Emory University

This study looks at whether a single booster dose of a meningitis B vaccine can protect young adults who got a different meningitis B vaccine at least 2.5 years ago. Researchers will measure immune responses in 125 healthy participants before and after the booster. The goal is to…

This early-stage trial tests whether infusions of stem cells from donated newborn tissue are safe for young people aged 4 to 39 with dilated cardiomyopathy, a condition where the heart becomes enlarged and weak. Up to 36 participants will receive three intravenous doses over 30 d…

This study tests whether community-based patient navigators can improve maternal health for Black women in a safety-net health system. 540 pregnant women with unmet social needs will be randomly assigned to receive either standard care or extra support from a navigator from mid-p…

This study tests a treatment called FBET to reduce elopement (wandering away) in children aged 4–12 with autism. About 50 children will receive either FBET or usual care at community clinics. Caregivers will help track progress and practice skills at home.

This study tests whether a caregiver-led telehealth program can help autistic children ages 5 to 12 who still have bowel accidents after completing treatment for bedwetting. About 150 children will take part. The program teaches caregivers strategies to manage encopresis, with th…

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This phase 1 trial is testing a new way to dose the chemotherapy drug melphalan for people with multiple myeloma who are getting a stem cell transplant. Instead of a standard dose, the amount is personalized based on each patient's blood levels after a test dose. The goal is to f…

This study tests whether a 12-week sleep-focused behavioral program can help adults with type 1 diabetes improve their sleep and blood sugar control. Participants learn sleep hygiene, stress management, and routines to target 7-9 hours of quality sleep. The study tracks sleep wit…

This study tests whether a program called Sisters for Heart Health can help farmworker women ages 18-50 reduce stress, feel less isolated, and improve their heart health. Participants will join weekly peer support groups led by trained community health workers for 10 weeks. The s…

This study tests a kidney health coaching program for Black patients with advanced chronic kidney disease. The goal is to help delay the need for dialysis or prevent early death. Researchers will also use a clinical decision support tool to improve screening and care. About 600 p…

This phase 2 trial tests whether adding the beta-blocker propranolol to the immunotherapy drug pembrolizumab can help shrink tumors in people with metastatic triple-negative breast cancer that has stopped responding to checkpoint inhibitors. About 37 adults with advanced, unresec…

This early-phase trial is testing whether combining an immunotherapy drug (atezolizumab) with targeted radiation and surgery is safe for people whose osteosarcoma has come back in the lungs. About 12 participants will receive the drug, radiation to one lung nodule, and then surge…

This phase 2 trial tests iberdomide, an immunotherapy drug, alone or with dexamethasone in 68 people with intermediate- or high-risk smoldering multiple myeloma. The goal is to see if the treatment can shrink or control the cancer cells and delay progression to active myeloma. Pa…

This early-stage trial tests a new drug called tegavivint combined with the chemotherapy gemcitabine in 24 people whose osteosarcoma (a type of bone cancer) has returned or not responded to prior treatment. The main goal is to find the safest dose of tegavivint when given with ge…

This trial tests a program called WeCare, which combines problem-solving therapy with support for taking HIV medication. It is designed for men who have sex with men (MSM) in South Africa. The study will enroll 60 participants to see if the program reduces depression and anxiety,…

This study tests whether a microbiome therapy—a capsule of healthy gut bacteria—can reduce drug-resistant bacteria living in the gut of hospitalized patients. About 40 adults who carry these superbugs will receive either the therapy or a placebo. The goal is to see if the treatme…

This phase 3 study is testing whether a low, personalized dose of FEIBA (aPCC) can safely control bleeding in children and adults with hemophilia A who have inhibitors and are already taking emicizumab. The study will measure how well the blood clots after FEIBA is given and trac…

This early-phase trial is testing whether combining two drugs—cabozantinib and enfortumab vedotin—can safely treat advanced bladder cancer that has spread. About 32 adults whose cancer worsened after standard treatments will receive the combo. The study aims to find the best dose…

This study looks at 200 infants under 1 year old who had heart surgery for congenital heart disease. After their breathing tube is removed, they will get one of two standard breathing supports: High Flow Nasal Cannula or Non-Invasive Positive Pressure Ventilation. The goal is to …

This study tests whether giving a combination of three chemotherapy drugs (gemcitabine, cisplatin, and nab-paclitaxel) before surgery can help shrink pancreatic tumors and improve outcomes. It includes 36 adults with pancreatic cancer that is either removable or borderline remova…

