Emory University

This study tested whether adding two drugs, paricalcitol (a form of vitamin D) and hydroxychloroquine, to standard chemotherapy could better control advanced pancreatic cancer that has spread. The goal was to see if this four-drug combination could shrink tumors more effectively …

This study tested whether Trikafta, a drug approved for cystic fibrosis, could help people with non-cystic fibrosis bronchiectasis (NCFBE), a different lung condition with similar symptoms. Thirty-two adults with NCFBE took Trikafta for four weeks while researchers measured their…

This study tested whether training doctors and giving them electronic decision tools could help children recover better from mild traumatic brain injuries (concussions). It involved 101 children aged 5-18 and their emergency, urgent care, and primary care doctors. Researchers fol…

This study tested whether teaching parents how to support their infant's social development very early can improve outcomes for children showing signs of autism. Researchers enrolled 269 families with infants as young as 6 months old, some at higher risk for autism. They compared…

This study tested whether using a continuous glucose monitor (CGM) helps heal diabetic foot ulcers better than standard fingerstick testing. Researchers followed 116 adults with type 2 diabetes and foot ulcers for 16 weeks after hospital discharge. They compared wound healing rat…

This study tested whether levodopa, a medication used for Parkinson's disease, could protect the retina from damage caused by diabetes. Researchers enrolled 230 adults with diabetes but no visible eye disease and gave them either a placebo or levodopa at different daily doses for…

This study tested two new approaches for a painful leg condition in runners. First, it tried using a special ultrasound scan instead of a painful needle test to diagnose the problem. Second, it tested if an injection of a medication similar to Botox could relieve pain and help ru…

This study tested a mobile app called UrApp, designed to help families manage a chronic childhood kidney disease called nephrotic syndrome. The app provided reminders for medication and urine testing, helped track results, and alerted doctors. Researchers compared 58 families usi…

This study tested whether a 6-week online group program could improve social connections and health for young Black gay and bisexual men living with HIV. The program involved weekly video meetings with discussions and activities. Researchers worked with a community organization t…

This study aimed to understand how different groups of asthma symptoms in children respond to a steroid injection. Researchers followed 68 children and teenagers with asthma that frequently gets worse for nearly a year. They tracked clusters of symptoms—like breathing problems, m…

This study tested if a simple computer alert could help doctors choose the best type of IV fluid for certain patients with sepsis, a life-threatening infection. Over 2,000 adult patients were randomly assigned to either have their doctors receive the alert or follow usual care. T…

This study tested whether an old, common blood pressure drug called spironolactone is safe and tolerable for older African American adults who have early memory and thinking problems. The goal was to see if the drug could help slow the decline in memory skills. A small group of 2…

This study tested a new way to help vulnerable patients manage type 2 diabetes within their regular primary care clinic. The clinic offered dedicated diabetes care days with a team of providers who also addressed food insecurity, housing concerns, mental health, and exercise barr…

This study tested a special therapy designed to help the brains of babies born prematurely develop more typically. The therapy involved gentle, coordinated sound and touch stimulation, often supported by a parent's recorded voice and scent. Researchers measured the babies' brain …

This study tested whether a non-invasive magnetic brain stimulation treatment (TMS) could help reduce PTSD symptoms and change related brain and stress responses. It involved 63 adults with PTSD from underserved communities to see if this approach is practical and effective. The …

This study tested whether a dietary supplement called citicoline could improve sleep and affect biological markers linked to Alzheimer's disease. It involved 100 older adults who had mild cognitive impairment (early memory problems) and poor sleep. Participants were randomly assi…

This study tested whether a home-based rehabilitation program delivered through a smartphone app and regular phone calls could help veterans with heart or lung disease. The goal was to see if this convenient, remote approach could improve patients' fitness, help them manage their…

This study compared two standard surgical approaches for treating trigger finger, a common hand condition where a finger gets stuck when bent. Researchers wanted to see if completely removing a small band of tissue (excision) works better than just cutting it (incision) at reduci…

This study tested a simple idea: if doctors see how their antibiotic prescribing habits compare to their peers, will they prescribe fewer unnecessary antibiotics? Researchers tracked 147 hospital doctors across four hospitals. Every two months, doctors received an email showing t…

