Emory University

This study looked at how healthy adults' immune systems respond to the oral cholera vaccine Vaxchora. Researchers measured antibodies and other immune cells in the blood to understand protection. 34 healthy volunteers took part. The goal was to see if the vaccine triggers a stron…

This study tested a new vaccine (NmCV-5) that protects against five types of meningitis bacteria in healthy infants in Mali. About 1,300 babies received either the new vaccine or an existing one at 9 or 15 months old. The goal was to see if the new vaccine is as safe and effectiv…

This study tested the drug Trikafta in 42 people with cystic fibrosis who have rare gene changes not normally treated with this medication. Participants took Trikafta for about four weeks, and researchers measured lung function and sweat chloride levels. They also used skin or bl…

This study looked at whether adding citrate to the fluid used during dialysis can slow the buildup of calcium in blood vessels. 54 adults on hemodialysis who already had some vessel calcification took part. Each person used both a standard fluid and a citrate fluid for 12 months …

This study gave clean-burning LPG stoves to half of 3,200 households in India, Guatemala, Peru, and Rwanda. Pregnant women and their children were followed for up to 5 years to see if cleaner air leads to higher birth weight, fewer cases of severe pneumonia, less stunting, and lo…

This study tested a new way to choose which IV fluid to give sepsis patients in the emergency room. Using vital signs like temperature and blood pressure, an algorithm identified patients who would benefit more from balanced crystalloids than normal saline. Over 2,000 adults acro…

This study tested whether an automated insulin delivery system works better than standard insulin injections for managing blood sugar in hospitalized adults with type 1 or type 2 diabetes. 130 patients on general medical or surgical floors were randomly assigned to either the aut…

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were split into three groups: in-person coaching, video call coaching, or just a list of resources. Researchers track…

This study tested a new way to manage type 2 diabetes for patients at a primary care clinic serving vulnerable populations. The clinic offered dedicated diabetes care days, continuous glucose monitoring, and help with social needs like food and housing. Researchers tracked change…

This study tested whether a smartphone app and regular phone calls could help people with heart disease complete their cardiac rehabilitation at home. 258 veterans took part. The goal was to see if this remote program improved exercise ability, symptom monitoring, and reduced hos…

This study tested whether adding two drugs—paricalcitol (a form of vitamin D) and hydroxychloroquine (an anti-malaria drug)—to standard chemotherapy could help people with advanced pancreatic cancer that has spread. Ten participants received the combination. The goal was to see i…

This study tested a program to help low-income smokers quit by making their homes and cars smoke-free. 918 adults received mailings and coaching calls to support creating these bans. The main goal was to see if more people quit smoking after 12 months compared to standard care.

This small study tested a group discussion program for men who have sex with men in South Africa who struggle to take their HIV medication (either daily prevention pills or treatment pills). The goal was to see if talking about common mental health problems could help them stick …

This study tested the drug Trikafta in 32 adults with non-cystic fibrosis bronchiectasis, a chronic lung condition. Participants took the medication for four weeks while researchers monitored lung function, symptoms, and weight. Some also gave skin or blood samples to see how the…

This study tested a mobile app called UrApp designed to help families manage childhood nephrotic syndrome, a chronic kidney disease. About 60 caregivers of children with the condition used the app or received standard care for one year. The goal was to see if the app improved med…

This early-stage study tested a combination of an immunotherapy drug (pembrolizumab) and precise radiation (stereotactic radiosurgery) in 25 people with melanoma or lung cancer that had spread to the brain. The main goal was to check for serious side effects. The approach aims to…

This study tested whether levodopa, a drug used for Parkinson's disease, can improve retinal function in people with diabetes who have early signs of diabetic retinopathy. Researchers measured electrical activity in the retina and used eye scans to track changes. The trial enroll…

This study compared two types of heart scans—CT and PET—to see how well they measure blood flow in people with coronary artery disease. Twenty adults who already needed a CT scan for their heart took part. The goal was to find out if the newer CT method works as well as the stand…

This study tested whether a special type of MRI (called DSC perfusion MRI) can help doctors tell the difference between radiation damage and tumor regrowth in people whose cancer has spread to the brain. Eight patients who had already received radiation therapy took part. The goa…

This study tested a program called Go Sun Smart Georgia to see if it helps outdoor workers protect themselves from the sun. About 312 workers and managers from different workplaces took part. Some workplaces got the program right away, while others waited. The study looked at whe…

This study tested a program to help adults who call the 2-1-1 helpline eat healthier and prevent weight gain. Over 500 adults aged 18 to 70 with a BMI of 20 or higher took part. The program was delivered over the phone and focused on improving diet quality based on national guide…

This study tested a method called Targeted Indoor Residual Spraying (TIRS) to see if it could prevent diseases spread by mosquitoes, like dengue, chikungunya, and Zika. Over 4,400 children aged 2 to 15 in Merida, Mexico took part. Researchers sprayed inside homes in certain neigh…