This phase II trial tests whether adding high-dose radiation to standard immunotherapy (pembrolizumab) and chemotherapy can help control metastatic triple-negative breast cancer that is PD-L1 positive. About 29 participants with at least two sites of metastatic disease will recei…

This phase II trial tests whether giving zanidatamab before surgery can shrink tumors in people with HER2+ colorectal cancer. About 38 participants will receive the drug intravenously, then undergo surgery. The study measures how much the tumor regresses and whether cancer return…

This study tests whether giving heart failure patients a one-page checklist of recommended medications helps doctors prescribe them more often. The checklist lists guideline-approved drugs and doses for heart failure with reduced ejection fraction. Researchers will enroll 4000 pa…

This study tests whether giving arginine (a natural protein) by IV can improve how cells produce energy in children hospitalized with COVID-19. About 21 kids aged 3 to 21 will receive one of three doses three times a day for up to five days. Researchers will measure changes in mi…

This study tests a combination of two targeted drugs (defactinib and avutometinib) plus an immunotherapy (nivolumab) in people with a specific type of advanced lung cancer (LKB1-mutant adenocarcinoma) that has stopped responding to standard treatment. The goal is to see if this t…

This early-stage trial tests a new drug called MRX-2843 combined with the standard targeted therapy osimertinib in people with advanced EGFR-mutant non-small cell lung cancer. The goal is to find the safest dose and see if the combination can stop tumor growth by blocking key enz…

This study looks at whether doing a small surgery early to remove blood from a deep brain bleed helps patients more than standard medical care. About 600 adults aged 18 to 70 with a specific type of brain bleed will take part. The goal is to see which approach leads to better rec…

This registry follows 735 people with mild Alzheimer's or mild cognitive impairment who are receiving an FDA-approved anti-amyloid drug (lecanemab) as part of their regular care. Researchers will track changes in memory, daily function, and caregiver needs over time to see how th…

This early-phase trial tests a personalized vaccine made from a patient's own tumor cells, given alone or with the immunotherapy drug pembrolizumab, for people with head and neck cancer that has returned or spread. The main goals are to check safety, find the best dose, and see i…

This early-phase study tests whether adding focused external radiation (SBRT) before a standard radioactive drug therapy (177Lu-DOTATATE) is safe and effective for people with large, inoperable neuroendocrine tumors of the digestive system. About 15 adults whose tumors have grown…

This phase 2 trial tests whether a year-long maintenance regimen of sirolimus (rapamycin) plus low-dose oral chemotherapy and celecoxib can improve 2-year survival without cancer progression in children with high-risk solid tumors. About 55 children and young adults (ages 1–30) w…

This study compares two different hormone therapy combinations (leuprolide plus abiraterone vs. relugolix plus abiraterone) in men with advanced prostate cancer who are also receiving radiation therapy. The goal is to see which combination causes less damage to the heart and bloo…

This study tests a shorter course of high-dose proton radiation for people with non-cancerous brain tumors like meningiomas and schwannomas. The goal is to see if fewer treatments can still control tumor growth while reducing side effects and being more convenient. About 70 adult…

This study tests whether giving regular blood transfusions during pregnancy can reduce sickle cell complications and pregnancy-related problems in women with sickle cell disease. About 50 pregnant women will be randomly assigned to receive transfusions or standard care. The goal …

This phase II trial is testing whether combining cabozantinib (a drug that blocks tumor growth and blood vessel formation) with pembrolizumab (an immunotherapy that helps the immune system attack cancer) can shrink tumors in people with advanced adrenocortical carcinoma. The stud…

This study tests a precise type of radiation called proton therapy for men with high-risk prostate cancer that has spread to lymph nodes. The goal is to see if targeting the tumor and nearby lymph nodes with protons causes fewer bowel and urinary side effects than standard radiat…

This phase II trial tests whether adding lovastatin, a common cholesterol-lowering drug, to the immunotherapy pembrolizumab can help shrink tumors in people with head and neck cancer that has returned or spread. The study will enroll 28 adults whose tumors express PD-L1. Research…

This phase II trial tests whether adding diclofenac, a common anti-inflammatory painkiller, can help control advanced non-small cell lung cancer when immunotherapy alone starts to show signs of failing. About 20 adults whose cancer has progressed while on standard immunotherapy d…

This early-phase trial tests whether adding low-dose interleukin-2 (IL-2) to the immunotherapy drug pembrolizumab (Keytruda) can better activate the immune system against stage IV non-small cell lung cancer. The study will enroll 15 people who have not had prior treatment for the…