This small, early-stage study tested the safety of combining two treatments for cancer that has spread to the brain: an immunotherapy drug (pembrolizumab) and a very precise form of radiation (stereotactic radiosurgery). The goal was to see if using them together was safe and cou…

This study tested a group therapy program designed to help men who have sex with men in South Africa. The goal was to see if improving mental health could also help them take their HIV prevention or treatment medications more consistently. The program adapted an existing, proven …

This study tested whether an automated insulin delivery system could better control blood sugar in hospitalized adults with type 1 or type 2 diabetes compared to standard insulin injections. 130 participants were randomly assigned to use either the automated system or receive sta…

This study tested whether connecting people with substance use disorders to a peer recovery coach during an emergency room visit helps them get support. It compared in-person coaching, video call coaching, and just giving out a resource list. The goal was to see if coaching helps…

This study compared two newer heart CT scan methods against the current best test (PET scan) for measuring blood flow to the heart muscle. Researchers enrolled 20 patients already scheduled for a standard PET scan to see if the newer CT scans could provide equally accurate inform…

This study tested whether helping smokers create smoke-free rules for their homes and cars could help them quit smoking. Researchers worked with 918 low-income patients from Georgia health centers, providing some participants with mailings and coaching calls about establishing sm…

This study tested a workplace education program called Go Sun Smart Georgia. It aimed to see if training worksite coaches and providing resources could help outdoor workers improve their sun protection habits, like wearing sunscreen and protective clothing. The program was offere…

This study tested whether providing clean-burning LPG stoves and fuel to households could prevent health problems linked to indoor air pollution. Researchers enrolled 3,200 pregnant women across four countries and gave half of them the new stoves, while the other half continued u…

This study tested whether a mobile app could help men at high risk for HIV in China test themselves more regularly and connect to care if needed. About 1,800 HIV-negative men were randomly assigned to either use the special app or receive standard information. Researchers checked…

This study tested a large-scale program in Rwanda to provide family planning services to women after giving birth. The program trained healthcare workers and community members to counsel over 21,000 women and couples about long-acting contraceptive options. The goal was to see if…

This study tested whether sending weekly text message reminders could encourage people with diabetes or at risk for diabetes to get tested for COVID-19 and follow other prevention steps. 290 adults in Georgia were randomly assigned to either receive these personalized text 'nudge…

This study tested a combined community and school program designed to prevent the start and increase of opioid and other drug misuse among teenagers. It involved over 900 10th-grade students from small rural towns within the Cherokee Nation. Researchers compared schools that rece…

This study tested whether spraying a special insecticide inside homes could prevent children from getting sick from diseases spread by Aedes mosquitoes, like dengue, Zika, and chikungunya. Researchers in Mexico enrolled over 4,400 children, aged 2 to 15, living in selected neighb…

This study tested whether a health coaching program delivered over the phone could help adults prevent gradual weight gain. Researchers worked with 512 people who called the 2-1-1 social services helpline, providing personalized guidance on creating healthier home environments an…

This study tested different doses of a drug called sugammadex to help patients wake up from muscle paralysis after surgery. It focused on patients who had already received the standard reversal drug (neostigmine) but were still partially paralyzed 15 minutes later. Researchers co…

This study tested an 8-week online course designed specifically for Black Americans caring for a family member with dementia. The course aimed to help caregivers feel more confident, reduce their stress and anxiety, and improve their ability to find information and work with doct…

This study tested whether a community-based self-management education program could help African American women with lupus feel better and use healthcare services less. 699 women participated, with some attending a 6-week class series and others receiving usual care for compariso…

This study developed and tested a new telehealth program called I-STRONG to help teenagers with sickle cell disease manage chronic pain. The program combines breathing exercises, relaxation techniques, and gentle movement training, and was specifically adapted with input from pat…

This study tested a wearable device called EyeControl that helps critically ill patients on breathing machines communicate. The device uses eye movements and blinks to let patients answer questions and call for help. Researchers wanted to see if the device was safe, easy to use, …

