HIV

This study checked how well the Prevnar 13 (PCV13) vaccine works to prevent pneumonia and related infections in adults with HIV. Researchers looked at health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The goal was to see i…

This early-stage trial tested a new HIV vaccine candidate in 57 healthy adults without HIV. The vaccine uses a protein designed to train the immune system to recognize HIV. The main goals were to check safety and see if the vaccine triggers a specific immune response. Results wil…

This study looked at how safe and effective the drug bedaquiline is for children and teens with a hard-to-treat form of tuberculosis (TB) that is resistant to the antibiotic rifampin. The trial included 54 participants, some of whom also had HIV. Researchers monitored side effect…

This study tested whether a weekly injection of PRO 140 could keep HIV under control in people whose virus was already suppressed by standard daily pills. Over 500 adults with a specific type of HIV (CCR5-tropic) switched from their usual combination therapy to PRO 140 alone for …

This study tested whether the statin drug pitavastatin could lower the risk of heart attacks, strokes, and other serious heart problems in over 7,700 adults with HIV who were already on HIV treatment. Participants were randomly assigned to take either pitavastatin or a placebo pi…

This study looked at what prevents people with HIV in northern Tanzania from getting care for heart attacks. Researchers tested a program where community health workers provided counseling, doctor visits, and phone calls to help control high blood pressure. The goal was to see if…

This study tested different methods of delivering HIV treatment to people in South Africa who had detectable virus or were not in care. About 874 adults took part. The goal was to see which approach—like incentives, community-based care, or home delivery—helped more people achiev…

This study tested a new program called iSTRIVE for 42 people with HIV who also use opioids or stimulants and were not well engaged in HIV care. The program taught emotion regulation and communication skills to help them stay in care and lower their viral load. The goal was to see…

This study tested a new medicine called LP-98, given as multiple shots under the skin, in 40 adults with HIV who had not taken any HIV drugs before. The main goals were to check if the shots are safe and how they affect the virus and the body. The results will help decide if LP-9…

This study tested a simple tool that helps doctors choose the right medicines to help people with HIV stop smoking. 371 participants who smoked at least 5 cigarettes a day took part. The tool aimed to increase the number of people who quit smoking for at least 7 days.

This study looked at whether people with HIV who have a low amount of virus in their body could safely switch from a three-drug treatment to a two-drug treatment. The goal was to keep the virus under control while reducing side effects and costs. 224 patients with well-controlled…

This study tested a program called Gender-affirming Abriendo Puertas for transgender women living with HIV in Santo Domingo. The program includes counseling, peer support, and community activities to help them stay on treatment and achieve viral suppression. About 120 participant…

This study looked at whether adults aged 50 and older living with HIV could safely switch from a three-drug pill to a simpler two-drug pill (DTG/3TC) while keeping the virus under control. About 200 participants who already had undetectable virus levels made the switch and were f…

This study looked at whether using genetic tests and checking drug levels in the blood can help doctors choose the right dose of HIV medication for each person. 190 adults starting HIV treatment for the first time took part. The goal was to see if this personalized approach reduc…

This study tested whether adding the drug efavirenz to standard HIV therapy is safe and can reduce the hidden HIV reservoir in the body. Seven adults with HIV on stable treatment took extra efavirenz for a period. Researchers measured virus levels in blood and tissues before and …

This study tested a program that gives small rewards to people with HIV who stop using stimulants like meth and take their HIV medicine. 37 adults took part in a primary care clinic. The goal was to see if this reward system is practical and helpful for managing both HIV and drug…

This study tested whether training healthcare providers to manage stress and reduce stigma could help people with HIV stay in care. Over 28,000 patients and staff at four health centers in Mozambique took part. The goal was to see if a low-cost program could improve patient reten…

This study tested two short programs for HIV-positive mothers and their children in China. One program focused on building resilience and coping skills, the other on improving medication adherence. The goal was to see if these programs could improve their quality of life and emot…

This small study tested a group discussion program for men who have sex with men in South Africa who struggle to take their HIV medication (either daily prevention pills or treatment pills). The goal was to see if talking about common mental health problems could help them stick …

This study tested a new medicine called Lipovirtide, given together with standard HIV drugs, in 64 adults with HIV who had never been treated before. The goal was to see if the combination could safely lower the amount of virus in the blood to very low levels. Participants receiv…