This phase 2 trial is testing a combination of two drugs, acalabrutinib and obinutuzumab, in people with untreated follicular lymphoma or other slow-growing non-Hodgkin lymphomas. The goal is to see if this drug pair can shrink tumors and control the disease. About 49 participant…

This phase 2 trial tests whether adding celecoxib (a painkiller) to two immunotherapy drugs (durvalumab and tremelimumab) can help control advanced or metastatic liver cancer. About 39 adults with liver cancer that has spread will receive the combination. The goal is to see if it…

This early-phase trial is testing a personalized vaccine made from a patient's own tumor, given alone or with immune-boosting drugs (pembrolizumab or ipilimumab), for triple negative breast cancer. The goal is to see if the vaccine is safe and can train the immune system to attac…

This early-phase trial is testing whether giving children with advanced neuroblastoma or osteosarcoma a special type of immune cell (gamma delta T cells) from a healthy donor, along with several standard cancer drugs, is safe and tolerable. The study will enroll 24 children aged …

This study tests whether a 12-week sleep improvement program can help adults aged 18-40 with type 1 diabetes manage their blood sugar and reduce distress. Participants will receive coaching based on motivational interviewing and behavior change techniques. The study will track sl…

This study tests an investigational drug called eptacog beta (SEVENFACT®) in 6 people with Glanzmann Thrombasthenia, a rare inherited bleeding disorder. For the first 3 months, participants use their standard treatments for bleeding; then they switch to the study drug to treat se…

This study tests whether giving standard immunotherapy drugs (ipilimumab and nivolumab) in the morning works better than giving them later in the day for people with advanced melanoma that has spread or cannot be removed. About 99 adults with stage IV melanoma will be randomly as…

This phase 2 trial tests proton beam radiation therapy in 20 adults with non-small cell lung cancer that has spread to chest lymph nodes (N2) and has been surgically removed. Proton therapy targets cancer cells while sparing healthy tissue, potentially reducing recurrence risk. R…

This study tests whether giving a special mix of gut bacteria (microbiota therapy) can safely reduce the amount of drug-resistant germs living in the gut. About 60 adults who carry these superbugs will either receive the treatment or be observed. The goal is to see if the therapy…

This study tests a program called CARE-D-Foot-Nav, where a diabetes educator acts as a personal navigator for people with diabetic foot ulcers. The navigator helps with blood sugar control, wound care, transportation, and emotional support. Researchers want to see if this extra h…

This study tests whether mindfulness meditation and a mild nerve stimulation device can improve nerve function and blood pressure in people with chronic kidney disease. About 150 participants with moderate kidney disease will take part. The goal is to see if these approaches can …

This study tests a new way to help people with opioid use disorder in rural Georgia. Emergency rooms will use video calls to connect patients with poison center doctors who can start medication (buprenorphine) and link them to peer recovery coaches. The goal is to see if this app…

This study tests whether using a Dexcom G7 continuous glucose monitor (CGM) instead of standard fingerstick blood sugar checks leads to better blood sugar control and fewer dangerous lows in hospitalized adults with type 1 diabetes. One hundred participants will be randomly assig…

This study tests the safety of a wearable device called Optune that creates low-intensity electric fields to disrupt cancer cell division in brainstem gliomas. Ten adults with this rare brain tumor will wear the device to see if it can slow tumor growth without serious side effec…

This trial tests whether the immunotherapy drug toripalimab can lower the chance of cancer coming back after surgery in people with mismatch repair deficient (dMMR) stage IIB, IIC, or III colon cancer. About 40 participants will receive toripalimab intravenously. The study will t…

This phase II trial tests whether atovaquone, a drug currently used to treat certain infections, can help control platinum-resistant ovarian cancer. The study enrolls 28 patients whose cancer has progressed within six months of their last platinum-based chemotherapy. Participants…

This phase 2 trial is testing whether a combination of belantamab mafodotin, pomalidomide, and dexamethasone can help prevent high-risk myeloma from returning after a stem cell transplant. About 34 patients who have already responded to transplant will receive the drug combo as m…

This study is testing whether a portable eye-tracking device can accurately screen 9-month-old infants for autism spectrum disorder (ASD). Over 2,000 babies will watch short videos while cameras track their eye movements. Researchers will then compare these results with standard …

This study tests whether a smartwatch algorithm can detect atrial fibrillation (AF), an irregular heartbeat that often goes unnoticed and raises stroke risk. Researchers will enroll 500 stroke survivors who will wear a standard heart monitor and a study-provided smartwatch for 30…

This study tests a new, non-invasive imaging device that uses red light to look at skin lesions. Researchers want to see if it can help doctors diagnose skin cancer without needing a biopsy. The study will enroll 10 adults with skin lesions at Emory University.

