App and coaching help men stick with HIV prevention pill

NCT ID NCT05072093

Completed Disease control Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested a program to help men who have sex with men (MSM) stay on daily PrEP (a pill that prevents HIV) and reduce sexually transmitted infections (STIs). 240 men in Atlanta used a mobile app that flagged when they might stop PrEP, then a peer counselor and doctor stepped in to offer support. The study also offered on-demand PrEP (taking pills only around sex) and long-acting injectable PrEP as alternatives. Participants were followed for up to 2 years to see if they stayed on PrEP and how many got STIs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PrEP (Truvada) and on-demand PrEP
What this could lead to: If successful, this approach could help men at risk for HIV stay on PrEP longer and reduce sexually transmitted infections.
What could go wrong: This is a completed Phase 4 study with 240 participants in one city, so results may not apply to everyone. The intervention relies on app use and counseling, which may not work for all.

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Conditions

The condition(s) this trial relates to.

sexually transmitted disease bacterial sexually transmitted disease prevention target HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV STI

Contacts and locations

Locations

PRISM Research Center

Atlanta, Georgia, 30322, United States

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