This study tested whether a program combining group savings, small business training, and mental health support could help people with HIV in Kenya stick to their medication and feel better. Over 800 participants took part. The goal was to improve viral suppression, reduce depres…

This study looked at whether dolutegravir, a newer HIV medicine, is safe and works well in pregnant women with untreated HIV. Sixty women in late pregnancy took either dolutegravir or standard HIV drugs. Researchers measured drug levels in the mothers and checked for side effects…

This study tested a program called Family Connections for HIV-positive youth aged 15-21 and their caregivers in Zambia. The goal was to help teens manage their HIV by achieving an undetectable viral load and reducing self-stigma through increased family and social support. About …

This study looked back at medical records of 800 people with HIV to compare two different drug combinations: a two-drug regimen (DTG/3TC) and a three-drug regimen (BIC/F/TAF). The goal was to see how well each kept the virus under control over 48 weeks. The study focused on real-…

This study tested a new clinic program to help people living with HIV. Over 10,000 patients used tablets to privately screen for substance use, depression, and anxiety during routine visits. Those who screened positive could then talk with an on-site specialist for counseling and…

This study tested two quick triage tests—CAD4TB software that analyzes chest X-rays and a C-reactive protein blood test—to see how accurately they can rule out pulmonary tuberculosis in adults with symptoms like cough or fever. Researchers enrolled 1,400 participants in Lesotho a…

This study tested whether a combination of improved HIV prevention and treatment tools, delivered through a community health program, could lower the rate of new HIV infections. Over 80,000 people aged 15 and older in East Africa took part. The approach focused on reaching everyo…

This study looked at how to give the HIV prevention pill (PrEP) to pregnant women in Sub-Saharan Africa in the best way. Researchers tested different doses in 54 pregnant women to see which dose provides enough protection without causing harm to the mother or baby. The goal is to…

This study tested a program called PALMS that uses live movement and sound to help African-American and Latino teen boys in juvenile justice or drug treatment centers reduce their risk of getting HIV. The program aimed to lower risky sexual behaviors and encourage HIV testing. Th…

This study adapted and tested a community-based HIV prevention program for people who inject drugs living along the U.S.-Mexico border. Researchers worked with 840 participants to understand how violence and stigma affect HIV risk, then used social networks, peer education, and c…

This study tested a program designed to help Latino men who have sex with men start taking PrEP, a daily pill that prevents HIV. 105 participants joined the study. The program was tailored to Latino culture and aimed to make it easier for men to get a prescription and stick with …

This study looked at whether giving HIV prevention pills (PrEP) right away at a syringe exchange program helps people stay HIV-negative. About 90 adults who were already part of the program and tested negative for HIV took part. Researchers measured how much of the medicine was i…

This study tested a digital program to help male couples create personalized plans to prevent HIV and other sexually transmitted infections. Over 770 couples joined, and researchers tracked their infection rates, communication, and commitment over 16 months. The goal was to see i…

This study tested two culturally adapted HIV prevention programs for African-born women living in the US. One program was one-on-one, the other was group-based. The goal was to see which better increased condom use and PrEP uptake. 149 HIV-negative women from Boston and NYC took …

This study tested a new once-monthly pill, MK-8527, to see if it is safe and how it works in people at low risk for HIV. 352 adults took either the pill or a placebo. The main goal was to check for side effects and how the drug moves through the body.

This study tested a mobile app called WeTest-WeLink to help high-risk men in China test themselves for HIV and connect to care. About 1800 HIV-negative men who have sex with men used the app or received standard information. Researchers checked how many completed self-testing and…

This study looked at whether offering HIV self-testing with online supervision helps young men who have sex with men (MSM) in Ho Chi Minh City get tested more often. One hundred participants aged 16-29 were enrolled. The goal was to see if this approach increases testing rates an…

This study followed 240 young men who have sex with men for two years to find better ways to help them stay on HIV PrEP (medication that prevents HIV) and avoid sexually transmitted infections. Participants used a smartphone app to track risks and received counseling if they thou…

This study tested whether a program made by and for women could help reduce the risk of HIV and other sexually transmitted diseases in women who use drugs. Over 500 women from the St. Louis area took part. They were split into three groups: one got basic HIV prevention advice, an…

This study tested a mobile app called SavvyHER designed to help Black women in the southern U.S. access HIV prevention tools and reproductive health information. Fifty-six Black women aged 18-44 who were HIV-negative and sexually active took part. The goal was to see if the app w…

This study tested a once-daily pill called Delstrigo as a 28-day treatment to prevent HIV after a possible exposure. 399 adults who came to the emergency room after a potential HIV contact took the pill. The main goal was to see how many people completed the full 28-day course.

