Immune cell combo shows promise for tough childhood cancers
NCT ID NCT05400603
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether giving children with advanced neuroblastoma or osteosarcoma a special type of immune cell (gamma delta T cells) from a healthy donor, along with several standard cancer drugs, is safe and tolerable. The study will enroll 24 children aged 1 and older whose cancer has not responded to or has returned after previous treatments. The main goal is to find the best dose of the immune cells to use in future studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
gamma delta T cells (immune cells from a healthy donor) plus dinutuximab, temozolomide, irinotecan, and zoledronate
What this could lead to
If it works, this could offer a new treatment option for children with neuroblastoma or osteosarcoma that has not responded to standard therapy.
What could go wrong
This is a very early, small phase 1 trial focused on finding a safe dose, not on proving effectiveness. The combination therapy may cause serious side effects, and the immune cells might not work as hoped.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Healthcare of Atlanta
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Email: •••••@•••••