This study looks at whether a simple blood test can help doctors decide if a head CT scan is really needed after a mild head injury. Researchers will collect blood samples from 350 adults with mild head trauma and see if the test results match the need for imaging. The goal is to…

This study tests whether a non-invasive brain stimulation technique called TMS, given within two weeks of a traumatic event, can prevent chronic PTSD. Researchers will measure changes in brain activity linked to fear and threat. The goal is to see if early intervention can reduce…

This study tests a program to help tribal households go smoke-free, aiming to reduce secondhand smoke exposure and prevent tobacco-related cancers. About 575 adults who smoke or live with a smoker and do not already have a smoke-free home will take part. The program focuses on ch…

This study tests whether a parent-led online program can improve sleep in autistic children aged 3 to 7 years. About 130 children will be randomly assigned to one of two behavioral sleep programs for 10 weeks. The goal is to see if the structured program reduces insomnia symptoms…

This study tests whether infliximab, an anti-inflammatory drug used for arthritis, can improve motivation and brain activity in people with schizophrenia who have high inflammation. Sixty adults with schizophrenia will receive either infliximab or a placebo, and researchers will …

This study looks at how Behavioral Activation (BA) therapy affects the brains of depressed teenagers. 136 teens aged 15-17 with depression will receive up to 16 therapy sessions focused on increasing rewarding activities. Researchers will use brain scans (fMRI) to see if BA thera…

This study tests a program called TRACT that helps cancer patients with travel to their radiation therapy appointments. Many patients miss or delay treatment due to transportation issues. The program provides navigation support and resources. Researchers will see if it is practic…

This study tests a robot-guided exercise program for people with mild to moderate Parkinson's disease. Participants will do exercises three times a week for three weeks, either in person or remotely. The goal is to see if the program is safe, doable, and helps improve movement an…

This study tests whether a single dose of MDMA, given alongside two weeks of daily exposure therapy, can reduce PTSD symptoms more than therapy alone. About 95 adults with PTSD will take either MDMA or a placebo during one therapy session. Researchers will check symptom changes o…

This study compares a standard opioid painkiller (oxycodone) to a placebo in people recovering from orthopedic surgery like joint replacements. The goal is to see if a non-opioid pain management plan can control pain just as well. About 80 adults having various orthopedic procedu…

This study tests whether exercising to beat-accented music helps older adults (65+) with memory concerns stay active and improve thinking skills. Eighty participants will be randomly assigned to a 6-month exercise program with or without special music. The goal is to see if music…

This study tests a web-based program called CARE-CITE that teaches family caregivers how to better support stroke survivors with arm exercises at home. The program includes virtual home visits and phone check-ins over four weeks. Researchers will measure improvements in arm funct…

This study tests whether a non-invasive device that delivers a mild electrical current to the head (cranial electrical stimulation) can reduce pain and other symptoms in veterans with Gulf War Illness. About 130 participants aged 40-80 will receive either real or sham stimulation…

This study tests whether gentle chest vibration or breath focus exercises can reduce symptoms of dissociation in people who have experienced trauma. Researchers will measure changes in brain activity and self-reported symptoms over 8 sessions. The goal is to understand if these s…

This study tests whether a pain management plan that limits opioids can help adults who need hip replacement surgery use fewer opioids while still controlling pain well. About 120 people having anterior total hip replacement will be randomly assigned to either the opioid-sparing …

This study is testing whether a painless brain stimulation technique called tDCS can reduce chronic pain in 100 military members and veterans. Participants will receive tDCS while taking part in a behavioral health program, and researchers will track changes in pain levels and da…

This study tests whether a low dose of naltrexone, a drug normally used for addiction, can safely reduce chronic nerve pain in people with HIV. About 60 adults with HIV and nerve pain will take the drug for 12 weeks and report their pain levels. The goal is to find a cheaper, non…

This study tests a virtual group program that teaches teens with inflammatory bowel disease (IBD) coping skills and heart rate biofeedback to reduce stress, anxiety, and depression. About 128 participants aged 13–18 will be randomly assigned to the program or a waitlist. The goal…

