Emory University

This study tested a new vaccine (NmCV-5) to protect infants against meningitis, a serious infection of the brain and spine. About 1,325 healthy infants in Mali received either the new vaccine or a standard one at 9 or 15 months old. The goal was to see if the new vaccine works as…

This phase 2 trial tested the oral cholera vaccine Vaxchora in 34 healthy adults to see how well it triggers protective antibodies and immune cells. Participants received a single dose, and researchers measured antibody levels, B cells, and T cell responses. The goal is to unders…

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with other treatments. Participants have a device surgically implanted to stimulate a specific brain area, then receive active stimulation for six months along with b…

This study tested whether a single dose of azithromycin can eliminate meningococcal bacteria from the nose and throat of healthy college students. Over 700 students participated, and researchers checked for bacterial clearance two weeks after treatment. The goal is to find a new …

This early-phase study tested whether the oral antibiotic rifaximin can reduce abnormal proteins in people with monoclonal gammopathy, a condition that can lead to blood cancers. Fifty adults with different types of gammopathy took the drug to see if it lowered their immunoglobul…

This early-phase trial tested two drugs together—pembrolizumab (Keytruda) and XL888—in 47 people with advanced gastrointestinal cancers like colorectal and pancreatic cancer that had spread or could not be removed. The main goal was to find the safest dose and check for side effe…

This study tested whether a drug called GM-CSF can improve symptoms and blood flow in people with peripheral artery disease (PAD), a condition where plaque narrows leg arteries, causing pain and limiting walking. 151 participants received either GM-CSF or a placebo for two 3-week…

This study tested giving focused radiation before surgery to people with cancer that spread to the brain. The goal was to see if this approach is safe and might lower the chance of the tumor coming back. 26 adults with brain metastases took part. The treatment aims to control the…

This phase I trial tested a special type of radiation called hypofractionated radiosurgery for people with large brain metastases (tumors that spread from other cancers). The goal was to find the safest and most effective dose while limiting damage to healthy brain tissue. Twenty…

This study looked at whether adding citrate to the fluid used during dialysis can slow the buildup of calcium in blood vessels. 54 adults on hemodialysis who already had some vessel hardening took part. Each person used a standard fluid for 12 months and a citrate fluid for anoth…

This study tested whether tamsulosin (Flomax) can reduce the risk of urinary retention and catheter-related infections in men aged 50 and older after elective surgery. Participants received either tamsulosin or a placebo after their catheter was removed. The goal was to see if th…

This study tested a program to help men who have sex with men (MSM) stay on daily PrEP (a pill that prevents HIV) and reduce sexually transmitted infections (STIs). 240 men in Atlanta used a mobile app that flagged when they might stop PrEP, then a peer counselor and doctor stepp…

This study tested whether using a continuous glucose monitor (CGM) instead of standard fingerstick testing helps people with type 2 diabetes heal foot ulcers faster. 116 adults who had been hospitalized for a diabetic foot ulcer were randomly assigned to use either a CGM or their…

This study tested a computer algorithm that uses vital signs to decide which type of IV fluid is best for sepsis patients. Over 2000 adults in emergency rooms were assigned to receive either the algorithm's recommended fluid or usual care. The goal was to see if personalized flui…

This completed study tested a behavioral program called WeCare for men who have sex with men (MSM) in South Africa. The program included individual sessions to identify problems and create action plans, plus group sessions for social support and coping with stigma. The goal was t…

This early study tested combining the immunotherapy drug pembrolizumab with precise radiation (stereotactic radiosurgery) in 25 people with melanoma or lung cancer that had spread to the brain. The main goal was to check for serious side effects. Researchers also tracked how long…

This study tested whether levodopa, a drug used for Parkinson's disease, can help people with diabetes who have early signs of eye damage (diabetic retinopathy). The goal was to find the best dose and understand how it works to improve the retina's electrical signals. 230 adults …

This study tested a special diabetes clinic within a primary care setting for patients with poorly controlled type 2 diabetes. The clinic brought together doctors, diabetes educators, nurses, behavioral health providers, and social workers to offer comprehensive care, including c…

This study tested whether Trikafta, a drug already approved for cystic fibrosis, can help people with non-cystic fibrosis bronchiectasis (NCFBE). Thirty-two adults took the medication for 28 days. Researchers measured lung function, quality of life, and weight, and also looked at…

This study tested whether a smartphone app and regular phone calls could help people with heart or lung disease complete rehabilitation at home instead of going to a clinic. The program included exercise tracking, education, and counseling over 12 weeks. Researchers wanted to see…

This phase II trial tested whether adding paricalcitol (a vitamin D drug) and hydroxychloroquine (an autophagy inhibitor) to standard chemotherapy could help shrink tumors in 10 people with advanced or metastatic pancreatic cancer. The goal was to see if the combination improved …

Trigger finger happens when a finger gets stuck in a bent position due to a thickened tendon pulley. This study compared two standard surgeries: cutting the pulley versus removing a piece of it. 80 adults were randomly assigned to one surgery and followed for a year to see which …

This study tested a program to help low-income smokers quit by making their homes and cars smoke-free. 918 adults received mailings and coaching calls to create smoking bans. The goal was to see if this approach led to more people quitting smoking for good.

