exercise ability. 200 participants are being recruited at Johns Hopkins University.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help identify why older adults with HIV tire more easily, pointing toward ways to improve their muscle function and quality of life.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly provide a new therapy. Results may not apply to all older adults or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV HIV INFECTIONS

Contacts and locations

Locations

Johns Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States

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