Emory University

This study tests a non-invasive pneumatic vest designed to apply pressure to the chest wall in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 who are on mechanical ventilators. The goal is to see if the vest can improve oxygen levels in the blood. Up …

This phase II trial tests whether combining three drugs—bendamustine, obinutuzumab, and venetoclax—can improve outcomes for people with untreated mantle cell lymphoma. Bendamustine and venetoclax are chemotherapy drugs that kill or stop cancer cells from growing, while obinutuzum…

This study aimed to see if an 8-week low-calorie diet (about 1,300 calories per day) could reverse isolated impaired fasting glucose, a form of prediabetes, in overweight adults aged 35 to 65. Participants would have received pre-prepared meals and been monitored for changes in b…

This early-phase trial is testing whether giving testosterone replacement therapy to men with low testosterone before and after major urologic surgery is safe and might improve recovery. Researchers will track quality of life, frailty, complications, hospital stay length, and rea…

This study tests whether a dedicated asthma navigator—a respiratory therapist who provides education, scheduling help, and phone support—can reduce repeat hospital visits for children aged 5–16 admitted to the PICU for asthma. The goal is to improve health equity by addressing ba…

This phase 2 trial is testing whether the drug cabozantinib can shrink tumors in 22 people with advanced kidney cancer before they have surgery. The goal is to see if the drug reduces tumor size enough to improve surgical outcomes and delay cancer return. Participants take caboza…

This early-phase trial is testing whether adding an experimental drug called VX15/2503 to standard immunotherapies (ipilimumab or nivolumab) can help treat stage IIIB-D melanoma that can be removed by surgery. About 41 participants will receive the drug combination before surgery…

This study tests whether giving two drugs—lenvatinib and pembrolizumab—before surgery can shrink tumors in people with locally advanced kidney cancer that hasn't spread to other organs. About 18 participants will receive the combination for 12 weeks before their operation. The go…

This study looks at whether giving a lower dose of radiation after robotic surgery can help people with HPV-positive throat cancer have fewer side effects, like trouble swallowing, while still controlling the cancer. About 33 adults with this type of cancer will receive the reduc…

This study tests whether virtual or in-person support helps teens with HIV stay in care and keep the virus under control. About 570 teens aged 15-19 in South Africa will receive either standard care or extra support to prepare for moving to adult clinics. The goal is to see which…

This study tests a daily combination of sirolimus, celecoxib, and low-dose chemotherapy in 46 children whose solid or brain tumors have returned or not responded to standard treatment. The goal is to see if this approach can shrink tumors or stop them from growing. While not a cu…

This study compares continuing oral diabetes medications (like metformin) versus switching to insulin in hospitalized adults with type 2 diabetes. About 255 participants will be randomly assigned to either stay on their usual pills or receive insulin injections. The goal is to se…

This study tests whether adding the drug abatacept to standard care can prevent graft-versus-host disease (GVHD) in children receiving stem cell transplants from unrelated donors. GVHD occurs when donor cells attack the patient's body, causing serious illness. The trial will enro…

This early-phase trial tests whether adding the drug isatuximab to standard chemotherapy can safely treat people with high-risk AL amyloidosis, a rare disease where abnormal proteins damage organs. Eleven participants will receive the combination to see if it reduces toxicity and…

This phase 2 trial is testing whether adding propranolol, a common blood pressure drug, to standard immunotherapy can help control advanced bladder cancer. The study enrolled 6 adults with urothelial carcinoma that has spread or cannot be removed by surgery. Researchers are prima…

This early-phase trial tests two drugs—venetoclax and tocilizumab—in people with a specific type of multiple myeloma (t(11;14)) that has come back or stopped responding to treatment. The study includes both African American and non-African American participants to see how safe th…

This study tests a combination of three drugs (chemotherapy, anti-angiogenesis, and immunotherapy) in 30 adults with advanced non-small cell lung cancer that worsened after standard treatments. The goal is to see if this triple therapy is safe and works better than current option…

This phase 2 trial is testing whether the immunotherapy drug atezolizumab, given before surgery, can help treat HPV-related throat cancer that can be removed. About 20 adults with stage I oropharyngeal cancer will receive two doses of atezolizumab followed by standard surgery. Th…

This study tests two drugs, pembrolizumab and cabozantinib, in 36 people with head and neck cancer that has returned or spread and cannot be surgically removed. The goal is to see if the combination shrinks tumors and delays cancer growth. Participants receive both drugs intraven…

This phase II trial is testing whether combining two drugs—niraparib and panitumumab—can help people with advanced colorectal cancer that has spread. The study includes 26 patients whose cancer has not responded to at least one prior treatment. The goal is to see if the combinati…

This early trial tests two oral drugs, defactinib and VS-6766, in 14 people with glioblastoma. The goal is to see how much drug reaches the brain tumor and check for side effects. Both drugs block different growth pathways that help glioblastoma cells grow. This study only looks …

This early-phase trial tests whether combining two types of targeted radiation is safe for men whose prostate cancer has returned after prostate removal surgery. The treatment uses a special scan to find cancer cells, then delivers high-energy rays and a radioactive drug directly…

This study tests whether using a blood test score (based on four proteins linked to heart risk) can help doctors choose the best treatments for people with coronary artery disease. 276 adults with stable heart disease will either get standard care or a customized plan that includ…