This study tests whether a non-invasive device that stimulates the vagus nerve in the neck can reduce withdrawal symptoms in people with opioid use disorder. About 103 participants will stay in the hospital for a week, receive either active or sham stimulation, and have brain sca…

This study tests whether a 6-day course of the steroid Medrol (methylprednisolone) can lower pain, nausea, and the need for opioid painkillers after foot or ankle surgery. About 180 adults having surgery at Emory will take either the steroid or a placebo, plus a small supply of h…

This study tests a 6-week videoconference program that teaches sleep-improving skills to older adults with memory loss or dementia and their care partners. About 80 participants will join either individually or together. The goal is to see if the program is practical, acceptable,…

This study compares two numbing medicines given as nerve blocks before total ankle replacement surgery. One is EXPAREL, a long-acting form of bupivacaine, and the other is standard bupivacaine. Researchers want to see if EXPAREL provides better pain relief and reduces the need fo…

This study tests whether slowly reducing the dose of the steroid dexamethasone after brain tumor surgery can lower side effects like high blood sugar and poor wound healing, while still preventing brain swelling. About 200 adults with certain brain tumors will be randomly assigne…

This study tests whether methylprednisolone works better than dexamethasone at preventing allergic reactions to motixafortide, a drug used to help collect stem cells for transplant in multiple myeloma patients. About 94 adults with multiple myeloma will be randomly assigned to re…

This study tests a behavioral program designed to reduce psychological distress (PTSD and depression) in Black transgender women who experience chronic stigma. The program includes weekly group sessions led by a community member and a nurse, plus online educational materials and …

This study tests a nerve block called ganglion impar neurolysis to see if it can reduce pain caused by radiation therapy for anal cancer. Five adults with localized anal cancer who are getting chemotherapy and radiation will receive the nerve block. Researchers will track pain sc…

This study tests whether in-person acupuncture or virtual acupressure can prevent joint pain caused by aromatase inhibitors, a common hormone therapy for breast cancer. It focuses on Non-Hispanic Black women with early-stage breast cancer, who are more likely to stop treatment du…

This study tests whether L-DOPA, a drug used for Parkinson's, can improve anhedonia (loss of interest or pleasure) in people with depression who also have high inflammation. Seventy adults aged 25-55 will receive either L-DOPA or a placebo for 8 weeks. Researchers will measure ch…

This study tests a small device that gently stimulates nerves in the ear to see if it can help relieve pain in children with sickle cell disease during a pain crisis. About 20 children hospitalized for pain will try the device. The main goal is to see if kids can tolerate it and …

This study tests an online program called CAN-DO that teaches dementia caregivers skills to handle healthcare, financial, legal, and family issues. 270 caregivers will take the course either right away or after a wait, and complete surveys over 6 months. The goal is to see if the…

This study tests a virtual, home-based exercise program for teens and young adults who had a brain tumor and received radiation. The goal is to see if the program helps with memory and attention problems, and how it affects gut bacteria. About 60 participants will be randomly ass…

This study tests whether taking oral progesterone (200 mg daily) can reduce psychological distress in transgender women who have been on hormone therapy for at least 6 months. It also looks at effects on sleep, breast size, quality of life, and heart health. About 40 participants…

This study tests whether playing online games like Connect 4 and Uno with a partner three times a week for 12 weeks can help older adults (ages 50-85) with and without mild cognitive impairment feel less lonely and more socially engaged. Participants will play via a special onlin…

This study tests a web-based program designed to help people with colorectal cancer and their caregivers manage common but distressing symptoms like fatigue, depression, sleep problems, pain, and brain fog. The program is for patients currently on chemotherapy and their main fami…

This study looks at whether mindfulness training can improve recovery for college athletes who need surgery for sports injuries. About 40 athletes aged 18-26 will either get mindfulness training or standard care. Researchers will track pain, physical function, and mental health f…

This study tests a group telehealth program called I-STRONG for teens with sickle cell disease who have chronic pain. The program combines mind-body skills with movement training to help teens cope better and reduce fear of pain. Researchers will enroll 155 teens aged 12-18 to se…

This study tests whether giving the chemotherapy drug oxaliplatin over 6 hours instead of the usual 2 hours can prevent or delay nerve damage in people with gastrointestinal cancers. About 60 participants will be randomly assigned to one of two infusion times. The goal is to see …

