Emory University

This study tests whether combining vidutolimod and nivolumab can help the immune system attack and destroy prostate cancer cells that have spread to other parts of the body. The trial includes men with metastatic castration-resistant prostate cancer who have already tried other t…

This study is for people with HPV-positive throat cancer, a type that usually responds well to treatment. After robotic surgery to remove the tumor, participants receive a lower dose of radiation than the standard amount. The goal is to see if this gentler approach can still cont…

This early-phase trial tests a drug called isatuximab in 11 people with a rare, high-risk blood disease called AL amyloidosis. The goal is to see if a slower, gentler treatment approach can control the disease with fewer side effects. Isatuximab is an antibody that helps stop abn…

This early-phase trial tests the safety and best dose of a radioactive drug (177Lu-rhPSMA-10.1) given after targeted radiation therapy in men whose prostate cancer has returned after prostate removal surgery. The study involves 6 participants and uses a special scan (PSMA PET) to…

This study tests whether giving the immunotherapy drug atezolizumab before surgery can help treat HPV-related throat cancer that can be removed. About 20 adults with stage I oropharyngeal cancer will receive two doses of atezolizumab before their planned surgery. Researchers will…

This early-phase study tests the safety and best dose of two drugs—venetoclax and tocilizumab—in people with a specific genetic subtype of multiple myeloma (t(11;14)) that has returned or stopped responding to treatment. The trial includes both African American and non-African Am…

This study looks at whether kidney transplant patients can safely switch from a monthly IV drug called belatacept to a self-injected drug called abatacept without harming their kidney function. About 87 adults who are at least 2 years post-transplant and on belatacept will be ran…

This study tests a daily combination of sirolimus, celecoxib, and low-dose chemotherapy in 46 children whose solid or brain tumors have returned or not responded to standard treatment. The goal is to see if this approach can shrink or stabilize the tumors. Researchers also track …

This study tests whether combining two drugs, niraparib and panitumumab, can help control advanced colorectal cancer that has spread. About 26 adults whose cancer has not responded to at least one prior treatment will receive the combination. The goal is to see how many patients …

This study tests whether combining two drugs, pembrolizumab and cabozantinib, can shrink tumors in people with head and neck cancer that has returned or spread and cannot be removed by surgery. The trial includes 36 adults with certain types of head and neck squamous cell carcino…

This study tests two ways to support teenagers living with HIV in South Africa as they move from child to adult clinics. About 570 teens aged 15-19 will get either in-person help or support through a phone app. The goal is to see which method works better at keeping them in care …

This early-phase study tests whether adding an experimental drug (VX15/2503) to standard immunotherapy (ipilimumab or nivolumab) helps the immune system better attack stage III melanoma that can be removed by surgery. About 41 adults with resectable melanoma will receive the drug…

This study tests a combination of three drugs (docetaxel, ramucirumab, and pembrolizumab) in 30 people with advanced non-small cell lung cancer that has worsened after standard chemotherapy and immunotherapy. The goal is to see if this triple therapy is safe and works better than…

This study looks at whether people with type 2 diabetes can safely keep taking their usual diabetes pills while in the hospital, instead of switching to insulin. About 255 adults aged 18-80 who are admitted to general medical or surgical units will take part. Researchers will com…

This study tests whether giving two drugs—lenvatinib and pembrolizumab—before surgery can shrink tumors in people with locally advanced kidney cancer that hasn't spread to other parts of the body. About 18 participants will receive the combination for 12 weeks before their operat…

This study tests whether the drug cabozantinib can shrink kidney tumors before surgery in people with locally advanced clear cell renal cell carcinoma. About 22 participants will receive cabozantinib before their operation. The goal is to see if the drug reduces tumor size and he…

This study tests adding propranolol, a blood pressure drug, to standard immunotherapy for people with advanced bladder cancer that has spread. The goal is to see if the combination is safe and helps control the cancer. Only 6 adults took part, and the study is no longer recruitin…

This study looks at whether using a blood test to measure certain proteins (biomarkers) can help doctors create a more personalized treatment plan for people with coronary artery disease. About 276 adults with stable heart disease will be split into two groups: one gets standard …

This study tests whether adding a drug called abatacept to standard anti-rejection medicines can prevent graft-versus-host disease (GVHD) in children and teens getting stem cell transplants from unrelated donors. About 30 participants with serious non-cancer blood diseases will r…

This study checks if a quick ultrasound called Velacur can accurately detect fatty liver disease (MASLD) in children aged 2 to 20. About 200 kids with suspected liver issues will get the ultrasound, and results will be compared to MRI or liver biopsy. The goal is to find a faster…

This study tests whether adding furosemide (a diuretic or "water pill") to a special PET/CT scan can reduce bladder radioactivity and improve detection of recurrent prostate cancer in 20 men whose PSA levels rose after prostate removal. Participants receive two scans—one with and…

This early trial tests a new imaging device called qOBM that helps surgeons see the edges of brain tumors during surgery. About 24 adults with certain brain cancers will be enrolled. The goal is to check if the device is safe and reliable for finding tumor margins.