This study tested a program called Couples Health CoOp Plus for young couples (ages 18-30) in Cape Town who use alcohol or drugs. The goal was to help them start and stick with HIV prevention (PrEP) or treatment (ART), reduce risky behaviors, and lower stigma in their communities…

This study looked at whether offering HIV prevention pills (PrEP) directly at pharmacies helps more people start and keep taking them. Over 5,800 people in Kenya took part across 60 pharmacies. Some pharmacies provided PrEP on-site, while others referred people to clinics. The go…

This study tested a combination HIV prevention approach for 120 men in Kisumu, Kenya, who had recently exchanged sex for money or goods. Participants were offered daily PrEP pills, along with tools like urine tests to check adherence, HIV self-testing kits, and text message remin…

This study tested a package of services to help adolescent girls and young women in Zambia get regular HIV testing and stay connected to care. The program included wellness clinics and community youth clubs to educate and support girls and their families. Over 2,000 girls aged 10…

This study created and tested a program to help Latino men who have sex with men get HIV prevention services (like PrEP) and mental health support. 90 participants from the Miami area took part. The goal was to see if the program could increase their use of these important health…

This study tested whether sending supportive messages via WhatsApp could encourage men who have sex with men in Mumbai and Thane to get tested for HIV and connect to preventive services like counseling or PrEP. Over 1,000 men took part. The goal was to see if a simple mobile tool…

This study tested whether a 12-week group therapy program based on cognitive behavioral therapy (CBT) is practical and well-liked by older adults with HIV. The program teaches skills to manage stress and adopt healthier habits. Fifty people aged 50 and older with well-controlled …

This small study tested whether a type of brain stimulation called TMS could help people living with HIV/AIDS who smoke reduce their cravings and attention to smoking cues. Four participants received either real or fake (sham) TMS sessions. The goal was to see if real TMS could i…

This study looked at whether a 16-week program of aerobic and resistance exercise could improve heart and muscle function and reduce inflammation in 33 HIV-infected veterans aged 50 and older. Participants exercised on treadmills and did strength training. The goal was to see if …

This study tested a new online therapy program designed to support the mental health of transgender and gender-diverse adults in Romania. The program consisted of 16 video sessions focused on LGBTQ-affirming counseling to help reduce depression, anxiety, and behaviors linked to H…

This study tested a new way to help women living with HIV get screened for HPV, a virus that can cause cervical cancer. The approach included simple scripts and videos to address fears and stigma. Over 980 women in Kenya took part, and researchers measured how many completed HPV …

This study tested whether using augmented reality (AR) on a smartphone helps men who have sex with men perform HIV self-tests more easily and confidently compared to standard paper instructions. About 200 participants in Hong Kong were split into two groups: one used an AR web ap…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS health problems like high blood pressure, diabetes, bone thinning, and kidney issues. Participants were on different anti-retroviral drug regimens, and researchers compar…

This study tested a program to help 219 incarcerated people with HIV, hepatitis C, or substance use disorder get health care after they leave prison. Participants worked with a nurse case manager before and after release to plan their care. The goal was to see if the program was …

This study enrolled over 1,100 people living with HIV whose dolutegravir-based treatment had failed (viral load over 1,000 copies/mL). Researchers collected blood samples and sequenced the virus's entire genome to identify drug-resistance mutations. The goal was to understand whi…

This study looked for undiagnosed HIV in 300 hospital patients who had signs or behaviors that put them at risk. Researchers used a quick finger-prick test at the bedside. The goal was to see how many people had HIV without knowing it, so they could get care sooner.