This phase 2 trial tests whether kidney transplant patients can safely switch from monthly belatacept IV infusions to weekly abatacept injections without losing kidney function. The study enrolls 87 low-risk adults who are at least two years post-transplant. Researchers will comp…

This phase 2 trial tests whether combining two drugs—vidutolimod and nivolumab—can help the immune system attack metastatic castration-resistant prostate cancer. Nivolumab blocks a protein that shuts down immune cells, while vidutolimod is designed to train those cells to target …

This early study tests a new imaging technique called qOBM that may help brain surgeons see tumor edges more clearly during surgery. About 24 adults with certain brain tumors (glioblastoma, astrocytoma, or oligodendroglioma) will have the device used during their planned tumor re…

This study checks if a quick ultrasound device called Velacur can accurately detect fatty liver disease (MASLD) in children aged 2 to 20. About 200 kids with suspected liver issues will get the ultrasound, and results will be compared to MRI or liver biopsy. The goal is to find a…

This study tests whether adding furosemide, a diuretic that increases urine flow, to a special PET/CT scan can reduce bladder radioactivity and improve detection of recurrent prostate cancer in 20 men whose PSA levels have risen after prostate removal. The goal is to see if this …

This study tests a program to help HIV-positive adults get the HPV vaccine, which can prevent HPV-related cancers. The program gives clinics and staff tools to encourage vaccination. Researchers will track how many people start and finish the vaccine series over two years.

This study tests whether giving expectant parents clear, factual vaccine information during pregnancy can increase their confidence and lead to timely vaccinations for themselves and their baby. Researchers plan to enroll 770 first-time parents with low-risk pregnancies. The stud…

This study tests a mobile app called Combine to help gay, bisexual, and other men who have sex with men in rural southern US get tested for HIV and STIs and start taking PrEP (a daily pill that prevents HIV). About 473 men will use the app and be placed into one of four groups: s…

This study tests whether a smartphone game called Tumaini can help prevent HIV among 1000 adolescents aged 12-14 in Kenya. The game teaches sexual health, risk reduction, and condom use through role-playing. Researchers will compare outcomes like age at first sex and condom use b…

This study looks at whether a 6-day course of oral steroids after orthopedic surgery can help reduce pain, nausea, and improve movement. About 500 adults having common surgeries like joint replacement or fracture repair will be randomly assigned to receive either standard care or…

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This study tests whether a single dose of MDMA, given during a 10-day intensive exposure therapy program, can improve PTSD symptoms more than therapy alone. About 40 adults with PTSD will participate at Emory University. The goal is to see if MDMA helps patients engage better wit…

This early-phase study tests the safety of combining the drug tolinapant with radiation therapy for people with head and neck cancer that has spread locally but hasn't been treated yet. Participants are those who cannot receive the standard chemotherapy drug cisplatin. The goal i…

This study tests whether adding mental health care to standard diabetes treatment improves mood and blood sugar control in adults with type 1 diabetes. Eighty participants will be randomly assigned to usual care or a collaborative care model that includes a behavioral health cons…

This study screens adults interested in fecal microbiota transplant (FMT) for Clostridium difficile infection. Researchers will collect medical information and run basic health tests to create a database of potential participants. The goal is to make it faster and easier to enrol…

This study tests a program called "Familia Bora" for couples raising young children in Tanzania. The program teaches positive parenting, stress management, and healthy communication. Researchers want to see if it helps parents bond with their children and supports early child dev…

This study in rural Guatemala tests whether community education can reduce the burning of plastic waste and lower people's exposure to harmful pollutants. About 400 women and community members from 16 villages will take part, with half attending 12 weekly working groups on waste …

This study looks at how certain hormone therapies for prostate cancer affect the heart. It compares two drugs, leuprolide and relugolix, given alongside radiation. The goal is to understand why some men develop heart problems and find ways to predict and reduce that risk. About 9…

This study was designed to see if a high-intensity interval training (HIIT) program is feasible and acceptable for adults aged 35-65 with overweight and slightly high fasting blood sugar (impaired fasting glucose). It planned to enroll 34 physically inactive participants and meas…

This study gives 30 healthy adults a single dose of the approved Ebola vaccine (Ervebo) and tracks their immune responses over time using blood, lymph node, and bone marrow samples. The goal is to understand how long the body 'remembers' the vaccine, which could guide future boos…

This study looks at how the RSV vaccine affects the immune system in adults aged 60 and older. Researchers will take blood samples before and after vaccination to find early signs of protection. The goal is to understand why some people respond better than others. 14 volunteers w…

This study tests a program called CHIMES designed to help young Black gay and bisexual men living with HIV get better mental health care. The program includes posters, provider training, mental health screening, and case management. Researchers will track whether it leads to more…

This study looks at how the HPV vaccine (Gardasil-9) triggers a strong and lasting immune response. Researchers will track 17 healthy adults aged 18-45 who receive three doses of the vaccine. By analyzing blood, saliva, lymph nodes, and bone marrow over several years, they aim to…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This observational study tracks HIV/STD prevention behaviors in 1,275 gay and bisexual men in Atlanta, Chicago, and San Diego. Participants complete surveys and HIV/STD testing over two years. The goal is to understand how men use PrEP, condoms, and other strategies, and to devel…