This early-phase study tests whether giving palliative radiotherapy together with the drug lurbinectedin is safe for people with extensive-stage small cell lung cancer that has spread beyond the chest. The goal is to relieve symptoms caused by the cancer. About 22 adults whose ca…

This study looks at whether releasing a small chest muscle (pectoralis minor) during reverse shoulder replacement helps reduce pain and improve arm movement. About 90 adults getting this surgery will be randomly assigned to have the muscle released or not. Researchers will compar…

This phase 2 trial tests whether taking sodium bicarbonate pills and doing regular stationary bike exercise can improve exercise capacity in people with chronic kidney disease (CKD). Researchers will enroll 156 adults with CKD, kidney transplant recipients, or healthy controls. P…

This study looks at whether the method of delivering voice therapy affects how well people with voice problems (like muscle tension dysphonia or vocal cord lesions) can communicate over a year. About 120 adults who do not smoke and have not had voice therapy or surgery recently w…

This study tests an online course for people who have recently become caregivers for a family member or friend with dementia. The program includes weekly video sessions and self-paced materials to help caregivers feel more confident and less stressed. Researchers will measure cha…

This study looks at whether a special therapy done at home through video calls can help infants with cerebral palsy use their weaker arm more. About 267 babies aged 4 to 13 months will be assigned to different sequences of the therapy or standard care. The goal is to see if the t…

This study tests whether a virtual exercise program can help children and young adults (ages 8-23) recover physical function and quality of life after a stem cell transplant. Participants will have twice-weekly, 30-minute online sessions with a physical therapist for 12 weeks. Th…

This early-phase trial tests whether giving the amino acid arginine alongside whole brain radiation is safe and how best to give it (by mouth or IV). Ten adults with cancer that has spread to the brain will receive arginine daily during their 10-day radiation course. The goal is …

This study tests whether baricitinib, an anti-inflammatory drug used for arthritis, can improve motivation and brain function in people with major depression who have high inflammation. One hundred adults aged 25-55 with depression and elevated C-reactive protein will receive eit…

This pilot study tests whether an individualized online home-based exercise program can reduce pain, fatigue, sleep problems, depression, and memory issues in gynecologic cancer survivors. Forty women who have finished cancer treatment will follow a tailored exercise plan via Zoo…

This study uses a special catheter to record detailed electrical signals from the heart during a standard procedure for dangerous heart rhythms (ventricular tachycardia). Researchers aim to better understand why these rhythms start and how to pinpoint the exact trouble spots. Ten…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This registry is following 5,000 adults with coronary artery disease who received a drug-coated balloon during a procedure to open blocked heart arteries. Researchers are tracking how often the treated artery fails, heart attacks, repeat procedures, and bleeding over the long ter…

This study looks at how blood sugar changes day-to-day in people with ketosis-prone diabetes as they go into remission. Researchers will use this data to build a math model that describes the remission process. The study involves 12 African American adults with a BMI of 28 or hig…

This study is testing a new, quicker way to diagnose autism in toddlers aged 16-30 months who are already flagged as high risk. Researchers will track how many families are referred, agree to join, and complete the process, including a telehealth option. The goal is to see if thi…

This study is testing whether a mobile app called Fabla-diabetesMM, which lets people record audio diaries, is easy and helpful for older adults with type 1 or 2 diabetes who also have other health conditions. Thirty participants will use the app and answer questions about their …

This study looks at whether listening to personalized, tempo-synchronous music playlists can help sedentary older adults exercise more and enjoy it. Researchers will track 150 community-dwelling seniors over 8 months as they participate in supervised exercise sessions with music.…

This study tests whether a low-added-sugar, high-fat diet can reduce diabetes risk in adults with cystic fibrosis (CF). Sixty participants will receive either a low-sugar or standard CF diet for 8 weeks. Researchers will measure changes in insulin production, body fat, and blood …

This study looks at whether inflammation in the brain causes symptoms like loss of interest and slow movement in depressed people with HIV. Sixty participants will receive either the anti-inflammatory drug baricitinib or a placebo for 10 weeks. Researchers will use brain scans an…

This study looks at how a single dose of ketamine changes brain chemistry and decision-making in people with major depression. Researchers will measure brain glutamate levels and stress responses in 140 participants. The goal is to understand why ketamine helps some people with d…

This study looks at whether a family history screening program can help more women in rural public health clinics get tested for genetic risks linked to breast and ovarian cancer. About 3,200 women over age 25 will take part. The goal is to see if the program increases the number…