This study tested a mobile app called WeTest-WeLink to help high-risk men in China test themselves for HIV and connect to care. About 1800 HIV-negative men who have sex with men used the app or received standard information. Researchers checked how many completed self-testing and…

This study followed 240 young men who have sex with men for two years to find better ways to help them stay on HIV PrEP (medication that prevents HIV) and avoid sexually transmitted infections. Participants used a smartphone app to track risks and received counseling if they thou…

This study tested two programs to prevent drug misuse among 10th graders in rural Cherokee Nation high schools. About 919 students from 20 schools took part, with some schools starting the programs right away and others later. The goal was to see if these programs could reduce al…

This study tested a mobile app called SavvyHER designed to help Black women in the southern U.S. access HIV prevention tools and reproductive health information. Fifty-six Black women aged 18-44 who were HIV-negative and sexually active took part. The goal was to see if the app w…

This study looked at whether giving tamsulosin (Flomax) to men aged 50 and older during surgery can lower their chances of having trouble urinating or getting a urinary tract infection after a catheter is removed. The trial involved 87 men having elective abdominal surgery. Resea…

This study looked at 80 adults with trigger finger to compare two standard surgical treatments: cutting the A1 pulley versus removing it. The goal was to see which method leads to less pain, stiffness, and recurrence. Participants were followed for one year after surgery, and the…

This study tested a drug called telotristat ethyl in 23 people with advanced pancreatic cancer who had lost at least 10% of their body weight. The goal was to see if the drug could help them stabilize or gain weight by reducing bowel movements. Maintaining weight may help patient…

This study tested whether a dietary supplement called citicoline could improve sleep and thinking in people with Alzheimer's disease. Twenty participants took the supplement and reported their sleep quality and daytime sleepiness. The goal was to see if citicoline, which has been…

This small study tested whether Botox injections can relieve the leg pain caused by Chronic Exertional Compartment Syndrome (CECS) in runners, potentially avoiding the need for surgery. Only 3 people took part, and the main goal was to measure pain changes over 3 months. The stud…

This study tested whether a dietary supplement called citicoline could improve sleep and thinking in 100 older adults with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's disease. Participants took citicoline or a placebo for several months. Researchers …

This study compared using a real-time continuous glucose monitor (CGM) to standard fingerstick testing in 116 adults with type 2 diabetes and foot ulcers. The goal was to see if CGM improves wound healing and reduces the burden of frequent fingersticks. Participants used either a…

This study tested a painless brain stimulation technique called tDCS in 38 veterans with chronic pain, PTSD, and depression. The treatment uses low-level electrical currents to calm overactive pain and stress circuits in the brain. Researchers measured changes in pain intensity a…

This study looked at 68 children with asthma who often have flare-ups. They received a steroid injection and were followed for 48 weeks to see how their symptoms changed and whether symptom patterns stayed stable over time. The goal was to better understand and manage their asthm…

This study looked at whether spironolactone, a blood pressure medication, is safe and tolerable for older African Americans with mild memory loss or early dementia. Twenty-five participants took either the drug or a placebo for one year. Researchers tracked side effects and measu…

This study tested whether a short course of steroids (Medrol Dose Pak) given after total knee replacement can reduce pain, nausea, and the need for painkillers. About 100 adults with knee arthritis took part. The goal was to see if this simple anti-inflammatory treatment helps pe…

This study tested whether using a battery-powered drill for bone marrow biopsy causes less pain and provides better tissue samples than the traditional manual needle method. 100 adults with plasma cell disorders (like multiple myeloma) took part. The goal was to see if the drill …

This study tested a program called I-STRONG, which combines mental and physical training to help teenagers with sickle cell disease cope with pain. 45 teens took part to see if the program was practical and well-liked. The goal was to reduce pain severity and its impact on daily …

This study tested whether taking zinc supplements could improve quality of life for patients with upper gastrointestinal cancers who were receiving chemotherapy. Researchers wanted to see if preventing zinc deficiency might help patients feel better during treatment. The study in…

This study gave 239 healthy adults the yellow fever vaccine to learn how the immune system reacts to a real viral infection. The vaccine is safe and effective, making it a good model for studying immune responses. Participants were followed for up to one year to measure their T c…

This study looked at whether giving educational materials to dialysis centers could help more people get on the kidney transplant waiting list, especially Black patients. Over 56,000 patients at about 750 dialysis centers across the U.S. took part. The goal was to see if this app…

This study looked at how well different doses of sugammadex work when the usual drug, neostigmine, doesn't fully reverse muscle relaxants after surgery. 46 adults having elective surgery took part. The goal was to find the fastest dose to restore normal muscle function. Results h…