This study aims to see if providing expectant parents with factual vaccine information during pregnancy can increase confidence in vaccines and lead to timely vaccinations for both mother and child. Researchers will enroll 770 first-time parents with a single, healthy pregnancy. …

This study tests a mobile app called Combine to see if it helps rural men who have sex with men get tested for HIV and STIs and start taking PrEP (a daily pill that prevents HIV). About 473 men in the rural southern U.S. will use the app and be assigned to one of four groups, som…

This study tests whether a smartphone game can help young people in Kenya learn about HIV and make safer choices. About 1,000 teens aged 12-17 will play the game and answer surveys. The goal is to see if the game delays first sex, increases condom use, and improves HIV knowledge.

This study tests whether a low-sugar diet can prevent non-alcoholic fatty liver disease (NAFLD) in Hispanic children ages 6 to 9 who are at higher risk. Over two years, 103 kids will either follow an intensive sugar-reduction plan or their usual diet. Researchers will measure liv…

This study tests whether a daily 1-hour session of gamma flickering light is safe and tolerable for people with Parkinson's disease who experience freezing of gait — a feeling that their feet are glued to the floor. The study involves 24 participants aged 50-80 who will use a lig…

This study looks at whether taking a 6-day course of the steroid methylprednisolone after common orthopedic surgeries (like joint replacement or fracture repair) can reduce pain, nausea, and improve movement compared to just getting a single dose of steroid during surgery. About …

This early-phase study tests whether combining the drug tolinapant with radiation therapy is safe and doable for people with head and neck cancer that hasn't been treated yet and has spread locally. Participants are those who can't take the standard chemo drug cisplatin. The goal…

This pilot study tests a 12-month lifestyle program (PRISEM) for 45 African American and White adults aged 50+ with mild cognitive impairment. The program includes group and individual activities focused on health education, nutrition, exercise, and stress management. Researchers…

This early-stage study looks at whether giving testosterone around the time of major urologic surgery is safe and can improve recovery in men with low testosterone levels. Researchers will track quality of life, frailty, complications, and hospital stay length in 56 participants.…

This study tests whether a single dose of MDMA (the drug in ecstasy) can make a proven talk therapy for PTSD work better. 40 adults with PTSD will receive MDMA on the second day of a 10-day intensive therapy program. The goal is to see if this combination reduces PTSD symptoms mo…

This study is testing a program called CHIMES to help young Black gay, bisexual, and other men who have sex with men (ages 18-29) who are living with HIV get better access to both HIV care and mental health services. The program will be offered at two clinics in Atlanta, and rese…

This study looks at how the immune system of adults aged 60 and older responds to an approved RSV vaccine. Researchers will measure antibodies and track side effects for 6 months after vaccination. The goal is to learn more about how the vaccine protects people and find early sig…

This study looks at how burning plastic waste impacts the health of women and communities in rural Guatemala. Researchers are comparing 8 villages where people attend weekly group sessions to reduce plastic burning with 8 villages that do not have these sessions. About 400 women …

This study looks at immune cells (B cells) from people with autoimmune diseases like lupus, people with infections, and healthy volunteers. Researchers want to understand how these cells differ between groups. The goal is to learn more about the immune system, not to test a new t…

This study tests a program called "Familia Bora" for couples raising a child under two in Tanzania. Trained community health workers lead weekly group sessions covering topics like positive discipline, stress management, and nutrition. The goal is to see if including both parents…

This study gives 30 healthy adults a single dose of the Ebola vaccine and then takes blood, lymph node, and bone marrow samples over time. The goal is to see how long the body's immune system remembers the vaccine. It does not test a new treatment or cure, but helps scientists un…

This study tracks daily blood sugar changes in 12 African American adults with ketosis-prone diabetes to build a computer model of how remission happens. Researchers will use continuous glucose monitors to collect data and create math models that may one day help predict how long…

This study looks at how hormone therapy for prostate cancer can affect the heart. Researchers are comparing two drugs, leuprolide and relugolix, to see which one is safer for the heart. About 94 men with non-spreading prostate cancer will take part. The goal is to find better way…

This study was designed to see if high-intensity interval training (HIIT) is a practical and acceptable exercise program for adults aged 35-65 with overweight and slightly high fasting blood sugar (prediabetes). The goal was to measure how easy it is to recruit and keep participa…

This study observes 1,275 gay and bisexual men in Atlanta, Chicago, and San Diego to understand their HIV/STD prevention strategies, including PrEP use and condom habits. Participants complete surveys and HIV/STI testing over two years. The goal is to identify gaps in protection …

This early study looks at how two oral drugs, defactinib and VS-6766, build up in glioblastoma tumors and the surrounding brain tissue. Fourteen adults with new or returning glioblastoma who need surgery will take a single dose of one drug before their operation. The main goals a…

This study observes how anemia and red blood cell transfusions affect oxygen levels in the digestive tract of extremely low birth weight infants (≤1250 grams). Researchers will analyze blood, urine, and stool samples to find markers that may predict serious gut problems like necr…

This study tracks 17 healthy adults aged 18-45 who receive the standard three-dose HPV vaccine. Researchers collect blood, saliva, lymph node, and bone marrow samples over five years to understand how the body builds and maintains strong antibody defenses. The goal is to learn wh…

This study looks at whether adding mental health support to regular type 1 diabetes care can improve both mood and blood sugar levels. About 80 adults will fill out online surveys every six months for 18 months. Some will also have at least one talk session with a behavioral heal…