Alzheimer's drug under the microscope: Real-World registry launches

NCT ID NCT05999084

ENROLLING_BY_INVITATION Disease control Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This registry follows 735 people with mild Alzheimer's or mild cognitive impairment who are receiving an FDA-approved anti-amyloid drug (lecanemab) as part of their regular care. Researchers will track changes in memory, daily function, and caregiver needs over time to see how the drug performs outside of clinical trials. Participants must be between 50 and 90 years old and have confirmed amyloid buildup in the brain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lecanemab (anti-amyloid monoclonal antibody)
What this could lead to: If successful, this registry could provide real-world evidence on how well anti-amyloid drugs work for Alzheimer's in everyday clinics.
What could go wrong: This is an observational registry, not a controlled trial, so results may be less definitive. The drug requires ongoing infusions and may have side effects like brain swelling or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

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Locations

Emory Cognitive Neurology Clinic at the Emory Brain Health Center

Atlanta, Georgia, 30322, United States
Georgia Memory Net Memory Assessment Clinic - Albany

Albany, Georgia, 31707, United States
Georgia Memory Net Memory Assessment Clinic - Atlanta

Atlanta, Georgia, 30303, United States
Georgia Memory Net Memory Assessment Clinic - Augusta

Augusta, Georgia, 30912, United States
Georgia Memory Net Memory Assessment Clinic - Gainesville

Gainesville, Georgia, 30501, United States
Georgia Memory Net Memory Assessment Clinic - Macon

Macon, Georgia, 31206, United States
Georgia Memory Net Memory Assessment Clinic - Savannah

Savannah, Georgia, 31406, United States
Georgia Memory Net Memory Assessment Clinic - Vidalia

Vidalia, Georgia, 30474, United States

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