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This study tested an automated insulin delivery system (the Omnipod 5) in 130 hospitalized adults with type 1 or type 2 diabetes. Patients were randomly assigned to use the automated system or standard insulin injections plus a continuous glucose monitor. The goal was to see if t…

This study tested a mobile app called UrApp designed to help families manage childhood nephrotic syndrome, a chronic kidney disease. 58 caregivers of children with the condition were randomly assigned to use the app or receive standard care for one year. The goal was to see if th…

This study tested the drug Trikafta in 42 people with cystic fibrosis who have rare genetic mutations not currently approved for this treatment. Participants took Trikafta for about four weeks, and researchers measured lung function and sweat chloride levels. They also used skin …

This study tests a new radioactive tracer called [F-18]MHF to see if it can detect infections around knee implants using PET scans. Researchers will compare the tracer's uptake in infected versus non-infected implants in 18 adults. The goal is to improve diagnosis and reduce unne…

This completed study tested whether a special type of MRI called dynamic susceptibility contrast (DSC) perfusion MRI can accurately tell the difference between radiation-induced brain damage and tumor regrowth in people whose cancer has spread to the brain. Eight patients who had…

This study compared two types of heart scans—CT and PET—to see if CT can measure blood flow to the heart as accurately as PET, which is the current gold standard. Researchers enrolled 20 adults with suspected coronary artery disease. Each participant received both a CT scan and a…

This study tested a mobile app called WeTest-WeLink to help high-risk men in China test themselves for HIV and connect to care. 1,800 HIV-negative men who have sex with men used the app or received standard information. The goal was to see if the app increased HIV self-testing an…

This study tested whether giving pregnant women in India, Guatemala, Peru, and Rwanda a clean-burning liquefied petroleum gas (LPG) stove and free fuel for 18 months could improve health outcomes for their babies. Over 3,600 households participated, with half receiving the LPG st…

This study tested a smartphone app designed to help Black women in the southern U.S. learn about and access HIV prevention tools, like PrEP, and other sexual health resources. Fifty-six women used the app or received standard information. The goal was to see if the app was easy t…

This completed trial tested two school-based programs—Connect and CMCA—to prevent drug and alcohol misuse among 10th graders in rural Cherokee Nation high schools. Over 900 students from 20 schools participated, with some schools receiving the programs and others serving as contr…

This study tested a 12-week program called Health Homes/Healthy Families for people who called the 2-1-1 helpline. The program included coaching calls, text messages, and mailed materials to encourage healthy eating and prevent weight gain. A total of 512 adults aged 18 to 70 wit…

This study tested whether spraying insecticide on indoor walls (Targeted Indoor Residual Spraying) can prevent diseases spread by Aedes mosquitoes, like dengue, chikungunya, and Zika. Over 4,400 children aged 2 to 15 in Merida, Mexico took part. Researchers tracked how many got s…

This pilot study tested a word game-based workbook to help people with diabetes learn about managing their condition, focusing on diet and carbohydrate control. 25 participants used the workbook during clinic visits or at home, completing puzzles and goal-setting exercises. The s…

This study tested whether giving teens extra doses of the steroid dexamethasone after scoliosis surgery could reduce inflammation, pain, nausea, and hospital stay. Forty-two adolescents with scoliosis were randomly assigned to receive either one standard dose or three extra doses…

This study tested a phone-based system that helps people with heart failure monitor their symptoms and get coaching on how to manage them at home. 50 patients used the system after being discharged from the hospital. The goal was to see if the system could help patients better ca…

This study tested whether transcranial magnetic stimulation (TMS), a noninvasive treatment that uses magnetic fields to stimulate brain regions, can improve PTSD symptoms and related brain activity. Fifty adults with partial PTSD received either active TMS or a sham procedure ove…

This study tested an online education program called 'Caregiving While Black' to help Black American caregivers feel more confident and less stressed while caring for a family member or friend with dementia. About 140 caregivers took part. The program focused on building skills a…