This study aims to find the best way to train early intervention providers to deliver high-quality services to children under 3 with communication delays or autism. Researchers will compare two training models for a program called Project ImPACT, measuring how well therapists lea…

This study looks at whether combining prism adaptation training with electrical stimulation can help people who have had a stroke and have spatial neglect (trouble noticing things on one side). Researchers will measure changes in pointing behavior, brain activity, and walking abi…

This study aims to understand why people with post-traumatic stress disorder (PTSD) have a higher risk of heart disease and high blood pressure. Researchers will measure nerve activity and test whether the drug losartan can lower high adrenaline levels during stress. The study in…

This study looks at how the amount of muscle and fat in the body affects glucose tolerance and lung function in people aged 16-30 with cystic fibrosis. Researchers will use MRI scans and glucose tests to track changes over two years. The goal is to use this information to improve…

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and often experience high blood pressure during physical activity. Researchers will test whether regular cycling exercise, a drug called Kuvan, or supplements like histidine and beta-alanine …

This study looks at why people with chronic kidney disease (CKD) have trouble exercising and why their blood pressure rises during activity. Researchers will measure muscle oxygen and acid levels in 110 veterans with and without CKD. The goal is to understand the body's response,…

This study looks at how much protein adults with PKU need, based on their specific genetic mutation and the special medical foods they eat. Researchers will measure how the body processes a harmless tracer to find the right protein levels. The goal is to improve dietary recommend…

This study looks at whether a special camp that teaches teens and young women with PKU or MSUD about their condition and nutrition can improve their pregnancy outcomes and quality of life. Researchers will compare the results of women who attended the camp to those who did not. T…

This pilot study is looking at how the immune system responds in people with early-stage triple negative breast cancer who receive standard chemotherapy plus the immunotherapy drug pembrolizumab before surgery. The goal is to see if certain immune markers in the blood or tumor ti…

This study tests a new group program called Compassion-Centered Spiritual Health Team Intervention (CCSH-TI) for healthcare workers at a cancer center. The program uses mindfulness and compassion exercises to help staff handle stress and improve teamwork. Researchers will enroll …

This study uses small pieces of heart tissue removed during necessary surgery in children with congenital heart disease. Researchers want to understand how calcium controls heart cell contraction and how infant heart cells differ from adult ones. They also aim to improve lab-grow…

This study is testing whether the antibiotic doxycycline, already used to prevent bacterial STIs after sex, also changes inflammation levels and the natural bacteria in the body. Researchers will enroll 200 men, including those with HIV and those on PrEP, and measure immune marke…

This study tests whether offering hearing tests close to home or remotely increases how many head and neck cancer patients get their hearing checked during treatment. Many patients on cisplatin chemotherapy or radiation near the ear can lose hearing, but not all complete recommen…

This study looks at whether a balance exercise called IVA is safe and helpful for adults who have vision problems, with or without inner-ear balance issues. Researchers will compare two groups: people with vision problems only and those with both vision and inner-ear problems. Pa…

This study looks at whether drinking pasteurized milk containing harmless, inactive flu virus particles could lead to a positive flu test from a nose or throat swab. Researchers want to help the CDC improve how flu is tracked. About 30 healthy adults aged 18-64 will drink the mil…

This study looks at how patients and doctors discuss immunotherapy, a type of cancer treatment. Researchers want to find out where patients get their information, what they understand, and how doctors explain it. They will also test if educational videos can help patients learn m…

This study aims to find the best ways to help families in Cambodia switch from wood or charcoal stoves to electric induction stoves. Researchers will track stove use and measure home air pollution in 6150 households across 65 villages. The goal is to see if this switch is practic…

This study gives healthy adults a controlled dose of flu virus to see how their immune system responds and how the virus travels through the air. Researchers will track who gets mild to moderate flu symptoms and monitor safety. The goal is to learn more about flu infection, not t…

This study looks at how deep brain stimulation (DBS) affects the ability to stop actions in people with Parkinson's disease. Researchers will measure brain waves and behavior during impulse control tasks before, during, and after DBS surgery. The goal is to understand how stimula…

This study tests a soft, wearable stethoscope that can continuously listen to a child's breathing and detect wheezing, a sign of an asthma attack. Researchers at Emory University will enroll 25 children hospitalized for asthma to wear the device for up to 8 hours. The goal is to …

This study tests whether a special type of MRI, called spectroscopic MRI, can help guide proton therapy for children with high-grade glioma. The MRI maps tumor metabolism without needing a contrast dye. Researchers hope this will allow more precise radiation targeting. About 25 c…

