HIV-Positive livers safe for HIV-Positive patients? landmark trial results

NCT ID NCT03734393

Completed Disease control Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This study looked at whether it is safe to transplant livers from deceased HIV-positive donors into HIV-positive recipients. Researchers followed 80 participants to track complications like graft failure, infections, and HIV breakthrough. The goal was to see if using HIV-positive organs could safely expand the donor pool for people with HIV.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Liver from an HIV-infected deceased donor
What this could lead to: If successful, this could expand the donor pool for HIV-positive patients needing liver transplants, reducing wait times and saving lives.
What could go wrong: This is a completed study with 80 participants, but results may not apply to all patients. Risks include graft failure, infections, and HIV-related complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AIDS chronic liver failure HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV

Contacts and locations

Locations

Columbia University Medical Center

New York, New York, 10032, United States
Emory University

Atlanta, Georgia, 30322, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Johns Hopkins University

Baltimore, Maryland, 21205, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
MedStar Georgetown Transplant Institute

Washington D.C., District of Columbia, 20007, United States
New York University School of Medicine

New York, New York, 11016, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
UPMC - University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Alabama, Birmingham

Birmingham, Alabama, 35294, United States
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States
University of California, San Diego

San Diego, California, 92103, United States
University of California, San Francisco

San Francisco, California, 94193, United States
University of Cincinnati

Cincinnati, Ohio, 45267, United States
University of Illinois at Chicago

Chicago, Illinois, 60612, United States
University of Maryland, Institute of Human Virology

Baltimore, Maryland, 21201, United States
University of Miami

Miami, Florida, 33136, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Tennessee Health and Science Center

Memphis, Tennessee, 38104, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Weill Cornell Medical College

New York, New York, 10065, United States
Yale University School of Medicine

New Haven, Connecticut, 06520-8022, United States

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