Vitamin d and malaria drug join forces against pancreatic cancer
NCT ID NCT04524702
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tested whether adding paricalcitol (a vitamin D drug) and hydroxychloroquine (an autophagy inhibitor) to standard chemotherapy could help shrink tumors in 10 people with advanced or metastatic pancreatic cancer. The goal was to see if the combination improved tumor response rates. Results are not yet widely available, but this small study may guide future research.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- paricalcitol (a form of vitamin D) and hydroxychloroquine (an autophagy inhibitor) added to gemcitabine and nab-paclitaxel chemotherapy
- What this could lead to
- If it works, this combination could improve tumor response in advanced pancreatic cancer, potentially leading to a new treatment option.
- What could go wrong
- This is a small, early-phase trial with only 10 participants, so results may not apply broadly. The added drugs could increase side effects without clear benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Emory Saint Joseph's Hosptial
Atlanta, Georgia, 30342, United States
-
Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a targeted antibody give pancreatic cancer chemo a boost?
- Can a Pan-RAS inhibitor outsmart pancreatic cancer?
- Can High-Dose vitamin c boost chemo against pancreatic cancer?
- Could a nerve zap stop cancer wasting? early trial tests device for cachexia
- New Antibody-Drug combo takes on Hard-to-Treat pancreatic cancer