This study tested a program called SPIRIT that helps people with end-stage kidney disease and their families plan for end-of-life care. The program involves two face-to-face sessions to improve understanding and agreement between patients and their chosen decision-makers. Researc…

This study tested a program called Keeping on Course for people with mild cognitive impairment (MCI) and their care partners. The goal was to teach communication skills and strategies to help them feel more in control while coping with MCI. 29 dyads (pairs) participated in the pr…

This study tested a new workbook filled with word games to help people with diabetes learn how to manage their condition. 25 participants used the workbook during clinic visits or at home to learn about carbohydrate management and diabetes terms. The goal was to see if this appro…

This study tested a computer program that uses vital signs from the first 8 hours in the hospital to sort sepsis patients into four groups. The goal was to see if these groups have different outcomes, which could help doctors choose better treatments in the future. About 1,900 ad…

This study looked at how the antibiotic doxycycline gets into rectal and vaginal tissues after different doses. The goal is to find a single dose that could protect against both HIV and other sexually transmitted infections. 45 healthy adults took part, and researchers measured d…

This study looked at how adults' immune systems respond to the live attenuated flu vaccine given as a nasal spray. Researchers want to understand why this vaccine is less effective in adults than in children. By measuring antibodies and other immune markers in 51 participants, th…

This study looked at whether text message reminders can encourage people with diabetes or at risk for diabetes to get tested for COVID-19. About 290 people in Georgia took part, with half getting the text reminders and the other half not. The goal was to see if the reminders incr…

This study tested a simple idea: give hospital doctors regular reports comparing their antibiotic prescribing rates to their peers. The goal was to see if this feedback would encourage them to prescribe fewer unnecessary antibiotics, which can cause side effects like diarrhea or …

This completed study looked at how much doxycycline builds up in rectal and vaginal tissues after taking one pill daily for seven days. Twenty-four healthy adults (assigned male or female at birth) took part. The goal was to gather data to help design better future studies on usi…

This study tested how to best apply STAR particles—tiny particles with microneedles—to healthy skin. The goal was to find the best method to create small punctures that could help future topical medications work better. Twenty healthy adults aged 18 to 39 took part. No active med…

This study looked at whether a program to offer family planning to women right after giving birth can work on a large scale in Rwanda. Over 42,000 people took part, including clinic directors, nurses, and community health workers. The goal was to see if the program is affordable,…

This study collected brain signals from 162 patients with brain injuries to create a database for developing noninvasive ways to measure pressure inside the skull. Participants had an existing pressure monitor and also wore a harmless ultrasound device on their head. The goal is …

This study tested a therapy where parents help their preterm babies with gentle sensory activities to improve brain development. 248 preterm infants took part, and researchers measured how their brains process multiple senses at once. The goal was to see if this approach leads to…

This study tested a special course called Caregiving While Black-LIVE for Black family members or friends caring for someone with dementia. The course aimed to help caregivers feel more understood by doctors and better able to find and use health information. Forty Black caregive…

This study looked at how two types of treadmill training—fast walking alone and fast walking with mild electrical stimulation—help people who have had a stroke improve their walking. Fifty-five stroke survivors took part to help researchers understand why these treatments work an…

This study tested a program to help children aged 5-18 recover from mild traumatic brain injury (concussion). The program involved doctors, families, and schools working together to improve diagnosis, management, and support. Researchers measured symptoms, quality of life, and re…

This study tested an online group program designed to help young Black men living with HIV feel more connected and improve their health. The program was adapted from an in-person version to be delivered via telehealth. Researchers worked with 60 participants to see if the online …

This study looked at whether a widely used self-management education program could improve health and reduce doctor visits for African American women with lupus. Nearly 700 women took part, and researchers measured things like communication with doctors, confidence in managing me…

This study tested whether teaching parents of 6-month-old infants at risk for autism how to support their child's social communication could improve development. About 269 families participated, with some receiving a web-based guide and others usual care. For infants showing earl…

This study tested whether transcranial magnetic stimulation (TMS) can improve PTSD symptoms and change brain activity in 63 adults. Researchers measured brain scans and startle responses before and after treatment. The goal was to find new brain targets and personalize PTSD care.

This study looked at whether taking statins (cholesterol-lowering drugs) changes how well the flu vaccine works. Researchers measured antibody levels in the blood and checked gut bacteria from stool samples in 63 adults aged 18-50. The goal was to understand how statins affect lo…

This study looked at different types of stitches and stitching methods used to close surgical cuts after hand, wrist, or arm surgery. The goal was to see if any method leads to less pain and better wound healing. About 160 adults having upper extremity surgery took part, and thei…

This study tested a wearable eye-tracking device to help critically ill patients on breathing machines communicate. Thirty ICU patients tried the device, learning to call for help and answer questions using only their eyes. The goal was to see if the device was safe, easy to use,…