This study followed 1,377 people living with HIV in Liberia over about 3 years. Researchers collected health data, blood and urine samples, and asked questions about symptoms and behaviors. The goal was to better understand how HIV affects people in Liberia and to help improve lo…

This study looked at how much of certain HIV medications get into breastmilk. Twenty healthy volunteers who were finishing breastfeeding took a single dose of one of the drugs. Researchers measured drug levels in blood and milk to understand the balance between safety for the bab…

This study looked at how to better manage high blood pressure in people living with HIV in South Africa. Researchers worked with over 4,300 patients and healthcare workers to find barriers to care and design a practical program for clinics. The goal was to improve blood pressure …

This study followed 384 people with HIV who were already taking the medication TAF. Researchers measured drug levels in dried blood spots to see if those levels could predict whether the virus stays suppressed. The goal was to better understand how medication adherence relates to…

This study asked 36 women about their thoughts on using vaginal products to prevent HIV and other sexually transmitted infections. Participants completed a questionnaire about their sexual behavior and how often they might use such products. The goal was to gather opinions to hel…

This study looked at whether eHealth tools like video chats, online monitoring, and apps can help families manage long-term childhood illnesses such as cancer, heart disease, and preterm birth. Researchers worked with 720 families in Sweden and Denmark to see if these digital aid…

This study tested a new communication strategy to encourage HIV testing in Uganda. The messages focused on how HIV testing can help preserve relationships and build healthy families, especially with the availability of PrEP (a pill that prevents HIV). Over 7,600 people from two h…

This study looked at 90 adults with HIV in Uganda whose virus is well-controlled by medication. Researchers measured the hidden HIV that stays in the body (the latent reservoir) and compared it to similar patients in the U.S. The goal was to learn more about this reservoir to hel…

This study involved 13 transgender women to see if taking feminizing hormones changes how well Truvada (PrEP) works to prevent HIV. Participants took Truvada alone and then with different doses of estrogen. Researchers measured drug levels in blood, cells, and colon tissue to und…

This study tested a peer education program where people already stable on methadone were trained to talk to friends in their social network who inject drugs, some of whom have HIV. The goal was to see if this approach could help more people get into drug treatment. 241 participan…

This study tested special toolkits to help women living with HIV in Ghana perform their own HPV tests at home. The goal was to increase cervical cancer screening rates. Researchers worked with 108 women and tracked whether they completed and returned the self-sampling kits. The s…

This study followed about 1,900 pregnant women (some with HIV, some without) and their children for two years to see how HIV and the drug dolutegravir affect weight gain and body fat. Researchers measured things like weight, body composition, and blood markers in both mothers and…

This study tested a simpler way to deliver HIV care for pregnant and postpartum women and their babies at a hospital in Kenya. The goal was to see if this approach could make clinic visits faster and still keep mothers and infants healthy. Researchers tracked how well the model w…

This study tested whether offering small cash rewards ($25-$40) encourages more HIV testing among African American, Latina, and low-income women who face barriers to testing. Over 300 women from community organizations like homeless shelters and domestic violence agencies took pa…

This pilot study looked at whether a couple-based counseling program could improve quality of life and relationship satisfaction for male couples where one partner has HIV and the other does not. 88 couples in China took part, with some receiving three counseling sessions and oth…

This study followed 450 transgender people (300 HIV-negative and 150 living with HIV) in Thailand, Vietnam, and the Philippines for two years. Researchers used surveys and lab tests to track new HIV cases, mental health, and social issues like stigma and discrimination. The goal …

This study looked at how well the Pfizer COVID-19 vaccine works in adults with weakened immune systems (like kidney transplant patients, people with cancer, or those on dialysis) compared to healthy adults. Researchers measured antibody levels and their ability to neutralize the …

This study created and tested a digital program for unmarried pregnant teenagers living with HIV in Kenya. The goal was to help them understand and cope with stigma, and build skills to talk about their HIV and pregnancy with family members. 169 teens took part, using the program…

This study looked at 171 people with HIV to see if insomnia makes pain worse and increases inflammation. Researchers measured pain sensitivity, sleep patterns, and blood markers. The goal is to confirm that treating insomnia could help reduce pain and inflammation in people livin…

This study looked at tissue samples from tonsils, lymph nodes, intestines, and lungs of people with HIV and healthy volunteers. The goal was to measure virus levels and immune cells to better understand how HIV behaves in the body during treatment. About 386 adults took part, and…

