Alzheimer's sleep breakthrough? tiny study tests citicoline

NCT ID NCT05200208

Completed Symptom relief Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether a dietary supplement called citicoline could improve sleep and cognitive function in 20 people with Alzheimer's disease. Participants took either citicoline or a placebo for 3 months, and researchers measured sleep quality, daytime sleepiness, and thinking skills. The goal was to see if this well-tolerated supplement might ease common sleep problems in Alzheimer's and potentially boost memory and attention.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: citicoline (dietary supplement)
What this could lead to: If it works, this could point toward a simple supplement to help Alzheimer's patients sleep better and think more clearly.
What could go wrong: This is a very small pilot study with only 20 people, so results may not apply to everyone. It's also too early to know if citicoline truly helps.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Parasomnias

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

Locations

Emory University School of Nursing

Atlanta, Georgia, 30322, United States
Goizueta Alzheimer's Disease Research Center

Atlanta, Georgia, 30329, United States

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