Could diabetes pills replace insulin shots in hospitals?
NCT ID NCT04416269
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares continuing oral diabetes medications (like metformin) versus switching to insulin in hospitalized adults with type 2 diabetes. About 255 participants will be randomly assigned to either stay on their usual pills or receive insulin injections. The goal is to see if the pills can control blood sugar just as safely and effectively during a hospital stay.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
oral antidiabetic drugs (metformin, sulfonylureas, pioglitazone, DPP-4 inhibitors, SGLT2 inhibitors)
What this could lead to
If successful, this could show that many hospitalized patients with type 2 diabetes can safely keep taking their usual pills instead of switching to insulin, simplifying hospital diabetes care.
What could go wrong
This is a moderate-sized Phase 4 trial, so results may not apply to all patients. Oral drugs may not control blood sugar as tightly as insulin in some hospitalized patients, and there is a risk of hypoglycemia or other side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Emory University Hospital
Atlanta, Georgia, 30322, United States
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Emory University Hospital Midtown
Atlanta, Georgia, 30322, United States
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Grady Memorial Hospital
Atlanta, Georgia, 30322, United States