This study looks at how people with mild cognitive impairment (MCI) and Alzheimer's disease adjust their walking when conditions change, like walking on different surfaces. Researchers will measure walking patterns, memory, and thinking skills in 10 older adults. The goal is to b…

This study gives healthy adults aged 18-49 a controlled dose of the H3N2 flu virus via nasal spray to observe how the immune system fights it and how the virus spreads. Participants stay in the hospital for 8-12 days for close monitoring, with follow-up visits over 5 months. The …

This study looks at how the amount of nicotine and the pH level in nicotine pouches influence how appealing and addictive they feel to young adult users. Researchers will have 84 participants try different pouches and rate their experience. The goal is to help regulators understa…

This study tests different message styles sent through the MyChart patient portal to see which one gets more patients interested in joining research studies. Up to 100,000 patients will receive one of several message types, such as a standard neutral message, a positive message, …

This study looks at how the immune system of people with lymphoma responds to flu and COVID vaccines. Researchers will measure antibody levels and immune cells over time in 200 participants with different types of lymphoma. The goal is to understand how lymphoma and its treatment…

This study looks at whether an educational supplement—using models and props during a face-to-face interview—can help African-American men newly diagnosed with early-stage prostate cancer better understand their treatment options and side effects. Researchers will interview 210 p…

This study looks at how mental stress impacts the small blood vessels of the heart in postmenopausal women with coronary microvascular dysfunction (CMD). Researchers will measure heart activity, stress responses, and daily symptoms in 150 women using imaging, questionnaires, and …

This study follows 45 people with PKU who are taking Palynziq to see how the drug changes their diet, brain health, and nutrition. Researchers will track protein intake and blood levels over time. The goal is to understand the full impact of Palynziq beyond just lowering phenylal…

This study looks at why people with PTSD have a higher risk of heart problems. Researchers will measure nerve activity and test if two daily therapies—a breathing technique or a mild nerve stimulation device—can calm the overactive nervous system. About 120 veterans with and with…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce these behaviors and improve quality of life. About 130 English-speaking adults with bipol…

This study compares a standard survivorship care plan to one tailored for low health literacy in 150 African American men who have finished treatment for localized or limited-spread prostate cancer. The goal is to see if the tailored plan helps them better understand their follow…

This study aims to understand how depression affects decision-making, especially when choices are difficult. Researchers will use brain stimulation techniques (TMS and TI) on 500 participants with depression and healthy controls while they perform game-like tasks. The goal is to …

This study is testing a new wearable patch that uses a microphone to listen to swallowing sounds in people who have trouble swallowing after a stroke. The patch is placed on the neck and records sounds during a standard swallowing X-ray test. Researchers will use machine learning…

This study looks at how muscle scarring in the esophagus relates to swallowing problems in people with achalasia. Researchers will use a special probe and muscle biopsies to measure scarring and muscle function. The goal is to better understand the disease so doctors can treat it…

This study follows children under 21 who have a genetic condition that raises their risk of developing cancer, along with their relatives. Researchers will collect health information and samples over time to better understand how these cancers develop and how to catch them early.…

This study explores whether a non-invasive brain stimulation technique called cTBS can disrupt the consolidation of fear memories shortly after a traumatic event. Researchers will use functional MRI and skin conductance responses to measure changes in brain connections and fear r…

This study compares two different screening methods for PTSD in pregnant Black women to see which one better improves mental health, use of prenatal and mental health care, and birth outcomes. About 804 Black women in their first trimester who have experienced at least one trauma…

This study looks at how radiation therapy for head and neck cancers affects the blood vessels in the neck. Researchers will use two types of PET/CT scans to compare images taken before and after treatment. The goal is to better understand and detect radiation-related vascular dam…

This study looks at how the amount of air in your lungs affects throat collapse during sleep in people with obstructive sleep apnea (OSA). Researchers will use a special camera to watch the throat while patients are sedated, and try changing lung volume with a chest device or nec…

This study is testing a group program called Weyera to see if it helps Ethiopian and Eritrean young adults (ages 18-29) in Atlanta feel better mentally and emotionally. The program focuses on building resilience and coping skills. Researchers want to know if the program is accept…

This study follows 120 men with hemophilia A who have developed inhibitors (antibodies that block standard treatment). Researchers will observe how doctors manage their condition using different therapies, including immune tolerance induction and newer drugs like emicizumab. The …