This study tested a 5-month group program called Sweekar to reduce stigma and increase HIV testing and medication adherence among transgender and gender-diverse adults in Nepal. 31 participants joined group sessions addressing social stigma and HIV prevention. The study measured …

This study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and blood to see if immune cells in fat are linked to insulin resistance. The goal was to learn more about the connection, not to …

This study looked at how cannabis affects thinking, balance, and walking in 25 older women, some with HIV and some without. Participants took either cannabis or a placebo, then did tests like walking while reciting letters and reaching forward without losing balance. The goal was…

This study tested whether a wrist alcohol biosensor and a smartphone app could help young adults (ages 18-29) with HIV track their drinking. 66 participants wore the sensor for 30 days and reported their alcohol use through an app. Some received extra engagement tools like person…

This early-stage study tested a single injection of a new drug called LP-98 in 36 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo. The main goal was to check for side effects and measur…

This study followed 56 people with HIV who were starting treatment for the first time. Researchers measured changes in body fat, heart function, and blood vessel health before and after starting HIV medications. The goal was to understand how HIV therapy might affect long-term he…

This study tested 660 Ukrainian refugees in Slovakia for HIV, syphilis, and hepatitis B and C using finger-prick rapid tests. The goal was to find out how common these infections are in this community. Participants received counseling and, if positive, were referred for confirmat…

This study tested a new online mindfulness program designed to help young gay, bisexual, and queer men cope with stress and reduce their risk of HIV. Nineteen participants from across the U.S. tried the program and gave feedback on how easy it was to use and how much they liked i…

This study created and tested a short play (ethnodrama) to change how communities view young women who take PrEP, a daily pill that prevents HIV. Researchers worked with 63 people, including young women, their partners, friends, healthcare workers, and community leaders. Particip…

This study tested a training program for labor and delivery providers in Tanzania to reduce HIV stigma during childbirth. The training used simulations and hands-on learning. Researchers compared how respectful care was before and after the training, based on reports from women w…

This study looked at whether having emergency room nurses experience an HIV test themselves could improve their knowledge and reduce stigma toward people with HIV. About 74 nurses from a hospital in Taipei, Taiwan took part. Half received standard learning materials, while the ot…

This study tested a new rapid HIV test for babies and young children in Zambia. The goal was to see if faster diagnosis helps more infected infants start antiretroviral therapy (ART) sooner. Over 1,600 HIV-exposed infants took part, and the results showed improved treatment initi…

This study tested whether an online mindfulness program is practical and well-liked by young gay, bisexual, and queer men at risk for HIV. Researchers enrolled 68 participants and randomly assigned them to either the mindfulness program or a control group. The main goal was to se…

This study looked at whether giving extra training and support to staff at Boys and Girls Clubs helps them run teen sexual health programs better. About 900 youth aged 10-14 took part. The goal was to see if this support leads to healthier attitudes and behaviors around sex, preg…

This study tested whether a Buddhist mindfulness program could help people living with HIV in Myanmar and Thailand feel less stigma and improve their quality of life. Nineteen participants took part in the program, and researchers measured changes in stigma and mindfulness. The g…

This study looked at whether a document called Voicing My CHOiCES helps young adults (ages 18-39) with cancer or other serious illnesses talk about their care preferences. Participants filled out surveys and used the document with a healthcare provider. The goal was to see if it …

This study tested a new program called STARS for transgender women who have experienced intimate partner violence. The program aims to reduce HIV risk by promoting condom use, PrEP, and HIV testing. 37 participants were randomly assigned to STARS or a relaxation program and follo…

This study looked at 320 people with HIV in Chile, some with metabolic syndrome, to understand how ongoing inflammation affects their health. Researchers used advanced tools like single-cell sequencing and flow cytometry to analyze immune and inflammatory patterns. The goal was t…

This study looked at whether it is safe and effective for people with HIV to receive organ transplants from deceased donors who also had HIV. Researchers followed 13 HIV-positive patients who agreed to accept an organ from an HIV-positive donor, as well as others who received org…

This study looked at 227 people with HIV who are on antiretroviral therapy to see if poor oral health (like gum disease and cavities) is linked to ongoing inflammation and metabolic problems. Researchers measured dental health, bone density, and quality of life. The goal was to u…