This study tested if adding a drug called telotristat ethyl to standard chemotherapy could help patients with advanced pancreatic cancer stop losing weight. The goal was to see if stabilizing weight could help patients better tolerate their cancer treatment and potentially improv…

This study tested a 6-week virtual program designed to help couples where one partner has mild cognitive impairment (MCI). The program taught communication skills and coping strategies to help both partners feel more in control and less stressed. Researchers measured whether coup…

This small study tested whether taking zinc supplements could improve the day-to-day quality of life for patients with certain hard-to-treat stomach and digestive system cancers while they were undergoing chemotherapy. Researchers wanted to see if preventing zinc deficiency could…

This small, completed pilot study explored whether a dietary supplement called citicoline could help improve sleep and thinking skills in people with Alzheimer's disease. Twenty participants were randomly assigned to receive either citicoline or a placebo pill daily for three mon…

This study tested a program called SPIRIT, designed to help patients with end-stage kidney disease and their chosen family members plan for difficult end-of-life care decisions. The program involved two guided conversations with a trained dialysis care provider. Researchers wante…

This study compared two tools used to take bone marrow samples from patients with blood cancers like multiple myeloma. Researchers tested whether a new battery-powered drill system was better than the traditional manual needle in terms of the quality of the sample collected, how …

This study tested a non-drug treatment for veterans suffering from both chronic pain and PTSD. Researchers combined a painless brain stimulation device (tDCS) with a therapy program to see if it could reduce pain and mental health symptoms. They also collected blood and saliva sa…

This study tested if adding a short, tapering course of steroid pills (a Medrol Dose Pak) after knee replacement surgery improves recovery. Researchers compared it to the standard single steroid dose given during surgery. They measured if the pill pack reduced patients' pain, nau…

This study tested a computer tool that runs in the background of hospital records to sort sepsis patients into four different groups based on their vital signs. The goal was to see if these patient groups have different health outcomes, like survival rates or need for intensive c…

This study collected detailed brain monitoring data from 162 patients with various brain injuries to build a database for future research. Participants had existing pressure monitors, and researchers used a noninvasive ultrasound device to record blood flow signals. The goal was …

This study aimed to learn how the human immune system responds to the yellow fever vaccine. Researchers gave the standard yellow fever vaccine to 239 healthy adults and tracked their immune responses for up to a year. The goal was to understand what makes this vaccine so effectiv…

This study aimed to understand how well the antibiotic doxycycline, taken by mouth, reaches rectal and vaginal tissues. Researchers measured drug levels in healthy adults to help design future single-dose prevention strategies that could protect against HIV and other sexually tra…

This study aimed to understand in detail how the body's immune system responds to Vaxchora, an FDA-approved oral cholera vaccine. Researchers enrolled 34 healthy volunteers to receive the vaccine and then measured various immune cells and antibodies in their blood and intestines.…

This study aimed to find out if taking statin cholesterol medication changes how well the flu vaccine protects you. Researchers compared the immune response to the flu shot in adults who took statins for two months versus those who did not. They also checked if the medicine chang…

This small study tested a new tool called STAR particles on healthy volunteers. Researchers rubbed these tiny, bumpy particles on the skin to create microscopic punctures, aiming to see if this makes the skin more absorbent for future topical medications like creams or gels. The …

This study aimed to understand how two different walking rehabilitation methods help people recover after a stroke. Researchers compared fast treadmill walking alone to fast treadmill walking combined with gentle electrical leg stimulation. They measured walking speed, endurance,…

This study tested whether providing educational materials to dialysis center staff and patients could improve fairness in getting on the kidney transplant waitlist. It involved over 56,000 patients across roughly 750 dialysis centers in the U.S. The goal was to see if better educ…

This study aimed to understand why the nasal spray flu vaccine provides strong, lasting protection in children but is less effective and shorter-lasting in adults. Researchers enrolled 51 healthy adults (ages 18-49) who received the FDA-approved nasal spray vaccine and provided b…

This study tested whether a new lab method could predict if people with rare cystic fibrosis mutations would benefit from the drug Trikafta. Researchers gave Trikafta to 42 patients with specific rare mutations not normally approved for the drug. They collected skin or blood samp…