This pilot study tested a 12-month lifestyle program (PRISEM) for 45 older adults with mild cognitive impairment. The program included group and individual activities focused on health education, nutrition, exercise, and stress management. The main goal was to see if the program …

This study tested whether partnered rhythmic dance is safe and helpful for people with early Alzheimer's disease. 76 participants were randomly assigned to either dance classes or a walking program for 12 months. The goal was to see if dance improves the ability to think and move…

This study tested whether having a personal pain coach helps people recover after orthopedic surgery for sports injuries. 148 patients worked with a Life Care Specialist either in person or by video to learn non-drug pain management skills like mindfulness. The goal was to improv…

This completed pilot study from Emory University tested whether a daily citicoline supplement could improve sleep quality, daytime sleepiness, and memory in 100 older adults with mild cognitive impairment (MCI). Participants took 1000 mg of citicoline for 3 months and completed s…

This study looked at how a steroid injection (triamcinolone acetonide) affects asthma symptoms in children aged 6 to 21 who have frequent flare-ups. 68 participants received the shot and were followed for 48 weeks. The main goal was to see if symptoms improved two weeks after the…

This study tested a program called I-STRONG, which combines mind and body training to help teenagers with sickle cell disease cope with pain. Researchers worked with 45 teens to see if the program was practical and well-liked. The goal was to reduce pain severity and improve dail…

This study tested whether a 6-week self-management workshop, called the Chronic Disease Self-Management Program, could improve health and reduce healthcare use in African American women with lupus. Nearly 700 women from the GOAL study took part. The program covers topics like dea…

This study tested a drug called telotristat ethyl in 23 people with advanced pancreatic cancer who had lost at least 10% of their body weight. The goal was to see if the drug could help them stabilize or gain weight by reducing bowel movements. Maintaining weight may help patient…

This pilot study tested whether a dietary supplement called citicoline could improve sleep and cognitive function in 20 people with Alzheimer's disease. Participants took either citicoline or a placebo for 3 months, and researchers measured sleep quality, daytime sleepiness, and …

This study tested whether spironolactone, a blood pressure medication, is safe for older African Americans with mild memory and thinking problems. Twenty-five participants took either the drug or a placebo daily for one year. The main goal was to check safety and tolerability, wi…

This study tested whether Botox injections could treat chronic leg pain in runners, a condition called chronic exertional compartment syndrome (CECS). Only 3 people took part, and they received Botox in specific leg muscles. The goal was to see if this could replace surgery, whic…

This study looked at whether taking zinc supplements can improve quality of life for people with advanced gastrointestinal cancers (like stomach, liver, or pancreatic cancer) who are receiving chemotherapy. Seventeen patients participated, and researchers measured their quality o…

This study tested whether a 6-day course of oral methylprednisolone (a steroid) after total knee replacement can reduce pain, nausea, and the need for opioid painkillers. 101 adults with knee arthritis were randomly assigned to receive either the steroid taper or standard care. T…

This study tested whether a painless brain stimulation technique called tDCS could help veterans suffering from chronic pain, PTSD, and depression. 38 veterans received tDCS sessions during an intensive outpatient program. Researchers measured changes in pain levels and mental he…

This study tested whether a battery-powered drill could make bone marrow biopsies less painful and produce better samples than the traditional manual needle. 100 patients with plasma cell disorders took part. Researchers measured pain levels and the quality of the biopsy sample.

This study tested five different low doses of sugammadex (a drug that reverses muscle relaxants) in 46 adults who still had muscle weakness after the standard reversal drug neostigmine. The goal was to see how quickly each dose restored normal muscle function. If a lower dose wor…

This completed study looked at 324 extremely low birth weight preterm infants (≤1250 grams) to see how anemia and red blood cell transfusions affect oxygen levels in their digestive tract. Researchers used a non-invasive device to measure tissue oxygen and collected blood, urine,…

This study looked at whether a partnered dance program (adapted tango) could improve inflammation, memory, and mood in African-American women who care for a family member with Alzheimer's disease. Fifty women between 45 and 65 years old took part. Researchers measured changes in …

This study tested a new way to help women with heart risks like high blood pressure or diabetes get better care after giving birth. Researchers interviewed new moms to understand what makes it hard to attend follow-up visits, then designed a coordinated care system. They tested i…

This study tested a program called SPIRIT that helps kidney dialysis patients and their families plan for end-of-life care. The program involved two face-to-face sessions to improve communication and decision-making. Researchers enrolled 852 patients and their surrogates from dia…

This study looked at how much doxycycline builds up in body tissues after taking it daily for 7 days. Researchers measured levels in rectal and vaginal tissues to help design better ways to prevent bacterial sexually transmitted infections (STIs). 24 healthy adults took part, inc…

This study looked at different types of stitches and stitching methods used to close cuts after hand, wrist, elbow, or shoulder surgery. The goal was to see if any specific stitch or technique leads to less pain and better wound healing. 160 adults having upper extremity surgery …

This study tested an online group program designed to help young Black men living with HIV feel more connected and improve their health. Researchers worked with a community board to adapt the program for online delivery, then tested it with 60 participants. The goal was to see if…

This study looked at whether a program to offer family planning to new mothers right after childbirth can work on a large scale in Rwanda. Over 42,000 women and healthcare workers took part. The goal was to see if training nurses and community health workers to provide counseling…

This study looked at why the live attenuated influenza vaccine (LAIV), given as a nasal spray, is less effective in adults than in children. Researchers measured antibody levels in 51 healthy adults after vaccination to understand the immune response. The goal is to use these ins…

This study tested whether a combination of therapist skin-to-skin care and a device that plays the mother's voice when the baby sucks on a pacifier could improve brain development in preterm infants. 248 babies born between 32 and 36 weeks gestation were enrolled. The goal was to…

This study tested a program called TEaM to improve how doctors and schools support children after a mild traumatic brain injury (concussion). The program included training for doctors and tools to help them communicate with schools and families. Researchers enrolled 101 children …

This study tested a sun safety program called Go Sun Smart Georgia (GSSG) for outdoor workers. 312 workers and managers from Georgia worksites took part. The program provided training and materials to encourage sun protection like sunscreen, hats, and shade. Researchers compared …

This study tested a computer program that sorts sepsis patients into four groups based on their vital signs in the first 8 hours. The goal was to see if these groups have different outcomes, which could help doctors choose the right treatments in the future. Over 1,900 adults too…

This study looked at ways to encourage COVID-19 testing and prevention habits among people with diabetes or at risk for it. About 290 participants in Georgia were split into two groups to compare the effects of a 16-week program. The goal was to see if the program increased testi…

This study tested how to best apply STAR particles—tiny particles covered with microneedles—to healthy skin. The goal was to find the right pressure and rubbing method to create small punctures that could help future topical medications work better. Twenty healthy adults took par…

This study tested a program called Keeping on Course for people with mild cognitive impairment (MCI) and their care partners. The program teaches communication skills to help them cope better together. 29 couples participated in the study, which measured how acceptable and useful…

This study tested a simple idea: give hospital doctors regular feedback showing how their antibiotic prescribing compares to their peers. Researchers provided educational sessions and bimonthly email reports to 147 hospitalists at four hospitals. The goal was to reduce unnecessar…

This study tested whether taking the statin drug atorvastatin changes the body's immune response to the flu vaccine. 63 adults took either a statin or a placebo for four weeks before and after getting the flu shot. Researchers measured antibody levels and checked for side effects…

This study tested two types of early help for infants who may develop autism. About 269 families with a baby at higher risk (because an older sibling has autism) took part. Some parents got a web-based guide to support their baby's social communication, and later, some received e…

This study looked at how fast treadmill walking, with or without a small electrical stimulation to the ankle muscles, helps people who have had a stroke walk better. Fifty-five participants who were at least six months past their stroke took part. The goal was to understand the b…

This study tested whether giving dialysis facilities regular reports on their performance could help reduce racial differences in who gets placed on the kidney transplant waiting list. Over 56,000 patients at about 750 dialysis centers across the U.S. took part. The goal was to s…

This study gave 239 healthy adults the yellow fever vaccine to learn how the immune system fights viral infections. Researchers measured the strength and quality of T cell responses over up to one year. The goal was to understand immune reactions, not to test the vaccine itself, …

This study tested whether a wearable eye-tracking device could help critically ill patients on breathing machines communicate. Thirty ICU patients tried the device, which lets them call for help or answer questions by moving their eyes. The goal was to see if it was safe, easy to…

This study tested a program called Caregiving While Black-LIVE, designed to help Black caregivers of people with dementia. The program includes online lessons and group sessions to teach skills like managing healthcare, home life, and self-care. Researchers measured whether it im…

This study gathered brain monitoring data from 162 patients with serious brain injuries, such as traumatic brain injury or stroke. Using a noninvasive ultrasound device, researchers recorded blood flow signals to build a database. The goal is to develop algorithms that could one …

This study tested how different doses of the antibiotic doxycycline reach tissues in the body. The goal is to combine it with HIV drugs into a single pill that could be taken just before sex to protect against both HIV and other sexually transmitted infections. 45 healthy adults …